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Inhibition of HDAC and Signal Transduction Pathways Induces Tight Junctions and Promotes Differentiation in p63-Positive Salivary Duct Adenocarcinoma
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CD4+CD8+ T follicular helper cells regulate humoral immunity in chronic inflammatory lesions
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Synergistic Antitumor Effect of Histone Deacetylase Class IIa Inhibitor with Lenvatinib in Hepatocellular Carcinoma
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Myoepithelioma of soft tissue and bone, myoepithelioma-like tumors of the vulvar region: Clinicopathological study of 15 cases by PLAG1 immunohistochemistry
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Review and approval of drugs against COVID-19 in Japan
Get PDFThree years have passed since The World Health Organization declared coronavirus disease (COVID-19) as a pandemic on 11 March 2020. In Japan, we have received benefits from new vaccines and drugs against COVID-19. Under the COVID-19 pandemic, these vaccines and drugs developed and approved outside Japan have been approved by Special Approval for Emergency system in Japan. However, this Special Approval system is not for approval of drugs originally developed in Japan. For approval by this Special Approval system, it is necessary to ensure safety and efficacy of the drug, requiring a time-consuming process. A new emergency approval system has been established in Japan through revision of the Pharmaceutical and Medical Device Act. Although this drug approval system under an emergency situation was established, information of safety and efficacy of the drug should be further accumulated after the approval and the use.journal articl
Relationship between occupational dysfunction and autonomy orientation in peoplewith schizophrenia
Get PDF本研究では，統合失調症を有する者の自律的志向性と作業機能障害との関連を横断的に検討することを目的とした．外来通院中の統合失調症を有する者46名を対象として，一般的因果律志向性尺度（GCOS），作業機能障害の種類と評価（CAOD），陽性・陰性症状評価尺度（PANSS），統合失調症認知機能簡易評価尺度（BACS）による評価を施行した．データ解析では，これらの尺度得点間の相関をSpearmanの順位相関係数にて検証し，一般化線形モデルにて従属変数をGCOSの自律的志向性得点,独立変数をCAOD潜在ランク，BACS総合得点，PANSS陰性尺度得点，独立変数間の交互作用項として主効果と交互作用を検証した．相関分析では，CAODの潜在ランクと自律的志向性得点との間に有意な負の相関が見られた（ρ=-0.294, p=0.048）．一方で，一般化線形モデルによる検証では有効なモデルは得られなかった（尤度比χ2=13.461, p=0.062）．以上の結果より，統合失調症を有する者の作業機能障害と自律的志向性との関連が明らかになった．departmental bulletin pape