98 research outputs found
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Colesteatoma : hallazgos clínicos y diagnóstico / Ángel María Hernández Guerra [y] María Resa Collado.
No full textEn Consulta de Difusión Veterinaria. Castellón de la Plana (Castellón, España) : Consulta de Difusión. Vol. 26, n. 251 (jun. 2018), pp. 39-43. ISSN 1135-0598.Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.consultavet.org/articulo-colesteatoma-hallazgos-clinicos-y-diagnostico-139
New drugs and therapeutic-diagnostic targets for fungal and parasitic diseases. Part II / M. Auxiliadora Dea-Ayuela and Dolores R. Serrano.
No full textEste artículo se encuentra disponible en la página web de la revista en la siguiente URL: http://www.eurekaselect.com/167132/articleEste es el post-print del siguiente artículo: Dea Ayuela, MA. and Serrano López, DR. (2018). New drugs and therapeutic-diagnostic targets for fungal and parasitic diseases. Part II. Current Topics in Medicinal Chemistry, vol. 18, n. 16, p. 1357, que se ha publicado de forma definitiva en https://doi.org/10.2174/156802661816181107142130This is the peer reviewed version of the following article: Dea Ayuela, MA. and Serrano López, DR. (2018). New drugs and therapeutic-diagnostic targets for fungal and parasitic diseases. Part II. Current Topics in Medicinal Chemistry, vol. 18, n. 16, p. 1357, which has been published in final form at https://doi.org/10.2174/156802661816181107142130
Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating / Dolores R. Serrano ... [et al.].
No full textEn European Journal of Pharmaceutics and Biopharmaceutics. Amsterdam (Países Bajos) : Elsevier. Vol. 124 (march 2018), pp. 13-27. ISSN 0939-6411. e-ISSN 1873-3441.Este artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.sciencedirect.com/science/article/abs/pii/S0939641117310639En este artículo también participan los siguientes autores: Carolina Galiana, Maria Auxiliadora Dea- Ayuela y Anne Marie Healy.This is the pre-peer reviewed version of the following article: Serrano López, DR., Walsh, D., O'Connell, P., Mugheirbi, NA., Worku, ZA., Bolas Fernández, F. et al. (2018). Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating. European Journal of Pharmaceutics and Biopharmaceutics, vol. 124 (march), pp. 13-27, which has been published in final form at https://doi.org/10.1016/j.ejpb.2017.11.015.Este es el pre-print del siguiente artículo: Serrano López, DR., Walsh, D., O'Connell, P., Mugheirbi, NA., Worku, ZA., Bolas Fernández, F. et al. (2018). Optimising the in vitro and in vivo performance of oral cocrystal formulations via spray coating. European Journal of Pharmaceutics and Biopharmaceutics, vol. 124 (march), pp. 13-27, que se ha publicado de forma definitiva en https://doi.org/10.1016/j.ejpb.2017.11.015Engineering of pharmaceutical cocrystals is an advantageous alternative to salt formation for improving the aqueous solubility of hydrophobic drugs. Although, spray drying is a well-established scale-up technique in the production of cocrystals, several issues can arise such as sublimation or stickiness due to low glass transition temperatures of some organic molecules, making the process very challenging. Even though, fluidised bed spray coating has been successfully employed in the production of amorphous drug-coated particles, to the best of our knowledge, it has never been employed in the production of cocrystals. The feasibility of this technique was proven using three model cocrystals: sulfadimidine (SDM)/4-aminosalicylic acid (4ASA), sulfadimidine/nicotinic acid (NA) and ibuprofen (IBU)/ nicotinamide (NAM). Design of experiments were performed to understand the critical formulation and process parameters that determine the formation of either cocrystal or coamorphous systems for SDM/4ASA. The amount and type of binder played a key role in the overall solid state and in vitro performance characteristics of the cocrystals. The optimal balance between high loading efficiencies and high degree of crystallinity was achieved only when a binder: cocrystal weight ratio of 5:95 or 10:90 was used. The cocrystal coated beads showed an improved in vitro-in vivo performance characterised by: (i) no tendency to aggregate in aqueous media compared to spray dried formulations, (ii) enhanced in vitro activity (1.8-fold greater) against S. aureus, (iii) larger oral absorption and bioavailability (2.2-fold higher Cmax), (iv) greater flow properties and (v) improved chemical stability than cocrystals produced by other methods derived from the morphology and solid nature of the starter cores.Esta artículo ha recibido apoyo económico de la Science Foundation Ireland bajo la siguiente referencia SFI/12/RC/2275
Effects of unstable shoes on trunk muscle activity in patients with chronic low back pain / Pablo Salvador Coloma ... [et al.].
No full textEste artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.sciencedirect.com/science/article/abs/pii/S0966636218307252?via%3DihubEn este artículo científico también participan los siguientes autores: María Dolores Arguisuelas, Julio Doménech-Fernández, Daniel Sánchez-Zuriaga, Juan José Amer-Cuenca, Javier Martínez-Gramage, Francisco Javier Montañez-Aguilera y Juan Francisco Lisón.Este es el pre-print del siguiente artículo: Salvador Coloma, P., Arguisuelas, MD., Doménech-Fernández, J., Sánchez-Zuriaga, D., Amer-Cuenca, JJ., Martínez-Gramage, J. et al. (2018). Effects of unstable shoes on trunk muscle activity in patients with chronic low back pain. Gait and Posture, vol. 64 (jul.) pp. 165-168, que se ha publicado de forma definitiva en https://doi.org/10.1016/j.gaitpost.2018.06.025This is the pre-peer reviewed version of the following article: Salvador Coloma, P., Arguisuelas, MD., Doménech-Fernández, J., Sánchez-Zuriaga, D., Amer-Cuenca, JJ., Martínez-Gramage, J. et al. (2018). Effects of unstable shoes on trunk muscle activity in patients with chronic low back pain. Gait and Posture, vol. 64 (jul.) pp. 165-168, which has been published in final form at https://doi.org/10.1016/j.gaitpost.2018.06.025Unstable shoe was developed as a walking device to strengthen the lower extremity muscles and reduce joint loading. A large number of studies have reported in asymptomatic adults increased electromyography (EMG) activity throughout the gait cycle in most of the lower limb muscles. However, no previous studies have explored the effects of wearing unstable shoes on trunk muscle activity in patients with chronic low back pain (CLBP). Therefore, the aim of the present study was to compare trunk muscle activity during gait using an unstable shoe and a conventional flat control shoe
in patients with CLBP. Thirty-five CLBP patients (51.1±12.4 yrs.; 26±3.8 kg/m2; 9.3±5.2 Roland Morris Disability Questionnaire score) were recruited from the Orthopedic Surgery Service at the Hospital to participate in this cross-sectional study. All participants underwent gait analysis by simultaneously collecting surface electromyography (EMG) data from
erector spinae (ES), rectus abdominis (RA), obliquus internus (OI) and obliquus externus (OE) muscles, while walking on a treadmill with flat control shoes and experimental unstable shoes. The results showed significantly higher %EMG activity in ES (mean difference: 1.8%; 95% confidence interval [CI] 1.3 to 2.2), RA (mean difference: 1.5%; 95% CI 0.3 to 2.7), and OI (mean difference: 1.5%; 95% CI 0.2 to 2.8) in the unstable shoes condition
compared to the flat shoes condition. Based on these findings, the use of unstable shoes may have potential implications in promoting spine stability, particularly in improving neuromuscular control of trunk muscles in CLBP treatment.Este trabajo ha sido financiado por la Universidad CEU Cardenal Herrera (INDI 16/35) y el Instituto de Salud Carlos III, España (PI12/02710).UCH. Financiación Nacional / UCH. Financiación UniversidadPreprin
Orally bioavailable and effective Buparvaquone lipid-based nanomedicines for visceral leishmaniasis / Lindsay Smith ... [et al.].
No full textEste artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://pubs.acs.org/doi/10.1021/acs.molpharmaceut.8b00097This is the pre-peer reviewed version of the following article: Smith, L., Serrano, DR., Mauger, M., Bolás-Fernández, F., Dea-Ayuela, MA. & Lalatsa, A. (2018). Orally bioavailable and effective Buparvaquone lipid-based nanomedicines for visceral leishmaniasis. Molecular Pharmaceutics, vol. 15, n. 7 (15 may), pp. 2570-2583, which has been published in final form at https://doi.org/10.1021/acs.molpharmaceut.8b00097.Este es el pre-print del siguiente artículo: Smith, L., Serrano, DR., Mauger, M., Bolás-Fernández, F., Dea-Ayuela, MA. & Lalatsa, A. (2018). Orally bioavailable and effective Buparvaquone lipid-based nanomedicines for visceral leishmaniasis. Molecular Pharmaceutics, vol. 15, n. 7 (15 may), pp. 2570-2583, que se ha publicado de forma definitiva en https://doi.org/10.1021/acs.molpharmaceut.8b00097.Nano-enabled lipid based drug delivery systems offer a platform to overcome challenges encountered with current failed leads in the treatment of parasitic and infectious diseases. When prepared with FDA or EMA approved excipients, they can be readily translated without the need for further toxicological studies, while they remain affordable and amenable to scale-up. Buparvaquone (BPQ), a hydroxynapthoquinone with in vitro activity in the nanomolar range, failed to clinically translate as a viable treatment for visceral leishmaniasis due to its poor oral bioavailability limited by its poor aqueous solubility (BCS Class II drug). Here we describe a self-nanoemulsifying system (SNEDDS) with high loading and thermal
stability up to 6 months in tropical conditions able to enhance the solubilisation capacity of BPQ in gastrointestinal media as demonstrated by flow-through cell and dynamic in vitro lipolysis studies. BPQ SNEDDS demonstrated an enhanced oral bioavailbility compared to aqueous BPQ dispersions (probe – sonicated) resulting in an increased plasma AUC0-24 by 55% that is four fold higher than any previous reported values for BPQ formulations. BPQ SNEDDS can be adsorbed on low molecular glycol chitosan polymers forming solid dispersions that when compressed
into tablets allow the complete dissolution of BPQ in gastrointestinal media. BPQ SNEDDS and BPQ solid SNEDDS demonstrated potent in vitro efficacy in the nanomolar range (<37 nM) and were able to near completely inhibit parasite replication in the spleen and 48 ± 48 and 56 ± 23% inhibition of the parasite replication in the liver respectively compared to oral miltefosine after daily administration over 10 days. The proposed platform technology can be used to elicit a range of cost-effective and orally bioavailable non-invasive formulations for a range of antiparasitic and infectious disease drugs that are needed for closing the global health innovation gap
Document of recommendations of the SEA 2018 : lifestyle in cardiovascular prevention
No full textEste artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.sciencedirect.com/science/article/pii/S0214916818300834?via%3DihubEl estilo de vida es un concepto complejo que incluye los aspectos externos a nosotros mismos que pueden modular e influir en nuestra salud. Los conocimientos sobre la relación entre el estilo de vida y el riesgo cardiovascular están lejos de proporcionar los niveles de evidencia que se han conseguido con los ensayos clínicos con fármacos, debido a que los estudios son escasos, fundamentalmente de tipo observacional y en grandes cohortes, con la dificultad añnadida de la no existencia de métodos seguros para conocer con precisión la ingesta diaria o lo largo de tiempo, así como la dificultad en la recogida de datos y en la medición de la adherencia debido a diferencias en la composición de los alimentos en distintas épocas y a la conducta alimentaria cambiante que posee el ser humano a lo largo del tiempo. En este documento nos hemos propuesto llevar a cabo una revisión actualizada y jerarquizada en base a las evidencias actuales, prestando atención a tres aspectos que tienen gran importancia patogénica y que podemos modificar directamente: la actividad física, el consumo de tabaco y el patrón de alimentación. Con ello pretendemos actualizar los nuevos conocimientos sobre su relación con el riesgo cardiovascular aportando evidencias útiles, constituyendo una herramienta sencilla dirigida especialmente a todos los profesionales de la salud implicados en el cuidado de personas con riesgo cardiovascular para trasladarlos a la práctica clínica, definiendo unas líneas de actuación sencillas y fáciles para ser transmitidas a las personas que reciban un consejo para la prevención primaria y secundaria de las enfermedades cardiovasculares. / Lifestyle is a complex concept that includes aspects external to ourselves that can modulate and influence our health. The knowledge of the relationship between lifestyle and cardiovascular risk does not attain the level of evidence achieved with clinical trials with drugs, because clinical studies are scarce and mainly of observational nature, albeit based on large cohorts. Nutritional epidemiology has the added difficulty of being based mostly on subjective dietary recall methods to ascertain nutrient and food intake over time, with the additional
problems of incomplete data collection, variable measurements of adherence due to seasonal and geographical differences in food composition, and the changing eating behavior that human beings have over time. The purpose of this document is to carry out an updated and hierarchical review of the relationship between lifestyle and cardiovascular disease based on current evidence, paying attention to three aspects that are of great pathogenic importance and are directly modifiable: physical activity, tobacco consumption, and diet. With this, we intend to update the knowledge on this relationship, construct evidence-based recommendations, and provide a simple tool for clinical practice especially directed to health professionals involved in the care of people at cardiovascular risk, defining simple and easy strategies for individuals who receive advice for the primary and secondary prevention of cardiovascular diseases
Influenza vaccine effectiveness in preventing hospitalisation of individuals 60 years of age and over with laboratory-confirmed influenza, Valencia Region, Spain, influenza season 2016-17 / Ainara Mira Iglesias ... et al.
No full textEste artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2018.23.8.17-00318Introduction: Seasonal influenza vaccination is widely recommended for people with risk factors, especially for people who are elderly. However, influenza vaccine effectiveness (IVE) varies year after year because of the variable antigenic composition of the circulating
viruses and the vaccine composition. Methods: We summarise the results of IVE and the impact of previous vaccination among subjects 60 years of age and over in a multicentre prospective study in the Valencia Hospital Surveillance Network for the Study of Influenza and Respiratory Viruses Disease (VAHNSI) in Spain. We applied the test-negative design taking
laboratory-confirmed influenza as outcome and vaccination status as exposure. Information about potential confounders was obtained from clinical registries or directly from patients. Results: Adjusted IVE was 19% (95% confidence interval (CI): −15 to 43). For patients
vaccinated in the current season but not in the two previous seasons, effectiveness was 49% (95% CI: −20 to 78) and for patients vaccinated in the current and any of two previous seasons, effectiveness was 29% (95% CI: −3 to 52). For those patients not vaccinated in the current season but vaccinated in any of the two previous seasons, effectiveness was 53% (95% CI: 8 to 76). Conclusions: Our data show a low vaccine effectiveness for the 2016/17 influenza season
Cemental tear : to know what we have neglected in dental practice / Po-Yuan Jeng ... et al.
No full textEste artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.sciencedirect.com/science/article/pii/S0929664617306046?via%3DihubCemental tear is a special kind of root surface fracture, contributing to periodontal and periapical breakdown. However, it is a challenge for doctors to diagnose, resulting in delayed or improper treatment. We reviewed the predisposing factors, location, radiographic/clinical characteristics, diagnosis and treatments of cemental tears. From the literature, patients with
cemental tear were mainly males, over 60 year-old. Possible predisposing factors include gender, age, tooth type, traumatic occlusal force and vital teeth. Cemental tears were common in upper and lower anterior teeth, single or multiple, and can be present in cervical, middle and apical third of roots. Morphology of cemental tears can be either piece-shaped or U-shaped.
Clinically, cemental tear shows a unitary periodontal pocket and signs/symptoms mimicking localized periodontitis, apical periodontitis and vertical root fractures. Treatment of cemental tears include scaling, root planning, root canal treatment, periodontal/periapical surgery,
guided tissue regeneration, bone grafting, and intentional replantation. Recurrence of cemental tear is possible especially when the fracture involves root apex. Extraction is recommended for teeth with poor prognosis. In conclusion, cemental tears can involve both periodontal and periapical area. Dentists should understand the predisposing factors and clinical features of cemental tears for early diagnosis/treatment to prevent bone loss/tooth extraction
Effects of polyacrylic acid pre-treatment on bonded-dentine interfaces created with a modern bioactive resin-modified glass ionomer cement and subjected to cycling mechanical stress / Salvatore Sauro ... et al.
No full textEste artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.mdpi.com/1996-1944/11/10/188
Valores de actividad física en niños de dos a siete años, medidos mediante actimetría durante cinco días consecutivos las 24 horas diarias
No full textEste artículo se encuentra disponible en la página web de la revista en la siguiente URL: https://www.nutricionhospitalaria.org/articles/01403/show#!Introduction: interpretation of accelerometer-derived physical activity in preschool children is confounded by differences in cut-off points.
Aim: the purpose of this study was to analyze physical activity in 2-to-7-year-old children to establish reference values for daily activity.
Methods: observational study in children aged 2-7 years, without chronic diseases and whose parents provided informed consent. The main
variable was physical activity, measured continuously over 120 hours (three workdays and two weekend days) by accelerometer. Secondary
variables were weight status (body mass index [BMI] Z-score) and gender. The relationship between the main variable and secondary variables
was determined through the t-test, ANOVA and the Pearson correlation coefficient. A multivariate model was used to obtain the standard deviation
(SD) of all possible combinations of values, constructing percentiles of normality (x ± SD and x ± 2·SD).
Results: one hundred and thirty-six children (35% of municipality children) were included in the study (54.4% of them were girls). Their weight
status distribution was: 25 underweight (18.4%), 54 normal weight (39.7%), 12 risk of overweight (8.8%), 22 overweight (16.2%) and 23 obese
(16.8%). The median age was 5.7 years and the mean physical activity was 592 counts/minute. The boys undertook more physical activity (p =
0.031) and the underweight and normal-weight children undertook more physical activity than the overweight and obese children (p = 0.012).
There were no significant differences according to age. The multivariate analysis showed significant differences (p < 0.001) according to gender
and weight status. In boys, physical activity decreased as weight status increased. In contrast, the girls in the extreme BMI groups obtained
higher levels of physical activity.
Conclusion: overweight and obese preschool children had lower levels of physical activity than normal weight children. Physical activity levels
were higher in boys. / Introducción: la interpretación de la actividad física medida mediante actimetría en preescolares es confusa debido a los diferentes puntos
de corte.
Objetivo: el objetivo de este estudio fue analizar la actividad física en niños de dos a siete años para establecer valores de actividad física diaria.
Método: estudio observacional en niños de dos a siete años, sin enfermedades crónicas y cuyos padres hubieran firmado el consentimiento
informado. La variable principal fue la actividad física, medida durante 120 horas ininterrumpidas (tres días laborables y dos días festivos)
mediante actímetros. Las variables secundarias fueron el estado de peso (puntaje z de índice de masa corporal [IMC]) y el sexo. La relación
entre la variable principal y las variables secundarias fue determinada mediante el test-t, ANOVA y el coeficiente de correlación de Pearson. Se
utilizó un modelo multivariable para obtener estándares de desviación en todas las posibles combinaciones de valores, construyendo percentiles
de normalidad (x ± DE y x ± 2·DE).
Resultados: participaron en el estudio 136 niños (35% de los niños del municipio); el 54,4% fueron chicas. La distribución de estado de peso
fue: 25 niños con bajo peso (18,4%), 54 normopeso (39,7%), 12 en riesgo de sobrepeso (8,8%), 22 con sobrepeso (16,2%) y 23 con obesidad
(16,8%). La media de edad fue 5,7 años y de actividad física, 592 cuentas/minuto. Los chicos realizaron mayor actividad física (p = 0,031) y
los niños con bajo peso y normopeso realizaron mayor actividad física que los niños con sobrepeso y obesidad (p = 0,012). No hubo diferencias
significativas respecto a la edad. El análisis multivariable mostró diferencias significativas (p < 0,001) respecto al sexo y el estado de peso. En
los niños, la actividad física decreció cuando aumentó el peso. Por el contrario, las niñas en grupos de IMC extremos obtuvieron mayores niveles
de actividad física.
Conclusión: los preescolares en situación de sobrepeso y obesidad presentaron niveles menores de actividad física que los niños normopeso.
Los niveles de actividad física fueron mayores en los chicos