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Association of step counts with cognitive function in apparently healthy middle-aged and older Japanese men
Get PDFBackground:
Increasing physical activity may prevent cognitive decline. Previous studies primarily focused on older adults and used self-reported questionnaires to assess physical activity. We examined the relationship between step count, an objective measure of physical activity, and cognitive function in community-based middle-aged and older Japanese men.
Methods:
The Shiga Epidemiological Study of Subclinical Atherosclerosis randomly recruited community-dwelling healthy men aged 40-79 years from Shiga, Japan, and measured their step counts over 7 consecutive days using a pedometer at baseline (2006-2008). Among men who returned for follow-up (2009-2014), we assessed their cognitive function using the Cognitive Abilities Screening Instrument (CASI) score. We restricted our analyses to those with valid 7-day average step counts at baseline and those who remained free of stroke at follow-up (n = 676). Using analysis of covariance, we calculated the adjusted means of the CASI score according to the quartiles of the average step counts.
Results:
The mean (standard deviation) of age and unadjusted CASI score were 63.8 (9.1) years and 90.8 (5.8), respectively. The CASI score was elevated in higher quartiles of step counts (90.2, 90.4, 90.6, and 91.8 from the lowest to the highest quartile, respectively, [p for trend = 0.004]) in a model adjusted for age and education. Further adjustment for smoking, drinking, and other cardiovascular risk factors resulted in a similar pattern of association (p for trend = 0.005).
Conclusion:
In apparently healthy middle-aged and older Japanese men, a greater 7-day average step count at baseline was associated with significantly higher cognitive function score.journal articl
トヨサト ビョウイン ニ オケル キュウセイ チュウスイエン チリョウ ノ ゲンキョウ
Get PDF目的）当院の虫垂炎治療の現状を評価し課題を探ることを目的とした．
方法）2017年8月から2023年9月の間に44例の虫垂炎患者が入院治療を受けた．それら44症例の入院日数、合併症、手術時間、手術室滞在時間について後方視的に検討した．
結果）44例中28例に手術が施行された．保存的治療群と手術群との間に入院日数に有意差は認めず、膿瘍の有無によっても両治療群の入院日数に有意な差は認めなかった．糞石の有無は治療法の選択に影響を与えていなかった．単純性虫垂炎に対する開腹手術と腹腔鏡手術では、手術時間（開腹手術35分 v.s. 腹腔鏡手術 57分）と有意に腹腔鏡手術が長く、手術室滞在時間は脊椎麻酔下開腹手術（75分）に対して腹腔鏡手術（129分）とさらに差は開いた．両手術法の間で入院日数、術後合併症には有意な差は認めなかった．
結論）入院日数においては保存的治療と手術治療による優劣は認めなかったが、退院の基準を見直すことによって入院日数を短縮できる可能性がある．腹腔鏡手術を進めていくにあたっては手術時間と手術室滞在時間の短縮が課題であり、手術手技を見直すとともに麻酔医との連携を深めていく必要がある．Objectives: Aim is to evaluate the quality and efficacy of our treatment for acute appendicitis.
Methods: Between August 2017 and September 2023, 44 patients received hospital treatment for acute appendicitis. We retrospectively examined the length of stay, complications, operative time and staying time in the operative room.
Results: Twenty eight of 44 patients were underwent appendectomy. No significant difference between non operative management (NOM) group and surgical therapy (ST) group was detected in length of stay regardless of the intraabdominal abscess. The operative time was shorter in open appendectomy (OA 35 min) than laparoscopic appendectomy (LA 75 min). Staying time in the operating room is much longer in LA (129 min) than OA with spinal anesthesia (75 min).
Conclusions: The length of stay was equal in NOM and ST groups. There is a possibility of shortening the length of stay by rationalizing the standard for discharge. To improve the advantage of laparoscopic operation, we need to shorten the operative time and staying time in operating room in cooperation with anesthesiologist.departmental bulletin pape
Relationship Between Hemoglobin Concentration and Cardiovascular Disease Mortality in a 25-Year Follow-up Study of a Japanese General Population - NIPPON DATA90
Get PDF滋賀医科大学博士（医学）Circulation journal. 2024 Apr 25;88(5):742-750.令和6年度thesi
Characterization of KIF20B as a novel prognostic biomarker and therapeutic target for breast cancer
Get PDF滋賀医科大学博士（医学）International journal of oncology. 2024 Apr;64(4):43.令和6年度thesi
Nardilysin in vascular smooth muscle cells controls blood pressure via the regulation of calcium dynamics
Get PDF滋賀医科大学博士（医学）Biochemical and biophysical research communications. 2024 Jun 18:712-713令和6年度thesi
High blood pressure and colorectal cancer mortality in a 29-year follow-up of the Japanese general population: NIPPON DATA80
No full textOnco-hypertension has been proposed, although associations of high blood pressure (BP) with cancer risk remain inconsistent. We examined associations of high BP with risk of mortality from stomach, lung, colorectal, liver, and pancreatic cancers independent of possible confounders in an analysis that excluded deaths within the first 5 years of follow-up to consider the reverse causality. In a prospective cohort representative of the general Japanese population (1980-2009), we studied 8088 participants (mean age, 48.2 years; 56.0% women) without clinical cardiovascular disease or antihypertensive medication at baseline. Fine-Gray competing risks regression was used to estimate hazard ratios for 10 mmHg higher BP adjusted for confounders including smoking, alcohol-drinking, obesity, and diabetes mellitus. During 29-year follow-up, 159 (2.0%), 159 (2.0%), 89 (1.1%), 86 (1.1%), and 68 (0.8%) participants died from stomach, lung, colorectal, liver, and pancreatic cancers, respectively. We observed a positive association of high BP with risk of colorectal cancer mortality but not with mortality risks from any other cancers. The association with colorectal cancer mortality for systolic and diastolic BP was evident in those aged 30-49 years (hazard ratios 1.43 [95% confidence interval, 1.22-1.67] and 1.86 [1.32-2.62], respectively) but not in those aged 50-59 years and ≥60 years (P for age interaction <0.01 for systolic and diastolic BP). The associations with colorectal cancer mortality were similar in the analyses stratified by smoking, alcohol-drinking, obesity, and diabetic status. In conclusion, high BP among young to middle-aged adults was independently associated with risk of colorectal cancer mortality later in life.journal articl
Evaluation of adipogenesis over time using a novel bioabsorbable implant without the addition of exogenous cells or growth factors
Get PDFBackground:
Breast reconstruction is crucial for patients who have undergone mastectomy for breast cancer. Our bioabsorbable implants comprising an outer poly-l-lactic acid mesh and an inner component filled with collagen sponge promote and retain adipogenesis in vivo without the addition of exogenous cells or growth factors. In this study, we evaluated adipogenesis over time histologically and at the gene expression level using this implant in a rodent model.
Methods:
The implants were inserted in the inguinal and dorsal regions of the animals. At 1, 3, 6, and 12 months post-operation, the weight, volume, and histological assessment of all newly formed tissue were performed. We analyzed the formation of new adipose tissue using multiphoton microscopy and RNA sequencing.
Results:
Both in the inguinal and dorsal regions, adipose tissue began to form 1 month post-operation in the peripheral area. Angiogenesis into implants was observed until 3 months. At 6 months, microvessels matured and the amount of newly generated adipose tissue peaked and was uniformly distributed inside implants. The amount of newly generated adipose tissue decreased from 6 to 12 months but at 12 months, adipose tissue was equivalent to the native tissue histologically and in terms of gene expression.
Conclusions:
Our bioabsorbable implants could induce normal adipogenesis into the implants after subcutaneous implantation. Our implants can serve as a novel and safe material for breast reconstruction without requiring exogenous cells or growth factors.journal articl
Blunted tachycardia and cardiac sympathetic denervation in isolated rapid eye movement sleep behavior disorder
Get PDFBackground:
Isolated rapid eye movement sleep behavior disorder (iRBD) serves as a prodromal phase of Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Blunted tachycardia (BT) during postural changes indicates neurogenic orthostatic hypotension, a marker of autonomic dysfunction. We aimed to investigate whether BT is associated with cardiac sympathetic neurogenic denervation. Additionally, we conducted a preliminary short-term follow-up to examine the potential prognostic significance of BT regarding phenoconversion and mortality.
Methods:
Forty-three patients with iRBD at Shiga University of Medical Science Hospital underwent active standing tests to identify BT, defined by a specific ratio of decrease in systolic blood pressure to inadequate increase in heart rate after standing, and orthostatic hypotension. 123I-metaiodobenzylguanidine myocardial scintigraphy (123I-MIBG) and dopamine transporter single-photon emission computed tomography (DAT-SPECT) were performed. Participants were followed up for 3.4 ± 2.4 years for phenoconversion and 4.0 ± 2.3 years for mortality assessment, and the risk of events was analyzed using log-rank tests.
Results:
Among the 43 participants (mean age, 72.3 ± 7.9 years; 8 female), 17 met the BT criteria. We found no significant comorbidity-related differences in hypertension or diabetes between the BT(+) and BT(-) groups. Orthostatic hypotension was more prevalent in the BT(+) group than in the BT(-) group (47.1% vs 7.7%, p = 0.003). BT(+) patients were older with a lower early and delayed MIBG uptake; however, no significant differences were observed in DAT accumulation. Phenoconversion was observed in seven (41.2%) BT(+) and seven (26.9%) BT(-) patients. Three deaths were recorded in the BT(+) group (17.6%) and three in the BT(-) group (11.5%). No significant differences were observed in the risk of phenoconversion or mortality between the groups.
Conclusions:
We have identified the possibility that BT reflects cardiac sympathetic neurogenic denervation in patients with iRBD. Future research is needed to elucidate the potential prognostic value of BT.journal articl
Statins Use and Recurrent Venous Thromboembolism in the Direct Oral Anticoagulant Era: Insight From the COMMAND VTE Registry-2
Get PDF滋賀医科大学博士（医学）J Thromb Thrombolysis. 2024 Aug;57(6):907-917.
doi: 10.1007/s11239-024-03002-0. Epub 2024 May 18.令和6年度thesi