Alberto Sols Biomedical Research Institute
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Pre-pack, private international law and proposal for a second directive of insolvency
No full textLa Propuesta de segunda Directiva en materia de insolvencia dedica parte de su articulado a la armonización de la regulación de los pre-packs en el seno de la Unión Europea y. al hilo de ella, se plantean ciertas dudas de Derecho internacional privado de cuyo análisis se ocupa este trabajo. Las dos cuestiones que se abordan son, en concreto, las referidas al tratamiento, esencialmente en relación con la competencia y el reconocimiento, de su fase de preparación y a la ley aplicable a los contratos vigentes, cuya cesión al adquirente se prevé. El análisis pone de relieve la necesidad de garantizar, a la hora de regular las cuestiones sustantivas, su coherencia con las normas de Derecho internacional privadoThe proposal for a second directive on insolvency devotes part of its articles to harmonising the regulation of pre-packs within the European Union and raises certain questions of private international law, which this paper analyses. The two issues addressed are, specifically, those relating to the treatment, essentially in relation to jurisdiction and recognition, of the preparatory phase and the law applicable to executory contracts whose transfer to the acquirer is envisaged. The analysis highlights the need to ensure, when regulating substantive issues, consistency with the rules of private international lawEste trabajo se realiza en el marco del Proyecto de Investigación financiado por el Ministerio de Ciencia e Innovación (Generación de Conocimiento 2022) titulado “Nuevas perspectivas de la insolvencia internacional: reestructuraciones preconcursales y concursales” (PID 2022-140017OB100
Advancing treatment strategies for solitary fibrous tumor: novel biomarkers and targeted therapies
No full textTesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina. Fecha de Lectura: 05-06-202
Controlling optoelectronic properties and aggregation of planar dipoles through symmetry-preserving modifications
No full textPlanar and symmetric molecular architectures with defined donor–acceptor distributions offer exceptional versatility for optoelectronic applications. Perylene monoimides exemplify these features, and here we systematically explore strategies to tune their dipole-like distribution while preserving symmetry. Correlating optical properties in solution and solid states with electron-donating and/or-withdrawing groups at the ortho positions reveals how subtle modifications control the intermolecular interactions and therefore, aggregation and optoelectronics. Single-crystal X-ray diffraction further uncovers distinct stacking modes, highlighting the decisive role of molecular design in tailoring functionality for diverse applicationsJ. G.-C. and T. T. acknowledge financial support from the Spanish MCIN/AEI/10.13039/501100011033 and European Union NextGenerationEU/PRTR TED2021-131255B–C43), (PID2020-116490GB-I00, MCIU/AEI/10.13039/501100011033/ FEDER, UE (PID2023-151167NB-I00), the Comunidad de Madrid and the Spanish State through the Recovery, Transformation and Resilience Plan [“Materiales Disruptivos Bidimensionales (2D)” (MAD2D-CM) (UAM1)-MRR Materiales Avanzados], and the European Union through the Next Generation EUfunds. J. G.-C. acknowledges his funding from “Ayudas María Zambrano para la atracción de talento internacional”(CA3/RSUE/2021-00243) from the Spanish Government/EU funds at Universidad Autónoma de Madrid, and “Ayudas de atracción de talento de la Comunidad de Madrid 2022” (2022T1/IND23907) supported by Comunidad de Madrid with EU funds at IMDEA Nanociencia. J. G.-C and T. T. acknowledge support from the “Severo Ochoa” Programme for Centres of Excellence in R&D (MINECO, grant no. SEV-2016-0686 and CEX2020-001039-S) at IMDEA Nanociencia. We acknowledge the generous allocation of computer time at “Centro de Computación Científica” at the Universidad Autónoma de Madrid (CCC-UAM). We also acknowledge the contribution of the facilities and the members of the Monocrystal DRX lab from the “Servicio Interdepartamental de Investigación” (SIdI) at the Universidad Autónoma de Madrid. We thank Irene Abajo-Cuadrado for the Fluorescence Lifetime measurements and acknowledge the facilities of “Parque científico tecnológico” from Universidad de Burgos for those measurement
Por Don Carlos. Textos Literarios, Imágenes y Sonidos de La I Guerra Carlista en Francia: Estudio crítico y corpus textual bilingüe, iconográfico y musical anotado
No full textEsta obra es resultado del proyecto «Proyecciones culturales europeas de un conflicto español: Textos literarios,
imágenes y sonidos de la I Guerra Carlista (1833-1840) en el Reino Unido, Francia y Portugal; edición,
estudio y transferencia» (Proyecto EURICAR’20), aprobado en la convocatoria 2020, proyectos de I+D+i,
de los programas estatales de generación de conocimiento y fortalecimiento científico y tecnológico del sistema
de I+D+i y de I+D+i orientada a los retos de la sociedad, en el marco del Plan Estatal de Investigación
Científica y Técnica y de Innovación 2017-2020 (Ref. PID2020-113486RB-I00). Financiado por MICIU/
AEI/10.13039/501100011033
Probabilistic and interpretable machine learning for high-stakes scenarios
No full textTesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Escuela Politécnica Superior, Departamento de Tecnología Electrónica y de las Comunicaciones. Fecha de Lectura: 12-06-2025This work has been supported by the Spanish Ministerio de Ciencia e Innovación, Agencia y del Fondo Europeo de Desarrollo Regional (grant reference PID2021125943OB-I00, MCIN /AEI/10.13039/501100011033/FEDER, UE), by the Spanish Ministerio de Ciencia; Innovación y Universidades (MCIU) and Agencia Estatal de Investigación (AEI), and also by the European Regional Development Fund (FEDER in Spanish, ERDF in English), by project RTI2018-098091-B-I0
Pilot-scale study of catalytic wet peroxide oxidation (CWPO) in a continuous stirred-tank reactor with in-line magnetic catalyst recovery
No full textThis research has been supported by the Spanish Ministry of Science and Innovation and AEI through the grants PID2019-105079RB-I00 and PID2022-139063OB-I00 funded by MCIN/AEI/10.13039/5011000110 33 and by ERDF A way of making Europe. N. Lopez-Arago thanks for the FPI grant (PRE2020-09452) funded by MCIN/AEI/10.130 39/501100011033 and by ESF Investing in your future. D. Ortiz thanks the Spanish Ministry of Universities (MIU) for the FPU predoctoral grant (FPU19/04816
Working memory load does not interfere with distractor suppression in the additional singleton task
No full textThe experimental program and raw data of Experiments 1–3 are publicly available via the Open Science Framework at: https://osf.io/xtsa2/Over the last decade, the additional singleton task has been widely used to study visual statistical learning. In this paradigm, participants are instructed to find a target while ignoring a series of distractors. In some trials, a salient singleton distractor is added to the search display, making the task more difficult. However, if the singleton appears more frequently in one particular location of the display, participants eventually learn to suppress attention towards this location. It has been suggested that this type of learning is probably implicit and independent of working memory (WM) resources. To our knowledge, only one study has explored the impact of WM in suppression effect (Gao & Theeuwes, Psychonomic Bulletin & Review, 27, 96–104, 2020). However, there are reasons to suspect that the amount and type of WM load used in that study may have been suboptimal to detect any effects on distractor suppression. The aim of the present study was to explore the impact of WM load on distractor suppression addressing these issues. Contrary to our expectations, our results confirm that this type of learning is indeed highly resilient even to strong manipulations of WM loadThis study was supported by grant PID2020-118583GB-I00 from Agencia Estatal de Investigación and FEDER, UE. FVC was supported by PhD fellowship PRE2018-085148 from Ministerio de Ciencia e Innovació
Hydrothermal carbonization and pyrolysis of sewage sludge: Plant growth effects of hydrochar and biochar
No full textWastewater treatment plants generate biosolids with high moisture content that can be transformed via hydrothermal carbonization (HTC) into hydrochar for agronomic application. This study compares the effects of fresh and washed hydrochar (HTC at 230 ◦C, 45 min) and biochar (pyrolysis at 650 ◦C, 1 h) produced from sewage sludge on seed germination and early plant development. Tomato (Solanum lycopersicum L.) and quinoa (Chenopodium quinoa Willd.) seeds were sown in marginal soil amended with 1 %, 3 %, and 5 % (w/w) of each char. The high inorganic content of sewage sludge resulted in hydrochars with significant ash content, rich in nutrients (Ca, Fe, Mg, P), but also in potentially toxic elements (Cr, Cu, Pb), whereas biochar showed lower concentrations of As, Cd, and Ni, and higher levels of B, K, Mg, Na and Mn, along with changes in pH and electrical conductivity. Fresh hydrochar significantly inhibited tomato seed germination (75–90 %), biomass (75–100 %) and shoot height or leaf area (50–100 %) depending on application rate. Hydrochar washing reduced phytotoxic compounds, resulting in plant performance comparable to the control. Quinoa, generally more stresstolerant, showed no significant differences in seed germination and growth, although dry biomass decreased with fresh hydrochar. Biochar enhanced seed germination and plant biomass. Lipid peroxidation increased with the lowest amendment rate of fresh hydrochar and biochar, despite no transcriptional changes of stress-related genes being detected. Overall, this study supports the use of washed hydrochar to improve tomato plant performance, although the effects of char amendments may vary depending on the plant specie
Computational design of an improved photoswitchable psychedelic based on light absorption, membrane permeation and protein binding
No full textPsychedelic compounds can induce rapid-acting and long-lasting antidepressant benefits. Understanding the role of their hallucinatory effects is crucial for shaping the future trajectory of antidepressant drug development. Photoswitchable compounds targeting the 5-HT2AR offer precise spatiotemporalcontrol over the activation of different downstream pathways. In this work, we computationally discovered PQ-azo-N,N-DMT (34), a photoswitch with improved features compared to the previously synthesized azo-N,N-DMT (1). The new compound shows tight binding to the 5-HT2AR, retaining all important interactions of lysergic acid diethylamide (LSD), exhibits positive membrane permeability, and has a strong red-shifted absorption that would allow photocontrol in the visible spectrumJ. J. N. acknowledges the support of the Comunidad de Madrid through the Attraction of Talent Program (grant reference 2022-5A/BMD-24244) and the Spanish Ministry of Science and Innovation through the projects PID2020-117806GA-I00 and CNS2022-135720 funded by MCIN/AEI/10.13039/501100011033. S. F. is grateful to Innovational Research Incentives Scheme Vidi 2017 with project number 016.Vidi.189.044, which is partly financed by the Dutch Research Council (NWO