International Journal of Ayurvedic Medicine
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Comparative Clinical study of Triphala Ghrita Aschyotan and Alcaftadine (0.25%) eye drop in the management of Vataj Abhishyanada w.s.r. to Simple Allergic Conjunctivitis.
Get PDFSushrutacharya has described the 76 types of eye diseases in his classical text ‘Sushrut Samhita’. One Chapter of eye diseases known as Sarvagata Roga which includes ‘Netraabhishyanda’. Vataja Abhishyanda is characterized by Nistodan (Pricking pain), Sangharsha (foreign body sensation), Shishirashruta (watery discharge), Alpa Shopha (mild chemosis), Vishushka Bhava (feeling of dryness), Parushya (dryness), and so on, which are very similar to most of the signs and symptoms of Simple Allergic Conjunctivitis. Based on the similarities of signs and symptoms, Vataja Abhishyanda can be co-related with Simple Allergic Conjunctivitis. Simple Allergic conjunctivitis is a common ophthalmic problem predominantly affecting the outdoor workers. The eyes are exposed to different environmental factors. The eye and eyelids are very common sites for allergic reactions. About 50% of conjunctivitis seen by primary physicians is allergic in nature. Triphala Ghrita Aschyotan is very effective in relieving the symptoms of Vataj Abhishyand w.s.r to Simple allergic conjunctivitis. Aim: To study the efficacy of Triphala Ghrita Aschyotan in Vataj Abhishyanda w.s.r to simple allergic conjunctivitis. Materials and Method: A total 60 patients of the age group 18-60 years presenting with signs and symptoms of Vataj Abhishyanda w.s.r to simple allergic conjunctivitis were selected randomly from OPD of the department of Shalakyatantra. The 30 patients of trial group were treated with Triphala Ghrita Aschyotana and 30 patients of control group were subjected to alcaftadine (0.25%) eye drop. Results: Triphala Ghrita Aschyotana is more effective as compared to alcaftadine eye drop . Trial drug provided more relief in most of the symptoms of Vataj Abhishyanda. Conclusion: Triphala Ghrita Aschyotan is an effective, safe and potent treatment of Vataj Abhishyanda w.s.r. to Simple allergic conjunctivitis.
Keywords: Vataj Abhishyanda, Simple Allergic Conjunctivitis, Triphala Ghrita, Aschyotana, Alcaftadine (0.25%) Eye drop
A comparative clinical study of Shatavari Ghrita aschyotana and Carboxy methyl cellulose 0.5% eye drop in the management of dry eyes with special reference to smartphone users
Get PDFAdvanced technologies like computers, Internet surfing, Smartphone use, T.V., use of Air conditioners, more polluted dusty hot environment etc. has completely changed the World. Due to this long-term exposure to visual display terminal a new group of eye and vision problems has emerged with dry eyes. Dry Eye disease is an inflammation of cornea and conjunctiva due to inadequate secretion of tears. No specific remedial measures have been mentioned for Dry Eye Disease in modern medicine. Considering all the lacunas of established treatment and increased prevalence rate of disease due to changing lifestyle it is necessary to look for alternative therapy which is safe, cheap, easily available, and more effective. Aim: To evaluate and compare the effect of Shatavari Ghrita Aschyotana and Carboxymethylcellulose 0.5%eye drop in patients suffering from Shushkakshipaka (Dry eye syndrome). Material and methods: A total 70 patients of the age group 20-30 years presenting with signs and symptoms of Shushkakshipaka w.s.r. to dry eye disease were selected randomly from OPD of the department of Shalakyatantra. The 35 patients of trial group were treated with Shatavari Ghrita Aschyotana and 35 patients of control group were subjected to Carboxymethylcellulose 0.5% eye drop. Results: Shatavari Ghrita Aschyotana is more effective as compared to Carboxymethylcellulose 0.5% eye drop.
Treatment of early stage diabetic nephropathy using Siddha drug Sirupeelai kudineer - Single Case Study
Get PDFBackground: Nephropathy is one of the major micro-vascular complications of DiabetesMellitus, which can be detected in the earlier stage by the investigation of urinarymicroalbumin excretion level, estimation of ACR and GFR. The Siddha drug SirupeelaiKudineer indicated for the complications of Diabetes Mellitus is selected for this Case study.The efficiency of the drug was reported by measuring the change in Renal function over theperiod of study and the KD QOL assessment. Case description: A male patient of 62 yearswith the history of DM and hypertension since 20 years came to the hospital with complaintsof bilateral pedal oedema, general weakness, frequent nocturnal micturition and weariness oflimbs since last two months. His renal profile and glycaemic index was deranged (SerumCreatinine -1.42 mg/dl; Blood Urea -54.3 mg/dl; Urine Micro albumin -99.45mg/L; UrineCreatinine -74.8 mg/dl; ACR -15.02 mg/mmol; eGFR - 64.5 ml/min; BSL (Fasting) -157mg/dl; BSL (Postprandial) -289 mg/dl). Patient was taking certain oral allopathic medicinesand injection huminsuline 30/ 70 in the dose of 35 units before lunch, and 30 units beforedinner subcutaneously. As per Siddha concept his three humours deranged and seen with theClinical features of Madhumega roga avathaigal and Neeradaippu. He was given Siddhamedicine Sirupeelai kudineer-120ml twice a day for the period of one month. Significantrelief in symptoms and improvement in certain renal parameters was noted in the subject.Conclusion: The clinical and laboratory parameters in this case study suggest that this drugmay be used along with other allopathic drugs in the treatment of Diabetic nephropathypatients
Quality standardization, Phytosome formulation and in vitro antioxidant activity of Moringa oleifera Lam: An Ayurvedic medicinal plant
Get PDFAim: To formulate and evaluate Moringa oleifera loaded phytosome for its in vitro antioxidant activity. Method: The plant material was analyzed for its quality by analyzing various pharmacognostical properties. The plant material was subjected for extraction by using maceration followed by soxhlet extraction using ethanol: water as solvent. The resultant extract was subjected for phytochemical investigations to assess the presence of plant metabolites. Furthermore, novel lipid based nano formulation such as phytosome was prepared by thin film hydration method. The prepared phytosomes loaded with Moringa oleifera extract was analysed for DSC, FTIR, particle size and entrapment efficiency. The optimized formulation (F3) was subjected for in vitro antioxidant activity. Thin Layer Chromatography was performed using Quercetin as standard and Methanol: Water as mobile phase. Results: The organoleptic evaluation revealed the plant is green, aromatic odour, slightly bitter taste erect stems, thick grey bark, flowers are white. Physicochemical parameters such as Moisture content, Total ash, Acid Insoluble ash, Water soluble ash values, Aqueous, Alcohol and Petroleum ether extractive values are found to be 8.5, 10.5, 5, 12.5, 12.5 and 2.5% respectively. The phytochemical investigation confirmed the presence of Alkaloids, Glycosides, Steroids, Terpenoids and Phenols. The compatibility study confirms that the excipients and drugs are compatible with each other. Among four prepared phytosomes with different ratios, formulation 3 exhibited smaller particle size such as 141nm and entrapment efficiency as 81%.Hence, formulation 3 is subjected for further antioxidant activity. With the IC50 value of 17.82µg/ml, formulation 3 showed promising antioxidant activity which was compared with standard ascorbic acid with IC50 33.53 µg/ml. Conclusion: The present work can be utilized for plant identification and standardization of Moringa oleifera for further research .Based on the results, it can be concluded that novel lipid based nanoformulation loaded with Moringa oleifera exhibited promising Antioxidant properties. The limitations arising from conventional dosage forms will be overlooked by the novel lipid based phytosomes with greater bioavailability and remarkable therapeutic effects
SEM-EDAX and ICP-OES analysis of Rasa Bhasma along with its Physico-chemical characterization
Get PDFAbstract- Rasa Bhasma is a Herbo-Mineral preparation mentioned by Shri Anantadeva Soori in his textbook Rasa Chintamani in the context of Parada Marana. Owing to its Hepato-protective indication, it was prepared as per the conventional method and was subjected to various physico-chemical parameters, assessment of inorganic elements, SEM EDAX and ICP-OES for the determination of Mercury. Results revealed that Rasa Bhasma was tasteless, grey coloured smooth powder having alkaline nature insoluble in water and alcohol but sparingly soluble in Chloroform with values total ash- 88.10%, acid insoluble ash- 83.03%, loss on drying-0.675%. Amongst inorganic elements, sodium, chlorides and sulphates were found to be present in the Bhasma. SEM/EDAX spectra show the results of Mercury, Sulphur, Carbon, Oxygen, in various spectrums. The % of Mercury is maximum i.e., between 65-75% each. Sulphur varies from 25-30%. Carbon is rich in quantity varying from 25-30%. In all the Spectrums, Mercury is associated with Sulphur, forming a major peak and small Mercurial peaks are also seen along with small peaks of carbon. 98.3% mg/kg Mercury was found to be present in the Rasa Bhasma by ICP-OES analysis. Physico- chemical parameters of Rasa Bhasma were found to be within normal limits concluding that the prepared Rasa Bhasma was of standard quality.
Comparative clinical efficacy of Tryushanadi Guggul and Navaka Guggul in Sthoulya (Overweight)
Get PDFSthoulya is Medovahastrotodusthijanya Vyadhi,which includes abnormal and excessive accumulation of Medodhatu in body. This is caused by lack of physical and mental activity,day dreaming,excessive intake of Madhur, Snigdhaahar results in increase Kapha Dosha and Meda which results in Sthoulya, which having symptoms of mild dyspnoea,thirst,drowsiness,excess sleep & appetite,offensive smell from the body,incapability to work and incapability to participate in sexual intercourseAim-Comparative Clinical Efficacy of Tryushanadi Guggul and Navaka Guggulin Sthoulya(Overweight) Material and Methods - Study comprisestotal 60 patients of Sthoulyarandomly divided into two equal groups. Group A(Experimental group) was treatedwith 1 gm Tryushanadi Guggul two times a day after meal with Honey and Group B (Control group) was treatedwith 1 gm Navaka Guggul will administered two times a day after meal with Honey for 30 days. Patients were assessed for Subjective parameters like Kshudrashwas, Swedadhikya, Atikshudha, Nidradhikya, and Objective parameters like Body weight in Kg, Body Mass Index (BMI) in Kg/m2, Waist Hip Ratio (WHR), and Mid Arm circumference (MAC) on 0,15, and 30th day, and Serum Lipid Profile was done on 0 and 30th day. Result – Significant improvement was observed inSubjective and Objective parameters. Conclusion –Tryushanadi Guggul is as effective as Navaka Guggul in the management of Sthoulya (Overweight). Hence Sthoulya can be effectively managed with Tryushanadi Guggul
Ayurvedic management of Asthimajja gata vatarakta (Avascular necrosis of head of the femur) – A case report
Get PDFAvascular necrosis is a condition where the bone tissue starts degenerating due to interrupted blood supply to the bone tissue. It is also known as ischemic bone necrosis, aseptic necrosis or osteonecrosis. From the contemporary medicine the management of AVN goes by pain management and joint replacement surgery. There is no direct correlation for AVN in Ayurveda. But concepts like Asthi kshaya, Asthi majja gata vata, Asthi majja gata Vatarakta symptoms stands very close to this disease condition. A female patient of age 42 came to the OPD complaining of pain in the bilateral hip joints with difficulty in walking since 6 months. MRI of the hip reveled grade 2 AVN of bilateral femur head. Patient was diagnosed as a case of Asthi majja gata Vatarakta with physical examinations. Pancha tikta ksheera kashaya, Lakshaguggulu, was given. Sandhaneeya mahakashaya gana Ksheera basti (enema with medicines processed in milk) was given to the patient for 14 days after sthanika snehana ans swedan . Pancha tikta ksheera kashaya has tikta and kashaya rasa. Tikta rasa has ashraya asharee bhava with asthi dhatu. Hence it improves the quality of asthi dhatu. Laksha guggulu helps in reducing the pain and improving the quality of rakta (rakta). Medicines included in Sandhaneeya mahakashaya gana are either Tikta, Kashya , Madhura. These rasa helps in reducing the rakta dushti (impaired circulation) and improves microcirculation. Ksheera basti helps in improving the quality of Asthi and majja dhatu. It also helps in reducing the pain in the affected region.
A Review on ethnomedicinal claims of Merremia gangetica Linn.
Get PDFAim: The medicinal plant Merremia gangetica Linn., family - Convolvulaceae, traditionally being used by the local healers due to its multiple therapeutic indications. Present review aims to collect currently available data on ethno-medicinal information and research updates on M. gangetica. Material and Methods: Available books related to traditional folklore uses of M. gangetica were searched from ethno-medicinal plants and published research articles. Along with various researches, name of reporting tribe and their place using the plant, vernacular names, parts used along with the therapeutic uses with specific methods of administration, if any, through either external or internal usages were also noted. Results: Across the globe in 2 countries and 8 states of India, M. gangetica has been reported for its traditional folklore therapeutic uses and in the management of 32 diseases conditions, various parts of the plants like whole plant, leaf, root and seed alone or along with other drugs are used either through external applications or internal administration. Maximum indicated in the treatment of rheumatism, neuralgia, headache, cough, etc. were reported. Whole plant has maximum application in 14, followed by leaf in 8, root in 4 and seed in 1 diseases condition. Pharmacological studies such as anti-arthritis, hepatoprotective, nephroprotective activities, etc. were also reported. Conclusion: M. gangetica is a folklore ethnomedicinal plant being used as medicine in rheumatism, neuralgia, headache, cough, etc. and also to establish its ethnic claims, plant need scientific evaluation through pharmacological and clinical studies
Raktamokshana - A Customary Perspective to alleviate De Quervain’s Tenosynovitis w.s.r. to Vatarakta - A Rare Case Study
Get PDFThe discovery of De Quervain\u27s Tenosynovitis was much acknowledged in classical books in terms of symptoms that could be associated to Vatarakta (Gout), but the disease\u27s nomenclature was only identified in the later period of global modernization. This case study describes a young woman who was pre-diagnosed with De Quervain\u27s condition and treated using the Vatarakta paradigm of treatment protocols, principally raktamokshana (Blood-letting). Raktamokshana with the advent of jalauka (leech) is taken into consideration in the study because Vata and Rakta (blood) are vitiated, which furthers the disease. Rakatamokshana is an excellent treatment option for De Quervain\u27s Tenosynovitis due to its efficiency, simplicity of administration, and safe therapy regimen. With outstanding results for pain management and the restoration of the functioning of the wrist joint, this therapy modality can therefore be recommended for the condition. Need of study: To evaluate the new conceptual idea for treating De Quervain’s Tenosynovitis that is non-invasive and helps to restoring the normal function of corresponding hand and wrist movements. Methodology: Current case report presents a 34-year-old woman with a right-hand dominant job whose primary complaints were pain, morning stiffness, localized burning sensation and swelling at the radial styloid process on the right hand at the base of the thumb for the past two months, who was diagnosed as De Quervain’s Tenosynovitis and was treated with Raktamokshana with Jaluka with two sittings. Conclusion: After first sitting she had 80% relief from symptoms and was totally symptomless after second sitting of Raktamokshana, helping new therapeutic regimen to treat the disease.
Genotoxicity Evaluation of Vaishvanara Churna - A classical Ayurvedic Formulation
Get PDFAims: The current study aimed to evaluate the genotoxicity of the Vaishvanara Churna, a polyherbal formulation by using Peripheral Blood Mononuclear Cells. The study was supported by the study of the content of heavy metals in the ayurvedic formulation. Background: Vaishvanara Churna is a classical ayurvedic formulation that is used for treating conditions, such as flatulence with gurgling sound (Adhmana), abdominal lump (Gulma); Duodenal ulcer (Parinamasula), Rheumatism (Amavata); heart disease (Hrdroga). Objective: The objective is to study the genotoxicity of Vaishvanara Churna on Peripheral Blood Mononuclear Cells using alkaline Single-cell Gel Electrophoresis and correlate the possible association of genotoxicity to the number of heavy metals present in the polyherbal formulation. Methodology: The Alkaline Single Cell Gel Electrophoresis was used to see the effects on the Peripheral Blood Mononuclear cells using 2% Hydrogen Peroxide as a standard oxidizing agent. Observation: Peripheral Blood Mononuclear Cells, isolated from a fresh human blood sample, were treated in vitro with varying concentrations of Vaishvanara Churna (0.2, 0.4, 0.8, 1.6, and 3.2 mg/ml of aqueous extract) using a standard protocol. It was found that none of the assessed concentrations of the ayurvedic formulation was toxic to Peripheral Blood Mononuclear Cells. Conclusion: Single-cell Gel Electrophoresis is a simple technique to evaluate the genotoxicity of any drug to Human Beings, and it can be used as an alternative to animal genotoxicity studies