International Journal of Ayurvedic Medicine
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Assessment of Quality Parameters and Identification of Garcinol in Vrikshamla (Garcinia indica) Using HPTLC- An Analytical Study
Full text linkThe tropical evergreen tree Vrikshamla (Garcinia indica Linn.), commonly referred to as kokum, has many health advantages, such as anti-inflammatory, anti-obesity, and antioxidant qualities. It contains bioactive substances with therapeutic uses for diseases like Dyslipidemia, cancer, diabetes, and cardiovascular disorders, such as anthocyanins, hydroxycitric acid, and garcinol. For Vrikshamla capsules to be consistent and effective, quality control and validation are crucial. Material and Methods: Vrikshamla capsules were procured from SDM Ayurveda Pharmacy in Udupi. Organoleptic, physicochemical (water-soluble extract, alcohol-soluble extract, pH, loss on drying, and heavy metals), microbiological characteristics and High Performance Thin -Layer Chromatography (HPTLC) were the main focus of the quality analysis, which was carried out in the Central Research Facility in accordance with in-house standard values requirements. Results: High water-soluble (94.71%) and alcohol-soluble (87.77%) extracts with a pH of 3.89 that fell within the normal range were shown by the physiochemical examination. After drying, the heavy metals were in compliance (≤20 ppm), and the loss was 1.12%. The absence of pathogens such as Salmonella spp., P. aeruginosa, and E. coli was verified by microbiological testing. Garcinol\u27s existence in the sample was confirmed by HPTLC analysis, which detected it at Rf 0.63. Discussion: According to the findings, Vrikshamla capsules are of a high calibre, and their pharmacological qualities are attributed to active ingredients like garcinol. Its application in the treatment of metabolic and chronic disorders is supported by its anti-inflammatory, anti-obesity, and neuroprotective properties. Conclusion: Vrikshamla capsules therapeutic value, especially for dyslipidemia, obesity, and inflammation, is confirmed by quality control and validation, underscoring its significance in Ayurvedic medicine
Highlights on the recent clinical studies and inventions in the use of natural products in the management of Covid-19
Full text linkNatural products (NPs), long regarded for their medical qualities, have recently seen a rise in interest as the world seeks viable therapies and prevention measures for COVID-19. Many reports have been published on the role of NPs in managing COVID-19. This article highlights the recent noteworthy clinical developments and inventions concerning the application of NPs to manage the COVID-19 pandemic. The non-patent literature for this review was obtained from PubMed, whereas patent information was obtained from the Espacenet databases. Recent clinical trials have explored the role of many NPs (spirulina; curcumin + piperine; xanthohumol; CurcuRouge®; virgin coconut oil; thyme oil; licorice extract; pomegranate juice; Ayurvedic and Chinese herbal formulations) in managing COVID-19. Multiple NPs formulations and compositions (dieckol; isobracin; phloroglucinol compounds; propolis + xylitol; Virofree TM; NRICM102; Terminalia chebula tannic acid + punicalagin; Cypress tree extract + Chlorine dioxide; Saussurea costus) with antiviral and immune-boosting potential have been recently patented for use in COVID-19 management. Many inventions are foreseeable, including new delivery systems of existing anti-COVID-19 NPs, derivatives of anti-COVID-19 NPs, drug repurposing of the marketed NPs, and new combinations (two or more NPs; NPs + existing anti-COVID-19 drugs; NPs + vaccine; NPs + monoclonal antibodies). Nonetheless, there is a great deal of room for innovation in the use of NPs in the control of COVID-19. Accordingly, NPs have the potential to play an increasingly important role in global healthcare to manage COVID-19 as studies continue
Development and nutritional evaluation of Ayurvedic-Based nutritional supplements: An exploratory study
Full text linkBackground: Nutritional deficiencies, particularly iron and protein insufficiency, are prevalent among school-going children and contribute to health issues like anemia and stunted growth. Traditional Ayurvedic principles offer a holistic approach to addressing these gaps. This study explores the development of an Ayurvedic-based supplementary product aimed at alleviating common nutritional deficiencies in children. Objective: To develop and evaluate an Ayurvedic-based supplementary product to improve iron and protein intake among school-going children, aiming to alleviate common dietary deficiencies. Methodology: Four experimental formulations were developed, three trials of biscuits and one trial of granules. Ingredients included Mudga (Vigna radiata (L.) R. Wilczek), Masha (Vigna mungo (L.) Hepper), Navaneeta (butter), Sharkara (sugar), Bala (Sida cordifolia L.) churna, Sariva (Hemidesmus indicus R. Br.) churna, Trikatu churna, Saindhava Lavana (rock salt), Loha Bhasma, milk, and ghee. Initial biscuit trials were evaluated for taste, texture, and palatability; however, issues of bitterness and poor texture prompted modification of ingredient proportions and ultimately a shift to a granule-based formulation. The granules were analyzed for macronutrients and iron content. Results: The granule-based product demonstrated significant levels of iron and protein, along with other essential nutrients, making it a promising product for addressing malnutrition in children. Conclusion: The Ayurvedic-based granule supplement offers a promising solution to combat nutritional deficiencies, particularly iron and protein, in school-aged children. Its rich nutritional profile, coupled with adherence to Ayurvedic principles, makes it an effective tool for improving children\u27s health and combating malnutrition
A Research on Comparative Methods of Isolation, Evaluation and Identification of Clitoria ternatea Plant
Full text linkClitoria ternatea (Butterfly pea) is a traditional medicinal plant known for its therapeutic properties, including antimicrobial, antioxidant, and anti-inflammatory activities. This study aimed to evaluate its phytochemical composition, physicochemical characteristics, and extraction efficiency using different techniques to support its pharmacological potential. Ethanolic extracts of Clitoria ternatea flowers were prepared using maceration, Soxhlet extraction, and ultrasonic-assisted extraction. Qualitative phytochemical screening was conducted to identify secondary metabolites, while physicochemical parameters such as total ash, water-soluble ash, loss on drying, and alcohol- and water-soluble extractives were assessed. The Soxhlet method yielded the highest extractive value (89%), followed by maceration (62%) and ultrasonic extraction (57%). Phytochemical screening confirmed the presence of key bioactive compounds, including flavonoids, alkaloids, saponins, tannins, steroids, and cardiac glycosides. Physicochemical evaluations were within acceptable limits, supporting extract quality and reproducibility. This study validates the traditional use of Clitoria ternatea and demonstrates its potential for further development as a phytopharmaceutical agent. Soxhlet extraction is recommended for optimal recovery of bioactive constituents. Further research is warranted to isolate specific compounds and explore their therapeutic applications through pharmacodynamic and clinical studies
Green Alchemy: Unveiling the Therapeutic Synergy of Tulsi, Aloe Vera, and Piper betle
Full text linkTraditional medicinal herbs have once again captured the attention of people throughout the world due to the growing need for safer, more environmentally friendly therapeutic options derived from plants. For their wide-ranging pharmacological effects, three of the most venerated plants in traditional medicine—Ocimum sanctum (Tulsi), Aloe barbadensis miller (Aloe Vera), and Piper betle—stand out. Reviewing the antibacterial, antifungal, antioxidant, and anti-inflammatory characteristics of these three herbs, this study delves into their synergistic potential. Each herb has strong bioactivity on its own, but by combining them, phytoconstituents like eugenol, aloin, and chavicol may unleash even more effectiveness. This study synthesises data from in vivo, clinical, and in vitro investigations to determine how these herbs influence inflammatory pathways, fight microbial resistance, and scavenge reactive oxygen species (ROS). When applied to wound healing, skin care, dental hygiene, and immunological modulation, the synergy shows great promise. There is scientific evidence that suggests new multi-herb therapies may be possible due to phytochemical interactions\u27 additive or even supra-additive effects. Some of the recent difficulties with standardisation, bioavailability, and formulation, as well as some of the potential benefits of using these plants in herbal medicines of the future. Tulsi, Aloe Vera, and Piper betle form a potent trinity for forthcoming biomedical advancement, which is particularly relevant given the rising popularity of green therapies and evidence-based Ayurveda
An open-labeled RCT of Triguna and Shadguna Makaradhwaja - Ayurvedic Herbo-mineral formulations on Madhumeha (type II Diabetes Mellitus)
Full text linkMakaradhwaja (Au:Hg:S) is Pramehagna (anti-diabetic) according to Rasatarangini (Classical Rasashastra text), to assess the efficacy of the test drugs in the Madhumeha (type II Diabetes mellitus) the study was designed. Guduchi Ghana (GG-Control-Gr. A), Triguna (Au:Hg:S=1:8:24) and Shadguna (Au:Hg:S=1:8:48) Makaradhwaja (TM+GG-Gr. B & SM+GG-Gr. C) were prepared according to the references of Rasatantrasara Siddha Prayoga Sangraha and Bhaishajya Ratnavali respectively. With permission from the clinical ethical committee; PGT/7/Ethics/2009-10/2157/24/09/2009; a randomized control trial (RCT) has been carried out in the outpatient department of Rasashastra & Bhaishajya Kalpana, IPGT & RA, GAU, Jamnagar, India. 250 mg capsule twice a day; before a meal with a quantity sufficient honey as a vehicle was given for 28 days with the follow-up of 6 weeks to 153 patients; before-after investigations viz. blood sugar fasting and postprandial, serum triglycerides, serum cholesterol, serum calcium, etc. were carried out. Statistical analysis has been evaluated with unpaired ‘t’, ANOVA, and Dunnett’s ‘t’ tests. TM group was highly significant statistically over GG treated group in decreasing Kshudhadhikya (polyphagia) i.e. 66.26%. The average fasting blood glucose was reduced by 10.13mg/dl, 19.14 mg/dl, 18.03 mg/dl, and post-prandial glucose by 15.58, 25.46, and 29.05 mg/dl in GG, TM, and SM respectively. TM and SM were found to be more effective than GG. Both the groups showed significant to a highly significant decrease in subjective as well as objective parameters as compared to the GG group. Amongst all; SM was slightly more effective than the TM
Isolation of Effective Wound Healing Compounds from Chloroform Fraction of Ethanol Extract of Ehretia Laevis Roxb.(KhanduChakka/AjanVruksha)
Full text linkPhytochemical analysis plays a very important role in identifying effective components of herbs. Ehretia Laveis Roxb. herb not much known to world identified for study having very good capacity of wound healing and pain relief. Ehretia laevis Roxb.is a rare species from the boraginaceae family.
For phytochemical analysis, ethanol extractions of Ehtretia Laevis Roxb. leaves were carried out using the soxhlet extraction method. Fractionation of collected ethanol extract was carried out using n-hexane, methanol, chloroform and water as a solvent with the help of a separating funnel. Wound healing action of n-hexane, chloroform, methanol and water extracts were carried out. It was observed that chloroform fraction was effective for wound healing in animal models and hence chloroform fraction of ethanol extract of Ehretia Laevis Roxb. was taken for further phytochemical analysis.
Column chromatography of chloroform fraction was carried out using silica gel. 5 Fractions were isolated by using Column Chromatography. Fraction -2 was in sufficient quantity and hence taken for wound healing study. Fraction -2- Dragendorff’s test- positive for alkaloids.
The rats were marked and divided them into 6 groups of 6 animals each. Isolated fraction-2-2%w/w treated group wound healing was 77.75±0.312 %. The Povidone iodineclosesthe wound by 96.63±0.205% which is close to the group appliedby 4% w/w ointments of isolated fraction-2 i.e. 94.10±0.146 %.
Fraction -2- was characterized for1H NMR, 13CNMR and LCMS. On comparing experimental data of fraction-2 , it is observed that the experimental data match with literature data of α amyrin and β amyrin. From this, we can conclude that the isolated fraction-2 is the mixture of α amyrin and β amyrin responsible for wound healing.
From the above study, we can conclude that mixture of α amyrin and β amyrin may have wound healing prosperities
Integrated Approach of Panchakarma and Viddha karma for the Management of Carpal Tunnel Syndrome: A Case Report
Full text linkBackground: Carpal Tunnel Syndrome (CTS) is a peripheral neuropathy that most commonly impacts the median nerve, characterized by pain, numbness, and tingling along the pathway of the median nerve. The prevalence of CTS is estimated to range between 4% and 5%. As the condition is prone to recurrence, there is a need to adopt management approaches that provides significant results. The clinical features of CTS can be correlated with Vata vyadhi in Ayurveda. Aim & Objective: To evaluate the efficacy of Panchakarma therapy and Viddha Karma combined with Yogaraja guggulu, Trayodashanga guggulu, Asthiposhak vati, and Sukhasarak vati in managing CTS by using Boston Carpal Tunnel Questionnaire (BCTQ) score. Methodology: A case report of 52-year-old male patient presented with pain in the right hand, accompanied by numbness, tingling sensations, and difficulty in performing routine activities for 3 months. On examination Tinel’s sign, Phalen’s maneuver were positive, with high BCTQ score, Visual Analogue Scale scored 7, and was advised to perform nerve conduction study. He was diagnosed with CTS with nerve conduction velocity less than 40 m/s. Panchakarma procedures such as Sthanik snehan (localized massage) with Nirgundi Taila, Shashtikshali pinda swedan (sudation with medicated cooked bolus of rice) for 15 days and 3 sittings of viddha karma (Dry needle puncture) at the interval of 5 days, along with internal Ayurvedic medications as mentioned above were adopted for 21 days. Results: Following the treatment, significant improvement was observed in all symptoms, with 67.5% relief in symptoms as reflected by BCTQ scores. Conclusion: Panchakarma therapy and Ayurvedic medications are effective in managing CTS
Impact of Dietary Supplementation with Haritaki - Terminalia chebula Retz. (Combretaceae) and Amalaki - Phyllanthus emblica L. (Phyllanthaceae) on Human Gut Microbiota: A Comparative Study
Full text linkThe gastrointestinal (GI) system plays a crucial role in systemic health, with gut microbiota influencing immunity, digestion, and metabolic functions. Ayurveda emphasises digestive health through botanicals like Haritaki - Terminalia chebula Retz. (Combretaceae) and Amalaki - Phyllanthus emblica L. (Phyllanthaceae), traditionally used to promote gut balance. This study aimed to evaluate the impact of Haritaki and Amalaki supplementation on gut microbiota composition in healthy elderly volunteers over an 8-week period. A randomised, open-labelled, controlled experimental study was conducted at Dr. D.Y. Patil College of Ayurved and Research Centre, Pune, involving 30 participants aged ≥ 60 years. Participants were assigned to two groups: Haritaki (Group A, n=15) and Amalaki (Group B, n=15), receiving 2 grams of the respective herbal powder twice daily with lukewarm water. Stool samples were analysed pre- and post-intervention using 16S metagenomic sequencing to assess microbial diversity and composition. Results demonstrated distinct microbial shifts. Haritaki reduced Firmicutes and Bacteroidetes while increasing Actinobacteria, enhancing microbial stability and immune modulation. Conversely, Amalaki increased Bacteroidetes and fibre-fermenting genera while reducing Firmicutes, promoting microbial diversity and metabolic balance. Both interventions optimised short-chain fatty acid (SCFA) production without inducing dysbiosis. These findings support the Ayurveda\u27s use of Haritaki and Amalaki in gut health, revealing their potential as microbiome modulators. Future studies should explore their long-term clinical applications and molecular mechanisms using functional metagenomics and metabolomics
Significance of Mahakumbh
Full text linkThe Mahakumbh, a grand spiritual festival in India, holds immense significance as described in ancient texts like the Vedas, Puranas, and Upanishads. Celebrated every twelve years at four sacred locations—Haridwar, Prayag (Allahabad), Ujjain, and Nashik—it symbolizes spiritual purification and divine blessings. The origins of the Kumbh Mela trace back to the churning of the ocean (Samudra Manthan) by gods and demons to obtain nectar (Amrit). This festival is deeply rooted in astronomical alignments and mythological tales, emphasizing the confluence of celestial bodies like Jupiter, the Sun, and the Moon. The Kumbh Mela serves as a platform for spiritual growth, self-purification through holy baths, and dissemination of divine teachings by saints and scholars