International Journal of Ayurvedic Medicine
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Ethno-medicinal survey on Folklore Practices for Jaundice in taluks of Belagavi
Full text linkIntroduction: Ethno-medicinal survey has been helping both Folklore and Ayurvedic practitioner hand in hand for regularly updating knowledge. Belagavi that comes under the roof of Western ghats has abundant flora throughout its region. The ethnomedicinal practices for Kamala (jaundice) weren’t explored. The prevalence of kamala, or jaundice, in India is 2.76 per 1000. Over the past one to two decades, there has been an increase in the incidence of liver injury due to changes in lifestyle, food consumption, and other variables. Newer and more effective drugs from ethno-medicinal practices could help tackle the disease more effectively. Materials & Methods: Two taluks of Belagavi—Bailhongal and Saundatti—were chosen for an ethnomedical survey because of their close proximity to water sources, because they were more susceptible to water-borne diseases. Using a semi-structured questionnaire, data regarding the herb usage, preparations, and habits of 23 folklore practitioners was collected between June 2024 and November 2024.Use value, fidelity level, diagnosis method, Rasa panchaka, formulation, and preparation were the subjects of the data analysis. Result & Discussion: During this survey, 40 plant species from 28 distinct families were observed; all of the plants were gathered, and a herbarium was made. The Use Value (UV) of Tinospora cordifolia and Sacchrum officinarum were 0.47 and 0.39, respectively. A total of 52 formulations with various preparation methods and administration methods were observed. Both therapeutic treatment and pharmacopeial preparations that are helpful in the management of Kamala (jaundice) can benefit from an improvement through phytochemical analysis and additional clinical research on the formulations
Experimental Evaluation of Anti-arthritic Activity of OstoCan-V50 Tablets Using Monosodium Iodoacetate-Induced Osteoarthritis in Wistar Rats
Full text linkBackground: Osteoarthritis (OA), a prevalent degenerative joint disorder, causes significant disability due to cartilage degradation, inflammation, and pain. Current treatments offer symptomatic relief but fail to modify disease progression and carry adverse effects. OstoCan-V50, a novel polyherbal formulation containing Withania somnifera (L.), Boswellia serrata Roxb. ex Coleb., Cissus quadrangularis (L.), Kukkudandatwak Bhasma, and Cannabis sativa (L.), holds potential as a safer, disease-modifying therapy. This study evaluates its anti-arthritic efficacy and safety in a preclinical model. Methods: Following the Animal Research: Reporting of In Vivo Experiments, Version 2.0 (ARRIVE 2.0) and Committee for the Control and Supervision of Experiments on Animals (CCSEA) guidelines, female Wistar rats with monosodium iodoacetate-induced osteoarthritis were divided into six groups (n=8), including controls, diclofenac (10 mg/kg), and OstoCan-V50 (12.87, 25.75, 51.5 mg/kg). Treatments were given orally for 28 days. Knee thickness, pain threshold, serum cytokines, haematology, radiology, and histopathology were assessed. Acute toxicity (2000 mg/kg) followed OECD Organisation for Economic Co-operation and Development Guideline 423(OECD). Data were analysed using ANOVA (p < 0.05). Results: OstoCan-V50 significantly reduced knee joint inflammation, increased pain threshold, and improved food intake, water intake, and body weight in MIA-induced osteoarthritis. Serum TNF-α and IL-1β levels decreased markedly (p < 0.0001), with the 51.5 mg/kg dose showing efficacy comparable to diclofenac. Haematological alterations were normalized, while radiology and histopathology demonstrated reduced joint damage and greater viable chondrocyte counts. No toxicity was observed at 2000 mg/kg in the acute study. Conclusion: OstoCan-V50 demonstrated significant anti-arthritic, anti-inflammatory, and analgesic effects with a safety profile superior to conventional therapy in the MIA-induced osteoarthritis model. The findings support its potential as a promising, safe, polyherbal candidate for disease modification in osteoarthritis and justify further evaluation in chronic models and clinical trials
Assessment of volatile oil content for quality control of commercial Samples of Guggulu viz. Commiphora wightii (Arn.): A critically endangered species
Full text linkThe oleo-gum resin of Commiphora wightii syn. Commiphora mukul (family: Burseraceae), aka Guggulu, is a popular and widely used drug in Indian Ayurvedic pharma industries and in rest of the world. To get the best and desired clinical effects, authenticity and quality of raw drugs is essential. For Guggulu, along with other parameters, volatile oil determination can be regarded as simple and reproducible test for confirming valid samples of Guggulu. We investigated the current scenario of market availability of raw Guggulu exudate in Pune city, India and four market samples from local vendors were investigated. Volatile oil from the raw sample was determined by Clevenger’s apparatus. It is noted that poor quality samples are available in markets, and these might be used for manufacturing of Ayurvedic products by some pharma industries, which further raises the quality control concern. To reduce the cost and make the product comparable with others in the market, quality of raw drugs must not be compromised. This study indicates the necessity of proper quality control of Guggulu. More cultivation and proper collection methodology of Guggulu is also needed to match the huge demand of this drug
Evaluation of Analgesic and Anti-inflammatory activity study of Polyherbal formulation ACUPEN in experimental animal models
Full text linkAim and Objective: Evaluation of Analgesic and Anti-Inflammatory activity study of polyherbal formulation ACUPEN in experimental animal models. Methodology: The acute toxicity test of the Polyherbal formulation ACUPEN was performed by OECD 423-guideline. Analgesic activity was evaluated using Eddy’s hot plate method & acetic acid-induced abdominal writhing test. The anti-inflammatory activity was measured using a digital vernier caliper with carrageenan-induced hind paw oedema. All drugs were given 1ml of 1% vehicle (CMC), Pentazocine 10mg/kg (i.p), Diclofenac 10mg/kg and Test drugs at doses 150, 300 and 600 mg/kg in 1% CMC (vehicle) were administered per orally in the experiment. Result and Discussion: Eddy’s Hot plate method results showed central analgesic activity through a long-lasting significant increase in response time from 30 minutes to 120 minutes in the Polyherbal formulation ACUPEN. In acetic acid-induced writhing ACUPEN exhibited dose-dependent peripheral analgesic activity. Amongst low, mid and high, the high dose (600mh/kg) showed significant (p<0.05) peripheral analgesic activity compared to standard drug. In the carrageenan-induced paw oedema method, the percentage inhibition of all the groups was compared at 1, 2, 3, 4, and 5 h, and it was found that high-dose ACUPEN (600mg/kg) showed highly significant P< 0.05 of % inhibition than the other groups. Conclusion: From the current study it has been concluded that the Polyherbal formulation ACUPEN was found to be safe for greater than 5000mg/kg body weight. The formulation exhibited both central and peripheral analgesic action in a dose-dependent manner in experimental models. The Polyherbal formulation has also exhibited anti-inflammatory activity too.
Dietary Vigilance Depicted by Priya Nighantu: A Portrayl
Full text linkAyurveda prioritizes diversified aspects of dietetics and nutrition. It elaborates therapeutic potential at the same time provided cautions its use. The recent surge in non-communicable diseases and global strategies for its prevention has drawn attention of world towards AYUSH. Ayusha Ahara provides a promising solution for promotion and preservation of health. However, precautions for regular consumption or overconsumption of certain ingredients are neglected which leads to development of various disease. Priya Nighnatu, is latest lexicons have discussed presently used dietary ingredients and recipes. Present review was done by meticulous review of diet explained by Priya Nighantu for pharmacovigilance concern. Out of total 722 reviewed dietary ingredients; 76 diets are reported for its effect on vitiation of Dosha (Vataprakopaka: 16; Pittaprakopaka: 10; Kaphaprakopaka: 24; Vata-kapha prakopaka: 6; Pitta-kapha prakopaka: 16; Vata-pitta prakopaka: 2, Tridoshaprakopaka:2), 26 diets reported for having vigilant action on Dhatu (Rasa: 3, Rakta:2, Mamsa: 1 and Shukra:20) and 78 diet vitiates Mala (Purisha:52, Mutra:24, Sweda: 2) in certain way. Apart from these, diet which affects organs and central nervous system are 19 and 8 in number respectively. The data has been presented in pictorial for easy capture and understanding of readers along with evidence based discussion. Priya Nighantu in toto have forwarded cautions and vigilance of 207 diets; if consumed on regular basis. A proactive approach towards these data will help practitioners, dietician, nutritionist and researchers to understand AYUSH Ahara, its therapeutic and vigilant application.
Keywords: AYUSH Ahara, Diet, Health, Pharmacovigilance, SDG:3, Well-bein
The Effect of Rasona Vati (Allium sativum) and Shuddha Guggulu Vati (Commiphora mukul) in the management of Gridhrasi
Full text linkBackground: Gridhrasi (Sciatica)is increasingly prevalent today, largely attributed to modern contemporary lifestyles, which have led to a marked rise in cases of low back pain and sciatica. Given these factors, there is a growing recognition of the limitations of conventional treatments, which typically focus on analgesics, physiotherapy, and surgical interventions. While these methods can offer temporary relief, they often fail to address the underlying imbalances within the body. This article aims to evaluate a reliable approach to managing Gridhrasi, addressing both symptoms and root causes to improve patient’s outcomes and overall quality of life. Objectives:To evaluate the efficacy of Rasona Vati (Allium sativum) and Shuddha Guggulu Vati (Commiphora mukul) in Gridhrasi. Materials and Methods:A randomized clinical study was conductedon 60 patients of Gridhrasi (Sciatica) and were evaluated on subjectiveparametersRuka, Toda, Stambha, Spandana, Gaurava, Tandra and Aruchi), and objective parameters of VAS Score, SLR and Low-Back Outcome Score by Greenough and Fraser). Results:The study assessed that both treatments yielded significant improvements across subjective and objective parameters.Shuddha Guggulu Vati outperformed Rasona Vati and showed promising improvement in reducing the symptoms of Gridhrasi
Development and evaluation of Palasha (Butea monosperma lam.) twak ointment: A herbal remedy
Full text linkPalasha, botanically identified as Butea monosperma Lam., belongs to the Fabaceae family and is commonly known as the "Flame of the Forest." It exhibits a range of therapeutic properties such as wound healing, diuretic, anthelmentic, anti-hemorrhoidal, and anti-inflammatory. Despite its varied uses globally, the procurement and preparation of Palasha twak avachurnana (dusting powder) remains a challenge. This study aimed to develop an effective Palasha (Butea monosperma Lam.) twak extract ointment. Palasha twak was authenticated and its physicochemical analysis was carried out at Central Research Facility, AYUSH Department approved, Ayurveda, Siddha, Unani Drug Testing Laboratory, Shri B M Kankanawadi Ayurveda Mahavidyalaya, Shahapur, Belagavi. Hydro-alcoholic extraction was carried out using a Soxhlet apparatus with 70:30 ethanol-water ratio, yielding 40 grams of extract from 150 kg of Palasha Twak powder., 0.5 gm and 1 gm of extract were mixed with 10 gm of ointment base to prepare 5% w/w and 10% w/w formulations. 10% w/w ointment was selected based on its physical characteristics. Results showed that the ointment had a dark brown color, a slightly astringent odour and a pH value of 6.40. The ash value was 8.316%, with no microbial load detected. The study concludes that developing ointments from herbal extracts like Palasha twak offers significant therapeutic and cosmetic benefits while being a cost-effective and environmentally friendly option for skincare
Antioxidant Potential and Phytochemical Screening of Mrudweekadi Kashayam – An analytical study
Full text linkIntroduction: The antioxidant potential of herbal formulations is gaining significant attention due to their potential therapeutic benefits in combating oxidative stress-related diseases. Mrudweekadi Kashayam, a traditional polyherbal formulation, is used in Ayurvedic medicine for various health benefits. This study aims to evaluate the antioxidant potential and phytochemical composition of Mrudweekadi Kashayam.
Methods: The formulation was procured from GMP certified pharmacy. The antioxidant potential was assessed using standard in vitro assays, including DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging, FRAP (ferric reducing antioxidant power) assays. The phytochemical screening was performed in the Central Research Facility of KAHER’s Shri BMK Ayurveda Mahavidyalaya, Shahapur, Belagavi.to identify the presence of bioactive compounds such as alkaloids, flavonoids, tannins, phenols, and saponins.
Results: Mrudweekadi Kashayam demonstrated significant antioxidant activity in all the assays, with the highest activity observed in the DPPH assay. The phytochemical screening revealed the presence of a rich profile of bioactive compounds, including alkaloids, flavonoids, tannins, phenols, and saponins. These compounds are known for their antioxidant properties and contribute to the overall antioxidant potential of the formulation.
Discussion: The findings indicate that Mrudweekadi Kashayam possesses potent antioxidant activity, which may be attributed to its diverse phytochemical composition. The presence of multiple bioactive compounds suggests a synergistic effect, enhancing the formulation\u27s ability to neutralize free radicals and mitigate oxidative stress.
Conclusion: Mrudweekadi Kashayam exhibits significant antioxidant potential and contains a variety of bioactive phytochemicals. This formulation may serve as a promising candidate for further research and development in the treatment and prevention of oxidative stress-related diseases.
Keywords: Mrudweekadi kashayam, Antioxident, DPPH, FRAP, Phytochemicals, Analytical stud
Pharmacological Networking of Sarpagandha (Rauwolfia Serpenatina) in Insomnia
Full text linkSleep is a complex physiological process and insomnia is a growing issue of psycho-somatic nature. This condition is stated in Ayurveda as anidra and has various treatment modalities. One such single drug of choice is Sarpagandha, Rauwolfia serpentina (Linn.) Benth. ex-Kurz, indicated for such diseases. Evidence-based medicine is vital for standardization in clinical applications. Network pharmacology predicts the action mechanism of therapeutic drugs on both the interactome and diseasome levels. Objective: Understanding the activity of sarpagandha in insomnia through network pharmacology, involving respective pathways and gene targets to enhance the therapeutic efficacy. Material and Methods: In this study standard methods were used for collection and interpretation. Phytochemicals were collected from PubChem Compound Identifiers (CIDs). Associate targets extracted from Gene Cards using specific keyword "insomnia". Disease & protein targets acquired through Venny 2.0 and predicted through Digip pred & Swiss Target Prediction. Shared targets were uploaded onto STRING database to create the network. Using Cytoscape 3.7.1 network linking of phytochemicals & corresponding targets achieved. KEGG enrichment bubble plot analysis was conducted to interpret the signaling pathways associated with insomnia targets. Results: The study identified 21 Phyto-constituents, that significantly modulates 58 diverse target proteins related to insomnia, through 49 different pathways, among which 14 were highly significant. Two phytochemicals found to exhibit the highest degree of connectivity by linking to 16 targets which include various key receptors and enzymes. These findings align with the Ayurvedic concept of treating insomnia
Evaluation of the efficacy of Ekal Dravya Jyotishmati (Celastrus paniculatus) in the management of Generalized Anxiety Disorder (Chittodvega) - A single-arm study
Full text linkBackground- Generalized Anxiety Disorder (GAD) is a mental disorder characterized by an anxious state of mind that presents with symptoms like restlessness, irritability, sleep disturbances, tension, palpitations, dry mouth, and sweating. It predominantly affects women, especially in midlife, with a prevalence of 10% among women over 35. In modern treatment, selective serotonin reuptake inhibitors (SSRIs) such as sertraline are commonly prescribed as first-line therapy. GAD is referred to as Chittodvega in Ayurveda. Jyotishmati (Celastrus paniculatus), is mentioned as a Medhya drug in the Ayurvedic texts that enhances cognitive function and emotional well-being potentially offering benefits for managing GAD.
Aim and Objectives- To evaluate the efficacy of Jyotishmati in the management of GAD (Chittodvega).
Materials and Method-
In this trial, a total of 35 patients were enrolled for the study. Patients between 20–50 years of age of either gender having symptoms of GAD (Chittodvega) and a Hamilton anxiety rating (HAM-A) scale score less than 24 (i.e., mild to moderate) were selected for the study. In the trial intervention, Jyotishmati Capsules 500 mg were given twice a day after food with water for 60 days.
Observations and Result- Data of 35 patients were used for statistical analysis and significant improvements were noticed in the HAM-A Score, Serum cortisol levels and the WHOQOL Score from baseline to the subsequent follow-ups on the 30th, 60th, and 90th day.
Conclusion- Jyotishmati Capsule is effective in significantly reducing anxiety symptoms, HAM-A Score, and Serum Cortisol levels and improves the quality of life of patients