International Journal of Ayurvedic Medicine
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Rapid UV/Visible Spectrophotometric Method for Hesperidin Estimation in Pharmaceutical Dosage Forms and Proniosomes
Get PDFA sensitive accurate UV/Visible spectrophotometric method was developed to determine hesperidin concentration through simple detection at low cost using rapid analysis. The analytical system reached ICH guideline standard validation which delivered both precision and accuracy results. The defined solution of methanol and phosphate buffer at pH 6.8 (30:70) established the best conditions for drug analysis. A method for determining maximum absorption wavelength demonstrated a value of 285 nm with its linear relationship represented by the equation y = 0.253x + 0.0138. The method displayed linear performance from 6-30 µg/ml with an R² value of 0.9987 which verifies its precise functioning. The analytical method achieved ICH guideline compliance for linearity, precision, specificity, robustness, ruggedness, accuracy and the determination of limit of detection (LOD-0.25 µg/ml) and limit of quantification (LOQ-0.78 µg/ml). Analysis of Hesperidin in proniosomes through the coacervation phase separation method was achieved successfully using UV/Visible spectrophotometry. The validation results showed that this method stands out for its high selectivity in addition to its precise and reproducible approach which makes it appropriate for hesperidin quality control in pharmaceutical monitoring of both bulk substances and formulated preparations. Through proniosomal formulation hesperidin gains higher stability along with improved delivery capabilities when applied topically. The validated approach provides medical laboratories with a both pragmatic and precise method to analyze hesperidin content in pharmaceutical settings
Anticancer effect of Vitex negundo Linn. (Verbenaceae) on MCF-7 Breast Cancer Cells and Its Antimicrobial Properties
Get PDFBreast cancer treatment presents significant challenges, with various therapeutic modalities often associated with side effects. Natural plant-derived compounds offer promising alternatives. Vitex negundo is a medicinal plant often used in ayurvedic medicine to treat a variety of ailments, some of which have been scientifically validated. Vitex negundo offers a potential natural alternative to conventional breast cancer treatments. In this context, Vitex negundo ethanolic extract has demonstrated to have potent activity against the breast cancer cell line MCF-7. Vitex negundo extracts expressed a dose-dependent cytotoxic effect against MCF-7, with increasing extract concentrations correlating to decreased cell viability. Notably, the extract selectively suppressed MCF-7 cell growth, with an inhibitory concentration of about 1000 μg/mL. Importantly, the extract appears to selectively target cancer cells, sparing normal, healthy cells. This selectivity is crucial for minimizing side effects often associated with conventional cancer treatments. Vitex negundo serves as a potential indigenous antimicrobial agent that has been evaluated by the paper disc method to identify microorganisms susceptible to the ethanolic extract. The results based on the well-diffusion method confirmed the extracts of antimicrobial activity against sensitive microorganisms
Comparative evaluation of efficacy of Trayodashanga Guggulu versus Rasona Pinda as an adjuvant with Katibasti in the management of Gridhrasi (Sciatica): RCT
Get PDFGridhrasi, listed among 80 Nanatmaja Vatavyadhis in Ayurveda, occurs due to vitiated Vata caused by a Vatavardhaka diet and lifestyle. When Vata, alone or with Kapha, affects the Grudhrasi Nadi, it results in symptoms similar to Sciatica in modern medicine. It reflects the Dosha imbalance\u27s role in nervous system disorders. Aim: Comparative evaluation of efficacy of Rasonapinda and Trayodashang guggul as an adjuvant to katibasti in the management of Gridhrasi (Sciatica). Material and Methods: The 60 patients of Gridhrasi randomly divided into two equal Groups. Group A were treated with Trayodashanga Guggulu 500mg twice a day with warm water after meal and Group B were treated with Rasona Pinda vati 500mg twice a day with warm water after meal for 30 days and katibasti with Dashamoola taila for initial 7 days in both groups. Patients were assessed at 0th day, 15th, 30th and 45th day parameters like Ruk, Stambha, Toda, Muhuspandana, Aruchi, Tandra, Oswestry-Disability Assessment, Walking time, Bowstring test, SLRT and Schober’s Test. Result: Statistically Significant improvement was observed during study in both the Groups in Subjective and Objective Parameters. Comparing both the Group A and B, Statistically more significant improvement was found in parameters like Ruk, Toda, Oswestry-Disability Assessment, Bowstring test, Walking time, Schober\u27s test and SLRT in Group B treated with Rasona Pinda with katibasti. Conclusion: Rasonapinda is more efficacious than Trayodashanga guggulu as an adjuvant to katibasti in the management of Gridhrasi”.
Phytochemical Study And Evaluation of Pediculicidal Activity of Herbal Plant Extracts of Pongamia pinnata, Annona squamosa, Tephrosispurpurea, Cassia obtusifolia and Melaleuca alternifolia
Get PDFBackground: Head louse (Pediculus humanus capitis) infestation is a significant public health issue in humans. Lice are becoming increasingly resistant to pediculicidal drugs; anti-lice chemicals have lost their efficacy, and hence substitutes for these drugs from medicinal plants have been proposed to treat lice infections. Objective: In this study report plant extracts from Annona squamosa (custard apple) (Family: Annonaceae) seed, Cassia obtusifolia (senna, sonamukhi) (Family: Leguminosae) seeds, Melaleuca alternifolia (tea tree) (Family: Myrtaceae) leaves, Pongamia pinnata (karanj) (Family: Fabaceae) leaves, and Tephrosia purpurea (unhali) (Linn.) (Family: Fabaceae) seeds were tested against the head louse. Method: Active constituents from leaves and seeds of medicinal plants were extracted using petroleum ether. The lice mortality time was assessed with the diffusion bioassay method using filter paper. Extracts of different concentrations (5% w/v, 10%w/v, 20% w/v, 30% w/v, 40% w/v, and 50%w/v) were analyzed for mortality. Result: Preliminary phytochemical screening showed the occurrence of bioactive compounds, especially carbohydrates, tannins, proteins, alkaloids, saponins, flavonoids and steroids in all extracts. The results were compared with chemical pediculicide (positive control; 1% w/w licel). Conclusion: The finding revealed plant extracts possess anti-lice activity at a concentration of 50% v/v
Preliminary pharmaceutico - analytical analysis and FTIR evaluation of Bhallataka (Semecarpus anacardium) before and after purification using Narikela jala (Coconut water) as shodana media
Get PDFBhallataka (Semicarpus anacardium Linn), commonly known as Indian marking nut, is a poisonous plant that is therapeutically used after proper shodhana (purification) in Ayurveda, an Indian system of medicine. Therapeutically, it is used extensively in the management of many diseases like Arshas (piles), Arbuda (cancer), etc. According to the Drugs and Cosmetics Act (India), 1940, it is mentioned in Schedule E-1 drugs (Poisonous drugs). The fruits of bhallataka (Semicarpus anacardium Linn) have their own poisonous property, and the oily fraction in the pericarp of the fruit is responsible for the toxic nature of the drug. Therefore, it should be used therapeutically only after proper shodhana (purification); as injudicious use of ashuddha (impure) bhallataka may result in toxic effects. It is hazardous to humans due to its irritant property, causing symptoms like burning sensation of the skin, blister formation, ulcer, and so on.
Various shodhana (purification) methods are mentioned in the Ayurvedic literature. Bhallataka shodana was done as per the reference, and preliminary analytical study, phytochemical evaluation, and FTIR analysis were conducted to understand the impact of shodhana (purification) on bhallataka (Semicarpus anacardium Linn). These obtained pharmaceutical standards can be taken as a reference for further research to know the impact of shodhana on ashuddha (impure) bhallataka and to compare the physicochemical parameters of ashuddha (impure) bhallataka and shuddha (pure) bhallataka (Semicarpus anacardium Linn)
Herbo Glow: Formulation and Evaluation of a Botanical Face Pack
Get PDFAim/Objectives: The main goal of this research was to create and test a herbal face pack that would improve the health and appearance of the skin by utilising all-natural components. The goal of the research is to create a face pack out of all-natural herbs as a substitute for manufactured cosmetics. Materials: As for the contents, we formulated it using a blend of popular herbal herbs that are well recognised for their beneficial effects on the skin. The skin-nourishing, antibacterial, and brightening characteristics of turmeric, neem, sandalwood, orange peel, and rose petals were among them. Multani mitti, also known as Fuller\u27s Earth, was one of them. Methods: A fine face pack formulation was created by drying, powdering, and blending the chosen herbs in the suitable amounts. Testing for organoleptic properties, particle size, pH, smoothness, spreadability, grittiness, and stability were all part of the physicochemical assessment of the finished product. Furthermore, patch testing was used to assess irritancy in the participants. Results: The physical properties of the herbal face pack were found to be desirable, including a fine texture, an appropriate pH, decent spreadability, and the absence of grittiness. After 30 days, the product\u27s physical and chemical properties had not changed. While testing on volunteers, we did not find any indications of skin irritation or negative consequences. Discussions: The findings indicate that the herbal face pack offers the intended cosmetic advantages, such nourishing the skin, enhancing its radiance, and washing it, without the hazards of synthetic ingredients. Using only pure herbal powders guarantees that the composition is safe, biocompatible, and effective. Conclusion: In conclusion, the results show that it is possible to create and test a cosmetic face pack that is completely herbal. To keep skin healthy and radiant, the mixture provides an alternative to synthetic cosmetic face packs that is safe, natural, and effective
Evaluation of Synergistic Anthelmintic Activity of Citrus Aurantifolia and Feronia Limonia Leaves Juice Extract Using Pheretima Posthuma Model
Get PDFWith rising anthelmintic costs and resistance, there\u27s a need for cost-effective alternatives. Synergistic effects of Citrus aurantifolia (Christm.) Swingle and Feronia limonia (L.) Swingle are unexplored. The prospective anthelmintic effects of Citrus aurantifolia (Christm.) Swingle (Acidlime) and Feronia limonia (L.) Swingle (kaitha) leaf juice, as well as the combination of leaf juice on Pheretima Posthuma, were investigated in the current study using in-vitro studies. The anatomical and physiological characteristics of Pheretima Posthuma are similar to intestinal roundworm parasites of human beings hence they are used for in-vitro study. Different concentrations (20% 50%, 100%) of juice of acidlime and kaitha and a combination of juice of both leaves were tested. Results were articulated in terms of time (min) of paralysis and death of worms. The usual medication albendazole is used as a positive control in these experiments, whereas saline water is used as a negative control. Results of Anthelmintic activity were observed in dose-dependent manner. A comparison of combination of juices of acidlime and kaitha leaves at 100% concentrate with Albedazole medication demonstrated a comparable anthelmintic activity. Albendazole (10mg/ml) while individual juice at 100%, 50%, and 20% concentrate showed less significant activity against worm Pheretima Posthuma. This study demonstrates the possibility of juice of kaitha leaves combined with acidlime leaves as anthelmintic drug. The concentration of a combination of juices showed a better anthelmintic effect when compared to individual juice. The drug\u27s phytochemical profile may be further examined to determine the active ingredient responsible for its anthelmintic effect
A case study of effect of dravyas from Ekasara gana on tobacco addiction withdrawal symptoms
Get PDFIn India as well as globally smoking is a serious social and public health problem. Tobacco use is one of the biggest social and public health issues in India and around the world. In India, there are plenty of options for smoking and smokeless tobacco, including jarda, pan masala, gutka, bidi, and cigarettes. Every year, tobacco usage claims the lives of almost six millions individuals globally. The World Health Organization (WHO) estimates that tobacco smoking caused 100 million premature deaths worldwide in the 20th century. If present tobacco use rates continue, this number is predicted to climb to 1 billion in India in the 21st century. For a variety of reasons, including peer pressure, stress, alleviation, sadness, and social media ads advocating smoking, people begin to smoke or chew tobacco. The lower socioeconomic classes like and prefer tobacco more than other drugs because it is more affordable and readily available. One tobacco addicted patient tried to quit chewing tobacco, but as withdrawal symptoms, he reported having headaches, indigestion, anorexia, anxiety and body aches. The patient was treated with powder of Punarnava (Boerhavia diffusa Linn.), Sheerisha( Albizzia lebbeck L.) and Sarpagandha (Rauwolfia serpentine L.) ghana vati for his withdrawal symptoms. These are dravya’s from Ekasara gana which helps patient to feel better by reducing their withdrawal symptoms and signs of tobacco dependence.
Clinical evaluation of the efficacy of Vajraka ghrita in management of Vicharchika (atopic dermatitis/eczema) – A single arm clinical study
Get PDFBackground: Ayurveda, an ancient medical science, offers profound insights into skin health through its understanding of "Kushtha," a term encompassing various skin ailments. Ayurvedic texts detail the etiology, classification, prognosis, and treatment modalities for Kushtha, highlighting the significance of "Ghritakalpana" in its management. Ghritakalpanas, medicated ghee formulations, hold particular importance in Kushtha treatment. Material and Methods: This study delves into the efficacy of "Vajraka Ghrita," a specific Ghritakalpana mentioned in classical Ayurvedic texts, in managing "Vicharchika" - a type of Kshudrakushtha akin to Atopic Dermatitis/Eczema in modern medicine. The research methodology involves a comprehensive review of classical Ayurvedic literature to elucidate the conceptual framework of Ghritakalpana in Kushtha management. Additionally, clinical evaluation of Vajraka Ghrita\u27s efficacy in Vicharchika management is conducted through a structured study design. It was a single arm clinical study with 40 subjects. The dose was 10 gms twice a day before meal with lukewarm water for a month. Results and Discussion: Preliminary findings indicate promising outcomes regarding the efficacy of Vajraka Ghrita in managing Vicharchika. By addressing symptoms such as severe itching, lichenification, and dryness, Vajraka Ghrita demonstrates potential as an adjunctive therapy for Atopic Dermatitis/Eczema. Vajraka Ghrita has very effective in treatment of Vicharchika about 7 patients having Marked relief which was >75%,29 patients having Moderate relief about 50-75%,3 patients having Mild relief 25-50%,1 patient having no relief i.e.< 25%.Further analysis and clinical trials are necessary to validate these findings and elucidate the mechanisms underlying Ghritakalpana\u27s therapeutic effects. This study underscores the relevance of integrating ancient Ayurvedic wisdom with modern medical approaches for comprehensive healthcare delivery
Comparative evaluation of Phalasarpi (medicated ghee) oral administration (paan) versus intrauterine instillation (uttarbasti) in management of anovulatory cyclein fertility (vandhyatva)
Get PDFAnovulatory menstrual cycle is one of major cause of infertility found approximately 40% cases of female infertility. In today’s fast-moving life, causes of infertility vary from faulty food habits, sedentary lifestyle, unstable mental state, depression etc. In contemporary science, ovulation induction is the most advised treatment apart from medications.However, not all causes of anovulation are amenable to treatment by ovulation induction. Thus, research into alternate approaches to treating anovulatory-based infertility is necessary. Ayurveda has included infertility under Vandhayatva. Uttar basti (intrauterine instillation of medicated drugs) and oral medications has been advised and practiced since long for the treatment of vandhatya (infertility). Phalasarpighritis used for the treatment of vandhatya (infertility) as advised by the Acharyas. Here, comparative study for the route of administration of the medicated ghee that is Phalasarpi Oral administration (paan) and Uttarbasti (intra uterine instillation) in infertility due to anovulatory cycle has been done.Methodology: - Two groups, A and B, were randomly selected from a total of sixty patients. Thirty patients from Group B received oral Phalasarpi (Medicated ghee) treatment, while thirty patients from Group A received Phalasarpi (Medicated ghee) intrauterine instillation treatment. Both groups were assessed using the Case Record Form and the results of the investigations.Observations and results were drawn accordingly. It was concluded that between these two,Phalasarpi Uttarbasti (intra uterine instillation) gives better results in increasing menstrual blood flow, endometrial thickness and timely ovulation, as it directly affects receptivity of hormones at local level as compared to the oral administration(paan)