Biomedical Photonics (BMP - E-Journal)
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СРАВНИТЕЛЬНЫЕ ИССЛЕДОВАНИЯ ЭФФЕКТИВНОСТИ ФОТОДИНАМИЧЕСКОЙ ТЕРАПИИ И КРИОДЕСТРУКЦИИ В ЛЕЧЕНИИ АКТИНИЧЕСКОГО КЕРАТОЗА
Get PDFThe results of a study on the effectiveness of photodynamic therapy with a photosensitizer fotoditazin and cryotherapy for actinic keratosis are represented in the article. The study included 80 patients with 215 lesions, among them erythematous form of actinic keratosis was diagnosed in 151 (70.2%) cases, hyperkeratotic form – in 46 (21.4%) cases, a pigmented form – in 12 (5.6%) and an atypical variant of the disease – in 6 (2.8%) cases. According to histological type the distribution of tumor was as follows: 19 (54.3%) cases were diagnosed as hypertrophic type, 6 (17.1%) – atrophic, 8 (22.9%) – bowenoid and 2 (5.7% ) – pigmented type. Patients from the study group received one session of photodynamic therapy using laser unit "LAMI" (662 nm) after 2 hours of application of fotoditazin 0.5% gel at dose of 0,2-0,3 ml per 1 cm2 of actinic keratosis focus with the following parameters: the energy density of the laser radiation – 200 J/cm2, power density – 0.14–0.48 W/cm2. In the control group patients underwent cryotherapy with liquid nitrogen with an exposure of 30-60 sec. The comparative analysis of the immediate results showed a tendency for the efficacy of photodynamic therapy to increase (the rate of complete regression was 92.5%) compared with cryotherapy (85.0%) (p>0,05). There were also a tendency for long-term results after photodynamic therapy to improve: three-year recurrence-free survival was 94.6% and 88.2%, respectively. For the photodynamic therapy there were significantly fewer adverse reactions, the epithelization time in lesions was significantly shorter. Compared with cryotherapy the photodynamic therapy provided significantly better cosmetic results (p <0.01), and can be used for out-patient treatment of patients with actinic keratosis.><0.01) and can be used for out-patient treatment of patients with actinic keratosis
Фотодинамическая терапия рецидива базальноклеточного рака кожи теменной области после лучевой терапии
Get PDFThe results of the clinical observation of patient with recurrent basal cell skin carcinoma of the parietal region occurred in 4 years after radiation therapy are represented. The patient underwent photodynamic therapy (PDT) using photosensitizer fotoditazin at a dose of 1.0 mg/kg; the laser power density was 0.45 W/cm2 , the laser energy density – 300 J/cm2 . Tolerability of the treatment was satisfactory. One year after treatment there was a cosmetically satisfying soft normotrophic scar with no attachment to underlying tissues in the site of the treatment of basal cell carcinoma. According to cytological study tumor cells were not detected. For five-year follow-up there was no recurrence.Приведены результаты клинического наблюдения за пациенткой с рецидивом базальноклеточного рака кожи теменной области, возникшим через 4 года после курса лучевой терапии. Больной была проведена фотодинамическая терапия с фотосенсибилизатором фотодитазин в дозе 1,0 мг/кг; плотность мощности лазерного излучения составила 0,45 Вт/см2, плотность энергии лазерного излучения – 300 Дж/см2 . Переносимость лечения была удовлетворительной. Через один год на месте лечения базальноклеточного рака остался удовлетворительный в косметическом отношении мягкий нормотрофический рубец, не спаянный с окружающими тканями. При цитологическом исследовании опухолевые клетки не обнаружены. При пятилетнем наблюдении – без рецидива
МЕТОДЫ ФОТОНИКИ ДЛЯ ОЦЕНКИ КАЧЕСТВА ПРИЖИВЛЕНИЯ КОЖНЫХ ТРАНСПЛАНТАТОВ
Get PDF In this review, based on more than 70 articles of Russian and foreign authors, methods of skin engraftment monitoring are discussed. Main processes occurring in skin on cellular and subcellular levels at different stages of engraftment are considered. Optical methods which allow performing non-invasive analysis of blood vessels, collagen concentration and form of cellular respiration (by NADH fluorescence) are described. Comparative analysis of nuclear and optical methods for engraftment monitoring highly developed and widespread nowadays is presented. The advantages of optical methods includes multifunctionality, usability and clarity of results, safety and low cost. In contrast to X-ray CT, MRI and ultrasound, optical methods can be used in monitoring mode. One of the promising directions for improving quality of engraftment due to antibacterial effect, photodynamic therapy, is described in details. The use of crystalline organic nanophotosensitizers (particularly aluminum phthalocyanine) is shown to be the most promising. The main distinctive feature of its application is that nanoparticles injected into wound surface or contact area of tissue graft are not photoactive until the moment the inflammation starts. The development of method for assessing skin condition by spectroscopic properties of tissue components (using fluorescent dyes and photosensitizers in molecular and nanoforms), which allows analyzing physiological state of skin (degree and rate of engraftment or rejection) and controlling certain biochemical and physiological parameters of a tissue graft or an entire area of affected skin is shown to be crucial
Фотодинамическая терапия меланомы В16 у мышей с новым фотосенсибилизатором борированным хлорином
Get PDFPilot studies of pharmacokinetics and pharmacodynamics of new photosensitizer liposomal boronated chlorine in mice with melanoma В16 were performed. Dynamics of drug accumulation in tumor and normal tissue (level of accumulation in tissues was assessed by means of fl uorescence) was studied. For intraperitoneal injection at a dose of 5 mg/kg the drug was shown to accumulate gradually in tumor and normal tissues with maximal fl uorescence values in 2–3 h after injection. Then fl uorescence intensity in tissues gradually decreased, achieving nearly initial base-line in 120 h after beginning of the study. The hotosensitizer accumulated in tumor tissue with average selectivity: contrast index for maximal drug accumulation in tissues accounted for 1.7–2.8. According to obtained data for following research the time interval between drug injection and irradiation of 3h was chosen. On the second stage of the study dependence of photodynamic therapy effi cacy on different parameters including photosensitizer dose for intraperitoneal injection (5–10 mg/kg), light dose (150–300 J/cm2) and power density (0.25–0.51 mW/cm2). The irradiation was performed by semiconductor laser on wavelength of 662±1 nm. The effi cacy was maximal for following regimen: photosensitizer dose of 5 mg/kg, light dose of 300 J/cm2, power intensity of 0.44 mW/cm2. For this regimen at the end of follow-up (21 days) complete tumor regression was obtained in 75% of animals and average coeffi cient of absolute tumor growth accounted for only 7.82.
Сочетанная фотодинамическая и дистанционная гамматерапия больной плоскоклеточным раком кожи
Get PDFResults of clinical follow-up of the patient with squamous cell skin carcinoma of the nasal dorsum are represented. The patient underwent a course of combined photodynamic therapy (PDT) with distant gamma-ray therapy. Distant gamma-ray therapy was performed daily during 12 days (single dose of 3 Gy, total dose of 36 Gy) with the first session 24 h after injection of the photosensitization. For PDT the photosensitizer photosens at dose of 0,3 mg/kg was used. The method of prolonged PDT was applied, sessions of laser irradiation were performed daily during 7 days. The PDT sessions were carried out 2 h after session of gamma-ray therapy using distant (150 J/cm2, 40 mW/cm2) and contact (500 J/cm2, 100 mW/cm2) modalities. According to multiple cytological studies after treatment there were no signs of tumor, but inflammation. Four months after treatment according to cytological data continued tumor growth was detected. The patient underwent an additional course of PDT. Currently the patient is under follow-up: no recurrence during 8 months after repeated treatment.
Пресс-релиз II академической школы «Фотодинамическая терапия и фотодиагностика: основы применения в клинической практике»
Get PDF.25–27 февраля 2015 г. на базе МНИОИ им. П.А. Герцена была проведена II академическая школа «Фотодинамическая терапия и фотодиагностика: основы применения в клинической практике». Организаторами школы выступили Национальная Фотодинамическая Ассоциация, ФГБУ «МНИОИ им. П.А. Герцена» МЗ РФ и «ИОФ им. А.М. Прохорова» РАН
Роль брахитерапии в лечении локализованных форм рака предстательной железы
Get PDFThe review is devoted to application of brachytherapy for treating the localized prostate cancer (PC). Statistics for incidence and detectability of this pathology and its dynamics for recent years are represented. Brief analysis of other methods which are conveniently used for treatment of PC, such as radical prostatectomy and external-beam radiotherapy, was performed. Advantages and disadvantages of these methods have been discussed. Brief history about the development of brachytherapy from first experience to wide-spread use in clinical practice is reported. The detailed review of series of large trials from Russia and other countries for efficiency and safety of brachytherapy in patients with prostate cancer for recent 15 years is also represented. Two types of brachytherapy in current clinical oncology i.e. low-dose technique with permanent implantation of microsources and high-dose temporary isotope implantation, specifics of its application in different groups of patients have been described. The procedure of brachytherapy and its three main steps i.e. planning, implantation and control assessment after implantation have been characterized in details. The conclusion about benefits of using of brachytherapy in the treatment of prostate cancer as minimally invasive and efficient method was made.