Fukuyama University Repository / 福山大学学術情報リポジトリ
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Chiral Recognition of Dikeopiperazine Cyclo(Pro-Gly) and Propranolol using (-)-Epigallocate-chin-3-0-Gallate
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High Expression levels of NADPH Oxidase 3 in the Cerebrum of Ten-week-old Stroke-Prone Spontaneously Hypertensive Rats
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Attitude Survey for Chronic Obstructive Pulmonary Disease with the Lung Age Measurement in the Health Festival for Citizens.
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From the viewpoint of the setting of the Western Regions in Kenji Miyazawa's novel "Magnolia Tree" - influence from Daitou Shimaji's personal experience discourse of his expedition to Indian Buddhist ruins
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A Study on the Copyrights concerning Works Created by Children in the Fields of Education and Nursing
Get PDFRestrictions by the copyright act are supposed to be imposed on materials which are used for educational purposes in schools or other educational institutions.
On the other hand, as for the restrictions on using and opening to the public of works created by children in the fields of
education and nursing, there are no clear provisions in the copyright act.
However, it is obvious that even children who have created works should enjoy their copyrights and their rights should be treated as strictly as those of adults.
In this article, what kind of problems can be brought about in the present state described above is dealt with and also the situations surrounding works created by children in the fields of education and nursing are speculated upon.departmental bulletin pape
Selective enhancement of wnt4 expression by cyclic AMP-associated cooperation between rat central astrocytes and microglia.
Get PDFAN10064550The wnt protein family has important members involved in cell differentiation, proliferation and plasticity expression; however, little is known about its biosynthesis processes. On the other hand, an increase in the intracerebral cyclic adenosine 3', 5'-monophosphate (cAMP) level leads to synaptic plasticity via the de novo synthesis of any protein. Here, the effect of dibutyryl cAMP (dbcAMP), a membrane permeability cAMP analog, on the wnt family was investigated in rat primary-cultured glial cells containing astrocytes and microglia. Among wnt3a, 4, 5a, 7a and 11 mRNA, only wnt4 expression was increased by longer treatment (24 h), compared with short treatment (2 h), with dbcAMP in a concentration-dependent manner, and its effect reached statistical significance at 1 mM. In cultures of isolated astrocytes or microglia, wnt4 expression was not affected by 1 mM dbcAMP for 24 h, and microglial wnt4 protein was undetectable even when cells were treated with the drug. Mixed glial cells treated for 24 h with 1 mM dbcAMP showed significantly increased wnt4 protein, as well as mRNA. Immunofluorescence manifested that cells that expressed wnt4 protein were astrocytes, but not microglia. Intraperitoneal injection of 1.25 mg/kg rolipram, a phosphodiesterase (PDE) IV inhibitor that can pass through the blood brain barrier and inhibits cAMP degradation specifically, showed a tendency to increase wnt4 expression in the adult rat brain after 24 h, and the increases in wnt4 mRNA and protein levels reached statistical significance in the hippocampus and striatum, respectively. This is the first finding to help elucidate the selective biosynthesis of central wnt4 through cAMP-stimulated microglia and astrocytes interaction.The wnt protein family has important members involved in cell differentiation, proliferation and plasticity expression; however, little is known about its biosynthesis processes. On the other hand, an increase in the intracerebral cyclic adenosine 3', 5'-monophosphate (cAMP) level leads to synaptic plasticity via the de novo synthesis of any protein. Here, the effect of dibutyryl cAMP (dbcAMP), a membrane permeability cAMP analog, on the wnt family was investigated in rat primary-cultured glial cells containing astrocytes and microglia. Among wnt3a, 4, 5a, 7a and 11 mRNA, only wnt4 expression was increased by longer treatment (24 h), compared with short treatment (2 h), with dbcAMP in a concentration-dependent manner, and its effect reached statistical significance at 1 mM. In cultures of isolated astrocytes or microglia, wnt4 expression was not affected by 1 mM dbcAMP for 24 h, and microglial wnt4 protein was undetectable even when cells were treated with the drug. Mixed glial cells treated for 24 h with 1 mM dbcAMP showed significantly increased wnt4 protein, as well as mRNA. Immunofluorescence manifested that cells that expressed wnt4 protein were astrocytes, but not microglia. Intraperitoneal injection of 1.25 mg/kg rolipram, a phosphodiesterase (PDE) IV inhibitor that can pass through the blood brain barrier and inhibits cAMP degradation specifically, showed a tendency to increase wnt4 expression in the adult rat brain after 24 h, and the increases in wnt4 mRNA and protein levels reached statistical significance in the hippocampus and striatum, respectively. This is the first finding to help elucidate the selective biosynthesis of central wnt4 through cAMP-stimulated microglia and astrocytes interaction.departmental bulletin pape
The Effect of Anthraquinones in Daiokanzoto on Increasing the Synthesis of Sennoside A-Metabolic Enzyme Derived from Bifidobacteria
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Writing on Ordinary Living in Local Areas: How Regional Zines and the Mass-Market Magazine ku:nel Depict Similar
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Questionnaire research on suicide prevention education for university students: The relationship between motivation, knowledge, and opinions on suicide and suicide prevention
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Learning Active Listening in Interpersonal Communication and Human Support
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