International Journal of Ayurvedic Medicine
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Evaluation of Efficacy of Aparajita (Clitoria ternatea Linn.) in the Management of Depression in Farmers of Vidarbha Region Chronically Exposed to Organophosphorus Compounds
Full text linkIntroduction: India is an agrarian country where pesticides and insecticides are abundantly used in farming. Organophosphorus compounds are the most common class of pesticides, known to inhibit acetylcholinesterase, thereby increasing acetylcholine levels in the central nervous system. Chronic exposure results in neuropsychiatric manifestations such as depression, often associated with suicidal tendencies. In Ayurveda, several Medhya Rasayana drugs are indicated for mental health disorders. Aparajita (Clitoria ternatea Linn.), traditionally described as Tridoshaghna, Aampachana, and Vishaghna, also possesses Sarpavishahara (anti-venom) properties. Aim: To evaluate the efficacy of Aparajita Mool (Clitoria ternatea Linn.) in the management of depression among farmers chronically exposed to organophosphorus compounds. Methods: A community-based survey was conducted in the Wardha district of Vidarbha, Maharashtra, to identify farmers with more than 12 months of chronic exposure to organophosphorus compounds. Eligible participants were clinically assessed using Hamilton Depression Rating Scale, and serum cholinesterase levels were measured. A total of 40 farmers with mild to moderate depression were enrolled after informed consent. The intervention consisted of Aparajita Mool Churna (1 g daily) for 6 consecutive months. Follow-up assessments were conducted at the 3rd, 6th, and 9th months. Results: Comparison of baseline and 9-month follow-up values demonstrated a highly significant improvement (p < 0.001) in both serum cholinesterase activity and Hamilton depression scores. Conclusion: Aparajita Mool exhibited considerable efficacy in reducing depression severity and normalizing serum cholinesterase levels in farmers chronically exposed to organophosphorus compounds. This study supports its potential role as an effective Ayurvedic intervention for occupationally induced depression
Exploring the antiproliferative activity of Unani formulation Itrifal Aftimoon (IA) on MCF-7 breast cancer cells: An In vitro screening
Full text linkUnani physicians provided a comprehensive elucidation of cancer, referred to as Saraṭān, along with several therapeutic approaches for its control. The canonical book of Unani medicine includes formulations composed of several compounds demonstrated to possess anti-cancer properties in humans. This research employed Itrifal Aftimoon (IA), a formulation including ten distinct drugs, to assess its antioxidant and anticancer properties on breast cancer cells. The DPPH assay was employed to assess antioxidant activity in MCF-7 breast cancer cells, while the MTT test was used to evaluate anticancer properties. The formulation was standardized, and HPTLC fingerprinting was conducted in anticipation of its potential future applications. The aqueous extract (AQ) exhibited the maximum activity, with an IC50 value of 61 μg/ml. Subsequently, the methanolic extract (ME) and the hydroethanolic extract (HE) demonstrated IC50 values of 71 μg/ml and 75 μg/ml, respectively while IC50 value for ascorbic acid was 21 µg/ml. The ME, HE, and AQ extracts exhibited anticancer activity with IC50 values of 64 μg/ml, 82 μg/ml, and 83 μg/ml, respectively. This contrasted with paclitaxel, which exhibited an IC50 value of 18 μg/ml. This study offers essential insights into the potential use of IA as a therapy for breast cancer
Mahua Oil as a Promising Antipsoriatic Agent: Insights from In Vitro Studies
Full text linkPsoriasis, a chronic autoimmune skin condition, aligns with the Ayurvedic classification of Kitibha, which results from vitiated Vata and Kapha doshas and the accumulation of Ama. This study investigates the therapeutic potential of Madhuca longifolia (Mahua) oil in the management of psoriasis. Organoleptic Evaluation, Physicochemical analysis (Acid Value, Saponification Value, Iodine Value) and Gas Chromatography-Mass Spectrometry (GC-MS) were performed To check authenticity and purity of the oil. In vitro evaluations on HaCaT keratinocyte cell lines were conducted to assess antiproliferative and anti-inflammatory activities. Results revealed that Mahua oil significantly reduced pro-inflammatory cytokines (IL-1β, TNF-α) and nuclear transcription factor NF-κB (p < 0.05). Furthermore, Mahua oil demonstrated inhibitory effects on COX-2 pathway, confirming its efficacy in modulating inflammatory responses. These findings support its traditional use and propose Mahua oil as a viable natural treatment for psoriasis
Indian Spices: An Insightful Review on Reported Antipsychotic, Antidepression, Neuroprotective and Anti-Anxiety Activities
Full text linkThe potential of traditional medicinal herbs to cure neurodegenerative diseases like Alzheimer\u27s disease (AD) has attracted more and more attention from researchers. Notably, a number of plants have long been used to enhance memory and cognitive performance, including Crocus sativus, Nigella sativa, Coriandrum sativum, Ferula assafoetida, Thymus vulgaris, Zataria multiflora, and Curcuma longa. By lowering oxidative stress, increasing antioxidant levels, and blocking acetylcholinesterase activity, their bioactive substances—carotenoids, monoterpenes, and polyphenols—have neuroprotective benefits. Additionally, by reducing levels of pro-inflammatory cytokines like IL-6, IL-1β, TNF-α, and total nitrite, these herbs control neuroinflammation. Taken together, these results provide credence to the medicinal potential of these herbs and their active ingredients in the treatment of depression, anxiety, and AD. Traditional medicinal potential in these findings, when combined, support the therapeutic potential of these plants and their active components in the treatment of AD, anxiety, and depression.
Ethanopharmacology, Pharmacognostic Exploration, Formulation and Evaluation of A Topical Gel Containing Euphorbia Hirta Linn Plant Extract
Full text linkThe medicinal plant Euphorbia hirta Linn, commonly referred to as asthma weed or pill-bearing spurge, can be found across tropical and subtropical regions. Its bioactive elements, which include flavonoids, alkaloids, tannins, and saponins, have been accountable for its medicinal qualities and have been utilised in traditional medicine for quite a while. A wide range of pharmacological actions, including anti-inflammatory, antibacterial, antifungal, antioxidant, and antidiabetic properties, have been demonstrated for E. hirta. Because of its broncho-dilatory and expectorant qualities, studies have also shown that it may help with respiratory ailments like cough, bronchitis, and asthma. E. hirta exhibits promise in the treatment of gastrointestinal issues, skin ailments, and a number of inflammatory conditions in addition to respiratory health. In order to fully investigate E. hirta\u27s medicinal potential, it is crucial to combine traditional knowledge with contemporary scientific study. To gain a greater understanding of the plant\u27s significance in modern medicine. In the current investigation, the ethnopharmacological assessment of the plant has been conducted. The formulation and subsequent evaluation of a topical anti-inflammatory gel incorporating Euphorbia hirta Linn. extract has been performed
Management of uterine fibroid with Siddha herbomineral formulation Nandhi mezhugu - A Case report
Full text linkThe Siddha system of medicine finds a significant place among the traditional health care systems worldwide. This system offers tremendous clinical outcomes in treating certain disease conditions that are complicated and surgically intervened by contemporary medical systems. Fibroid uterus, which is a pressing global concern, can be well managed with Siddha medicines. The Siddha classical text Siddha vaithya thirattu indicates that the classical herbomineral Siddha formulation - Nandhi Mezhugu for the management of Karuppai vippuruthi (Uterine fibroid). The present case report presents a 48-year-old female with complaints of excessive bleeding in menstrual time (6 to 7 pads\day), dysmenorrhea, feeling of fullness in lower abdomen, frequent urination, low back pain, pain in upper and lower limbs and constipation. She visited the Reproductive and Child Health OPD, Siddha Central Research Institute, Chennai-106, in the month of December 2017. Her ultra-sonogram (USG)-abdomen revealed the confirmatory diagnosis of Uterine fibroid. The patient was treated with Siddha traditional medicine Nandhi mezhugu twice a day with palm jiggery. The treatment consisted of 7 days and a gap of 7 days for a period of 6 Months. During treatment, she was showing signs of improvement in her symptoms of menstrual flow and pelvic pain normalized after 4 months. The follow up USG abdomen revealed the successful outcome with absence of fibroid. The present case report supports the use of traditional herbal medicines in the management of Uterine fibroid.
An Anatomical Study of Drushtipatal (Retina) with Special Reference to Fundus Photo and its Correlation with Dehaprakruti- An observational study
Full text linkAs the Prakruti of an individual is unique to him and has various variations related to others, similarly the retinal patterns(structures) have uniqueness and has variations related to others. The study of retinal patterns through fundus photo is often a neglected aspect of physical examination (Dehaprakruti) but with practice and expertise, a good quality of fundus photo print can be obtained to analyse Dehaprakruti of an individual. Aim and Objective: To study the various patterns of fundus photo and its correlation with Dehaprakruti. Material and Method: 90 individuals of three different Dehaprakruti fulfilling the criteria of selection were examined and selected with each group of Prakruti containing 30 individuals. Dehaprakruti Parikshan was done with the help of standard proforma. Avoiding bias of both eye structures we have studied only single right eye of each individual through fundus photographs for variation in structural patterns of retinal vascular tortuosity, branching and fundal glow and observation are drawn. Discussion and Conclusion: There is a statistically significant correlation between Vata Pradhan Dehaprakruti and severe vascular tortuosity, severe vascular branching and blackish red fundal glow. There is a statistically significant correlation between Pitta Pradhan Dehaprakruti and moderate vascular tortuosity, moderate vascular branching and reddish fundal glow. There is a statistically significant correlation between Kapha Pradhan Dehaprakruti and mild vascular tortuosity, mild vascular branching and dull fundal glow. There is a statistically significant association of Dehaprakruti with retinal structural patterns
Efficacy of whole system Ayurveda protocol for rheumatoid arthritis – A case series
Full text linkIntroduction: Rheumatoid arthritis (RA) is a chronic inflammatory disease that shows etiological and clinical association with Aamavata, specified by Ayurveda. RA is a component of the medical condition complex, Aamavata. The mainstay of treatment for RA is a class of medications known as DMARDs; however, they have several drawbacks when used in the long term. Drugs with strong efficacy and low toxicity profiles are required to treat this crippling condition. Therefore, the whole system Ayurveda protocol for RA was designed. Objective: To evaluate the efficacy of the whole system of Ayurveda protocol for rheumatoid arthritis. Methods: Patients attending OPD of the Department of Kayachikitsa, diagnosed with rheumatoid arthritis according to the 2010 ACR classification Criteria for RA along with symptoms of Aamavata according to Ayurved. In the present clinical case series, eight patients with RA were diagnosed and recruited, of which four completed the treatment. Deepan-Pachan, Snehapan, Virechan, and Vaitrana Basti with herbomineral drug combination given for 60 days according to the treatment protocol of Aamavata described by Chakradatta. Assessments were done through various clinical measures, like the 2010 ACR classification Criteria, RA factor, ESR, WOMAC score, and Sandhishool with VAS Score. Results: The Ayurved treatment protocol showed a significant reduction in the signs and symptoms of Aamavata, the 2010 ACR Criteria, RA factor, ESR, WOMAC score, and Sandhishool with VAS Score. Conclusion: The treatment protocol for Aamavata described in the classical text of Ayurved can be effective in Aamavata, which significantly improves the patient\u27s quality of life
A fortified cereal and Ayurveda herb-based diet (Guducyadi krushara) for Sickle cell disease (~Pandu) - A case report
Full text linkIntroduction: Sickle Cell Disease (SCD) is considered as Beeja-Dustijanya and Pitta Dosha pradhan Vyadhi, which is counter with a drug-diet plan to alleviate the Crisis and symptoms of SCD, as the genetic origin of the disease makes it non-curable. A diet made with herbs having antioxidant, rejuvenating properties is core for the treatment of disease, and "Guducyadi Krushra" is one among them. In the present study, a 12-year-old female child (diagnosed case of Sickle Cell Disease) was treated for 30 days with the Guducyadi Krushara as add-on dietetic management along with conventional therapy with hydroxyurea and folic acid. Methods: In this study, Guduci is taken as the primary Immunomodulator, processed to form Krushra made up of rice and green gram, and prescribed as a diet regimen for patients with Sickle Cell anemia. Results: There is significant relief in the symptoms of crisis, pain, fatigue, and loss of appetite in the patient treated with Guducyadi Krushra as Pathya Aahara. which was not observed with conventional therapy alone. Discussion: The antioxidant, Anti-sickling, and rejuvenating properties of Guduci help to alleviate the symptoms of SCD and help to maintain the Quality of life of the patient. It promotes the healthy RBCs and prevents the sickling. Additionally, Krushara (Gruel) is easy to digest and has nutritive value and is accepted in different ethnic populations of India and hence easy to administer with good acceptance by children. It helps to maintain adherence and compliance to the therapy, which yields results. Conclusion: The use of Ayurveda herbs with diet as a regime will help to improve the clinical outcome and integration approach to reduce the burden of diseases like childhood SCD.
An Ethnobotanical Survey of Medicinal Flora Employed in Cancer Management in Kutch District, Gujarat, India
Full text linkBackground and Aim: This study documents the efficacy of traditional herbal wisdom from Kutch, Gujarat, to treat cancer. Experimental procedure - The ethnobotanical survey conducted in the Kutch district, Gujarat, India, spanned from December 2022 to December 2023 and utilised a cross-sectional study design. Employing random sampling techniques, we engaged with 147 individuals, of whom only 72 possessed traditional knowledge regarding plants used in cancer treatment. This survey meticulously documented details such as the specific parts of the plant used (roots, shoots, leaves, and flowers), the methods of preparation for herbal remedies, and their modes of administration (whether orally or externally). The herbal formulations were categorised into Swarasa, Kalka, Kwath, Hima, Phant, and the prescribed dosages. Results: The study reveals the medicinal use of plants in Kutch for cancers like breast (UV 20%, FIC 21%, FL 22%), hepatocellular (UV 14%, FL 16%), colon (UV 12%, FL 9%), and lung (UV 11%, FL 15%). Other cancers treated include cervical, oral, leukemia, colorectal, pancreatic, skin, prostate, osteosarcoma, and ovarian. Predominant plant parts used are leaves (40%), roots (25%), seeds (12%), and bark (10%). Conclusion: The research underscores traditional healers\u27 vital role in preserving ethnomedicinal knowledge, offering profound insights and potential breakthroughs in cancer treatment. Investigating phytochemicals can uncover potent anticancer agents, revolutionising therapy and integrating ethnomedicine with modern biomedical research