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Comparison of relapse rates, postoperative infections and operation time between BSSO and DO: a meta-analysis
Get PDFPurpose: Differences in common complications and operation times suggest that complications after mandibular advancement surgery for Class II mandibular hypoplasia using bilateral sagittal split ramus osteotomy (BSSO) and distraction osteogenesis (DO) require further evaluation. The aim here is to compare relapse and postoperative infection incidences and operation times by meta-analysis to provide information for surgeons in selecting the appropriate surgical method and to inform patients about the complication risks of both.Method: A comprehensive search using Medline, PubMed, Web of Science, Cochrane Library, EBSCO, CQVIP, CBA, CNKI, and SinoMed and the Internet until February 2017 was performed. Only randomized controlled trials (RCTs), controlled clinical trials (CCTs), and retrospective studies (RS) were included. We performed study selection, data extraction, and risk of bias assessment and meta-analyses with fixed and random effects models based on statistical heterogeneity. Data were combined using Review Manager software.Results: In total, 388 articles were retrieved; 8 met our inclusion criteria: 4 RCTs, 1 CCT, and 3 RSs. Five of the included articles were analyzed regarding horizontal and vertical relapse. Although horizontal relapse was not significantly different between treatment options (P=0.65), vertical relapse was (P=0.03). Three and 2 studies were included in analyses of postoperative infections and of operation time; both showed significant differences between treatment options (P=0.0009 and P=0.006, respectively).Conclusion: This analysis revealed lower incidence rates of vertical relapse and postoperative infections after BSSO, with the operation time also being significantly shorter. More high-quality RCTs are needed for a more reliable and convincing conclusion
A Unique Case Report of Hypertrophic Osteoarthropathy Associated With Endometrial Cancer and Literature Review.
Get PDFIntroduction: In this manuscript, we present an oncological case of hypertrophic osteoarthropathy (HOA) associated with endometrial cancer.Presentation of the case: A 46 year-old woman with a history of endometrial cancer (ER+/PR+) presented with hemoptysis and severe diffuse muscle and joint pain, intractable to hydromorphone and non-steroidal-anti-inflammatories. She was diffusely tender to palpation, prominently in the bilateral lower extremities. Bone scintigraphy showed diffuse osteoblastic activity in all extremities, most prominent in the tibiae, concordant with HOA. Patient was treated with zoledronic acid (ZA) and ketorolac, achieving adequate pain control. Conclusion: HOA has been associated with multiple primary malignancies, as well as other medical conditions. Its association with endometrial cancer has been rarely described in the literature. The pathophysiology of this disorder is poorly understood. More studies are needed to further enhance our understanding of this rare disease
Isolated Parotid Metastasis from Small Cell Lung Cancer
Get PDFWorldwide, lung cancer accounts for the most cancer mortality in both men and women with 1.6 million deaths in 2012. Small cell lung cancer usually present as a disseminated disease in over 70% of the patients. Common site of metastasis include liver, adrenal, bone and brain. However, metastasis to parotid gland is uncommon described only in case reports. A 75-year old male presented with a mass on right parotid gland, biopsy confirmed metastatic small cell carcinoma. CT chest showed 5.5cm right hilar mass and mediastinal adenopathy T2bN2M1b, stage IV disease. He underwent chemotherapy Carboplatin and Etoposide. Small cell lung cancer diagnosed from isolated metastasis to parotid gland is rare. Physicians should be aware of pulmonary source when presented with a parotid tumor. Overall, the finding has a poor prognosis but main modality of treatment is palliative with systemic chemotherapy and possible irradiation for symptomatic control.
Leiomyosarcoma of Colon Presented as Retroperitoneal Mass: A Rare Case Report
Get PDFIntroduction: Retroperitoneal tumors are lesions with diverse pathological subtypes that originate from the retroperitoneal space. About forty percent of these tumors are benign. These lesions are often surrounded and associated with vital abdominal blood vessels; therefore, a complete surgical resection is difficult.Presentation of the case: Here we are presenting a 42-year-old female presented with abdominal lump from last two monthswith persistent abdominal pain from one month. The computed tomography and ultrasound scan confirmed the presence of a solid retroperitoneal tumor. She underwent surgical exploration and histology confirmed that the tumor composed of spindle shaped cells disposed in intersecting fascicles, whirling and storiform pattern. The tumor cells are oval to spindle shaped with blunt ended nuclei, dispersed chromatin and moderate amount of cytoplasm. On immunohistochemical staining, tumor cells were positive for vimentin. The patient was followed up for two years, with no evidence of tumor recurrence. No standardized guidelines have been established for its treatment because too small a number of cases have been reported, but surgical resection was considered the treatment of choice. In summary, we report a unique case who developed leiomyosarcoma of colon presented as retroperitoneal mass.Conclusion: In this case report we described this rare occurrence of leiomyosarcoma of colon and highlight the diagnostic difficulties such cases can pose along with a review of relevant literature
Antifungal activity of mangrove rhizobacterium Pseudomonas aeruginosa against certain phytopathogenic fungi and its growth characterization
Get PDFAntimicrobial substances are widespread and they are likely to play an important protective role. Marine bacterium has been recognized as producer of important antimicrobial substances which has an exceedingly bright future in the discovery of life saving drugs. The present study was carried out to screen the antifungal activity of mangrove rhizobacteria against certain phyto pathogens from Manakudi estuary, Kanyakumari District, Tamilnadu. Around 20 colonies obtained in Zobell marine agar plates were screened for antifungal traits. Among the 20 isolates, the candidate bacterial isolate exhibited good anti fungal ability. Identification of strains was carried out and confirmed by cultural, biochemical and 16S rDNA sequences. The potent strain was identified as Pseudomonas aeruginosa. Various process factors such as different pH, temperature, carbon and nitrogen sources and NaCl were tested for the bacterial growth in static and shaking conditions. The isolated Pseudomonas aeruginosa possesed a variety of promising properties that favoured as a better biocontrol agent. In the present investigation antifungal activity of the mangrove isolate was tested against common pathogens like Penicillium sp., Candida sp., Aspergillus sp., Aspergillus fumigatus, Aspergillus flavus, Pescalotionbsis sp., Fusarium oxysporum and Glomerella cinculata. The candidate bacterium showed inhibitory action to the tested fungal pathogens except Fusarium oxysporum and Glomerella cinculata.
Performance of Brinjal (Solanum melongena) Genotypes through Genetic Variability Analysis
Get PDFThe physiomorphological divergence was assessed in fifteen brinjal genotypes by using cluster mean analysis and mean difference to identify parental genotypes for future breeding program in order to develop new high yielding varieties in randomized complete block design with three replications. Plant height, days to first flowering, number of branch and number of fruits per plant have the highest percent of variations among the traits. The genotypes under the experiment were grouped into five clusters. The highest inter cluster distance was found between cluster III and IV followed by IV and V. According to relative contributions of the nine characters length of fruit and yield per plant have the prominent influence towards varietal improvement. Selecting genotypes from distant clusters probably provide promising recombinants and better segregants for future breeding platform
Polymer/Graphene Nanocomposite: Preparation to Application
Get PDFGraphene has emerged as a topic of huge scientific interest due to its high surface area, exceptional mechanical properties, electron transfer, and other physical properties. In polymers, this one-atom thick 2D crystal may significantly enhance the physical properties at very small loading level. In this review, essential characteristics of polymer/graphene nanocomposite have been discussed. Moreover, fabrication techniques (in situ method, solution route, melt technique) frequently employed for polymer/graphene nanocomposite have been discussed. Applications of these nanocomposites in Li-ion batteries, electronic devices, and solar cells have been conversed along with the current challenges associated with processing and scalability of these materials
Fish Liver Biomarkers for Heavy Metal Pollution: A Review Article
Get PDFHeavy metals as dangerous and long lasting pollutants in environment have been widely studied and monitored. Liver is the most important organ in storage and detoxification of these pollutants. Assessment of indicators, including changes in intermediate active components between the liver and pollution effect, provide sensitive liver biomarkers and can be a suitable index for health condition of fish. In addition, fish liver is a favorite model to study interaction between environmental factors and liver structure and performance. This review studies variety of liver biomarkers in molecular- cellular (damage to chromosome, DNA and lysosome; increasing metallothionein and ferritin levels), biochemical-physiological (transaminase enzymes and oxidative enzyme parameters) and morphological-histopathological levels, and investigates advantages and disadvantages of these levels. Moreover, restrictions and landscape in the future is discussed for these biomarkers exposed to heavy metals pollution. There are many liver biomarkers that can be used for identification of initial heavy metal pollution, assessment of health condition of fish and ability of fish to defense against pollution challenges. Some of these biomarkers are special for heavy metal pollution while the others are non-specia
Betel Quid Addiction: Blessing or curse, A study of North East Population of India
Get PDFIntroduction: Oral cancer is most common cancer in males and third most common in females, one of the main causative agent being use of chewing betel quid (BQ). Areca nut (Areca catechu), a major component of BQ, contains certain alkaloids that give rise to nitrosamines. CYP2A6 genetic polymorphism were studied among the Eastern and North eastern indian population .Methods : In this present study subjects were screened from Department of E.N.T. Oral and Maxillofacial surgery of RKMSP hospital, Kolkata and different areas of Eastern and North Eastern states of India. Polymorphism of CYP2A6 gene was studied from EDTA blood .Results: Some of the cases had more than one addiction. It has been found that most of the subjects had betel quid chewing habit. Early metabolizer are susceptible to oral cancer where as in case of poor metabolizers chances are less.Conclusion: Betel quid has an immense role in changing the oral pathology and developing oral cancer.
Renal Failure due to Direct Infiltration of Chronic Lymphocytic Leukemia: Case report and Review of Treatment
Get PDFBackground: Chronic lymphocytic leukemia (CLL) is a cancer due to the uncontrolled growth and accumulation of mature B lymphocytes in the bone marrow and blood. Asymptomatic kidney involvement of CLL is fairly common but renal failure secondary to CLL is very rare.Case Presentation: Less than twenty cases of acute renal failure due to the direct CLL infiltration have been reported in the literature. Given the rarity of this complication, there is no standard of care on how these patients’ treatment should be approached. We present a case of renal failure in a patient with a longstanding history of CLL.Conclusion:In order to guide future management, our discussion features a detailed review of the literature with a focus on the various treatment modalities used in this very rare complication