International Journal of Ayurvedic Medicine
Not a member yet
1492 research outputs found
Sort by
Assessment of in vitro diffusion of Chincha Lavan Taila: An Ayurveda medicated oil
Get PDFMedicated oils are used for external as well as internal administration to treat various disorders. In Ayurvedic literature Murchhana is a procedure carried out on crude oil as treatment to enhance properties of oil. In this study, Chincha Lavan Taila a medicated formulation is prepared by two procedures Murchhita Chincha Lavan Taila (MCLT) and Amurchhita Chincha Lavan Taila (ACLT). This study aims to assess the in-vitro diffusion of Chincha Lavan Taila formulated by processed sesame oil and crude sesame oil. The in-vitro rate and extent of permeability of drug dosage forms are good markers to access the absorbance of the drug. The objective of this study is to evaluate the drug release of both oils by using in- vitro absorbance methodology of Franz diffusion cell apparatus. The in- vitro absorbance was studied in Franz diffusion cell apparatus at pH 3 and pH 8. The samples were collected and analysed under UV spectrophotometer to note absorbance of oil at different wavelength. It was noted that in the buffer solution of pH 8, there was maximum absorbance of all the samples. This experimental study shows that both formulations have well sustained absorption through gastrointestinal tract. The results indicate that the rate of absorption exhibited to be higher in MCLT compared to ACLT. This work helps to develop a new method to evaluate intestinal absorption and compare formulation for therapeutic efficacy and drug absorbance.
Fighting COVID-19: A Study to Compare Viable Treatment Options across Different Medical Systems
Get PDFDuring COVID-19, while many drugs from conventional medicine (CM) were falling short, those from Ayurveda, Siddha, Herbal Medicine, and Traditional Chinese Medicine (TCM) showed promising potential. The published recovery-aimed clinical studies on medicines from above-mentioned systems were retrieved. For CM, meta-analyses of studies using ICMR-protocol drugs, viz. hydroxychloroquine, azithromycin, favipiravir, ivermectin & remdesivir were searched. For other systems, preferably active-controlled, stand-alone studies, were considered. Their general characteristics, efficacy and safety outcomes were documented. The outcomes were evaluated on basis of a methodology inspired from ‘WHO-Minimal common outcome measure set for COVID-19 clinical research’. The CM drugs were utilized either in multiple combinations or independently. Most studied combination was HCQ and azithromycin. HCQ efficacy was studied in biggest sample. These drugs did not exhibit significant efficacy for early clinical recovery and viral clearance. The adverse event (AE) incidences were also prominent. Barring TCM, studies using Ayurveda regime Tab. Immunofree and Cap. Regimmune and CVO+C, were done in only symptomatic patients. The efficacy of Tab. Immunofree- Cap. Regimmune regime was better than conventional care including azithromycin and favipiravir. The AE incidences in these studies were minimal. Medicines from alternative systems except CM exhibited better efficacy and safety in all outcome measures
A systematic review on exploration of therapeutic potential of Aparajita (Clitoria Ternatea Linn)
Get PDFAparajita (Clitoria ternatea Linn), is an herb widely distributed in the humid, lowland tropics of Africa, Asia, and Central America. Aparajita is known for its katu, tikta, kashaya rasa, and vishaghna (which alleviate toxins) properties. It is used in the treatment of various diseases and is a major ingredient in various anti-poisonous formulations. Pharmacologically, it has actions like insecticidal, cholinergic, antioxytocic, antihistaminic, analgesic, diuretic, purgative, laxative, and abortifacient. A systematic review is attempted based on preclinical studies to prepare a strong platform for the clinical utilisation of Aparajita as a main drug. The research papers reporting the study of Clitoria ternatea Linn in animals (In vivo and in vitro) were searched for systematic review. The literature search was performed using keywords like \u27preclinical studies on Aparajita,\u27 \u27animal studies on Aparajita,\u27 and \u27pharmacological studies on Aparajita,\u27 in combination with various effects in animals, in the following databases: PubMed/Medline, Scopus, Science Direct, Google Scholar, AYUSH Research Portal, and DHARA for studies published up to December 2021. Many preclinical studies reported that Clitoria ternatea Linn has diuretic, nootropic, anti-asthmatic, anti-inflammatory, analgesic, antipyretic, antidiabetic, antilipidemic, antioxidant, and wound healing properties. In the contemporary view, several pharmacological studies and preclinical studies prove the effectiveness of Clitoria ternatea Linn in various diseases. However, very few clinical studies of Clitoria ternatea Linn were done. Further clinical research should be conducted to establish the therapeutic potential of the drug Aparajita
Apis mellifera honey: Healing effects - A value chain view from mountain agriculture
Get PDFAims and objectives: This study systematically investigates Apis Mellifera honey as an integral component within the beekeeping value chain, specifically emphasizing its role in apicultural mountain production.
Methods: The research delves into multifaceted dimensions, encompassing agronomical and territorial profiles, generated through the utilization of the Paintmap online software. Additionally, the investigation employs experimental and statistical perspectives, utilizing SPSS and Excel software for analysis.
Important observations and results: The outcomes of this comprehensive analysis reveal a noteworthy evolution in the Apis Mellifera honey market, particularly during the prevailing pandemic circumstances. The findings elucidate a discernible surge in market development over recent years. Ultimately, the paper posits that the value chain associated with Apis Mellifera mountain honey originating from European Romania substantiates a substantial foundation for mountain production and agricultural practices. In summation, this exploration contributes to the scholarly understanding of the intricate dynamics within the apicultural sector, shedding light on the pivotal role of Apis Mellifera honey in sustaining robust mountain production and farming activities
Pre-clinical study on hypo-testicular activity of hydro-ethanol (60:40) extract of Areca catechu (L.) in albino rat: Dose-dependent response
Get PDFThe study focused to assess the dose-dependent hypo-testicular activity of hydro-ethanol seed extract of Areca catechu (10, 20 and 40 mg/ 100 g body weight) in albino rats. For this purpose, body weight, reproductive organo-somatic indices, as well as motility, count, hypo-osmotic swelling and acrosomal cap status of sperm along with the quantity of testicular androgenic key enzyme activities, serum testosterone, oxidative stress sensors, seminal vesicular fructose (SVF), apoptosis linked gene expression study and histology of testicular tissue for spermatokinetics were covered here. All the said doses revealed a significant (p<0.05) downward deviation in spermiological profile, serum testosterone, SVF levels, activities of testicular ∆5,3β and 17β-HSD, seminiferous tubular diameter compared to the vehicle-treated control (VTC). In contrast to the VTC, activities of superoxide dismutase and peroxidase were decreased along with elevation in the levels of thio-barbituric acid reactive substances significantly (p<0.05) in testis and sperm pellet of extract-treated groups. Testicular pro-apoptotic Bax gene expression was elevated and anti-apoptotic Bcl-2 gene expression was diminished significantly (p<0.05) after extract treatment compared to the VTC. Non-significant changes (p>0.05) were noted in hepatic acid and alkaline phosphatase activities which focused the non-toxic characteristics of said extract in general. This study interpreted that, 40 mg showed drastic hypo-testicular efficacy cum necrotic changes compared to other doses though the therapeutic dose that cross the borderline of fertile sensors from spermiological indicators is 20 mg dose. Liquid chromatography-mass spectrometry analysis of the said extract showed that ten phyto-molecules belong to flavonoid, alkaloid and isoflavone groups mainly
A case study on the management of Prathishyaya (Chronic Allergic Rhinitis) using Bharangi Arka Nasal Spray
Get PDFThe omnipresence of Prathishyaya among school-aged groups is overlooked until the complications like kasa, swasa and rajayakshma come into being. Pratishyaya if taken heed of in the initial stage, helps to frustrate the looming effects of its complications. Bharangi Arka is cited as an effectual remedy for Prathishyaya in the Arka Prakasha of Ravana. Prescribing medications for children is usually challenging as they often resist taking them and so, Ayurveda formulations when transmuted into more palatable forms can have salutary impacts on children than classical forms. This case study was carried out on an 8 ½ years old male child with sneezing, runny nose and chronic symptoms including nasal itching and obstruction in particular. Prathishyaya was diagnosed after a proper clinical evaluation. Bharangi Arka in the form of nasal spray was opted as the sole drug in the treatment. Assessment of symptoms was done using Total Nasal Symptom score on the 7th, 14th, 21st and 28th days of the first month of the treatment and at the end of the following two months. Subsidence of all the symptoms was observed in the patient almost in the 4th week. This corroborates the stupendous action of Bharangi Arka nasal spray on Pratishyaya and it could usher in a way for further research to be carried out on the potency of nasal sprays in Ayurveda
Evidence based Osteogenic, anti adipogenic and anti- senescence action of Centella asiatica extract on Dental pulp stem cells
Get PDFAim: Centella asiatica linn family of Apiaceae has been used as a traditional medicine as anti-aging remedy to minimize the severity of aging problems. However the effects of Centella asiatica on stem cell differentiation and anti-aging activity are not fully understood. In this investigation we tested the effect of an aqueous extract of Centella asiatica on senescence and osteogenic, chondrogenic and adipogenic differentiation of human dental pulp stem cells ( hDPSCs). Methods: DPSC (n = 10) from the human pulp was treated with various concentrations of Centella asiatica(CA). The cytotoxicity of CA assessed using the MTT. The hDPSCs were then induced to osteogenic, chondrogenic, and adipogenic differentiation for 6 and 21 days using either CA alone or a combination of Centella asiatica with an appropriate induction media. We also evaluated the early and late passage senescence activity of DPSC. Key finding: Our data demonstrate effect of CA extract on adipogenesis, chondrogenesis and osteogenesis, and anti-aging activity. We found that there was initial increase in adipogenesis which was diminished in long-term culture. Similarly, the extract was found to enhance chondrogenesis and osteogenesis and reduced senescence as revealed by β-galactosidase staining. Significance: The present study demonstrated for the first time that the CA extract was able to inhibit adipogenesis, senescence, and accelerated osteogenesis in DPSCs. Overall results show that CA (Mandukaparni) extract can be used to treat osteoporosis, delay aging and reduce obesity
Formulation and Physicochemical Evaluation of a Herbal Dentifrice Formulated with Myristica fragrans (Nutmeg): An In Vitro Study
Get PDFAim: Dental plaque is the primary etiological factor of two of the most commonly encountered global oral health problems; dental caries and periodontal disease. The toothbrush-dentifrice combination is an essential aid in preventing them. There are several commercial chemical toothpastes available, but as of late herbal toothpastes have become more popular amongst people. Thus, the aim of this study was to formulate a novel herbal dentifrice with Myristica fragrans (Houtt.) (nutmeg), and compare its physicochemical properties with a commercially available herbal dentifrice without nutmeg. Material and method: A pilot study was conducted wherein the toothpaste was formulated under sterile conditions using various concentrations of nutmeg, tulsi leaves powder and clove powder as the main herbal ingredients. All herbal ingredients were 100% organic and certified by the Food Safety and Standard Authority of India (FSSAI). Its properties were compared and evaluated with a commercial herbal toothpaste and the most optimum formulation was then selected to be a part of the study. The properties evaluated were organoleptic parameters (colour, texture, appearance, taste, odour), pH, foamability, abrasiveness, gritty matter, homogeneity, stability and spreadability. Results: The results revealed that in comparison to the commercial herbal toothpaste, the formulated herbal toothpaste with nutmeg exhibited improved foaming ability, abrasivity, spreadability; and comparable texture, consistency, colour, gritty matter, homogeneity and stability properties. However, it had less favourable odour and taste. Conclusion: The overall results of the research provide convincing evidence of the satisfactory physicochemical properties of the nutmeg toothpaste. However, further research is warranted to test other significant properties of the toothpaste
Scientific Study of Dalhanokta Anguli Pramana (Measurement) with reference to Purusha Ura Vistaar (Male Chest Breadth)
Get PDFIn Ayurveda the word “Pramana” refers to measurement. Ayurveda classic have explained the normal measurements of Anga Pratyanga in terms of Ayama (length), Vistaar (breadth), Utsedha (height) and Parinaha (circumference) with the help of Swa-Anguli Pramana (measurement by own finger). In the ancient time length, breadth, and height of body’s parts measured by using the technique of Anguli Pramana in which measurements of parts of body have given in terms of Swa-Anguli. It can be the perfect parameter irrespective of age, sex, race and place etc. Principles of Ayurveda have given the individualistic approach rather than the generalized by providing the concept of Swa-Anguli Pramana. Acharyas said that before we start the treatment one should do the Ayu Pariksha (longativity of life) of that patient which is depends upon proper measurement of parts and sub parts of body along with Sara of body. Present study was taken to validate the Dalnhokta Anguli Pramana of Purusha Ura Vistaar (Male chest breadth) which was given as 24 Angula. The data of Purusha Ura Vistaar of 60 healthy volunteers was collected and statistically analyzed. As the very less work has been done the current study was conducted.
Keywords: Anthropometry, Swa-Anguli Pramana (measurements by own finger), Measurements, Diameter, Ayam (length)
Quality Control and Phytochemical Profiling of a Polyherbal Traditional Indian Medicine by GC-MS method
Get PDFIntroduction: Gomutra (Cow\u27s urine) has been described to be the most effective substance of animal origin. It is useful in treating various diseases due to its pharmacological activities. Nevertheless, due to its pungent smell, palatability, shelf life and fresh availability have always remained a problem. So it is very much essential to modify it into different dosage forms. One of its traditional dosage forms is Gomutrasava, an alcoholic fermented product indicated in the management of Shvitra (vitiligo). Aim & objective: The study is planned for Pharmaceutical preparation and quality control assessment of Gomutrasava. Material & Methods: Gomutrasava was prepared according to a reference from Astanga Hrudaya. This formulation was tested for organoleptic characters and physicochemical parameters, including Gas Chromatography-Mass Spectrometry (GC-MS). Observation & Results: After fermentation colour of Gomutrasava appeared dark brown with specific cow urine smell. pH, specific gravity at 25ºC, reftractive index, brix, viscocity, total solid content, alcohol content, reducing sugar, non reducing sugar of Gomutrasava were 5.41, 0.967 wt/ml, 1.394, 37º, 1.38/sec, 37%, 6%, 0.96%, 0.07% respectively and test for methanol and microbial contamination were negative. GC-MS revealed some compounds attributed to antimicrobial, anticancerous and antifungal activities. Conclusion Thus this data combined with analytical data will be used for clinical study and treatment of Shvitra (Vitiligo), Kushtha (Leprosy) and various skin diseases