Alberto Sols Biomedical Research Institute
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Coinage Metal-Catalyzed Divergent Heterocyclizations of Underexplored N‑Propargyl Hydrazides
No full textHerein, we disclose metal-catalyzed tunable annulations of uncharted alkyne-tethered hydrazides for the divergent preparation of diazacyclic frameworks. Cationic gold facilitates the O-cyclization, providing valuable [1,3,4]oxadiazine scaffolds with total selectivity, whereas silver catalysis promotes controlled N-cyclization to access N-acyl pyrazoles. Furthermore, density-functional-theory-based theoretical investigations support two different pathways (ionic versus radical) operating in the catalytic heterocyclization reaction of the same N-propargyl hydrazide substrateThis work was supported by MCIN/AEI/10.13039/ 501100011033/FEDER (Project PID2021-122183NB-C21), Comunidad de Madrid (Projects P2022/BMD-7236 and IND2023/BMD-27036), and JSPS (23K06031). A.S. acknowledges the support of the UAEU through an internal start-up grant in 2023 (Grant Code G00004400). J.M.-C. thanks F. K. Hansen (University of Bonn), and S. Gobec (University of Ljubljana) for the in vitro pharmacological results of compounds 1 and A. V. Dobrydnev (Enamine, Ltd.) for providing generous amounts of propargylhydrazine. The authors thank Prof. F. Javier Cañada (CIB−CSIC) and the NMR service of the Margarita Salas Center for Biological Research (CIB−CSIC) for their collaboration and providing access to the NMR instruments. Y.S.R acknowledges the support of UAEU through a regional research grant (#12S244
Public services and perceptions of Government performance
No full textTesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Derecho, Departamento de Ciencia Política y Relaciones Internacionales. Fecha de Lectura: 27-06-202
Collective Sex as a Collective Text: Liberté by Albert Serra Through the Optics of Roland Barthes
No full textThis article examines Albert Serra’s Liberté (Serra in Liberté. France, Spain, Portugal. Idéale Audience / Andergraun Films / Lupa Film / Rosa Filmes.1.85:1, 132 min, 2019)—both the film and the video art installation, first exhibited the same year at the Reina Sofía Museum in Madrid, under the title Personalien—alongside Roland Barthes’s reading of texts by the Marquis de Sade, proposing a conceptual juxtaposition between Barthes’s approach and the aesthetic and rhetorical dimensions of Serra’s work. Barthes advocates for a purely formal interpretation of Sade, privileging structure over narrative or moral positioning, and engaging with such elements as the perpetual construction of libertine language, the defence of impossibilia, and humour, among others. The composition and fragmented discourse of Liberté resonate with this framework, revealing a cinematic logic that resists conventional storytelling and undermines superficial understandings of artistic and sexual freedom. At the same time, the article highlights how Serra’s work, operating on the threshold between cinema and video art, incorporates performative elements that intensify the viewer’s hyper-awareness of their position in relation to the screen. By intertwining formal optics with a visual and rhetorical analysis of the film, this study unpacks a conceptually unstable and ambiguous artwork—at once serious and playful, abstract and corporeal, present and vanishin
Lauren Gunderson (b.1982)
Get PDFThis essay situates American playwright Lauren Gunderson (b.1982) in the present theatrical scenario. Three times the most produced playwrights in the US (in seasons 2017–2018, 2019–2020, and 2022–2023), Gunderson provides guidelines to understand her work: from her writing of lighter pieces and the more politically committed ones to her revision of classic texts and her original historical dramas. Gunderson presents herself as a feminist playwright who relocates women in their place in history while writing plays for both men and women. This essay also discusses Gunderson’s role as a drama and theatre theorist by paying close attention to her 2015 speech, “Survival of the Storied: Why Science Needs Art and Art Needs Science.” Here, Gunderson argues the need for and value of featuring the stories of women scientists on the stage and reminds us of the inherent power of good plays to move audiences into action in order to make a better world—a common goal shared by Science and Ar
La convergencia de las reglas de contratación pública y disciplina presupuestaria en el sector público instrumental
No full textLa contratación pública y la disciplina
presupuestaria se han convertido en los últimos
años en dos de los sectores de referencia del
Derecho público europeo. Las reglas de contratos
públicos garantizan la competencia entre los
operadores económicos y la inexistencia de
distorsiones en el funcionamiento del mercado
derivadas de la adquisición de bienes y servicios
por los poderes adjudicadores. Por su parte, la
disciplina presupuestaria está encaminada a la
supervisión de las finanzas públicas con el objetivo
de evitar que los Estados miembros alcancen
déficits excesivos. A pesar de que estos objetivos
puedan parecer, a primera vista, dispares, el
análisis de la regulación de estos sectores permite
apreciar una clara convergencia entre ellos. Este
estudio examina las similitudes y diferencias
existentes en ambos grupos normativos, sus
entrecruzamientos y las consecuencias que se
derivan de su aplicación conjunta. En concreto, se
centra en el impacto de estas reglas sobre el sector
público instrumental y el proceso subyacente de
reestructuración que se está llevando a cabo
mediante la configuración de conceptos jurídicos
funcionalesPublic procurement and budgetary discipline have
become two of the most important branches in
European public law. On the one hand, public
procurement rules ensure competition between
economic operators and the absence of distortions
in the functioning of the common market resulting
from the procurement of goods and services by
contracting authorities. On the other hand,
budgetary discipline is aimed at monitoring public
finance seeking to avoid excessive deficit in
Member States. Although these goals may seem
different, an analysis of these provisions shows
clear convergence between them. This study
examines the similarities and differences between
the two sets of rules, their crosslinks and the
consequences following their implementation. In
particular, it focuses on the impact of these rules on
the public sector and the underlying restructuring
process that is taking place through the
development of functional legal concept
Sustainable investing among young generations: balancing ideals and financial realities
No full textThis study examines the attitudes and behaviors of young investors toward sustainable finance, focusing on the gap between awareness and actionable investment choices. Utilizing a mixed-methods approach, the research combines survey data capturing young investors' attitudes and financial portfolio analyses from a European institution to explore behavioral patterns and preferences in sustainable finance. The findings reveal a significant discrepancy: while environmental awareness and knowledge of sustainable finance are high, these factors do not necessarily translate into sustainable investment preferences. Key barriers include risk aversion, perceived high costs, and limited availability of attractive ESG investment options. The study highlights the need for targeted educational programs and policy interventions to bridge the gap between ideals and actions. Limitations include a small sample size and reliance on self-reported data, which future research should address. These findings contribute to the growing literature on sustainable investing and offer actionable insights for financial institutions and policymaker
Efecto de los “Programas de Educación Emprendedora” sobre el autoempleo de los jóvenes en riesgo de exclusión social en Ecuador
No full textTesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias Económicas y Empresariales, Departamento de Estructura Económica y Economía del Desarrollo. Fecha de Lectura: 28-03-2025La falta de políticas o estrategias de inversión en educación y salud han afectado al bienestar y la calidad de vida de los latinoamericanos por parte de la administración pública. Así, las organizaciones sociales buscan presionar a los gobiernos por la atención a sus necesidades, generación de empleo y la vigilancia de la explotación de sus recursos. En este marco, se plantea como objetivo principal de esta tesis, determinar el nivel de influencia de los programas de formación profesional para jóvenes en riesgo de exclusión social en su nivel de autoempleo. Programas puestos en marcha en colaboración con agentes económicos, sociales y de la administración pública para el desarrollo local sostenible de sus territorios. Para ello se empleó un enfoque combinado (cuantitativo y cualitativo) de investigación mediante las técnicas de observación, cuestionario y entrevista. En los resultados se destaca la identificación de las características que deben cumplir los participantes de los Programas de Educación Emprendedora PEE, y cómo deben participar de las instituciones locales y actores de la sociedad civil. Esto ha permitido realizar una serie de recomendaciones de estrategia y propuesta de políticas de gobierno en torno a los PEE. Todo ello además permitirá incrementar la participación social e interinstitucional; permitiendo mejorar el tejido productivo con la generación de empleo para fomentar la transformación social y encaminar al territorio hacia el desarrollo local sostenible; utilizando los recursos tangibles e intangibles del propio territori
Sistemas termo-fotocatalíticos basados en óxidos para reducción de dióxido de carbono
No full textTesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Química Inorgánica. Fecha de Lectura: 14-03-202
Los verbos frasales
No full textEste libro ha sido publicado en abierto con ayuda del proyecto de investigación, referencia
2021-1-HR01-KA220-HED-000027562, de la Unión Europe
Light-matter interactions at the nanoscale. Non-linearities, electrons and exciton polaritons
No full textTesis Doctoral inédita leída en la Universidad Autónoma de Madrid, Facultad de Ciencias, Departamento de Física Teórica de la Materia Condensada. Fecha de Lectura: 08-04-202