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Regulation of Food Allergy via Microbiota
Food allergy is a pathological condition in which the immune system's tolerance of food antigens
is disordered. In peripheral tissues, regulatory T cells are an important T cell subset for inducing
immune tolerance to food allergens. The groups of commensal bacteria Clostridium cluster IV and
XIVa are identified as an inducer of regulatory T cells in the gut. It was also clarified that butyric
acid, one of metabolites from these bacteria, is an inducer of regulatory T cells. These findings
suggest that butyric acid produced by these bacteria is an important metabolite for regulation of gut
immune systems and food allergy. However, it was unclear what dietary nutrients are substrates for
fermentation of these bacteria in order to produce butyric acid.
In this paper, an outline is given of current findings for microbiota and metabolites, gut mucosal
immunity, dietary fibers and oligosaccharides, and the prebiotic effect of dietary fibers on the
regulation of allergy is reviewed
ブラック・マウンテン・カレッジにおけるジョン・ケージの2つのイベントをめぐって : 偶然性の音楽の発生に関する試論
福井大学教育地域科学部紀要(芸術体育学 音楽編) , 6, 201