E-Jurnal Universitas Tunas Husada Tasikmalaya
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Uji Aktivitas Antivirus dari Senyawa Turunan Katekin terhadap M-Protease SARS-COV 2 secara In Silico
No full textCOVID-19 adalah penyakit yang disebabkan oleh SARS-CoV-2. Katekin mempunyai aktivitas antivirus terhadap M-Protease SARS-CoV-2. Namun belum diketahui kestabilannya pada molecular dynamic.Tujuan penelitian ini untuk mengetahui senyawa turunan katekin terbaik sebagai anti COVID-19 dan mengetahui kestabilannya.Penelitian ini dilakukan dengan metode molecular docking dan molecular dynamic. Hasil molecular docking katekin galat dan epikatekin galat memiliki nilai binding affinity terendah yaitu -12,44 Kkal/mol. Hasil docking dengan molecular dinamyc terdapat kesamaan asam amino dan ikatan hidrogen. Sehingga disimpulkan bahwa katekin galat dan epikatekin galat diprediksi mempunyai aktivitas terbaik terhadap protein target dan stabil setelah molecular dynamic
Ultrasonic degradation of perfluorooctane sulfonic acid (PFOS) correlated with sonochemical and sonoluminescence characterisation
No full textSonolysis has been proposed as a promising treatment technology to remove per- and polyfluoroalkyl substances (PFASs) from contaminated water. The mechanism of degradation is generally accepted to be high temperature pyrolysis at the bubble surface with dependency upon surface reaction site availability. However, the parametric effects of the ultrasonic system on PFAS degradation are poorly understood, making upscale challenging and leading to less than optimal use of ultrasonic energy. Hence, a thorough understanding of these parametric effects could lead to improved efficiency and commercial viability. Here, reactor characterisation was performed at 44, 400, 500 and 1000 kHz using potassium iodide (KI) dosimetry, sonochemiluminescence (SCL), and sonoluminescence (SL) in water and PFOS solution. Then the degradation of PFOS (10 mg / L in 200 mL solution) was investigated at these four frequencies. At 44 kHz, no PFOS degradation was observed. At 400, 500 and 1000 kHz the amount of degradation was 96.9, 93.8 and 91.2%, respectively, over four hours and was accompanied by stoichiometric fluoride release, indicating mineralisation of the PFOS molecule. Close correlation of PFOS degradation trends with KI dosimetry and SCL intensity was observed, which suggested degradation occurred under similar conditions to these sonochemical processes. At 1000 kHz, where the overall intensity of collapse was significantly reduced (measured by SL), PFOS degradation was not similarly decreased. Discussion is presented that suggests a solvated electron degradation mechanism for PFOS may occur in ultrasonic conditions
Direct Current Contact-Mode Triboelectric Nanogenerators via Systematic Phase Shifting
No full textThe intermittency and discontinuous nature of power generation in Triboelectric Nanogenerators (TENGs) are arguably their most significant drawback, despite the promise demonstrated in low-power electronics. Herein, we introduce a novel technology to overcome this issue, in which, built-in systematic phase shifting of multiple poles is used to design a pseudo direct-current TENG. Unlike previous attempts of constructing near direct-current TENGs that base on the segmentation of electrodes of a sliding mode TENG, this technology introduces a new method that depends on planned excitation of constituent TENG units at different time intervals to obtain the necessary phase shifts, achieved by their structural design that contains an asymmetric spatial arrangement. Therefore, the direct current generation for TENG, which was previously limited to the sliding mode TENG units, are expanded to contact-mode TENGs. The technology allows for continuous and smooth operation of the driven loads and paves the way for a new dawn in energy scavenging from mechanical sources. We use the distance-dependent electric field (DDEF) platform to design the systematic phase shifting technology, which is experimentally demonstrated via a free-standing mode TENG (FSTENG) based design, to power a number of prototype devices. The resultant power output of the TENG indicates a crest factor close to 1.1 at relatively low frequencies, the best reported values for TENGs with contact-mode basic units, to date. This work provides a highly awaited solution to overcome the intermittency and sporadic nature of TENG outputs, thus, promoting the field towards powering next generation autonomous and mobile electronics
Compressive Near-Field Localization For Multipath RIS-aided Environments
No full textReconfigurable intelligent surfaces (RISs) are considered among the key techniques to be adopted for sixth-generation cellular networks (6G) to enhance not only communications but also localization performance. In this regard, we propose a novel single-anchor localization algorithm for a state-of-the-art architecture where the position of the user equipment (UE) is to be estimated at the base station (BS) with the aid of a RIS. We consider a practical model that accounts for both near-field propagation and multipath environments. The proposed scheme relies on a compressed sensing (CS) technique tailored to address the issues associated with near-field localization and model mismatches. Also, the RIS phases are optimized to enhance the positioning performance, achieving more than one order of magnitude gain in the localization accuracy compared to RISs with non-optimized phases
Adapting sanitary inspections for the monitoring of small drinking water supplies in Iceland
No full textClostridium butyricum RH2 Alleviates Chronic Foot Shock Stress-Induced Behavioral Deficits in Rats via PAI-1
No full textBalanced Performance Assessment under uncertainty: An Integrated CSW-DEA and Balanced Scorecard (BSC)
No full textData Envelopment Analysis (DEA) is a mathematical programming model that calculates the relative efficiency of homogenous Decision Making Units (DMUs). The conventional DEA models used to calculate the efficiency require the exact amount of inputs and outputs; in real business situations, however, it is often impossible to determine the exact numeral value of some inputs and outputs. At the same time the Common Set of Weights (CSW) overcomes the weakness of DEA models for assessment under same conditions. On the other hands, it is important to considering the balance in evaluation and calculation of indicators. This study develops a new model to calculate the CSW in fuzzy environments, considering the balanced environment using the Balanced Scorecard (BSC). Our proposed model is linear for fairly and equitably evaluating the DMUs on the same scale, also enables us to deal with fuzzy environment and greatly reduces the computational complexities for enormous volumes of data in many real applications and treat difficulties in fuzzy DEA models. From a managerial point of view, this paper aims to provide an integrated framework to form a better strategic decision-making process about organization performance, which ultimately leads to the competitive advantages and success of the organization in the long run. Finally, in the field of performance management, the proposed model was applied to evaluate the performances of ten manufacturing enterprises in to confirm the validity and applicability of the proposed approach
A numerical analysis of particulate matter control technology integrated with HVAC system inlet design and implications on energy consumption
No full textImaging Excited-State Dynamics in Two-Dimensional Semiconductors with Emerging Ultrafast Measurement Techniques
No full textImproving sanitary inspections for small drinking-water supplies
No full textThe risk-based approach to drinking-water safety management has been widely adopted within the water sector since 2004 when the World Health Organisation (WHO) championed the use of Water Safety Plans (WSPs) as a comprehensive risk assessment and risk management approach that encompasses all steps in water supply from catchment to consumer. Due to the high resource requirements for full WSP implementation, an alternative risk assessment approach is required where WSP rollout is either not feasible or warranted, which is often especially pertinent within small drinking-water supplies.Sanitary inspections (SIs), which typically consist of a set of questions to identify observable breakdowns in supply protection; and sources and pathways of contamination, may serve numerous functions including use within the WSP of a large supply; as a basic or introductory WSP for a small supply; and as a tool for water safety surveillance activities. The use of risk assessments within the drinking-water sector is not novel, however the first suite of global SI templates was published just 24 years ago in the 1997 WHO Guidelines for Drinking-water Quality (GDWQ). With the impending publication of the subsequent edition of these GDWQ, which are often used to guide development of regulations such as the new European Union (EU) Drinking-water Directive (DWD), review of the content and format of the SI forms to be included within the revised publication was timely.This study used a mixed methods approach to improve SIs for small drinking-water supplies. In addition to the rigorous review and revision of the WHO SI forms based on literature review; group discussion; and expert and practitioner review, additional research questions relating to the consistency of SI answering between cohorts; the effect of training on SI answer consistency; approaches to SI adaptation; and the impacts related to SI implementation were all tested and investigated using qualitative and quantitative methods both online and during field studies in Iceland, Malawi and Uganda.The main contribution to the literature stemming from this research, which demonstrates the originality, rigour, and significance of the work, will be the publication of the revised suite of SI forms in the new WHO GDWQ. These resources will be used widely for practical implementation of risk assessments either by direct use of the WHO templates, or by use as a reference point for adaptation. The research related to SI adaptation undertaken during this study will provide an initial point of reference for those endeavouring to adapt or develop their own SI materials.The main limiting factor of each individual research objective was the use of small sample sizes, which was due to restricted PhD study resources. The future advancement of SIs will rely heavily on their digitalization. SI forms that can be adapted in real-time to adjust to unique supply circumstances or configurations, or that guide inspectors who possess low levels of knowledge by showing interactive examples of operational definitions or risks, are examples of how technology could further improve the SI approach. Considering the potential for software to recognise that, for example, certain combinations of risk factors and metadata, such as rainfall, may cause an increased threat to water quality, the SI may soon become the most powerful tool for drinking-water management and surveillance