International Journal of Ayurvedic Medicine
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Comparative evaluation of Chakramarda ointment and Psoralin ointment along with Guduchi capsule in the management of KitibhaKushtha (Psoriasis)
Get PDFIn Ayurveda skin disorders are mentioned under Kushtharogaadhikar and categorized into seven Mahakushthas and eleven Kshudrakushthas. Among all the Kshudrakushthas, Kitibhakushtha is one of the types. Sign & Symptoms of Kitibhakushtha are Kina Khara Sparsham (rough on touch), Shyava Varna (blackish brown color) and Kandu (itching). It is a Tridoshaja with the predominance of Vata-Kapha along with the involvement of Twak, Rakta, Mamsa and Lasika in the Samprapti. Nidanas of KitibhaKushtha are Aaharaj, Viharaj, Upsargaja and Krimija. KitibhaKushtha can be correlated with psoriasis due to similarities in symptoms. Aim and objectives: -Evaluation of comparative efficacy of Chakramarda ointment versus Psoralin ointment with capsule Guduchi internally in the management of Kitibha Kushtha (Psoriasis).
Material and Methods - This study comprises a total of 60 patients in which patients in Group A were treated with Chakramarda ointment once daily in the morning after bath and 2 Guduchi capsules 500mg thrice a day internally whereas patients in Group B were treated with Psoralin ointment once daily in the morning after bath and 2 Guduchi capsules 500 mg thrice a day internally for 30 days. Patients were assessed for subjective parameters like Kandu, Shyav Krishna Varna and Rookshata and objective parameter PASI scale. Result – Significant improvement was observed in Subjective and Objective parameters. Conclusion- Chakramarda ointment is as efficacious as Psoralin ointment in the treatment of KitibhaKushtha. Hence Kitibha Kushtha can be effectively managed with Chakramarda ointment
Comparative evaluation of efficacy of Kulattha Gutika with Atorvastatin in the management of Dyslipidemia (Medoroga) - RCT
Get PDFIntroduction: Dyslipidemia is the disorder of lipoprotein metabolism manifested by an elevation of the total cholesterol, the low-density lipoprotein (LDL) cholesterol, the triglyceride concentrations, and a decrease in the high-density lipoprotein (HDL) cholesterol concentration in the blood. Today’s unhealthy food habits and sedentary lifestyle are the main causative factors for Dyslipidemia. It is not defined in Ayurveda, it can be related to a number of conditions, including "Medoroga, Rasa Raktagata Snehavruddhi Shonitabhishyandana, and Dhamanipratichaya" based on similarities in etiology, pathogenesis, and manifestations. Aim: Comparative evaluation of Efficacy of Kulattha Gutika and Atorvastatin in the Management of Dyslipidemia (Medoroga). Material and Methods: Study comprises total 60 patients of Dyslipidemia randomly divided into two equal groups. Group A (Experimental group) was treated with 1gm Kulattha Gutika thrice a day before meals with warm water and Group B (Control group) was treated with 10 mg Atorvastatin at night before sleep with water for 45 days. Patients were assessed for Objective parameters like Lipid profile (S. TCH, TG, LDL, HDL, VLDL) and BMI was done on 0 and 45th day. Result: Statistically significant improvement was observed in objective parameters like TCH, HDL, LDL, VLDL, and TG in both groups. But in BMI Statistically significant improvement was observed in group A, treated with Kulattha Gutika. Conclusion: Kulattha Gutika is as efficacious as Atorvastatin in managing Dyslipidemia (Medoroga) and is an economical alternative without adverse effects.
Evaluation and method development for quantification of Piperine in Hutabhugadi Churna by RP- HPLC
Get PDFAim and Objective: The current work was aimed at preparing the Hutabhugadi Churna in the laboratory and evaluating the same including the method development for the estimation of a marker compound Piperine by using RP-HPLC. Methods: Prepared Hutabhugadi churna was subjected for macroscopic, physical, and chemical evaluation considering WHO guidelines. The methanolic extract was subjected for estimation of Piperine as marker using RP-HPLC. Results: The macroscopic characteristics like colour, odour and taste are recorded. The physical characteristics like loss on drying, ash value, extractive value, swelling index, foaming index, powder properties like angle of repose, bulk density, tapped density, compressibility index etc. were determined. Total phenolic content, total flavonoid content, preliminary phytochemical screening was also carried out. The results are compared with marketed formulation of Hutabhugadi churna. The retention time of the standard Piperine was found to be 5.517, while the Piperine in extracts of laboratory and marketed formulations was found to be was found to be 5.554 and 5.562 respectively. The concentration of Piperine in laboratory and marketed formulation was found to be 0.17 %w/w and 0.18 % w/w respectively. The method developed was also validated. Conclusion: The laboratory made Hutabhugadi churna and marketed formulation of Hutabhugadi churna was comparatively evaluated. The resulting data will be useful for the standardization of the Hutabhugadi churna, an Ayurvedic formulation
Investigating the Quality of Life in Patients with Tuberculosis: A Study in Southwest Iran
Get PDFIntroduction: Tuberculosis is one of the most common diseases of the present era, which affects the quality of life of patients. The present study was conducted with the aim of investigating the quality of life of patients with pulmonary tuberculosis referred to health centers in Ahvaz city. Methods: The current research is a cross-sectional study that was conducted on 75 patients with tuberculosis who referred to the health centers of Ahvaz city in 2021 through a simple random sampling method of patients with tuberculosis. Data collection tools include: demographic variables checklist and sf-36 standard questionnaire (Survey short-form 36-item health) which was collected in person. After completing the sampling, the data were analyzed using SPSS version 21 statistical software and descriptive and inferential statistical tests using independent t-tests, analysis of variance and chi-square. Results: The lowest average score was related to limited physical activity followed by psychological problems and social functioning. Also, independent t-test results showed that the average scores of quality of life in men and women, pulmonary and non-pulmonary tuberculosis patients, and the patient\u27s place of residence are statistically and significantly different. Conclusion: According to the results, tuberculosis and its treatment affect the social performance, psychological and emotional aspects of the patients\u27 quality of life
Management of Shukrakshaya (Oligospermia) by implementing traditional Ayurveda treatment: A case report
Get PDFOligozoospermia (Low sperm count) is one of the most common causes of male infertility today, which is easily diagnosed via semen analysis, keeping in mind the semen qualitative parameters preset by WHO. There is however no clear reason as to why the condition occurs except for the congenital reasons. Heat, smoking, alcohol are certain factors that might affect the sperm count, are being studied. Ayurvedic scriptures explain Shukra Dhatu vitiation by Vata-Pitta-Kapha which leads to Shukra Dosha like Ksheen or Alpa Shukra or Shukrakshaya. The article here presents a case of a 35-year-old healthy male patient with a known case of Oligozoospermia (8 million/mL), infertile for 5 years, who was successfully managed by Ayurvedic intervention within a period of about 5 months. Accordingly, his condition was diagnosed as Shukrakshaya in the OPD, and his Ayurvedic intervention was thoroughly planned. The case was managed by initiating Agnidipaka and Aampachaka Chikitsa, followed by using Virechana for Shodhana. Later the patient was taken on Shaman-Vajikarana & Balya Chikitsa for 3 months, where a significant rise in the sperm count variables depicting normal values was observed, discussed further in this article
Metabolomics Profiling of Boerhavia diffusa (Punarnava): High-Resolution Mass Spectrometry Unveils Hepatoprotective Metabolites
Get PDFBoerhavia diffusa (Punarnava), a highly valued medicinal plant in Ayurveda, has been traditionally used for its hepatoprotective properties. Despite its extensive use in treating liver disorders, the specific bioactive compounds and underlying mechanisms responsible for its hepatoprotective effects remain largely undefined. This study utilizes High-Resolution Mass Spectrometry (HRMS) to comprehensively analyse and profile the bioactive compounds in Boerhavia diffusa, aiming to uncover its hepatoprotective potential at the molecular level. The HRMS analysis revealed a diverse spectrum of phytochemicals many of which are associated with anti-inflammatory, antioxidant, and liver-regenerative activities. These compounds were further explored for their interactions with key hepatic pathways, particularly in mitigating oxidative stress, inhibiting inflammatory mediators, and regulating enzymes crucial for liver function and detoxification. The study further explores potential mechanisms of action of these phytochemicals through reviews of existing pharmacological data, proposing a multifaceted approach to liver protection that includes scavenging free radicals, reducing lipid peroxidation, and inhibiting pro-inflammatory cytokines. The findings underscore the potential of Boerhavia diffusa as a natural therapeutic agent for liver diseases, reinforcing its place in both traditional and modern medicine. These findings could facilitate the development of novel plant-based therapeutics aimed at liver health. 
Evaluating the pharmacokinetics and bioavailability of Pterygota alata inflorescence based on HRMS study to determine the reservoirs of Ayurvedic components with an emphasis on their potential therapeutic use for diabetes mellitus
No full textDiabetes indeed requires a comprehensive approach, and dietary changes play a crucial role in managing the condition. While traditional methods like Ayurveda have been used for centuries to address various ailments, including diabetes. Pterygota alata, commonly known as the "winged seed" tree, has been explored for its potential antidiabetic properties in Ayurveda. Research into its efficacy and safety is ongoing, with some studies suggesting promising results. As with any herbal remedy, individuals with diabetes must consult healthcare professionals before incorporating them into their treatment regimen. While herbal products can complement conventional therapies, they should not replace them entirely. Additionally, potential interactions with other medications and individual variations in response should be carefully considered. Through UHPLC-Q-TOF-MS/MS system major antidiabetic component such as Agmatine, Migitol, Trigoneline, Betaine, Theophylline, Quercetin, Kaempferol, Isoliquiritigenin, Esculetin, Rutin, Ferulic acid, Eriodictyol, Naringenin, Luteolin, Salsonilon, Apigenin, Hesperitine, Carvone, Ursolic acid, Betulin, Lupeol, Eugenol
A comparative study to assess the impact of an Integrated yoga module on different types of Headache: A study Protocol
Get PDFAim: The study is focusing on investigating the effect of yoga as a complementary therapy in reducing headache frequency, intensity, and duration, and its impact on quality of life in affected individuals. Background: Neurological disorders like headaches can significantly impact quality of life and daily routines. To manage these issues, patients can reduce stress, sleep, dietary changes, and physical activity. This study aims to evaluate the effectiveness of yoga as a physical movement in managing neurological issues like headaches. The intervention includes behavioral lifestyle modifications, asanas pranayama, and meditation sessions. The results will enhance yoga\u27s effectiveness in controlling neurological disorders and their associated headaches. Future research will explore the potential mechanisms of yoga and its impact on chronic conditions. Methods: A comparative study trial has been designed for a study to be conducted in Sir Sundar Lal Hospital of Varanasi, Banaras Hindu University. A total of 100 patients will be recruited and will be offered to take medication and yoga or only take medications and will be evaluated from base line to follow-up through different parameters of headache frequency, headache intensity and quality of life. The yoga group will receive yoga session through online mode, weekly 2 sessions for aprox. 60-min and the control group will receive Medication of Standard therapy. Conclusion: The effect of a pre-designed yoga module in managing headaches, focusing on outcomes like intensity, frequency, and quality of life. The findings could lead to new healthcare opportunities and enhance neuro management research, practice, and policy
Comparative analysis of Marma Vastu and Sira Marma Vidha Laxanas in The Context of Stroke Syndrome
Get PDFMarma shareera concepts were comprehensively discussed in Sharera Sthana of SushrutaSamhita, Marma locations; their types as well as the categorization of their fatalities are very much relevant till today. Here an effort is made to establish a relative hypothesis in vascularpathologies. A detail description is made on anatomical tissues or marma vastu especially on siraand dhamani which are involved in the marma injuries and also can be assessed by either in Sadhopranahara and vaikalykar marma viddha laxanas with the contemporary details of Brain stroke syndrome. The Brain stroke or Stroke syndrome is when blood flow to the brain isblocked or there is sudden bleeding in the brain. There are two types of strokes. A stroke that occurs because of blood flow to the brain is blocked called an ischemic stroke. Hemorrhagicstroke is due to bleeding into the brain by the rupture of a blood vessel. Hemorrhagic stroke maybe further subdivided into intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH).ICH is bleeding into the brain parenchyma, and SAH is bleeding into the subarachnoid spacemore specifically, nontraumatic (spontaneous) ICH.The brain cannot get oxygen and nutrients from the blood. Without oxygen and nutrients, brain cells begin to die within minutes. Theleaked blood results in pressure on brain cells, damaging them. The burden of stroke isincreasing in India; stroke is now the fourth leading cause of death and the fifth leading cause ofdisability. Research suggests that the incidence of stroke in India ranges between 105 and152/100,000 people per year. So, there is a need of understanding such disabilities by the meansof our concepts and try to avoid these by following certain regimes and activities which areexplained in our classics
Development of standard manufacturing process of Tryushanadya Lauha – An organo-metalic preparation
Get PDFTryushanadya Lauha (TL) is one of the herbo-mineral formulations in many Ayurvedic texts. Tryushanadya Lauha consists Loha Bhasma and Tryushana, which includes Pippali (Piper longum Linn), Maricha (Piper nigrum Linn), and Shunti (Zingiber officinale Roscoe), Cavya (Piper chaba Hunter), Citraka (Plumbago zeylanica Linn), Bakuchi (Psoralea Corylifolia Linn), and Lavana (salt), which includes Saindhava (Sodium chloride), Aubhida (sodium carbonate), Vida (Ammonium chloride), and Sauvarchala (Sodium sulphate). This study is an effort to develop the standard operating process for manufacturing of Loha Bhasma and Tryushanadya Lauha. As per the reference of Rasatarangini, Loha Bhasma (incinerated ash of iron) was prepared in three batches. The processing of Loha Bhasma (ash of iron) was performed by adopting, Shodhana (purification), a special heating process and Marana (incineration). For the process of Levigation decoction of Triphala was used. Puta (heating process) was given in Electric Muffle Furnace at a temperature of 500 0C. The percentage of loss was 49.9% after purification. During Loha Bhasma (incinerated ash of iron) preparation 14.7%loss and 85.3% gain were observed. This Loha Bhasma was used for the preparation of TL. During TL preparation, 0.6% loss was observed & 99.3% was obtained. This study will give the direction for the standard manufacturing process of Loha Bhasma (incinerated ash of iron) and Tryushanadya Lauha