International Journal of Ayurvedic Medicine
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Management of Herpes Zoster solely employing Ayurveda: A case report
Get PDFBackground: Varicella-zoster virus (VZV) causes two distinct clinical syndromes: varicella (chickenpox) and herpes zoster. Though human-specific, varicella-zoster virus infections can last for a few hours or even a day or two outside of humans. Herpes zoster is similar to Visarpa disease in Ayurvedic texts. Visarpa spreads very rapidly to many different body parts. Because it spreads throughout the body, it is also known as Parisarpa. Analysing the herpes zoster symptoms, it reveals vitiating Twak, Rakta, and Mamsa Dhatu, with vitiation of Vata-Pitta-dominated Tridosha. This helps us understand the gravity and importance of the disease. Visarpa is not a chronic illness like Kushtha (skin diseases), but, if left untreated, might lead to severe complications. Material and methods: A 25-year-old female with the main complaint of gradually erupted vesicles on the ventral aspect of her right forearm and excruciating burning pain, erythema, and mild itching. The patient was treated with Patolakaturohinyadi Kashayam, powders of Sariwa (Hemidesmus indicus R.Br.), Yashtimadhu (Glycyrrhiza glabra Linn.), Amalaki (Emblica officinalis Gaertn.), Gandhaka rasayana. Shatadhauta ghrita and Durva ghrita were used for local application. Observation and Result: With the aid of internal treatment employing these yogas, the patient shown optimistic outcomes, and herpes zoster was successfully treated with Ayurveda
A Case Study of Scalp Psoriasis managed with Ayurvedic principles
Get PDFPsoriasis is a persistent, visible skin disorder that has a significant impact on a person\u27s physical and psychological well-being. It is one of the most pressing concerns of social significance. Skin disorders are widespread as a result of a changed lifestyle, lack of physical activity, unsanitary habits, mental stress, and overeating. It is tough to treat because of its high recurrence; it is an auto-immune, non-contagious condition that is extremely difficult to cure, according to modern medicine. According to Ayurveda, all skin disorders are grouped together under the term \u27Kushtha\u27. Despite the fact that the heading is the same for all skin disorders, there is further division and naming of skin diseases based on the doshas involved, which play an important part in determining the disease\u27s treatment path. Scalp psoriasis is clinically similar to Eka Kushtha, which is referenced in the Samhitas. A case study of Scalp Psoriasis managed with Ayurvedic principles Shodhana Chikitsa is presented in this paper. In this study, a 25-year-old male patient with scalp psoriasis was treated, who presented with symptoms of dandruff like flaking, silvery white scales, reddish plaque, and severe itching. Ekakushtha (Scalp psoriasis) was diagnosed, and the patient was treated with both external and internal drugs, including Vaman (therapeutic vomiting) and Shamanachikitsa (palliative treatment). During treatment, the patient noticed a significant reduction in symptoms. In this case study, Vaman karma followed by palliative treatment was found to be a more effective treatment choice for Scalp Psoriasis.
Pharmacognostic Evaluation and Quantification of Quercetin in Muntingia Calabura Leaves and Fruits Using HPLC Method
Get PDF The present is to evaluate the pharmacognostic character of Muntingia Calabura and estimation of quercetin in flavonoid rich leaves and fruit fractions. Pharmacognostic studies were carried out in terms of morphological, microscopic characters, physicochemical parameters and HPLC fingerprint analysis of leaf and fruit extracts of Muntingia calabura samples using standard methods. Further, the extracts were used to analyze total phenol, flavonoid contents and estimated antioxidant activities using DPPH. fruit size. and color of Muntingia calabura was the distinguishing morphological character observed in the present study. The detailed powder microscopy of leaf confirmed the presence of fibers, trichomes, vascular bundle and Xylem vessel. and fruits with specified Epicarp, Reticulate xylem vessel, starch grains, Endosperm, oil globules, parenchymatous tissue. Physicochemical parameters like ash values, and extractive values. were determined. Preliminary phytochemical screening showed the presence of alkaloids, glycosides, steroids, carbohydrates and flavonoids. Using HPLC Profiling, Standard quercetin was found to have a retention time of 7.313 while flavonoid-rich leaf and fruit had retention times of 7.245 and 7.210, respectively. Based on the results of the research, it was discovered that Muntingia calabura, fruit and leaves contain a variety of secondary metabolites with strong antioxidant ability. The morphological and histological traits of Muntingia calabura, leaves and fruit can be witnessed under a microscope. Using HPLC Profiling for Quantification of Quercetin in flavonoid rich fraction of leaves and fruits
Evaluation of Comparative Efficacy of Vidarikandadi Churna and its Modified Dosage Form for Assessment of Growth, Strength, and Stamina in Albino Rats
Get PDFVidarikandadi Churna (VC) is a Polyherbal formulation suggested for karshya that is also said to be beneficial for weight gain and development. Yogaratnakara mentions Vidarikandadi churna as a formulation. Many formulations are cited for their nootropic and antioxidant qualities. Vidarikandadi Churna is one of the preparations. Traditional meals are high in the nutrients that growing children require. On Wistar male rats, we conducted a research to examine the strength, stamina, and growth-promoting abilities of conventional supplements and traditional health supplements. Aim: Pharmaceutical analytical study of Vidarikandadi Churna and its modified dosage form and assessment of their comparative efficacy for Strength, Stamina, and Growth as compared to standard supplements in albino rats. Objectives: To assess and compare the strength, stamina, and growth parameters in VC, VB, and standard supplements. Material and Methods: A total of 30 Wistar male rats were used in the study. Five groupings of animals were formed. Except for the Normal control group, all of the rats were given health supplements. For 30 days, groups II, III, IV, and V received Milk, Complan, Vidarikandadi Churna, and Vidarikandadi Biscuits but no health supplement (control group). A swim endurance test was used to assess the strength and stamina of Wistar rats in each group, and growth was assessed by measuring body length and body weight. Observation and Results: A group of rats with the greatest development (body length and weight), strength, and stamina were studied. Group V rats had the most strength and stamina, followed by Group IV, Group III, and Group II rats. Group V rats gained the most, followed by groups IV, III, and II, in that order. Conclusion: In the current study, we discovered that group V rats had the most strength and stamina, followed by groups IV, III, and II, and that group V rats had the greatest growth, followed by groups IV, III, and II, respectively
In Vitro evaluation of anti-urolithiatic activity of Piper betle L.
Get PDFUrolithiasis or kidney stone is the most frequently occurring urinary disorders seen all over the world. They are saturated crystals formed due to the minerals present in the urine. It majorly comprises calcium oxalate, uric acid and phosphate crystals. The phosphate crystals, known as struvite, are formed due to the urinary tract infections. Although there are various synthetic medications, the use of traditional medicines / plants has been a promising method to treat kidney stones. To investigate the antiurolithiatic potential of traditional plant - Piper betle, the aqueous extract of Piper betle leaves was used. This extract was tested on two different crystals, first onto the raphides present in Colocasia esculenta leaf which is analogous to the calcium oxalate crystals. Second on the struvite crystals prepared from the crystallization method. The study showed there was a considerable decrease in the amount of raphides present in Colocasia esculenta and the same effect was seen on struvite crystals, which reveals that the leaves of Piper betle have an effect in dissolving and/or minimising the size of both crystals, thus substantiating the traditional claim. It is concluded that the leaves of Piper betle have beneficial inhibitory effect on in vitro crystallization of calcium oxalate and struvite crystals
A Randomised Active Controlled Clinical Trial to Evaluate the Efficacy of Vyoshadi Yoga versus Simethicone drop in Udarshula (Infantile Colic)
Get PDFBackground: Infantile colic is said to be the most common complaint among few weeks to 6 months of age babies and is characterised by continual sobbing. Acharya Kashyapa has portrayed a disease named ‘Udarshula,’ which shows the same clinical features as ‘Infantile colic. The present study aimed to evaluate the efficacy of ‘Vyoshadi Yoga in Udarshula. Material and Methods- This study belongs to Randomized Active controlled clinical trial which comprises total 40 patients of Udarshula randomly divided into two equal groups. Group A (Trial group) was treated with Vyoshadi Yoga two times a day after feeding with Honey and Group B (Control group) was treated with Simethicone drop administered two times a day after feeding for 14 days. Assessment of Udarshula was done by using the parameters of the FLACC scale, Subjective Criteria and Parent Questionnaire on 0,3rd ,7th, and 14th day. Results- Positive results were seen in both groups. After application of Wilcoxon Sign Rank test, it has been observed that both the formulation of Vyoshadi Yoga and Simethicone were found to be equally significant P-value=0.01<0.05 in both groups. On the 28th day, post follow-up showed both the group were reduced the symptoms of Infantile colic and improvement was seen. Conclusion- Significant results were noted in both the interventions. No ADR was reported. Further large sample studies with standard control would render better evidence in results with justification
Pre-conception care rendered to a male factor of Pyospermia/ Leukocytospermia leading to conception and Healthy pregnancy of the female counterpart – A case report
Get PDFBirth of a child is said to be no less than a miracle. The conception per say happens through the contributions by both the male and the female counter parts and is equally influenced by them. It is important to evaluate both the partners for a healthy conception. Ayurveda explains four important factors which are required for the manifestation of the garbha or for the conception to take place; they are rutu, kshetra, ambu and beeja. Alteration in any of the four factors might cause a hindrance for conception. Hence, evaluating these factors in both male and female counter parts as applicable is of utmost importance prior to conception. A male patient aged 34 years consulted us for pre conception care with a trying period of 6 months and marital life of 6 months. He was advised to undergo semen analysis which revealed presence of a large number of leukocytes in the semen sample and hence was diagnosed as pyospermic/leukocytospermic, which can be understood as pooti puya shukra dushti in Ayurveda, which can further be classified as a pittaja shukra dushti in a broader sense. He was treated with shodhana procedures of virechana and nasya to correct the beeja dushti followed by vajikarana chikitsa to enhance the health of beeja. Post treatment pus cells in semen reduced completely. Patient’s wife was able to conceive with a healthy intrauterine foetus with an anomaly scan showing no structural abnormality of the foetus.
A Siddha Management of Attai vidal with internal and external medicines for Naalavibatha Punn (Varicose Ulcer): A Case Report
Get PDFAccording to various classical Siddha literature, the varicose ulcer is compared with the symptoms of Naalavibatha punn / Naalasurrutu punn / Naalaviruvu punn. Treat varicose ulcers by prescribing Siddha internal medicines and external therapies. On August 5, 2022, a 48-year-old female patient attended the OPD of Santhigiri Siddha Medical College and Hospital, Trivandrum, with the following complaints: dilatation of veins, present in the right lower limb for 6 years; hyperpigmented lesion with itching and swelling above the medial malleolus of the right lower limb for 6 months; and an ulcer present above the medial malleolus for the last 3 months. She had a known case of varicose veins and had taken sclerotherapy three times but did not have satisfaction with the allopathic medication. The majority of the symptoms were significantly reduced in 60 days under the Siddha medications, such as a combination of Siddha preparation (Parangipattai Chooranam, Sangu Parpam, and Silasathu Parpam), Rasa gandhi mezhugu for internal, Padikara neer washing, wound dressing with Mathan thailam for external for 2 months, and attai vidal (leech application) done in 3 sittings in the gap of 10 days. No recurrence of any chronic varicose ulcer was observed during the 1 year of follow-up, and relevant preventive Siddha medication for Naalavibatha punn was given. The doctor advised the patient to do exercises that strengthen the legs and compression therapy. To summarize, the case report exhibited that Siddha leech therapy with both internal and external medications is very effective in the management of varicose ulcers
Synergistic Effect of BuylatedHydroxyanisole (BHA) and AscorbylPalmitate to Prevent Oxidative Degradation of Drug: A Dual Antioxidant Strategy
No full textObjective: The objective of this study is to investigate the synergistic effect of butylatedhydroxyanisole (BHA) and ascorbylpalmitate (AP) in preventing the oxidative degradation of a model drug. Oxidative degradation is a significant challenge in pharmaceutical formulations, leading to reduced efficacy and shelf life of drugs. BHA, a synthetic antioxidant, and AP, a lipid-soluble derivative of vitamin C, are examined for their combined effect in stabilizing drug formulations by neutralizing free radicals and delaying oxidation. Materials and Methods: A model drug sensitive to oxidative degradation was used for the study. The drug formulation was prepared with BHA, AP, and their combination at various concentrations. Control samples without antioxidants were also prepared. The samples were subjected to accelerated oxidation conditions, including exposure to light, heat, and oxygen. Drug degradation was monitored using high-performance liquid chromatography (HPLC) to quantify the remaining active pharmaceutical ingredient (API) over time. The synergistic effect of BHA and AP was assessed by comparing the degradation rates of formulations with single antioxidants and those with the combined strategy. Results and Discussion: The combination of BHA and AP exhibited a more pronounced protective effect against oxidative degradation compared to each antioxidant used individually. The HPLC analysis showed that formulations containing both BHA and AP had a significantly slower rate of drug degradation under accelerated conditions. The synergistic mechanism likely involves BHA acting as a primary antioxidant, scavenging free radicals, while AP regenerates BHA, enhancing its antioxidant capacity. This dual antioxidant strategy proved more effective in stabilizing the drug than either compound alone, suggesting an enhanced formulation stability. Conclusion: The study demonstrates that the combination of BHA and AP provides a synergistic antioxidant effect, effectively preventing oxidative degradation of the drug. This dual antioxidant strategy holds promise for enhancing drug stability, prolonging shelf life, and improving formulation performance
In-Vitro Acetylcholine Esterase Enzyme Inhibition Potential of Siddha Formulation Vilvaver Chooranam: A Neuroprotective Assay
Get PDFBackground and Aim: Alzheimer\u27s disease (AD) is a progressive neurodegenerative condition evidenced by significant cognitive dysfunction. The state of cognitive impairment is made worse by increased levels of the enzyme acetylcholinesterase (AChE), which is crucial in the hydrolysis of the neurotransmitter acetylcholine (ACh). Siddha therapy gaining higher momentum in recent days due to its global acceptance considering its broad spectral safety and therapeutic window. Siddha originated from the southern geographic landscape of Asia now spreading its wings across the bounders in managing dreadful diseases like AD. The main objective of the present study is to evaluate AChE inhibition of the Siddha formulation Vilvaver Chooranam (VVC). Materials & Methods: In-Vitro Acetylcholine esterase enzyme inhibition Potential of Siddha formulation Vilvaver Chooranam by Ellman’s method. Results:Results obtained from the study clearly demonstrate that the formulation VVC has shown promising acetylcholinesterase at stipulated concentration dose-dependently. Maximum percentage inhibition of about 54.53 ± 3.475 % was observed at 500μg/ml with the IC50 value of 411.9 ± 30.6 µg/ml when compared to that of the Physostigmine, a known AChE Inhibitor with a maximum inhibition 93.44 ± 4.434 % at the concentration of 40μg/ml with the IC50 value of 10.38± 5.29 µg/ml. Conclusion: These findings demonstrate the remarkable potential of these extracts as valuable sources of antioxidants with interesting acetylcholinesterase inhibitory activity.