International Journal of Ayurvedic Medicine
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Importance of Kumbh Pilgrimage
Full text linkThe Kumbh pilgrimage, particularly at Haridwar, holds immense spiritual significance in Hinduism. Haridwar, also known as Mayapuri, is one of the seven sacred cities and a major site for Kumbh Mela, which occurs every twelve years, with Ardh Kumbh being held every six years. The region is associated with multiple sacred places such as Gangadwar, Kankhal, and Triganga, where holy rituals and pilgrimages are believed to cleanse devotees of their sins. Haridwar\u27s connection with the descent of the Ganga, as facilitated by King Bhagirath, further elevates its sanctity. The story of Goddess Sati’s self-immolation and Lord Shiva’s intervention adds to its significance, emphasizing that bathing in these sacred waters can lead to liberation and fulfillment of desires. The narrative of the pilgrimage also includes tales of various Tirthas (holy sites) where devotees achieve various spiritual benefits, such as liberation from sin, divine blessings, and eternal happiness. This article highlights the historical and mythological importance of Haridwar and other significant places like Prayag, and explores the rituals associated with these sacred sites. The Kumbh Mela, especially, is portrayed as an opportunity for devotees to cleanse themselves spiritually, renew their faith, and seek salvation through rituals and offerings. The legends associated with these sacred locations further underscore their power to bring peace, happiness, and liberation to those who participate with devotion
Existence and Importance of Kumbh-Parva in the Vedas
Full text linkThe Kumbh Parva, an ancient religious festival, holds significant cultural and spiritual importance in Indian society. This sacred gathering is based on the Vedic principles and is one of the largest religious congregations globally. The festival’s origins can be traced to ancient Vedic texts, where the word "Kumbh," meaning "pitcher," has multiple interpretations symbolizing purification, abundance, and spiritual unity. The festival, held at specific sacred locations like Prayag, Haridwar, Ujjain, and Nashik, symbolizes a confluence of physical, mental, and spiritual cleansing. In the Vedas, Kumbh is associated with the divine and is described as a means to purify the body and soul, allowing participants to attain spiritual liberation. The festival also promotes social unity, devotion, and human cooperation, transcending individual differences. The Vedic scriptures, such as the Rigveda, Samaveda, and Atharvaveda, all reference the Kumbh, linking it with both material and spiritual blessings. The Kumbh festival is thus not only a celebration of faith but also a manifestation of India’s rich cultural heritage, where each action, be it bathing in the holy rivers or meditating, is considered to purify the individual. Through its spiritual essence, Kumbh serves as a reminder of the importance of virtuous deeds and the eternal pursuit of happiness and liberation
An observational study on assessing the quality of life in patients with moolam (anorectal diseases) reported at Ayothidoss Pandithar Hospital, National Institute of Siddha, Chennai
Full text linkIntroduction: The Siddha system identifies Moolam as a major anorectal disorder influenced by diet, lifestyle, and psychosomatic factors. This study assesses the impact of Siddha interventions on quality of life in patients with Moolam, addressing physical, psychosocial, and defecatory aspects, while analysing preventable etiological risk factors. Objectives: Primary objective: To assess the quality of life in patients with Moolam (Anorectal diseases) reporting at OPD of Ayothidoss Pandithar Hospital, NIS before and after taking Siddha interventions through HEMO-FISS QoL questionnaire and QoLAF questionnaire. Secondary objective: To assess the etiological factors with respect to diet, habits and occupational history mentioned in Siddha classical text.Materials and methods: This observational study (IEC No: NIS/24/IEC/2023/MP/40; CTRI/2023/08/056647) involved 60 patients aged 20–60 years with anorectal diseases (hemorrhoids, fissure, fistula), selected from 100 screened cases based on inclusion and exclusion criteria. After obtaining informed consent, QoL data were collected at baseline and after 48 days of Siddha interventions through regular OPD. Results: The study results showed that there is a statistically significant reduction (p value<0.001) in HEMO-FISS & QOLAF questionnaire scores, in patients who underwent Siddha interventions on comparing scores of baselines. Discussion: Anorectal disorders significantly affect quality of life, yet most Siddha studies focus only on symptom relief. This study highlights the holistic Siddha approach, targeting physical, psychological, and lifestyle factors through internal medicines, external therapies, Yoga Maruthuvam, and diet, thereby improving overall well-being and preventing recurrence. Conclusion: Based on the reduction of clinical symptoms and HEMO-FISS QoL & QoLAF Questionnaire scoring, it can be concluded that Siddha interventions are effective in the treatment of Anorectal diseases.
A randomised control clinical trial to evaluate the efficacy of Yashadamrita malahara in Shuddhavrana
Full text linkIntroduction: Every day many wound patients reach to the various hospitals and surgery is branch where wound is inevitable. Wound Healing is most important process for which the medical sciences are advancing from ancient time till today to provide the quality of the medicine and procedure which heals the wound fast without any complication. Acharya Sushruta described treatment of wound in detail and explained 60 upakramas which aid healing at various stages of wound. Many Acharyas have used khanija (minerals) and aushada (plant sources) for wound healing. In Rasa Tarangini one such medication explained is Yashadamrita Malahara (ointment) in shuddha vrana (non-contaminated wounds). Methods: A Randomized clinical, comparative study was undertaken. The samples were of age between 20 – 70 years, irrespective of gender, religion, occupation etc.fulfilling the inclusion criteria were selected. Total 30 patients randomly divided into two equal and identical clusters consisting of 15 patients each. The patients of Group A were dressed using Yashadamrita Malahara and patients of Group B were dressed with Jatyadi taila for 14 days. Assessment was done on the basis of shuddha vrana lakshana (Bates Jensen wound assessment tool). Results: The reduction in total score for Group A (mean = 9.60, S.D.= 1.55) and that in Group B (mean =8.67, S.D. =1.45) were not significantly different (P-value = 0.099) at 5% level of significance as observed by unpaired t test. Conclusion: Yashadamrita malahara shows equipotent effect with known standard drug in reducing sadhyavrana
Lantana Camara Linn: Unveiling a reservoir of novel antiepileptic compounds through systematic review
Full text linkEpilepsy affects approximately 52.5 million people worldwide, with one-third experiencing treatment-resistant seizures despite available antiepileptic drugs (AEDs), while Lantana camara, traditionally regarded as an invasive weed, has emerged as a compelling candidate for epilepsy treatment based on traditional knowledge and scientific investigations. This structured review comprehensively analyzes current knowledge of Lantana camara\u27s anticonvulsant properties, examining its phytochemical composition, mechanisms of action, and therapeutic potential as a novel antiepileptic agent. A systematic literature search was conducted following PRISMA 2020 guidelines across Google Scholar, PubMed, Science Direct, and Web of Science databases using relevant search terms to identify research on L. camara\u27s anticonvulsant properties. Key findings include isolation of ursolic acid stearoyl glucoside (UASG) by Kazmi et al. (2012), which demonstrated anticonvulsant activity in seizure models, while recent studies revealed L. camara\u27s multifaceted therapeutic mechanisms involving GABAergic modulation, antioxidant properties, neuroinflammatory regulation, and ferroptosis inhibition. These investigations collectively demonstrate the plant\u27s ability to modulate multiple pathways in seizure generation and propagation, establishing its potential as a multi-target therapeutic agent. L. camara exhibits promising potential for developing novel antiepileptic medications, particularly for drug-resistant cases, with potentially better safety profiles than conventional AEDs, however, critical gaps remain including comprehensive toxicological studies, standardization of active compounds, and clinical translation requiring future research focu
An Investigating the antioxidant and antiproliferative activity of Mimusops elengi Linn Extract against Hepatocellular Carcinoma
No full textThe antioxidant profile of the methanolic extract of Mimusops elengi was measured using various antioxidant assays, and the cytotoxicity was evaluated using MTT and Alamar blue assay against a hepatocellular carcinoma cell line (Hep-G2). In the DPPH radical scavenging assay, IC50 values were 91.55±0.02 µg/ml. Superoxide Radical Scavenging IC50 Value is 57.14 ±0.088 µg/ml, Nitrogen Scavenging IC50 Value is 15.88 ±0.028 µg/ml, CUPRAC IC50 Value is 7.731±0.5 µg/ml, FRAP IC50 Value is 14.32 ±0.046 µg/ml, Hydroxyl radical scavenging IC50 value is 22.46 ±1.02 µg/ml, and ABTS IC50 value is 4.00±0.08 µg/ml. the cytotoxicity study by MTT Assay the IC50 Values 34.98± 0.24, Alamar Blue Assay, it was showed that when the HepG2 cell line was exposed to various concentrations of the sample on different treatment doses, MEME Mean Fluorescence intensity (MFI%) of Alamar blue was found increasing with decrease of Treatment Dose of sample MEME. The highest MFI was estimated at 105.20 % at a 3.601 µg/ml dose of sample MEME, while the Lowest MFI% % (99.24%) was observed at a higher treatment dose of 14.405 µg/ml for Sample MEME concerning the control
In-Vivo Anti Oxidant Effect of Mukta Pishti against Paracetamol Induced Hepatic Damage in Wistar Albino Rats
Full text linkMukta Pishti is a unique Herbo-mineral calcium containing formulation in Ayurveda. It is widely practiced as anti-ulcerative and antacid but traditionally it has mentioned as Ayushya, Vrishya, Rasayani, Balya kara etc. which has broad spectrum use to enhance our quality of life.
This study aimed to evaluate the antioxidant activity of Mukta pishti in Wister albino rats, particularly its protective effects against paracetamol (PCM)-induced hepatic damage by oxidative stress.
Mukta pishti was prepared through a traditional Ayurvedic process, including shodhana with jayanti patra swarasa and bhavna with Gulaba arka over 21 days. A total of 30 Wister albino rats were divided into five groups, for a 14-day treatment protocol: vehicle control, negative control (PCM), standard (silymarin), and two Mukta pishti treatment groups (100 mg/kg and 200 mg/kg) body weight. Biochemical analyses of serum and liver tissues were conducted post-treatment to assess oxidative stress markers, including glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), and malondialdehyde (MDA).
Mukta pishti administration significantly reduced MDA levels (p<0.001) and increased GSH (p<0.001), SOD (p<0.0001), and CAT levels (p<0.0001) in serum, indicating strong antioxidant activity, particularly at the 200 mg/kg dose. Liver homogenate results varied, suggesting enzyme interactions affecting oxidative stress markers.
Mukta pishti exhibits significant antioxidant properties, potentially through mechanisms involving cell membrane stabilization and activation of antioxidant enzymes. These findings support its traditional use in treating oxidative stress-related conditions and highlight its therapeutic potential in liver protection against toxic agents. Further studies are needed to elucidate the specific pathways involved in its protective effects
Identification of Bioactive Phytocompounds present in Methanolic Extract of Neolamarckia cadamba Leaves from Ranchi district of Jharkhand
Full text linkThe purpose of this study was to identify the bioactive phytocompounds present in the leaves of Neolamarckia cadamba found in Ranchi district of Jharkhand, India. Neolamarckia cadamba is used among the locals for ethnomedicinal purposes. In this study methanolic extract of Neolamarckia cadamba leaves was used for performing GC- MS for the analysis of respective phytocompounds. The major phytocompounds identified were α- tocopherol (12.73%), n- hexadecanoic acid (11.23%), gamma.-Sitosterol (8.43%) and Squalene (7.32%). These identified phytocompounds possesses different kinds of biological activities such as anti- inflammatory, antioxidant, antimicrobial etc. These biological properties of identified phytocompounds recommends Neolamarckia cadamba as a plant of medicinal importance
Evaluation of Enzymatic In-vitro anti diabetic activity of Butea monosperma (Lam.) Kuntze
Full text linkBackground: About 830 million people worldwide have diabetes, the majority living in low and middle- income countries. The diabetic population has to consume antidiabetic medicines for a long duration due to its chronic nature. Herbal formulations are preferred due to lesser side effects and low cost. Ancient Ayurvedic texts has mentioned Palash, Butea monosperma, (Lam.) Kuntze which belongs to Fabaceae Family, in Diabetes Mellitus. The management of diabetes can be achieved by reducing post- prandial hyperglycemia by delaying the activities of the enzymes α-amylase and α- glucosidase which are responsible for the digestion of carbohydrates and absorption of glucose in the digestive tract, respectively. Objectives: The study aimed to evaluate the in vitro inhibitory potential of water-soluble extracts of Butea monosperma (Lam.) Kuntze (Palash Ghana) on α-amylase and α-glucosidase enzymes, which play a crucial role in carbohydrate digestion and glucose absorption. Material and Methods: Palash Ghana was prepared by decoction and solidification methods, extracting water- soluble components of the whole plant. α-Amylase inhibitory activity was assessed using the Dinitrosalicylic Acid method with concentrations ranging from 50 to 250 µg/mL. α- Glucosidase inhibition was evaluated using the p-NPG method at concentrations between 100 and 500 µg/mL, with Acarbose as a positive control. Result and Conclusion: Palash Ghana exhibited a dose-dependent inhibitory effect on α-amylase, with a maximum inhibition of 83.12% at 250 µg/mL. In contrast, α-glucosidase inhibition was moderate, reaching 22.16% at 500 µg/mL. The findings suggest that Palash Ghana may serve as a potential natural antidiabetic agent.
Effectiveness of Thokkanam Therapy (Siddha Physical Manipulation Technique) in the management of Kumbavatham (Periarthritis of Shoulder joint)- A Case Report
Full text linkPeriarthritis shoulder is an inflammatory disorder characterised by pain, stiffness, restriction of shoulder movements and functional disability. Though it is a common musculoskeletal condition, its management remains a huge challenge to the orthopaedic surgeons due to unsatisfactory effectiveness of the available treatment modalities. In Siddha system of medicine, this condition is referred to as Kumbavatham. It is one among the 80 types of Vatha diseases, caused due to vitiated Vatha humour. Various internal and external treatment modalities are indicated for the management of Vatha diseases. Thokkanam is a type of external therapy modality, in which physical manipulation procedures are done by hands of the physician on the body of the patient with or without application of medicated oil. Thokkanam as a standalone treatment modality is not yet subjected to scientific evaluation. Hence this study reports the successful management of a 61-year-old male patient. He reported with complaints of pain and restricted movements in the right shoulder joint for the past one year to Puramaruthuvam department of Ayothidoss Pandithar hospital (APH)- National Institute Siddha (NIS). He was diagnosed with Kumbavatham and the treatment was started. Thokkanam with Kunthriga thailam was carried out for 14 days. Following the treatment, pain and restriction of movements subsided. The prognosis was assessed using VAS score, goniometric measurements of range of movements and Shoulder pain and disability index (SPADI) score. VAS score improved from 10 points to 2 points, SPADI score improved from 96.76% to 6.9% and goniometric measurement improved from restricted movements to normal range of movements following treatment. These findings may encourage the use of Thokkanam therapy with Kunthriga thailam in the management of Kumbavatham