International Journal of Ayurvedic Medicine
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Antidiabetic activity of aqueous root extract of Chlorophytum borivilianum on streptozotocin induced diabetic rats
Full text linkTo identify and characterize the synthetic components from the roots that are responsible for the activity, as well as to assess the plant Chlorophytum borivilianum\u27s pharmacological effectiveness in diabetes both in vitro and in vivo. The goal of the current study was to examine the ethnomedical application of aqueous extract from the roots of Chlorophytum borivilianum as a possible anti-diabetic drug in rats with STZ-induced diabetes. The biological activities of the extract were examined both in vitro and in vivo. Water was utilized as a solvent for cold maceration, while TLC and column chromatography were employed for fractionation. The structures of the isolated compounds were validated by mass spectroscopy and liquid chromatography. The aqueous extract of Chlorophytum borivilianum Sant. & Fern. (Liliaceae) roots revealed the presence of phytoconstituents with therapeutic effects, including dihydrocapsaicin, deserpidine, reserpine, biliverdin-IX-α, and vitamin C. After giving a dose orally in comparison to the oral hypoglycaemic medication metformin, dihydrocapsaicin was detected, and the Chlorophytum borivilianum root aqueous extract fraction significantly decreased elevated blood glucose levels. Every outcome is dose-dependent. The presence of the anti-diabetic chemical dihydrocapsaicin was demonstrated from the aqueous extract. The parameters associated with diabetes can be inhibited by the aqueous extract of Chlorophytum borivilianum root
Evaluations of nephro-protective activity of poly-herbal hydroalcoholic extract against streptozotocin-induced nephrotoxicity and renal dysfunction
Full text linkObjective our research work aim was the assessment of the nephroprotective activity of poly-herbal hydroalcoholic extract against streptozotocin-induced nephrotoxicity and renal dysfunction. Poly-herbal hydroalcoholic extract of (PHHE) nephrotoxicity activity was determined using the streptozotocin-induced nephrotoxicity and renal dysfunction method. Poly-herbal hydroalcoholic extract of 200 and 300 mg/kg was given for eight weeks to selected animals rat models. The biochemical parameters like as lipid profile, renal functional, antioxidant enzyme level, anti-inflammatory factors and histopathological evaluations parameters were used for estimation of nephroprotective activity. PHHE also reduced the levels of creatinine, blood urea nitrogen, total cholesterol, triglycerides, advanced glycation end products and albumin in serum and urine, respectively. PHHE drastically increased the antioxidant parameters in the kidney and histological evaluation. All of these evaluations parameters results were exposed that PHEE has potential antioxidant, and anti-glycation activities. Exhibited significant therapeutic effects and was found to be the potential same as standard glimepiride drug. The experimental results were found to be significant nephroprotective action of PHHE extract on STZ induced diabetic nephroprotective animal model. Conclude the PHHE can use for the treatment and management of diabetic nephropathy disease.
Ayurvedic management of Alcohol Withdrawal: A Case Study
No full textIntroduction: Hazardous alcohol use accounts for 5.1% of the global disease burden, with 7.1% in males and 2.2% in females. Chronic alcohol consumption is associated with liver diseases such as fatty liver, hepatitis, and cirrhosis, as well as other health issues like pancreatitis, gastrointestinal disorders, malnutrition, vitamin deficiencies, and cancer. Withdrawal symptoms often accompany cessation. In Ayurvedic medicine, effective treatments for alcoholism and withdrawal symptoms (Madatyaya) are well-documented. Main clinical findings: In this case a 32 yrs old male patient presented with symptoms of insomnia, anxiety, nausea, restlessness, depression, headache and discomfort persisting for a duration of 15 days. The individual had developed a chronic dependency on alcohol over a span of 8 years, but ceased its usage 2 months ago as a result of concurrent health concerns. Currently, he is manifesting these symptoms as withdrawal symptoms. Diagnosis: Patient was diagnosed with Alcohol withdrawal syndrome. Intervention: The patient had ayurvedic treatment including meditation, counselling, and the use of Kharjuradi mantha, Drakshasava, Sutashekhar rasa, Phalatrikadi kwath and Medhya yoga. Outcome: With improvement in the signs and symptoms of alcoholism, this therapy strategy aims to improve the patient\u27s condition
Traditional Therapies for Modern Ailments: Ayurveda in Avascular Necrosis Management
Full text linkAvascular necrosis (AVN), also known as osteonecrosis or ischemic bone necrosis, refers to the necrosis of bone tissue resulting from a compromised blood supply. The management of AVN is aimed at preserving structural integrity and functional capacity and alleviating pain. Various surgical interventions, including drilling, bone graft insertion, modified Whitman or Colonna reconstruction, and prosthetic insertion, are commonly employed to address the condition. However, these procedures are associated with high costs and a poor prognosis. The present patient exhibits a constellation of symptoms, including joint pain (sandhishoola), muscle wasting (mansbalkshaya), insomnia (aswapna), and persistent discomfort (santata ruk), which are consistent with the diagnosis of asthimajjagata vata according to Ayurveda. In the present study, a 45-year-old patient was managed with Tiktaksheera basti (medicated enema) and other internal medications. Throughout the treatment course, the patient was monitored for complications, with no adverse events observed. Symptomatic improvements were assessed using a questionnaire that graded signs and symptoms before and after treatment. Conservative management of AVN utilising Ayurvedic principles significantly relieves symptoms, improves the necrotic condition of the femoral head, and enhances quality of life. This case presents a unique opportunity to explore the efficacy and safety of Ayurvedic interventions in the management of bilateral femur AVN, offering valuable insights for future research and clinical practice
Unveiling the Effect of Virechana by Trivrutta-Haritaki Yoga in the Management of Sthaulya w.s.r to Obesity: A Case Series
Full text linkIntroduction: The ancient system of Ayurveda has long recognised the importance of detoxification therapies for maintaining holistic health. Virechana Karma, a prominent purification procedure, is vital in Ayurveda therapeutic interventions. This article explores the efficacy of Virechan karma, illuminating its role in cleansing the body and addressing various health concerns, such as Sthaulya, through the use of Trivrutta-Haritaki Yoga. Obesity is the most common metabolic disorder and is one of the oldest documented diseases. It is an increasing problem worldwide as lifestyle changes and fast food chains gain popularity. Obesity in India has reached epidemic proportions in the 21st century, affecting 5% of the country’s population as numerous are to be accounted for. As per a study by ICMR-INDIAB held in 2015, the prevalence rate of obesity and central obesity were 11.8%- 31.3% and 16.9%-36.3%, respectively. Materials and methods: In this study, 10 patients are diagnosed as Sthaulya with classical signs and symptoms. A treatment protocol is applied to them, including Rukshana, Snehapana with Goghrita, Virechana by Trivrutta-Haritaki yoga, and Sansarjana karma with follow-up. The assessment was done before Rukshana and after the Sansarjana Karma in terms of weight, body mass index, circumference of the chest, abdomen, mid-thigh, and waist-hip ratio. Result and discussion: A significant reduction is seen in body weight, body mass index, the circumference of the chest, abdomen, and mid-thigh, and waist-hip ratio. Conclusion: Trivrutta-Haritaki yoga showed a significant weight reduction, BMI, Circumference of Chest, abdomen mid-thigh, and WHR
Effect of Jayantyadi Churna in the Management of Medoroga – A Case Study
Full text linkIntroduction:The global burden of lifestylediseases is rising steeply in the modern period. Sedentary lifestyleis the result of modernization and the advancement of science and technology. One of the main lifestyle disorders that affect a person\u27s physical, emotional, and social well-being is obesity, often known as being overweight (Sthoulya). In this case report, Ayurveda intervention in sthaulya is reported. Thirty-seven-years old obese female presented with gradual increase in body weight along with dyspnea on minimal exertion, bad body odour, excessive hunger and thirst, fatigue and bilateral knee joint pain to Mahatma Gandhi Ayurveda College Hospital and Research Centre, Wardha, Maharashtra,India. Aim: To evaluate the effect of Jayantyadi Churna in the Management of Medoroga Methodology: The patient was given Ayurveda treatment in the form of Jayantyadi Churna along with diet and physical activity for six months. The patient was assessed for improvement in signs and symptoms of obesity. Results: Jayantyadi Churna along with diet and physical activity is found to be effective in the management of Medoroga (obesity)
Knowing the unknown medicinal benefits of Punica granatum L. on oral health - A Review
Full text linkFor centuries, Ayurvedic medicines have been used for the treatment of large variety of diseases. Many types of plants are rich in medicinal properties and have been utilised to treat oral and systemic illnesses. A growing number of people are becoming interested in using different ayurvedic medications for dental health. Punica granatum, often known as a "pomegranate," is a member of the Punicaceae family. According to researches, various extracts of pomegranate peels have been found to contain a broad range of phytochemicals. Pomegranates and their compounds have been suggested as a healthy substitute treatment for a variety of ailments. The combinatorial characteristics of these substances are much greater than the efficiency of the separate components. Pomegranate fruit has been shown to have antioxidative and anti-inflammatory properties. Ellagitannins is one of the most essential bioactive constituents, may combine with the intestinal microbiota and impact its metabolic activity. Certain pathogens, such as Clostridia species, S. aureus, and P. aeruginosa, have already been demonstrated to be inhibited by punicalin and punicalagin. Pomegranate is quickly gaining popularity as an antioxidant booster, antioxidants extracted from pomegranate are polyphenols, hydrolyzable tannins, and anthocyanins. The extracts were proven to be effective over several bacteria, methicillin-resistant and methicillin-sensitive S. aureus, E. coli, S. typhi, and other streptococci. Many studies have also shown positive results and more are still on the go. Even though there is a lot of information for antioxidant, antibacterial, anti-inflammatory, and antifungal activities, additional clinical trials are required to explore the unexplored properties of this fruit
In-vitro antidiabetic, Hepatoprotective activities and HPTLC finger print profile of Azadirachta indica flower
Full text linkAs per Siddha literature Azadirachta indica A.Juss relieves nausea, dry mouth, loss of taste, vomiting, prolonged pain and stomach worms; the infusion /decoction of neem flower improves the strength and cures ulcer. Objective: The core objective of the current evaluation is to study the antidiabetic activity against α-amylase and α-glucosidase, carbon tetrachloride induced hepato-protective activity from the ethanolic extract of Azadirachta indica and to study HPTLC of ethanolic extract as a quality regulatory parameter of the authentic drug. Methods: The in-vitro antidiabetic activity was assessed by measuring the inhibition of α-glucosidase and α-amylase. The 3,5-dinitrosalicylic acid method was used for the α-amylase inhibition assay, and α- glucosidase from Saccharomyces cerevisiae of enzyme inhibition assay, with minor modifications made to the standard drug acarbose of each activity. In -vitro experimental study involved administration of CCl4 to goat liver homogenate in in-vitro to induce hepatotoxicity. Experimental protocol involved 6 experimental groups each containing goat liver homogenate. Results: The extract exhibited a substantial level of anti-diabetic activity when related with standards. As the concentration of neem flower increased, there was a concomitant increase in the α-amylase inhibition activity. The result was significant as the A. indica showed 39 % inhibitory activity with 200 μg concentration as compared to 36 % inhibitory activity exhibited by acarbose for the same concentration. Conclusion The extract revealed statistically significant decline in protein levels, liver biomarkers like alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase in extract exposed group as compared to control group
IR, XRD and Antacid studies of some commercial samples of Eggshell based Ayurvedic medicine: Kukkutandtwakbhasama
Full text linkABSTRACT:Kukkutandtwak bhasma (KB) is a chicken eggshell based Ayurvedic medicine which is well known for its use as calcium supplement, treatment on leucorrhea, anemia ,diarrhea and stomach disorders. In the present communication, the IR and XRD studies of some commercial samples of KB are studied to find out major constituents of this traditional medicine which are responsible for its antacid capacity. Comparative study of four samples under study confirms that the main constituents of KB is a mixture of Calcium carbonate and Calcium hydroxide or only Calcium carbonate. The antacid capacity of the samples are explored using acid base titration method, which are correlated with the main constituents of the bhasma samples.
Key Words:Eggshell, Kukkutandtwak bhasama, XRD, IR, Antacid capacit
A Comparative Analysis of Emulsion Stability and Therapeutic Outcomes in Classical and Modified Madhutailika Basti
Full text linkMadhutailika basti, a key ayurvedic therapeutic enema composed of Madhu, saindhava lavana, sneha, kalka and kashaya, relies heavily on the stability of its emulsion for optimal therapeutic effectiveness. This study aimed to compare the emulsion stability of Madhutailika basti prepared using classical and modified methods, focusing on physical and chemical stability. The classical method involved sequential mixing of ingredients according to traditional ayurvedic procedures, while the modified method replaced madhu with guda in group-B and madhu and guda together in group-C to enhance emulsion stability. Emulsion stability was evaluated through organoleptic properties and analytical tests. A pilot study was done on 24 patients. Group A (Madhu) exhibited superior stability (12 hours), ease of preparation, and optimal PH (5.5) compared to Groups B and C. Analytical tests confirmed oil-in-water emulsions, with Group A showing balanced stability and therapeutic efficacy. Clinical outcomes demonstrated significant improvements in Samyaka Niruha Lakshanas, with no adverse effects reported. While modified formulations are viable, the classical Madhu-based method proved most effective, emphasising the importance of traditional preparation techniques for consistent stability, safety, and therapeutic benefits in Madhutailika Basti