Varna Medical University Press: Journals
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Elucidation Of Hub Genes And Pathways Associated With Gut Microbiome Dysbiosis And Mild Cognitive Impairment
Get PDFBidirectional communication route of brain and gut, gut-brain axis, was suggested to contribute to mild cognitive impairment (MCI) through inflammatory bowel disease (IBD) as gut microbiome dysbiosis occurs. Therefore, this study aimed to predict the gene signatures, and the potential molecular network associated between gut microbiome dysbiosis and MCI. To initiate the study, datasets (GSE13367, GSE140829, GSE36701 and GSE63063) were extracted from Gene Expression Omnibus (GEO) and the differentially expressed genes (DEGs) were selected based on the Log2 fold change >1.0 with p-value < 0.05 for both MCI and IBD. The shared DEGs between MCI and IBD were identified, and inputted into Database for Annotation, Visualization and Integrated Discovery database (DAVID) to perform gene ontology (GO) for functional enrichment analysis. The functional pathways were selected based on p<0.05 and FDR <0.05. The GeneMANIA was used to construct the protein-protein interaction (PPI) network. This study identified 1061 common shared DEGs between MCI and IBD. Based on the GO enrichment study, majority of the genes were involved in protein binding for molecular function, signal transduction biological process and cytosol for cellular component. The co-expression network showed that leukocyte cell-cell adhesion and Type 1 interferon function might contribute to IBD and MCI. Further elucidation studies on DEGs showed that leukocyte cell-cell adhesion signaling pathway would be the main pathogenesis pathway leading to both diseases, in which 8 genes involved were CD3E, PTPRC, GRAP2, CD86, VAV1, SEMA4D, FYN and LYN. Thus, further studies especially in the perspective of neuroinflammation is worth to be explored
Management Of The Epidemic Process Of Scarlet Fever By Raising Awareness Among Parents Of Children In Kindergartens
Get PDFOpportunities for applying AI in big cities
Get PDFThe urban population is constantly growing, with migration towards the big cities. As the population increases, the problems of big cities deepen - traffic, crime, pollution. As a result of the search for solutions to the problems, the concept of smart cities arose. The goal is to make life in cities more comfortable, healthy and peaceful. To achieve these goals is based on artificial intelligence (AI) technologies such as machine learning, video image processing and neural networks. Thanks to them, many tasks related to planning, monitoring and management can be solved. The problems of cities range from solving household issues to managing infrastructures. The smart city offers some solutions in the field of traffic, environment, waste management, energy provision, intelligent transport, planning, etc. The aim of the paper is to examine the possible applications of the smart city and present a conceptual model
Ready for self-service checkout areas?
Get PDFRetailers today have a wide arsenal of technology solutions at their disposal to help them deliver a rich customer experience before, during and after the costumer sales journey. Technological solutions for self-fulfillment of commercial operations in self-service checkout areas are a well-known tool that is gaining popularity due to strategic decisions to optimize company labor costs and the growing demands for contactless shopping imposed and left as a lasting effect of the COVID-19 pandemic. In an evolutionary context, these technological innovations undergo continuous development and upgrading to offer an experience deployed on the complex possibilities of combining the modern achievements of information and communication technologies, including Artificial Intelligence, and the continuous challenge of stimulating their use by customer
Second-hand clothes in the modern conditions
Get PDFIn modern conditions, the role, importance and interest in second-hand clothes is increasing, which is a prerequisite for scientific research. The main purpose of the scientific article is to present second-hand clothes in modern conditions. The methods used in writing the scientific article are descriptive-analytical method, systematic approach, study of the works of authors, comparative analysis, method of observation, induction, deduction. The study presents the main aspects of second-hand clothes, as well as some research related to them. In the conclusions, the main results of the research are summarized and the main directions for future research in the scientific field are presented
The personalization in retailing - problems and challenges
Get PDFThe concept of personalization, which is based on the idea of a personal relationship with consumers, is not at all a new concept for business. It has been used in the world of marketing and retailing for a long historical period. But in modern conditions, personalization rises to a whole new level, and is carried out through new mechanisms. It becomes an essential component of modern retailing, a key element of competitive strategy, as well as a sustainable competitive advantage. Today, modern consumers expect personalization throughout their entire interaction with a retailer – across all possible touch points (online and offline). The article examines the evolution of the concept of personalization from the traditional marketing approach to the interruption marketing and permission marketing; the relationship between personalization and permission marketing; the opt-in marketing; the relationship between personalization and interruption marketing; the e-marketing mix and the place of personalization in it. The challenges to personalization are examined, which are technological, financial, organizational, and also related to the privacy and protection of consumers personal data
Tracheal (accessory) bronchus – a case report
Get PDFIntroduction: Tracheal bronchus (also known as accessory bronchus) is a congenital anatomical variant in which an additional bronchus originates directly from the supracarinal trachea. This type of anomaly usually arises about 2cm above the carina but can occur anywhere along the trachea, from the cricoid cartilage to the tracheal bifurcation.Case Presentation: We present a case from our practice of a 62-year-old male, who arrived at our Multidisciplinary Emergency Department with complaints of sudden onset of dyspnea and high blood pressure with values of 225/125mmHg. The patient was admitted to the Clinic of Pulmonology and Phthisiology. He also reported having mild haemoptysis for the last 2 to 3 months. It was decided that a contrast-enhanced computed tomography scan with contrast enhansement should be performed, for the evaluation of possible pulmonary thromboembolism (PTE). As a result of the imaging study an accessory right bronchus was identified as an incidental finding.Results: After excluding PTE as a possible diagnosis, the following changes were identified on the CT scan: accessory right bronchus located about 20mm from the carina; multilobulated retrotracheal gas structure (differential diagnosis - atypical accessory pulmonary segment; extraluminal mediastinal gas collections; tracheal diverticulosis); a perihilar tumour formation in the left lung, causing stenosis of the left main bronchus and its lobar branches; a combination of subsolid micronodules and ground glass opacities affecting most of the left lower lobe.Conclusion: Tracheal bronchus is a congenital anomaly of the bronchial tree, often remaining entirely asymptomatic. Follow-up of such a finding should be done by an interdisciplinary team
Contemporary Challenges for Teaching Staff in Higher Medical Education
Get PDFINTRODUCTION: Since the beginning of the new millennium, humanity has been confronted with a variety of challenges. The search for effective solutions to address these challenges has led to the development of numerous strategic documents at both the European and national levels, including initiatives for the development and modernization of education.AIM: To highlight the challenges facing higher education, particularly teaching staff in higher medical schools, and to outline potential actions to address these challenges.MATERIALS AND METHODS: Literature sources, strategic and normative documents related to the development of higher education in Europe and the Republic of Bulgaria, as well as internal normative documents of the Medical University of Varna, were used. The following methods were applied: theoretical analysis, summarization, and drawing conclusions.RESULTS: The modernization of higher education in the Republic of Bulgaria, particularly in higher medical schools, aligns with the development guidelines of other EU member states and supports collective efforts to establish a unified European area for higher education. However, the creation of such an area inevitably raises the issue of developing and implementing uniform standards across different fields of education to ensure the comparability of national outcomes. It also highlights the need for a unified educational information system to facilitate the rapid dissemination of information through new educational technologies.CONCLUSION: The analysis of literature sources, strategic, and normative documents clearly highlights that the modernization and development of higher education depend significantly on teaching innovation. This requires effective interaction among peer entities within the institutionalized educational process and ongoing training for teaching staff