International Journal of Ayurvedic Medicine
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Assessment of Adjuvant Effect of Ethanol Extract of Sadabahar (Vinca rosea Linn.) in Type 2 Diabetes Mellitus Management: A Case Series
Get PDFManagement of Diabetes mellitus (DM) controls hyperglycemia, other aspects of pathology remain untouched. Hence quest for a better remedy that can show multiple actions and correct different aspects of pathology is needed. Whole plant extract and leaf extracts of Sadabahar (Vinca rosea Linn.) show anti-hyperglycemic activity in alloxan-induced diabetic rats by regeneration of β-cells of pancreas. However, this plant has not been evaluated yet in humans. So, this study was designed to check the tolerability and effectiveness of Sadabahar in patients with type II DM (T2DM). Methods: Six cases of T2DM patients with fasting blood sugar level (FBS) between-125 mg/dl to 300 mg/dl and postprandial blood sugar level (PP2BS) between - 140 mg/dl to 500 mg/dl were enrolled. Patients received the drug in three doses- 2 grams per day (gm/day), 3 gm/day, and 5 gm/day in groups A, B, and C respectively for 15 days with their anti-diabetic medicine and a routine lifestyle. Result: The results showed a reduction in FBS and PP2BS in all groups, with Group C showing the most significant improvement. The Baseline FBS values of Group C were 219 mg/dl and 295.8 mg/dl decreased to 165.6 mg/dl and 203 mg/dl, respectively, while PP2BS decreased from 370 mg/dl and 363.4 mg/dl to 284.6 mg/dl and 330 mg/dl. No adverse events were observed. Conclusion: All three doses of Sadabahar lowered blood sugar levels and no adverse event was noted during study time. Among them, 5 gm/day (group C) was the most effective and safe dose in T2DM patients
Stability study of Ashtaguna manda As Ready-To-Eat (RTE) form – An Ayurveda Based Therapeutic Diet Formulation
Get PDFThis article discusses the standardisation of Ashtaguna manda as Ready-To-Eat (RTE) form, an Ayurveda-based therapeutic diet formulation used for conditions like Jwara, Ajeerna and Agnimandya. Ashtaguna manda, which is noted for its properties such as deepana (appetizer), paachana (digestive), basti-shodhana (cleansing of the urinary bladder), rakta-vardhana (blood enhancer), and ruchikara (taste enhancer), is known to restore normal digestive functions. Ashtaguna manda is subjected for usage in fresh form/ within 24 hours. So, the preparation of Ashtaguna manda was subjected to powder form as Ready-To-Eat (RTE) food. The preparation was standardised and analysed for its organoleptic, physical characteristics and physico-chemical properties. In terms of organoleptic characteristics, Ashtaguna manda in RTE form exhibited a whitish colour at initial month (0 day), which turned creamish white after three and six months of storage. The odour remained unchanged for up to six months. The pH value, indicating acidity and alkalinity was 6.45 at initial month (0 day), 5.26 at three month, and 5.39 at six month, showing slight acidity. The total solids ranged from 1.534% at initial month (0 day) to 1.746% at three month and 1.850% at six month. Specific gravity was 1.007 at initial month (0 day), 1.012 at three month, and 1.009 at six month. Non-reducing sugars were present, aiding in consistency and preservation, while reducing sugars were absent throughout the six month storage period. Carbohydrates, proteins, and fats were present throughout the six month storage. The sample showed no presence of E. coli, S. aureus, P. aeruginosa, and S. abony during the six month storage. The total bacterial count was 03 cfu/gm, 05 cfu/gm, and 07 cfu/gm and the total fungal count was 01 cfu/gm, 03 cfu/gm, and 05 cfu/gm at initial (0 day), three and six months respectively. The established parameters were found to be adequate for standardising Ashtaguna manda as RTE therapeutic food made available in sachet form
Management of Amavata through kati vasti and matra vasti with Eranda beeja ksheera paka – A single arm open-label trial
Get PDFIntroduction: In Amavata, the Vata Dosha is vitiated and Ama accumulates in the sandhi. When ama localises in the body\u27s tissues or joints, it may cause the afflicted joints to experience pain, stiffness, swelling, soreness, and other symptoms. Eranda Paka, a remedy for Amavata that includes Eranda Bija as one of its constituents, has been employed. Materials and Method: Based on the inclusion criteria, a total of 50 patients visited the outpatient department of Krishna Ayurved hospital, Ahmedabad Ayurved hospital, HPC Engineering Co, Krish Engineers, for this study. Individuals with traditional manifestations of Angamarda, Aruchi, Trishna, Hrullasa, Gaurava, Jwara, Shula, Shotha, and so forth were chosen. Results: Eranda paka significantly (p=<0.0001) improved the objective parameters, after the treatment 28% patients were without Angmardana, 30% patients were without Aruchi, 52% patients Trishna condition was normal, 30% patients Hrullasa condition was normal, 20% patients were without jwara, Apaka and Gaurava condition, 24% patients were without Agnimandya and 30% patients Daurbalya condition improved. In addition, after the treatment a significant improvement also reported in ESR, eosinophil and Rh factor. Conclusion: Amavata can be correlated with modern medicine Rheumatic arthritis. Ayurveda explains it as an imbalance of Ama and vata. Eranda Paka significantly improved the both subjective and objective parameter. Along with disease symptoms, a significant improvement reported in biochemical parameter i.e., Rh factor. After the treatment a significant improvement reported Amavata condition.
Evaluation of anti-hypothyroid effects of Jalakumbhi Lavana with Piper longum L.: An integrative case study in Ayurvedic treatment
Get PDFHypothyroidism, described by deficient thyroid chemical creation, is a common endocrine problem influencing millions around the world. Its side effects incorporate exhaustion, weight gain, and mental impedance, altogether influencing personal satisfaction. While customary Ayurvedic writing examines Galganda, much the same as hypothyroidism, direct notices of thyroid problems are restricted. In this unique situation, this study investigates the capability of Jalakumbhi Lavana joined with Pippali in overseeing hypothyroidism, drawing matches with current ways to deal with its treatment. Jalakumbhi, referred to naturally as Pistia stratiotes, has phytochemical constituents possibly valuable in thyroid capability adjustment. Lavana Kalpana, a plan including salts, including normal salt (Saindhava Lavana), helps with drug conveyance and retention. Furthermore, it goes about as a potentiate, upgrading helpful impacts. The cooperative energy between Jalakumbhi Lavana and Pippali, a notable Ayurvedic spice with mitigating and bio enhancing properties, offers a promising road for tending to hypothyroidism
LC-MS profiling of Kanchnar Guggulu - A polyherbal Ayurvedic formulation using two solvent systems
Get PDFKanchnar Guggulu is an Ayurvedic Polyherbal Formulation made up of 12 ingredients. Liquid chromatography coupled with mass spectrometric detection is a powerful analytical technique for separating, identifying, and quantifying various analytes within a mixture. Objective: This study aims to characterise the phytochemical composition of Kanchnar Guggulu using two different solvent systems: (100% Water + 0.1 % Formic acid) and (100 % Acetonitrile + 0.1 % Formic acid). Materials and Methods: Samples obtained from a GMP-certified pharmacy underwent solid-liquid extraction employing two distinct solvents, followed by LC-MS analysis. Results: Analysis revealed the presence of 1976 & 859 phytochemical compounds in the (100% Water + 0.1 % Formic acid) and (100 % Acetonitrile + 0.1 % Formic acid) extracts, respectively. Notably, 696 phytochemicals were common in both extracts, likely due to slight differences in solvent polarity. Among Total Compounds from polar solvent, 17.68% Steroids,15.24 % Terpenoids, 15.8 % Alkaloids, 9.75 % Phenolic compounds, 6.7 % Hormones, 4.8 % Flavonoids, 3.65 % Lactones, 3.65 % Carboxyllic acid & Derivatives,3.4 % Esters & Lactones, 2.43 % Organic acid,2.43 % Nitrogen-Containing Compounds,1.82 % Carbohydrates & Sugar derivatives, 0.6 % Saponins were found. And among Total compounds from Nonpolar solvent 14.81% Alkaloids, 14.81 % Terpenoids, 11.11% Esters,12.96 % Fatty acid & derivative,7.4 % Steroidal compounds,7.4 % Hydrazones, 5.55 % Cinnamic acid derivative, 3.7 % Lactones, 3.7 % Quinones, 3.7 % Piperazine derivatives and 1.85 % Acridines were found. Conclusion: 2291 unique phytochemical constituents were identified in the two solvent extracts of the same sample, highlighting the significance of solvent selection in phytochemical profiling studies
Exploring the Connection between Sleep Quality and Digestive Function in Young Women: Insights from Ayurveda\u27s Perspective on Agni - A Comprehensive Study
Get PDFIntroduction: This cross-sectional analytical study delves into the intricate connection between sleep quality and digestive function among female volunteers aged 20-30 years, focusing on Ayurvedic principles, particularly the concept of Agni. The research, conducted at our institute and its surroundings, involved 186 female participants. Methods: Employing a cross-sectional survey, the study assessed sleep quality, digestive symptoms, and Agni status among female participants. Statistical analysis was conducted to explore associations between variables. Sleep patterns were evaluated using the Pittsburgh Sleep Quality Index (PSQI), while digestive function was assessed using a modified Gastrointestinal Symptom Rating Scale (GSRS) questionnaire. Agni types were determined following the MUHS proforma for Agni assessment. Results: The data highlights a significant association between disturbed sleep and heightened gastrointestinal symptoms. Individuals experiencing disrupted sleep predominantly exhibited Tikshna Agni, in alignment with Ayurvedic principles correlating irregular sleep with digestive imbalances. Notably, Vishamagni, characterised by irregular digestive fire, was prominently observed in individuals with disturbed sleep. Conclusion: This study underscores the intricate relationship between sleep quality and digestive harmony, particularly emphasising the role of Agni. Addressing irregular sleep patterns and their impact on Agni status is vital for maintaining optimal digestive health. The findings advocate for integrating interventions targeting sleep quality into healthcare practices. Future research should explore specific sleep improvement strategies and consider additional lifestyle factors to promote holistic health and well-being
Comprehensive Assessment and Validation of an Integrated Premenopausal Symptom Questionnaire
Get PDFPre-menopause indicates a period before menopause where a woman undergoes a transitional period where several symptoms come into existence due to the fluctuating ovarian hormones. The symptoms are quite complex with the involvement of different systems, making it difficult for health providers to diagnose and advise management aptly. The study aims to develop an integrated pre-menopausal questionnaire to assess premenopausal symptoms. The integrated pre-menopausal questionnaire was developed by including confounding factors and symptoms available in Ayurvedic literature, contemporary textbooks, and clinical observations by Prasoothi Tantra and Stree roga (Obstetrics and Gynaecology) experts. Premenopausal symptoms and confounding factors were incorporated into the questionnaire in the form of 36 questions under five sections and were assigned a score from 0 to 4 based on the strength of literature evidence and expert opinion. The questionnaire was subjected to validation i.e. face validation, content validation; and construct validation followed by factor analysis and reliability statistics. This tool is believed to be an important landmark in diagnosing pre-menopausal symptoms in pre-menopausal women so that an early intervention can be implemented. The questionnaire, finalized after expert committee review and recommendations, was also validated for its sensitivity and specificity to detect pre-menopausal symptoms in Palakkad District through a pilot study.
Comparative efficacy of Ayaschurnadi yog and Dhatri loha in management of Garbhini pandu (Iron deficiency anaemia in pregnancy)
Get PDFEffective management of iron deficiency anaemia during pregnancy is vital for the well-being of both the mother and the fetus. In Ayurveda, this condition is referred to as Garbhini Pandu, characterized by symptoms like panduta (pallor), weakness loss of appetite along with a deficiency of blood (Rakta Dhatu) and impaired nourishment of the body and fetus. Ayurvedic medicine offers various herbo-mineral formulations to address this condition. This study compares the efficacy of Ayaschurnadi Yog and Dhatri Loha in the management of Garbhini Pandu. Participants were randomly divided into two groups i.e. Group A- trial group and Group B- control group. Group A were treated with Ayaschurnadi Yog while Group B were given Dhatri Loha. Outcomes were assessed using subjective parameters such as pallor (panduta) of nails (nakha), conjunctiva (netra), tongue (jivha), palm and sole (hastapadatala), loss of appetite (agnimandya), weakness (daurbalya), palpitations (hrudspandana), and leg cramps (pindikodveshthana). Objective evaluation was based on hemoglobin levels (gm%) assessed on the 15th, 30th and 45th day. The assessment parameters were noted before and after treatment. Observations were noted and summarized in tabular form. The results demonstrated that both formulations were effective in alleviating symptoms of Garbhini Pandu. However, Ayaschurnadi Yog showed superior efficacy in symptom relief and hemoglobin improvement. Statistical analysis confirmed the significant effectiveness of Ayaschurnadi Yog, making it a promising alternative in the Ayurvedic management of Garbhini Pandu
Ayurvedic approach in the management of depression: A case report
Get PDFNowadays, depression is the most prevalent psychiatric condition. The WHO estimates that 280 million people worldwide suffer from depression. Avasada and Vishada are two ailments that are referenced in the Ayurvedic Samhitas and have a close connection with depression. Acharaya Charak states in "Vishado Rogavardhanam" that this is the primary cause of any ailment getting worse. Many medications are available in allopathy science to treat mental health conditions, but they come with a lot of side effects. Prolonged use of these drugs puts the patient in progressively terrible conditions that eventually turn fatally. A 37 years old male patient approached the outpatient department with complaints of anger, irritability, loss of activities and energy, khanadit nidra (Disturb Sleep) since from 4 years, pichil malapravarti since from 4 months. Patient past history of Schizophrenia before 12 years and taken treatment of allopathy medicine. Also, history of hypertension since, 8 years under medication. Patient was not willing for allopathy medicine. Patient came to OPD for Ayurvedic treatment. He was treated as per the Ayurvedic line of treatment panchakarma with shirodhara and internal medicines Syrup Brahmi Prash, Guduchi Ghanavati, Saraswatarishta, Avipattikara Churna, Cap. Tagar, Jatiphaladi Vati, Triphala Guggulu, Manasa Vatakam, Saraswatarishta, Cap. Nidrayog, Himasagara Taila, Cap. Purnachandrodaya, Cap. Rasayana. Treatment was continued for 5 months with a follow up monthly. Hamilton\u27s Depression Rating Scale (HDRS) was utilized to assess the patient prior to and following the intervention
Elucidating the anti inflammatory potential of bio active hydrogel from Carica papaya leaf extracts using combination of in silico and in vitro methods
Get PDFThe investigation on medicinal plants have been gaining importance around the world especially in Asian nations due to the presence of wide range of bioactive phytochemicals. The presence of diverse bioactive compounds makes medicinal plants more demandable for curing several diseases, such as inflammatory diseases, and diabetes. Carica papaya is one such plant found very commonly throughout the country and reported to have a massive traditional properties. The present study addresses the in vitro and in silico study of the plant leaf extract for a potential anti inflammatory effect. The plant showed adequate anti-inflammatory effect through in silico and in vitro models. The compounds identified by GC-MS are put through molecular docking studies and virtual toxicity studies. Out of all the compounds, pigenin (-9.9 kcal/mol), quercetin (-9.4 kcal/mol), and kaempferol (-9.2 kcal/mol) have the best binding energy as compared to the standard diclofenac indicating that the extract can find its usage as anti-inflammatory drug. Further the claim was confirmed by in vitro study using BSA method. As compared to standard diclofenac (IC50: 0.47 mg/ml) the IC50 value of papaya extract was found to be only 0.198 mg/ml indicating a significant increase in inhibition at low concentration of the extract. A set of hydrogel formulations were designed to deliver the extract and it was found that formulation F3 containing 0.5% w/v extract was the most suitable with pH of 7.02 and spreadability of 15.11 gcm/s. Hence, a highly potent natural anti-inflammatory formulation is reported to be developed in this study