International Journal of Ayurvedic Medicine
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Pharmaceutical Standardisation of Lakshadi Guggulu Vati and Tablet w.s.r to the Method of Preparation
Full text linkIntroduction: Standard operating procedure for pharmaceutical preparation of Lakshadi Guggulu Vati and Tablet has been developed in the present research work to compare the traditional method of Tablet preparation with the modern pharmaceutical procedure. Material and Methods: Three samples each of classical Lakshadi Guggulu vati were prepared as per Vrindmadhav and A.F.I to develop Standard Operating Procedure (SOP) for the drug. Also three samples each of Lakshadi Guggulu tablet by wet granulation method according to the same references were prepared for comparison of the pharmaceutical procedures. For the purification process of Guggulu 1:4 ratio of crude Guggulu and purification media (Triphala Kwatha) was taken. Observation and Result: Mean % yield of Lakshadi Guggulu Vati and Tablet as per the references of Vrindmadhav and A.F.I. were found to be 87.28%, 92.92% and 90.26%, 95.88% respectively. 700g of Guggulu Shodhana by Parisravana requires 3-4 hrs duration with an average yield of 62-66 %. In the preparation of drug by classical pharmaceutical procedure 10-12% loss was observed while preparing drug by modern pharmaceutical procedure 4-8% loss was observed irrespective of references taken for the process. Conclusion- Pharmaceutically it is better to prepare tablet instead of Vati, as the percentage loss in Vati preparation was high which in turn elevates the cost of medicine.
Seasonal Preventive effect of Samshamani vati over Ritu-Haritaki on disorders of Varsha Ritu (monsoon) w.s.r. to Quality of Life (QoL) - a Comparative Clinical Study
Full text linkIntroduction: Seasonal changes can lead to dosha imbalances, increasing illness vulnerability. Samshamani Vati (SV), containing Guduchi Satva, is a monsoon-specific prophylactic that enhances Agni and reduces the occurrence of common colds, coughs, and fever. This study was designed to compare the effects of Samshamani Vati over Ritu-Haritaki in preventing diseases during Varsha Ritu (monsoon). Aim: To study the effect of Samshamani vati over Ritu-Haritaki in preventing diseases of Varsha Ritu in the participants. Materials & Method: A randomised controlled trial was conducted with 60 healthy volunteers prone to monsoon-related illnesses. Participants were divided into two groups: Group A received Haritaki Churna (3g) with Saindhava Lavana (1g) & Group B received Samshamani Vati. Both groups took their respective formulations once daily on an empty stomach with warm water for 60 days. Baseline and post-treatment evaluations were performed on days 0 and 60, measuring Total Leukocyte Count (TLC), Differential Leukocyte Count (DLC), Erythrocyte Sedimentation Rate (ESR), and WHO Quality of Life (WHO-QOL) scores. Results: Group B (SV) demonstrated a significant reduction in seasonal disorders and symptoms in 60% of participants, with improved WHO-QOL scores (p<0.05). Conclusion: Samshamani Vati showed significant efficacy over Ritu-Haritaki in reducing disease incidence during Varsha Ritu
The human side of healthcare: A quality-of-life study among Ayurved doctors in COVID-19 pandemic
Full text linkThe COVID-19 pandemic posed significant challenges globally, with India facing a severe outbreak starting in March 2020. Ayurvedic doctors were integral in managing the health crisis, especially during the second wave, amidst extreme stress, increased patient load, and personal health risks. This study aimed to assess the quality of life (QoL) of Ayurvedic doctors in Pune who served as frontline workers during the pandemic. Conducted from June to July 2021, the cross-sectional observational study involved 100 Ayurvedic doctors who had worked for more than six months during the pandemic. Using the WHOQOL-BREF questionnaire, the study evaluated their QoL across physical, psychological, social relationship, and environmental domains. The findings revealed significant stress, negative emotions, physical fatigue, and challenges in the work environment, with mean scores of 50.04 in the psychological domain, 56.82 in the physical domain, 59.53 in the environmental domain, and 65.58 in the social relationship domain. The study concludes that the pandemic adversely affected the QoL of Ayurvedic doctors, highlighting the need for improved support, resources, and professional development to enhance their preparedness and well-being in future health crises.
Antibacterial and Antifungal activity of Arseno-Mercurial formulation Sameerapannaga Rasa: An in-vitro study
Full text linkBackground: Sameerpannaga Rasa (SPR) is a herbomineral formulation categorized as a Kupipakwa Rasayana, one of the four types of Rasayanas in Rasashastra.
Materials & Methods: After proper shodhan of the individual ingredients, the SPR was prepared by the kupipakwa method and the anti-microbial activity was assessed through standard and internationally accepted methods like MIC (Minimum inhibitory concentration) & MBC (Minimum bactericidal concentration) methods.
Results and Discussion: The minimum inhibitory concentration of Sameerapannaga rasa showed very good inhibitory activity against all the tested organisms. SPR demonstrated strong antimicrobial activity against S. aureus, K. pneumoniae, C. albicans, S. sanguis, and S. pneumoniae at low concentrations (0.9 mg). Sameerapannaga rasa exhibited antimicrobial effects against S. epidermidis (31.25 mg), P. aeruginosa (125 mg), P. mirabilis (62.5 mg), E. coli, and C. krusei (7.8 mg).
Minimum bactericidal concentration of Sameerapannaga rasa showed very significant inhibitory activity against all the tested organisms. SPR demonstrated strong antibacterial and antifungal activity against E. coli, S. pneumoniae, and C. albicans at low concentrations (0.9 mg). It also showed activity against S. aureus (15.6 mg), K. pneumoniae (1.96 mg), S. sanguis (7.8 mg), C. krusei (62.5 mg), P. aeruginosa and P. mirabilis (125 mg), and S. epidermidis (250 mg).
Conclusion: The results of both Minimum inhibitory concentration and Minimum bactericidal concentration methods provided scientific evidence of the potential antimicrobial activity of SPR, therefore Sameerapannaga rasa could be considered as a potential alternative to the contemporary treatment
Efficacy of Vidanga Arka in Karnashoola with special reference to Otomycosis - A Randomized controlled clinical study
Full text linkIntroduction: Karnashoola is one among the Karna Rogas, characterized by Shoola, Kandu and Srava. Among the type of Karnashoola, Vata-kaphaja Karnashoola can be correlated to Otomycosis and also it being the commonest in occurrence has been selected for the present study. Madhu has Tridoshaghna, Lekhana, Ropana and Vranashodhana property also indicated in Karnshoola.This was taken as control drug.Vidanga Arka mentioned in the Arkaprakasha is useful in the management of Krimi, also Vidanga is known for its Vedaanahara property. Objectives: To evaluate the efficacy of Vidanga Arka in the management of Karnashoola (Otomycosis). Materials and methods: After securing ethical clearance and registering the trial with the CTRI, 30 subjects satisfying the inclusion criteria and diagnosed with Karnashoola were randomized into two groups (15 in each group). Group A and Group B was treated with Vidanga arka and Madhu ear drop for 7 days respectively. Objective [parameters were assessed using Aural endoscopy and recorded on the baseline, 7th, 14th, 21st and 28th day. The data related to the within the group response at different time intervals in Group A & B were assessed by Friedman’s test for repeated measures. To evaluate the difference between the groups with regards to parameters, Mann Whitney rank sum test was carried out. Result: Study indicates that Vidanga arka and Madhu are equally effective in the management of Karnashoola (Otomycosis) (p<0.05). Conclusion: The study concludes that both Vidanaga Arka and Madhu Ear drop has beneficial effect in the management of Karnashoola (Otomycosis)
Comparative evaluation of Punarnavadi guggul tablet formulation for anti-inflammatory activity
Full text linkPunarnavadi guggul represents a traditional polyherbal formulation utilized in the treatment of dermatological conditions, jaundice, dropsy, edema, hyperuricemia, and rheumatism. The present investigation sought a comparative analysis of the three marketed formulations of Punarnavadi Guggul tablet for its in vivo anti-inflammatory properties. The anti-inflammatory effects were assessed using the carrageenan-induced rat paw edema model and the cotton pellet granuloma method. The animal groups treated with laboratory-prepared formulation PF (150 mg/kg) showed significant antiinflammatory activity comparable to the standard drug. Existing literature indicates that guggulsterone E, Z, and deodarone are implicated in the anti-inflammatory effects, whereas gallic acid, ascorbic acid, polyphenols, and flavonoids contribute to its antioxidant properties. The formulated tablet exhibited pre-eminent anti-inflammatory properties when compared to commercial formulations, but all formulations showed noteworthy bioactivity
Mimusops elengi Phytoconstituents In-silico Prediction for Alzheimer Disease
Full text linkObjective: Alzheimer\u27s disease (AD), which predominantly affects older adults, is the primary cause of dementia, impacting 46 million people worldwide. By 2030 and 2050, respectively, there will be 74.7 and 131.5 million persons with AD, as the incidence rises exponentially every five years. The goals of treatment are to control symptoms, lessen clinical decline, and manage the burden of illness. Our study included in-silico testing of the phytoconstituents of Mimusops elengi for immunosuppressive effectiveness in the treatment of Alzheimer’s. Methods: Molecular docking is performed using Discovery Studio to evaluate the pattern of interaction between the crystal structure of the malarial proteins (PDB ID: 7UJQ & 7Q8V) and phytoconstituents from the Mimusops elengi plant. Swiss ADME and pkCSM were later used to test for both the pharmacokinetic profile and toxicity respectively. Result: According to the docking results, quercetin (-8.4 kcal/mol), myricetin (-8.5 kcal/mol), aesculin (-8.1 kcal/mol), and myricitrin (-9.3 kcal/mol) -9.7 kcal/mol for spinasterol Aesculin (-7.7 kcal/mol), Quercetin (-9.3 kcal/mol), Myricitrin (-9.9 kcal/mol), and Catechin (-8.2 kcal/mol) for 7UJQ macromolecule -8.2 kcal/mol of spinasterol The 7Q8V macromolecule\u27s catechin (-9.1 kcal/mol) had the best binding to immunosuppressive action when compared to all other standards. Additionally, ADMET experiments showed that the pharmacokinetics and toxicity parameters were within acceptable bounds. Conclusions: The binding potential of phytoconstituents with an eye toward immunosuppressive function showed promising results. Along with providing important information on clinical treatment and pharmaceutical research, it encourages the use of Mimusops elengi
Cross sectional survey study on menstrual patterns among female students of health science with reference to Ahara
Full text linkBackground: Ayurveda is a science that focuses on promoting health and treating illnesses. In the present era, the population is becoming more susceptible to various illnesses due to pollution, excessive job pressure, poor eating habits, and an unhealthy lifestyle. Especially women who have to balance both professional and personal lives are facing a lot of health issues. Our Swasthya is dependent upon three Upsthambas, namely Ahara, Nidra, and Brahmacharya. Among all these three Ahara has been given prime importance for healthy life of individual. Ahara also is referred to as the superior medicine, or Mahabhaishajya. Due to the disturbance of lifestyle or food habit for a long period, later it results in various ailments or syndrome. Material and Method - A cross-sectional survey was conducted among female health education students aged 16 to 30 years. A total of 150 female students who were selected at random and were evaluated between August 2023 and October 2023 using a questionnaire. Result – Based on the questionnaire, the results show that due to lack of regularity in daily routine, disturbance in eating habits there is great adverse impact seen in the menstruation pattern of girls. Discussion – The altered lifestyle especially diet in modern era has made great impact on physical as well as mental health of all individuals. This become evident as we see its effect on the menstrual symptoms which are results of improper dhatu formation at physical level and also alteration of hormones due to mental instability
Comparative Study of Yogic Practices and Vyayama on Certain Physical and Mental Variables in Healthy Individuals
Full text linkIntroduction: Now a days, erratic lifestyle, characterized by poor dietary habits, sedentary behaviours, busy schedule and stress have led to rising concerns about physical and mental well-being because these lead to arise of different illnesses condition. There is growing worldwide interest in traditional health practices like Yoga and Vyayama (exercise), as they are seen as complementary to conventional medicine. Studying both practices together offers a thorough grasp of how they support mental and physical well-being, resulting in more holistic wellness approaches. Objective: The aim of this research is to evaluate the effect of yogic practices and vyayama on certain physical and mental variables in healthy individuals. Material and methods: About 150 healthy volunteers fulfilling the inclusion and exclusion criteria have been registered randomly in three different groups for total period of 3 months. Three distinct follow-ups were conducted to evaluate changes in various objective parameters i.e., Flexibility, Agility, Body Mass Index (BMI), Muscular Strength and subjective criteria, Mental Health Inventory (MHI) – Multiple Sclerosis Quality of Life Inventory (MSQLI). Results: Results of this study showed that vyayama had greater effect on physical variables like and yoga had greater effect on mental variables. On intragroup comparison (Wilcoxon Singed Rank Test) there was statistically significant result seen in flexibility, BMI, and mental health in group A. On intragroup comparison there was statistically significant result seen in agility and muscular strength in group B. Conclusion: This study shows that the significance of Yoga and Vyayama as effective, non-pharmacological interventions for improving certain physical and mental variables. Their natural and holistic approach to enhancing well-being, without any side effects, makes them especially beneficial as preventive health measures
Therapeutic Potential of Terminalia arjuna (Arjuna) in Managing Melasma: A Review of Mechanisms and Applications
Full text linkBackground: There are many causes of melasma. Melasma occurs mainly because of heredity, hormones, and the environment, mainly UV radiation. Melasma causes abnormal melanin production in the skin, resulting in patches of irregular pigmentation. It can cause serious cosmetic as well as psychological problems in the afflicted individuals. Although hydroquinone is a widely used man-made drug, its side effects prompted individuals to look for other natural remedies. Objective: This review explains how Terminalia arjuna works to bleach the skin. It explains its antioxidant activity, anti-inflammatory activity, and its modulating activity of melanin synthesis, all of which are implicated in Melasma. Discussion: Terminalia arjuna contains antioxidants like flavonoids, tannins, and phenolic acids. These reverse oxidative stress, one of the causative factors of Melasma. Its anti-inflammatory effect also protects the skin against harm through inhibition of damaging inflammation. Bark extract can affect melanin production through the control of an important enzyme tyrosinase. It also inhibits protein and skin pigmentation damage owing to environmental and metabolic stress. Conclusion: The therapeutic significance of Terminalia arjuna in the management of Melasma results from its multi-action against melanin pigmentation etiology. As a powerful, natural drug, it can be used in skin care routines to remove dark spots. Studies on its active components and products could potentially render it even more beneficial in modern skin care