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Differential chromatin loop and long-range gene regulation analyses in mouse brains using the WashU Epigenome Browser
No full textv, 16 p.Previous research of knockout gene experiments in mouse strains C57BL/6 (BLK6) and DBA/2J (DBA) has suggested that the genes Lsamp, Ptprd, and Nptx2, which code for neuronal proteins, are key determinants of behavioral differences in fear, anxiety, and pain responses. To further explore the underlying mechanisms behind these genes, tissue samples were sequenced and analyzed for conformational differences in chromatin packaging, captured in Hi-C data; transcriptomes, captured using RNA-seq; and chromatin conformations, recorded in ATAC-seq data. Using the EpigenomeBrowser from WashU St. Louis (WUSTL), we show that the molecular underpinnings of differential phenotypes and long-range gene regulation was not illuminated using this visualization technique, and that simultaneous visualization of multiple datatypes reflects the importance of promoter regions in gene regulation
Power, Influence, and Decision-Making: Emergency Department Healthcare Workers’ Responses to Pediatric Patients With Suicidal Ideation
No full text1 broadside. 48"W x 36"HHealthcare workers are in a unique position in that they can
both be oppressed and take part in the oppression. This
research focuses on the duality of healthcare workers treating
suicidal ideation in this space: how healthcare workers are
influenced by the systems that they work within, and how
they themselves influence the decision making while
considering their positionality. The results are parallel with
current discussion around limited resources in healthcare for
mental health emergencies and reflect the influences of
neoliberalism, biopolitics, and kyriarchy within medicine.Kalamazoo College. Department of Anthropology and Sociology and Human Development and Social Relations (HDSR). Hightower Symposium, 202
Effect of Temperature Variation on Endurance Swimming Capacity of Juvenile White Sturgeon (Acipenser transmontanus)
No full textiv, 33 p.White sturgeon (Acipenser transmontanus), a species within one of the most globally threatened taxa, are highly susceptible to changes in their environments due to unique life history traits. Specifically, juvenile white sturgeon are impacted by altered watershed dynamics caused by water diversion structures such as dams, weirs, irrigation ditches, or levees. One location of great concern is the Sacramento-San Joaquin (S-SJ) watershed where decades of water diversion has brought on great changes to the temperature, flow, and management of the area. This study looks to primarily identify the impact of water temperature on the endurance swimming capacity of juvenile white sturgeon, at different water velocities. Juvenile white sturgeon were exposed to differing water temperatures and speeds, to identify a relationship to endurance swimming capacity. Juveniles swam for longer periods of time at warmer temperatures, as there was a statistically significant decrease in time to fatigue after 35 cm s-1 for fish reared at 18°C and 13°C and for fish at 23°C, a statistically significant decrease in time to fatigue after 42 cm s-1 . These results indicate that in the wild, altered water temperatures may greatly impact swimming dynamics. However, regardless of temperature, water velocities greater than 49 cm s-1 are more likely to increase the risk of mortality of juvenile white sturgeon. Future research must work to design and modify these diversion structures in order to decrease juvenile mortality and conserve wild population
Towards the Synthesis and Characterization of Mn(II) Polypyridyl Complexes for Photochemical Applications
No full textvi,18 p.Coordination complexes of transition metals that have long-lived charge-separated excited states have many photochemical applications such as solar energy conversion and photoredox catalysis. The traditionally used transition metals are in the second- and third-row, including Ir(III), Ru(II), and Re(I), which are both expensive and scarce. For this reason, researchers have attempted to find are developing photoactive complexes with alternative other transition metals. For this project, manganese was chosen as the metal-of-focus as it is cheap, relatively non-toxic, and has a wide range of oxidation states. Our goal is to prepare photoactive manganese complexes: In particular, Mn(II) is air-stable, making it a convenient starting point for research. In this work, we describe the synthesis of tridentate polypyridyl ligands N,N’-dimethyl-N,N’-dipyridin-2-ylpyridine-2,6-diamine (ddpd) and di-2,6-(2-pyridylcarbonyl)pyridine (dcpp). The synthesis of their corresponding Mn(II) complexes was then attempted but resulted in the protonation of the ligands without any coordination occurring
The Life of William Morris: A Desire to Create Beautiful Things
No full text5 p.This exhibit highlights the work of William Morris, founder of the Kelmscott Press, including his decorative designs for wallpaper, textiles, and books. It also delves into his socialist beliefs. Items on display include fabric and wallpaper samples as well as The Works of Geoffrey Chaucer; Monopoly, or How Labour is Robbed; Alfred Tennyson's Maud, A Monodrama; and a correspondence from A.M. Todd
Exploring Strategies for Enhancing Electronic Health Records and Reducing Disparities in Healthcare Delivery
No full textv, 24 p.As my experience for my Senior Integrated Project (SIP), I completed an internship at the Colorado Institute in Biostatistics (CoSIBS) in Denver, Colorado, during the summer of 2022. I was part of a selective cohort of undergraduate and graduate students participating in an intensive seven-week program sponsored by the National Heart Lung and Blood Institute (NHLBI). I worked with a team of students to employ supervised machine learning and a variety of statistical methods to complete a research project evaluating electronic health records (EHRs). We focused on person-centered narratives in EHRs with the goal of identifying how implementing personal narratives for patients with life-limiting illnesses can affect the overall patient experience to improve psychological, emotional and general well-being. From the research, I learned that EHRs have the potential to greatly improve the efficiency and quality of healthcare delivery but their implementation has also resulted in disparities in access and outcomes for some patient populations. A literature review was conducted to explore strategies for enhancing EHRs and reducing these disparities. The review identified several key themes, including the importance of user-centered design, the need for training and support for healthcare professionals, and the role of interoperability in improving EHRs. Additionally, the review found that addressing social determinants of health and engaging patients in their own care can be effective in reducing disparities. Overall, the review suggests that a multifaceted approach is necessary to fully realize the benefits of EHRs while also addressing disparities in healthcare
Cardiovascular Disease : a review of treatment efficacy and disease complications
No full textii, 22 p.Cardiovascular disease is responsible for the leading cause of death globally (Mc Namara et al., 2019). Cardiovascular disease encapsulates several conditions, which are all responsible for often unbearable symptoms and reactions experienced by cardiology patients. Although mortality and the morbidity rate of the disease are extremely high, recent studies show decline in mortality rates and stability in survival rates of patients with cardiovascular disease (Amini et al., 2021). Several effective treatments for conditions for atrial fibrillation have been made possible, through medicinal treatment plans that include anticoagulants and β-blockers (Nielsen et al., 2016; Kim et al., 2022). Additionally, innovative techniques, such as stem cell therapy have proven to be effective in managing coronary heart disease (Kastrup, 2010). This review will focus on the importance of cardiovascular disease management through a variety of medical treatments and strategies, as well as an assessment of the effectiveness and limitations of these treatments, finally, possible future directions or suggestions for limitations will be proposed throughout the review, towards the overall management of cardiovascular disease
”Illegality” and Bordering Politics surrounding Latinx Migrants: Through a Legal Lens
No full text1 broadside. 48"W x 36"HThis paper argues that “fear" or assumed danger
regarding the Latinx body, is present due to how borders
transfer on to the body, rather than how the border is
embodied further discussed by author Paloma Villegas,
and the ultimate confines of the state's mobility of white
supremacy through law. This also brings about concepts
of who has the right to live a meaningful life, and even
who has the right to simply live.
Then emerges the concept of hope for a borderless
future. Author Mary Romero argued in 2008 that
currently through popular discourse, members of society
have learned to police one another; this system of
policing, if reversed, offers opportunity for change. I n
2020, author Huertas argued that there is power in
viewing the migrant as a political actor, who can act on
behalf of society towards the premise of a borderless
world.Kalamazoo College. Department of Anthropology and Sociology and Human Development and Social Relations (HDSR). Hightower Symposium, 202
Habermas’ Critical Social Theory and the Evolution of Money
No full text30 p.Money plays a terrifyingly dominant role in our lives. In one way or another, it is interrelated with almost every aspect of modern society and because of this prevalence, it is difficult to imagine a world without it. This system works as a store of value, a medium of exchange, and a unit of account. Money functions as a store of value in that we can put it in our bank account and expect that it will be worth relatively the same amount tomorrow. It functions as a medium of exchange through how we can exchange it for goods and services. Finally, it functions as a unit of account through the way we can say things like “that pack of gum is worth $2.” We can assign a value to any good or service by using a currency as the unit with which we assign value. This system and the way in which we use it has evolved over time as our economy and system of governance has developed. The sociologist and philosopher Jurgen Habermas, through his critical social theory, provides powerful concepts that can be used to analyze the development of this system. Habermas seeks to understand how our systems are created and how they affect the way in which these systems can help or hinder communication. Through his epistemic dualism exploring the interplay between systems and lifeworld, Habermas creates a critical social theory which reconciles Hegelian idealism and Marxist materialism
Design and Synthesis of 2-Methyl Tryptamine-Maleimide Hybrids as a Potential Antitubercular Agents
No full textviii, 19 p.Over 2.8 million antibiotic-resistant infections occur every year in the United States. Of these infections, drug-resistant tuberculosis is of particular concern, especially for multi-drug resistant strains. Hybridization is a novel way to synthesize antibacterial drugs with unique mechanisms of action. 2-Methyl tryptamine and 3,4-diaryl maleimide structures were selected for hybridization based on previous research demonstrating their biological activity against tuberculosis. In this study, an optimized route was found to effectively synthesize pure 2-methyl tryptamine by modifying procedures from published literature. The reaction time and rate of addition of 5-chloro-2-pentanone were manipulated to produce a pure 2-methyl tryptamine to be used for hybridization. 3,4-diaryl maleimide structures were synthesized based on previous research in the lab. With the synthesis of each component, 8 maleimide-2-methyl tryptamine hybrids were successfully synthesized (52-122% yield) and 4 were purified (21-47% yield)