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地域で生活する統合失調症者がパーソナルリカバリーの停滞・後退に影響すると捉える社会環境とその変化のプロセス ～北海道在住者を対象としたインタビューから～
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Abnormal［18F］fluorodeoxyglucose accumulation to tori tubarius in IgG4-related disease
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Human papillomavirus testing and cytology using physician-collected uterine cervical samples vs. self-collected vaginal samples and urine samples
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Evaluation of the Effects of the Japanese Herbal Medicine “Goreisan” on Traumatic Cerebral Edema in Rats and Identification of Active Ingredients in Cultured Astrocytes
Get PDFPurpose: Traumatic brain injury is associated with a high mortality rate, and the ensuing cerebral edema further raises the fatality rate. Goreisan（Oryeongsan）, a traditional Japanese herbal Kampo medicine, has been recently shown to be effective against chronic subdural hematoma and cerebral edema associated with tumors or ischemia. However, no study has reported these effects of Goreisan. Thus, we investigated the effect of Goreisan on cerebral edema occurring as a sequela of traumatic brain injury and explored the possible mechanism underlying its activity.
Methods: Goreisan was administered to rats after the induction of traumatic brain injury via the open-skull controlled cortical impact method, and brain water content was measured. In astrocyte cultured cells, cellular edema was measured after exposure to Goreisan, Sojutsu（a crude constituent of Goreisan）, and β-eudesmol（an ingredient of Sojutsu）.
Results: Seven days after traumatic brain injury surgery, the brain water content of rats treated with Goreisan was significantly lower than that of rats treated with saline（P = 0.0035）. Swelling was significantly suppressed in the Goreisan-, Sojutsu-, and β-eudesmol-exposed groups（P = 0.013, 0.0383, and 0.0010, respectively）.
Conclusion: Goreisan appears to be effective in suppressing traumatic cerebral edema, and the effect may be mediated by its components, Sojutsu and β-eudesmol.departmental bulletin pape
Difference in immunohistochemical findings among anti‐PD‐L1 antibodies and their relationships with CD4+ and CD8+ T cells in Japanese melanoma patients
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Enhanced nuclear localization of phosphorylated MLKL predicts adverse events in patients with dilated cardiomyopathy
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