Alberto Sols Biomedical Research Institute
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When eco-anger (but not eco-anxiety nor eco-sadness) makes you change! A temporal network approach to the emotional experience of climate change
No full textTítulo del postprint: It is time to focus on eco-anger rather eco-anxiety: A temporal network approach to the emotional experience of climate changeResearch on the emotional experience of climate change has become a hot topic. Yet uncertainties remain regarding the interplay between climate change-related emotions (i.e., eco-anxiety, eco-anger, eco-sadness), general emotions (i.e., regardless of climate change), and pro-environmental behaviors. Most previous research has focused on cross-sectional studies, and eco-emotions in everyday life have seldom been considered. In this preregistered study, 102 participants from the general population rated their eco-emotions (i.e., eco-anxiety, eco-anger, eco-sadness), general emotions (i.e., anxiety, anger, sadness), and pro-environmental intentions and behaviors daily over a 60-day period. Using a multilevel vector autoregressive approach, we computed three network models representing temporal (i.e., from one time-point to the next), contemporaneous (i.e., during the same time-frame), and between-subject (i.e., similar to cross-sectional approach) associations between variables. Results show that eco-anger was the only predictor of pro-environmental intentions and behaviors over time. At the contemporaneous level, the momentary experience of each eco-emotion was associated with the momentary emotional experience of the corresponding general emotion, indicating the distinctiveness of each eco-emotion and the correspondence between its experience and that of its general, non-climate-related emotion. Overall, our findings 1) emphasize the driving role of eco-anger in prompting pro-environmental behaviors over time, 2) suggest a functional and experiential distinction between eco-emotions, and 3) provide data-driven clues for the field's larger quest to establish the scientific foundations of eco-emotionsData collection was supported by the FRS-FNRS Belgian National
Science Foundation (Research Grant: "J.0087.23"; Project: "Attention2Threat4Adaptation") awarded to Alexandre Heeren. Alba Contreras was
funded by an FSR Incoming (MOVE-IN) Postdoctoral Research Fellowship, Universit´e Catholique de Louvain and World Excellence Postdoctoral Research Fellowship, Wallonie-Bruxelles International (WBI). Camille Mouguiama-Daouda was funded by a research fellowship from
the “Agence Nationale des Bourses du Gabon and a "Special Research
Funds"-FSR research grant from the Universit´e catholique de Louvain.
Alexandre Heeren (Research Associate) and M. Annelise Blanchard
(Research Fellow) are both also funded by the Belgian Fund for Scientific
Research (Fonds de la Recherche Scientifique-FNRS, Belgium). The
funders had no influence on the study design, data collection, analysis,
decision to publish, or writing of the articl
Analysis of tumoral, stromal and glycolitic markers in the response basal cell carcinoma and Bowen disease to photodynamic therapy in real life
Get PDFBackground: Photodynamic therapy (PDT) is a widely-used non-surgical treatment for non-melanoma skin cancers, including basal cell carcinoma (BCC), actinic keratoses (AK), and Bowen's disease (BD). PDT has high success rates, but various factors, can influence treatment response. This study investigates the clinical, histological, and molecular factors that affect the efficacy of methyl aminolevulinate PDT (MAL-PDT) for BCC and BD. Methods and Patients: Prospective observational multicentric study performed between May 2019 and January 2021 with 64 patients included. Clinical data such as tumor thickness, location, and histological subtype were recorded. Immunohistochemical analysis was performed on tumor samples to assess the expression of biomarkers including p53, β-catenin, and GLUT1. Results: Tumor thickness was found to be a critical determinant of MAL-PDT response, with thicker nodular BCCs showing reduced response rates compared to thinner, superficial BCCs and BD lesions. Immunohistochemical analysis revealed that p53 positivity was associated with better treatment outcomes, while increased β-catenin and cytoplasmic GLUT1 expression correlated with resistance to PDT. On the other hand, the metabolic profile of the tumors indicated that tumors with higher glycolytic activity were less responsive to treatment, therefore, using metformin, a glycolytic inhibitor, as a potential adjuvant therapy to improve outcomes in resistant tumors should be considered. Conclusion: This study emphasizes the importance of personalized approaches in the use of MAL-PDT, tailoring treatment according to tumor-specific characteristics. Biomarkers such as p53, β-catenin, and GLUT1 can serve as predictive tools for PDT response, helping clinicians identify patients who may benefit from alternative or combined treatments to enhance therapeutic efficacyThis project received support from the Instituto de Salud Carlos III and Fondos Feder Europeos, MINECO (FIS PI21/00953; PI21/00315
Fiscalidad de actos y negocios jurídicos en el seno de la familia. Estudio particular de las adjudicaciones de bienes tras el divorcio
No full textAn improved method to generate secondary nanoplastics and oligomers: application in ecotoxicology
No full textRecent studies have highlighted the ecotoxicological effects of conventional primary nanoplastics (NPLs); however, the impacts of secondary NPLs and oligomers (Olig), especially those derived from biodegradable plastics, formed through fragmentation and natural degradation processes (e.g., photooxidation) remain underexplored. This gap is partly due to challenges in producing sufficient quantities for toxicity testing. An improved method to generate non-photooxidized (NP) and photooxidized (P) secondary NPLs and Olig from polybutylene adipate co-terephthalate (PBAT), a biodegradable plastic commonly used in agriculture mulching, which involves the mechanical breakdown of PBAT-microbeads with or without prior photooxidation is presented. PBAT was irradiated at ∼9.34 kW m−2 (approximately 120 times the solar irradiance) for 96 h, irradiation that corresponds to ∼16 months of average sunlight in the Iberian Peninsula (7.7 kWh m−2 per day). The toxicological effects on Chlamydomonas reinhardtii, a model green microalga of primary producers in freshwater ecosystems, were also assessed. The protocol yielded 0.199 mg of secondary NP-PBAT-NPLs and 10.275 mg of NP-PBAT-Olig per gram of PBAT-microbeads. PBAT-NPLs presented irregular spherical morphologies and hydrodynamic sizes ranging from 56.71 to 69.86 nm. HPLC and MALDI-TOF analysis identified linear and cyclic Olig, ranging from dimers to 19 repeated-units Olig. PBAT-NPLs and PBAT-Olig exhibited negative surface charges, suggesting colloidal stability in water. While PBAT-NPLs and PBAT-Olig did not inhibit algal growth in the short term, they induced reactive oxygen species overproduction at the environmentally relevant concentration of 0.01 mg L−1 and caused membrane depolarization, impaired photosynthesis and lipid peroxidation at 10 mg L−1. Non-photooxidized PBAT-NPLs exhibited the highest toxicity, followed by photooxidized PBAT-NPLs and both non-photooxidized and photooxidized PBAT-Olig. This study provides an efficient method for producing reference secondary NPLs and Olig and underscores the potential risks of PBAT towards primary producers in freshwater ecosystemsThe authors acknowledge the financial support provided by the Spanish Government, Ministry of Science and Innovation Grants TED2021-131609B-C32/33, PID2020-113769RB-C21/C22, PLEC2021-007693 and RyC2021-034953-I from the European Union “NextGenerationEU/PRTR
Advancing diagnostics with BODIPY-bismuthene DNA biosensors
Get PDFIn this work, an electrochemical biosensor is prepared based on few-layer bismuthene hexagons (FLBHs) and a water-soluble BODIPY (BDP) derivative (BDP-NaSO3) for early infection diagnosis. In particular, the detection in advance of a virus sequence in nasopharyngeal swab samples was developed. The combination of the FLBHs and BDP-NaSO3 facilitates the direct, sensitive, and specific detection of gene viruses without the need for any prior amplification step. This work demonstrates that the FLBHs provide an improved electrochemical platform for immobilizing thiolated DNA capture probes that increase the sensitivity of the biosensor, while BDP-NaSO3 serves as a newly powerful electrochemical indicator of the hybridization event. As a proof of concept, SARS-CoV-2 was selected as the model virus. The developed biosensor demonstrated selective, rapid, and straightforward detection of the specific sequence RNAdependent RNA-polymerase (RdRp) of SARS-CoV-2 with a detection limit of 4.97 fM and a linear range from 16.6 fM to 100 fM. Furthermore, this platform successfully detects the virus directly in nasopharyngeal swab samples with a viral load of at least 19 Cts without being subjected to any prior amplification stage. Finally, the high stability of the biosensor response, which has been working under ambient conditions for over one month, the selectivity and rapidity for specific virus detection, and the requirement of low-volume samples for the determination are remarkable characteristics that make it ideal for its potential application in clinical diagnosis in point-of-care settingsThis work was financially supported by the Spanish Ministry of Economy and Competitiveness (PID2020-116728RB-I00, RED2022-134120-T, PID2023-150844OB-I00, PID2022-138908NB-C31, and PID2021-122299NB-I00), the Community of Madrid (REACT-UE NANOCOV-CM and Y2020/NMT6469), the Spanish Ministry of Science, Innovation and Universities (TED2021-129738B-I00, TED2021-130470B-I00, and TED2021-129999B-C32) and the “María de Maeztu” Programme for Units of Excellence in R&D, CEX2023-001316-M. Laura Gutiérrez-Gálvez gratefully acknowledges the financial support of a Formación del Profesorado Universitario (FPU) grant from the Spanish Ministry of Universities (FPU19/06309). Estefanía Enebral-Romero received financial support from the “Nanotecnología para detección del SARS-CoV-2 y sus variantes, NANOCOV” project and a contract as a pre-doctoral researcher funded by a grant CEX2020-001039-S, supported by MCIN/AEI/10.13039/501100011033. We also acknowledge María U. González and Raquel Alvaro for their help with fluorescence microscopy and EDAX mapping, respectively, and the services of the MiNa Laboratory at IMN and funding from CM (project S2018/NMT-4291 TEC2SPACE), MINECO (project CSIC13-4E-1794) and the EU (FEDER, FSE). We also acknowledge the “Servicio de Microbiología, Hospital Universitario Ramón y Cajal and Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)” for providing the clinical samples. We acknowledge the support from the “(MAD2D-CM)-UAM” project funded by Comunidad de Madrid by the Recovery, Transformation and Resilience Plan and by NextGenerationEU from the European Unio
Chaves Amieva, Óscar. Imágenes cautivas. Arte, violencia política y cultura visual en España (1923-1959). Madrid: CSIC, 2023, 461 págs.
Get PDFEstudio de intervención nutricional para evaluar el efecto sobre la saciedad de dos yogures funcionales enriquecidos con fibra dietética soluble o proteína vegetal en un colectivo de personas sanas
Get PDFTesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina. Fecha de Lectura: 21-02-2025El estudio ha sido financiado a través de una convocatoria pública competitiva del
Ministerio de Economía y Competitividad de España (MINECO) a través del
Programa CIEN (SATISFOOD) del Centro para el Desarrollo Tecnológico Industrial
(CDTI
Impacto de la pandemia COVID-19 en la atención del código ictus por el Servicio de Urgencias Médicas de Madrid (SUMMA 112). Aprendizaje para situaciones epidémicas similares
Get PDFTesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina. Fecha de Lectura: 04-02-202
El papel de la orientación educativa en las etapas de infantil y primaria en el marco del derecho a la educación inclusiva
Get PDFTesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Psicología. Departamento de Interfacultativo de Psicología Evolutiva y de la Educación. Fecha de Lectura: 20-02-2025La presente Tesis Doctoral se ha llevado a cabo con el apoyo del Ministerio de Economía,
Industria y Competitividad (EDU 2017-86739-R), el Ministerio de Ciencia e Innovación
(PID2021-124951OB-I00) y la Comunidad de Madrid y el Fondo Social Europeo en el
marco del proyecto titulado “Madrid sin Barreras: discapacidad e inclusión social”
(H2015-HUM/3330
Implementación de equipos móviles de perfusión abdominal normotérmica para la donación en asistolia controlada en la Comunidad Autónoma de Madrid. Análisis de viabilidad y resultados
Get PDFTesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Medicina, Departamento de Medicina. Fecha de Lectura: 24-02-202