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Polysomnographic features prior to dream enactment behaviors in isolated rapid eye movement sleep behavior disorder
Get PDFObjective:
This study aimed to identify electroencephalogram correlates of dream enactment behaviors (DEBs) and elucidate their cortical dynamics in patients with isolated/idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD).
Methods:
This cross-sectional study included 15 patients with iRBD. Two REM sleep periods in routine polysomnography were compared: the 60 s preceding the DEBs ("pre-representative behavior" [preR]), and the 60 s with the least submental electromyogram activity ("background" [BG]). Six EEG frequency bands and electrooculogram were analyzed; power spectra, coherence and phase-locking values in four 15-s periods were examined to assess trends. These indices were also compared between preR and BG.
Results:
Compared with BG, significantly higher delta power in the F3 channel and gamma power in the F4 and O2 channels were observed during preR. For functional connectivity, the widespread beta-band connectivity was significantly increased during preR than BG.
Conclusion:
Before notable REM sleep behaviors, uneven distributed higher EEG spectral power in both very low and high frequencies, and increased wide-range beta band functional connectivity, were observed over 60 s, suggesting cortical correlates to subsequent DEBs.
Significance:
This study may shed light on the pathological mechanisms underlies RBD through the routine vPSG analysis, leading to detection of DEBs.journal articl
Relationships of Proton Pump Inhibitor-Induced Renal Injury with CYP2C19 Polymorphism: A Retrospective Cohort Study
Get PDF滋賀医科大学博士（医学）Clinical pharmacology and therapeutics. 2024 May;115(5):1141-1151.令和6年度thesi
Associations among plasma markers for N-methyl-d-aspartate receptor hypofunction, redox dysregulation, and insufficient myelination in patients with schizophrenia
Get PDFBackground:
Several hypotheses regarding the pathomechanisms of schizophrenia have been proposed. If schizophrenia is a unitary disease, then these pathological processes must be linked; however, if such links do not exist, schizophrenia may best be considered a group of disorders. Only a few studies have examined the relationships among these pathomechanisms. Herein, we examined the relationships among deficient myelination, NMDA receptor hypofunction, and metabolic dysregulation by measuring various plasma markers and examining their correlations.
Methods:
Plasma samples were collected from 90 patients with schizophrenia and 68 healthy controls. Concentrations of nardilysin (N-arginine dibasic convertase, NRDC), a positive regulator of myelination, the NMDA receptor co-agonist d-serine and glycine, various additional amino acids related to NMDA receptor transmission (glutamate, glutamine, and l-serine), and homocysteine (Hcy), were measured. Concentrations were compared using independent samples t-test or logistic regression, and associations were evaluated using Pearson's correlation coefficients.
Results:
Plasma glycine (t = 2.05, p = 0.042), l-serine (t = 2.25, p = 0.027), and homocysteine (t = 3.71, p < 0.001) concentrations were significantly higher in patients with schizophrenia compared to those in healthy controls. Logistic regression models using age, sex, smoking status, glutamine, glutamate, glycine, l-serine, d-serine, homocysteine, and NRDC as independent variables revealed significantly lower plasma d-serine (p = 0.024) and NRDC (p = 0.028), but significantly higher l-serine (p = 0.024) and homocysteine (p = 0.001) in patients with schizophrenia. Several unique correlations were found between NMDA receptor-related amino acids and NRDC in patients with schizophrenia compared to those in healthy controls, while no correlations were found between plasma homocysteine and other markers. No associations were found between plasma marker concentrations and disease status or cognitive function in patients with schizophrenia, except for a significant correlation between plasma glycine and full intelligence quotient.
Conclusion:
Reduced myelination and NMDA receptor hypofunction may be related to pathological mechanisms in schizophrenia, while homocysteine dysregulation appears to be an independent pathological process. These results suggest that schizophrenia may be a group of disorders with unique or partially overlapping etiologies.journal articl
Relationship Between Hemoglobin Concentration and Cardiovascular Disease Mortality in a 25-Year Follow-up Study of a Japanese General Population - NIPPON DATA90
Get PDFBackground:
Deviations of hemoglobin from normal levels may be a factor in cardiovascular disease (CVD) risk; however, conclusive evidence is lacking. In addition, preclinical conditions may influence hemoglobin concentrations, but studies focusing on reverse causation are limited. Thus, we examined the relationship between hemoglobin concentrations and CVD mortality risk, considering reverse causation.
Methods and results:
In a prospective cohort representative of the general Japanese population (1990-2015), we studied 7,217 individuals (mean age 52.3 years; 4,219 women) without clinical CVD at baseline. Participants were categorized into sex-specific hemoglobin quintiles (Q1-Q5) and data were analyzed using the Cox proportional hazards model adjusted for possible confounders. During a 25-year follow-up, 272 men and 334 women died from CVD. Adjusted hazard ratios for CVD mortality across sex-specific quintiles, using Q3 as the reference, were significantly higher for Q1 (1.40; 95% confidence interval [CI] 1.08-1.82) and Q5 (1.49; 95% CI 1.14-1.96), and remained significant after excluding deaths within the first 5 years of follow-up to consider reverse causation (1.35 [95% CI 1.02-1.79] and 1.45 [95% CI 1.09-1.94], respectively). A similar U-shaped association was seen between transferrin saturation levels and CVD mortality, but after excluding deaths within the first 5 years the association was significant only for Q1.
Conclusions:
Low and high hemoglobin concentrations were associated with an increased risk of CVD mortality.journal articl
カンゴガク OSCE ニオケル ヒョウカシャカン ノ イッチド ノ ケントウ : レイワ 4ネンド ジッシ ニヨル ヒョウカ カラ
Get PDF本論文の目的は、本学看護学科において令和4年度に実施された看護学OSCE (Objective Structured Clinical Examination；以下OSCEとする）の評価について、評価者間の一致度を分析することにより、今後の看護学OSCEの評価方法に関し検討することである。本学で実施している看護学OSCEの6領域6課題について、各課題につき2名の評価者間の一致度について分析した。看護学OSCE受験者59名について、受験者1名につき試験評価者2名が別々に評価したデータを対象とした。評価者間の一致度は、設定した6課題ごとの総スコアについては級内相関係数（intra-class correlation coefficients ; 以下ICCとする）を用いて検証した。6課題の総スコアにおけるICCは0.461-0.978と中程度の一致からほぼ完全な一致が認められた。また、各課題の評価項目を内容から「基本的コミュニケーション」、「看護技術（アセスメント）」、「看護技術（適切な実施）」、「応用的実践」の4カテゴリに分類し、カテゴリごとのスコアについて評価者間の一致度をκ係数により評価した。各課題におけるカテゴリ別のκは0.348-1.000と課題の内容による差異はあるものの軽度から高い一致が認められた。今後は、評価項目について評価の一致を検討しつつ、課題の特徴を捉え課題の組み合わせ等において可能な限り工夫や検討をする必要があると考えられた。departmental bulletin pape
Expression of proinflammatory cytokines and proinsulin by bone marrow-derived cells for fracture healing in long-term diabetic mice
Get PDF滋賀医科大学博士（医学）BMC Musculoskelet Disord. 2023 Jul 18;24(1):585.令和5年度thesi
Depletion of transit amplifying cells in the adult brain does not affect quiescent neural stem cell pool size
Get PDF滋賀医科大学博士（医学）Neural stem cells (NSCs) are maintained in the adult mammalian brain throughout the animal's lifespan. NSCs in the subependymal zone infrequently divide and generate transit amplifying cells, which are destined to become olfactory bulb neurons. When transit amplifying cells are depleted, they are replenished by the quiescent NSC pool. However, the cellular basis for this recovery process remains largely unknown. In this study, we traced NSCs and their progeny after transit amplifying cells were eliminated by intraventricular infusion of cytosine β-D-arabinofuranoside. We found that although the number of neurosphere-forming NSCs decreased shortly after the treatment, they were restored to normal levels 3 weeks after the cessation of treatment. More importantly, the depletion of transit amplifying cells did not induce a significant expansion of the NSC pool by symmetric divisions. Our data suggest that the size of the NSC pool is hardly affected by brain damage due to antimitotic drug treatment.令和5年度doctoral thesi
在宅療養資源としての訪問看護ステーションの地域差と非医療施設死亡との関連 : 人口10万人以上30万人未満の市区を単位としたエコロジカルスタディ
Get PDF滋賀医科大学修士（看護学）令和5年度thesi