Biomedical Photonics (BMP - E-Journal)
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Эффективность фотодинамической терапии при лечении больных ранним раком желудка
Get PDFThe experience of photodynamic therapy for early gastric cancer is described in the article. The treatment results in 68 patients who were excluded for convenient surgical treatment because of advanced age or severe co-morbidity are represented. 63 patients had single tumor, 5 patients – 2 tumors. Four Russian agents: photogem, photosens, radaсhlorin and alasens, were used for photodynamic therapy. The treatment session was performed under local anesthesia during routine endoscopy with diode laser with wavelength consistent with photosensitizer (photogem – 630 nm, photosens – 670 nm, alasens-induced protoporphyrin IX – 635 nm, radaсhlorin – 662 nm). The short-term results were analyzed 1 month after treatment according to endoscopy, morphological study, CT, ultrasound or endosonography. For 73 lesions complete regression was observed in 53 (72.6%) and partial regression in 20 tumors (27.4%). The efficacy of photodynamic therapy was shown to be directly associated with tumor size. Thus, for tumors up to 1 cm regression occurred in 100% of cases, up to 1.5 cm – in 70.8%, up to 3 cm – in 65.2%, up to 5 cm – in 58.3%. The median survival rates accounted for 7.31 years, 3-year survival – 83±5%, 5-year - 69±8%. The experience showed that the developed method of photodynamic therapy was promising in treatment for early gastric cancer as an alternative to surgery.
Флюоресцентная лапароскопия у больных раком желудка
Get PDFThe results of fluorescence laparoscopy in 60 patients with gastric cancer in P.A.Herzen MCRI are represented in the article. All patients had gastric cancer stage III. Undifferentiated cancer was diagnosed in 3 (5%) patients, signet ring cell carcinoma – in 42 (70%), low differentiated adenocarcinoma – in 15 (25%). Fluorescence diagnosis was performed using fluorescence laparoscope by Carl Storz (Germany) with wavelengths 380-460 nm and alasens given per os at a dose of 30 mg/kg body weight 3 h before study. During the investigation the examination of parietal and visceral peritoneum, great omentum with instrumental revision of pelvic organs was made. The technique of fluorescence diagnosis and assessment of its results are described. According to results of the study occult tumor microdissemination over peritoneum was detected in 10 (16.7%) patients. The sensitivity of fluorescence laparoscopy in patients with gastric cancer accounted for 87.5%, specificity – 76%. The data of fluorescence diagnosis allowed to perform staging of tumor process and influenced on following management.
Пресс-релиз II всероссийской конференции с международным участием «Актуальные вопросы фотодинамической терапии и фотодиагностики»
Get PDF.17–18 октября 2013 г в Москве на базе МНИОИ им. П.А. Герцена и ИОФ им. А.М. Прохорова РАН прошла II Всероссийская конференция с международным участием «Актуальные вопросы фотодинамической терапии и фотодиагностики»
Применение локальной флюоресцентной спектроскопии в комбинации с методикой флюоресцентной визуализации при цистоскопии
Get PDFThe method of fluorescence visualization of bladder tumors combined with fluorescence spectroscopy developed in P.A. Herzen MCRI is described. The efficacy of the method was proved by results of diagnostics in 198 patients with superficial bladder cancer. In the study group 67 patients had primary tumor, 131 patients had recurrence of superficial bladder cancer after previous treatment. In 3.5% patients the lesion was determined as carcinoma in situ, in 29.5% – non-invasive papillary carcinoma, bladder cancer with invasion into submucosal layer of bladder wall occurred in 67% of cases. Diagnostics was performed 1.5–2 h after instillation of 50 ml 3% solution of alasens into bladder. The data analysis was made with calculation of the diagnostic parameter and value of tumor/normal mucosa fluorescence contrast. The total number of fluorescence spectra accounted for 528. All determined areas of fluorescence were studied morphologically. During fluorescence spectroscopy 53 areas of fluorescence were determined on visually intact mucosa under white light, showed high values of diagnostic parameter. Morphological study proved severe dysplasia (3%), carcinoma in situ (95%) and bladder cancer (2%). Correlation between data of local fluorescence spectroscopy and morphological study of biopsy specimen was assessed, values of diagnostic parameter, характеризующих intact urothelium, areas of inflammation and moderate dysplasia, severe dysplasia and bladder cancer were estimated. Local fluorescence spectroscopy combined with visual assessment of fluorescence image allowed to increase specificity of cystoscopy from 70% to 85%, total accuracy – from 80% to 86%, with improvement of predictive value for positive result from 0,67 to 0,94.