International Journal of Ayurvedic Medicine
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A Gastro Retentive Drug Delivery System of Perindopril using Natural Polymer – Development and Optimization
No full textGastro retentive floating matrix tablet provides drug delivery at the controlled rate, improve bioavailability and prolong the retention of dosage forms in gastrointestinal tract. Okra gum, a mucilage-rich extract derived from the okra plant (Abelmoschus esculentus), holds significant value in both Ayurvedic medicine and modern pharmaceutical sciences. Knowing the importance of Okra gum, aim of present investigation is to develop gastro retentive floating matrix tablet of Perindopril using Avicel pH 102 as a directly compressible material; Citric acid for production of acidic microenvironment and sodium-bi-Carbonate as gas generating agent. Pre-compression parameters of powdered blend as well as prepared batches were studied and found within the range. FTIR of physical mixture (Perindopril, Okra gum and HPMCK4M) suggesting no incompatibility. Formulation batch F8floated, and remained buoyant without disintegration with swelling index value 42.32%, releasedPerindopril 92.92% about 12 hours might be due to combine use of HPMC K4M & Okra gum; showed higher correlation coefficient (r2-value) followed Korsmeyer Peppas release kinetics. DSC thermogram of F8 confirms uniform dispersion of drug in an amorphous form as endothermic peak was below 126.00. No significant changes in physiochemical properties, drug release profile as well as drug content of optimized F8 batch when subjected to stability at 40± 20temperature with relative humidity 75±5% for three monthsindicating there was no degradation and change in the matrix system
In vitro anticancer activity of Psoralea corylifolia Linn. seeds on human cancer cell lines
Get PDFMedicinal herbs are increasingly gaining recognition as valuable complementary therapies for cancer. Numerous clinical studies have highlighted the positive impact of herbal medicines on cancer patient’s survival, immune response and quality of life, particularly when used alongside conventional treatments. The present study has been conducted to assess the anticancer activity of Psoralea corylifolia Linn. seed aqueous extract and hydroalcoholic extract against 8 human cancer cell lines (MCF-7, HeLa, PC-3, K-562, HT-29, MDA-MB-231, DU-145 and Hep-G2). The SRB assay was used to evaluate the inhibition of cell growth. The results indicated that Psoralea corylifolia Linn. seed aqueous extract showed negligible anti-cancer property against all the cancer cell lines tested. However, Psoralea corylifolia Linn. seed 50% hydroalcoholic extract showed GI50 values of 34.6 µg/ml, 46.1 µg/ml, 30 µg/ml and 28.9 µg/ml against Breast cancer cell line (MCF-7), Cervical cancer cell line (HeLa), Prostate cancer cell line (PC-3) and Leukemia cancer cell line (K-562) respectively. Further, the 50% hydroalcoholic extract was altered with respect to the solvent used, method of preparation etc. and subsequently evaluated for its anticancer potential. The results revealed that Psoralea corylifolia Linn. soxhlet extract in absolute ethanol showed significant anticancer activity in all the above 4 cell lines with GI50 values <10 µg/ml
In Vitro Diffusion and Bioavailability Assessment of Gandharva Haritaki Churna: An Ayurvedic Herbal Formulation Study
Get PDFMedicated oils are used both externally and internally to treat a variety of illnesses. In Ayurvedic literature, Murchhana is a method used to improve the qualities of crude oil. In this study, Gandharva Haritaki Churna (Powder), a medicinal formulation, is made using two procedures: processed (Murchhita) Erand Taila (PET) and unprocessed (Amurchhita) Erand Taila (AET). The purpose of this study is to evaluate the in-vitro diffusion of Gandharva Haritaki Churna prepared using processed and crude castor oils. The in-vitro rate and permeability of a pharmacological dosage form are excellent indicators of the drug\u27s absorption. The aim of this study is to assess the drug release of both powders utilizing in vitro absorbance methods using the Franz diffusion cell apparatus. The in-vitro absorbance was measured in a Franz diffusion cell equipment at pH 4, 7, and 9.2. The samples were collected and tested with a UV spectrophotometer to determine the absorbance of Churna (Powder) at various wavelengths. It was discovered that the buffer solution with a pH of 9.2 had the highest absorbance of all samples. This experimental study demonstrates that both formulations have good sustained absorption via the gastrointestinal tract. The results show that the rate of absorption was greater in PGHC compared to UGHC. This work contributes to the development of a new approach for evaluating intestine absorption and comparing formulations based on therapeutic efficacy and drug absorbance
A case study on Ayurvedic management of primary open angle glaucoma with special reference to Adhimantha
Get PDFIn the world, glaucoma ranks second in terms of causes of irreversible blindness, and third in India. In India, an estimated 11.2 million persons aged 40 and older have glaucoma, including 6.48 occurrences of POAG. The goal of the disease\u27s management is to reduce intraocular pressure using existing medication like Carbonic anhydrase inhibitors, Beta blockers, and Prostaglandin analogues. Not every patient will benefit from these treatments. This case study concerns a 22-year-old male patient who came to Shalakyatantra OPD complaining of pain in his right eye, diminished vision in both eyes, redness in the Rt. eye, and a feeling of heavy eyes. The patient was diagnosed with primary open angle glaucoma and was taking eye drops Dorzalomide T. Upon examination, the patient\u27s distant visual acuity was 1 meter finger count in the right eye and Hand Movement Positive in the left eye. Right eye intra ocular pressure measurements were 41 mmHg and Lt eye were 10 mmHg. In ayurveda, above symptoms can be correlated with Adhimantha mentioned in Sarvagata roga. Patient was treated with Deepan, Pachana, Virechana and Vata- kapha shamak internal medications along with therapeutical procedures like Pindi, Jalaukacharana for around 3 months. The right eye\u27s visual acuity significantly improved both throughout and after the course of treatment. The intraocular pressure returned to its baseline. Every symptom from before had entirely subsided. Therefore, it can be said that the Ayurvedic method helps to provide a complementary treatment plan for POAG
A cross-sectional observational study on socio-demographic and health status of SC population in selected villages of Gwalior and Bhind Districts
Get PDFBackground: In India, the Scheduled Castes (SCs) constitute a significant portion of the population, historically marginalized due to social and economic factors. The Scheduled Castes (SC) make up 15.62% of Madhya Pradesh\u27s total population, highlighting their significant presence in the state. Understanding the socio-demographic and health status of the SC population is crucial for formulating effective policies and programs aimed at addressing their unique needs and improving their overall well-being. Objective: The study aimed to generate demographical and epidemiological data of Scheduled Caste (SC) people in the selected area, along with screening of adult SC population for hypertension, anemia, diabetes and obesity. Materials and Methods: The study was conducted in nine SC populated villages of Gwalior and Bhind districts of Madhya Pradesh during the period of 2020-21. For this purpose, the study team conducted door to door survey and data was collected methodically from participants after informed consent through a standardized format. Data regarding population, personal hygiene, food habits, occupation, addictions etc. was collected. The collected data underwent thorough analysis using descriptive statistical methods, encompassing measures of frequency and data position. Results: The data showed inadequate drainage, drinking water purification at home, insufficient health care services and low literacy rate specially in woman. Majority of the people were not having any non-communicable diseases. Hypertension/CVD was the commonest non-communicable disease. 92.1% of population had normal Body Mass Index and Obesity was observed in only 0.2% population. Males were found to be more anemic than females. Conclusion: By shedding light on the socio-demographic and health-related disparities faced by the SC population in Gwalior and Bhind districts, it can be concluded that literacy rate should be improved in females and more attention to be paid towards anemia in males. Hypertension or prehypertension was also reported in considerable population which may be due to COVID outbreak and again a study regarding its prevalence may be planned. These diseases may be attributed to poor personal hygiene, lack of health awareness including hazards of addictions, low socio-economic conditions and insufficient primary health care services.
Evaluation of Anti-bacterial activity of Charakokta Vishaghna Gana tablet against Cutibacterium acnes: An In-vitro study
Get PDFThe present research study aims to assess and authenticate classical recipes with scientific evidence. To evaluate the in vitro anti-bacterial potential of Vishaghna Gana tablet and its constituents against Cutibacterium acnes, a causative organism of Acne vulgaris. This study also assessed the morphological and physicochemical parameters of the Vishaghna Gana tablet. The results of morphological and physicochemical tests of the tablets were hardness, weight variation, friability, thickness, disintegration, ash value, extractive value and ph, as per CCRAS pharmacopeial standards. The formulated tablet showed a rounded shape with yellowish-brown color and typical odour and taste. The antibacterial screening was carried out by disc diffusion and punch well techniques on Brucella Blood Agar under anaerobic conditions and compared with azithromycin as a standard control. Tests were done in triplicate for reliability. In an in-vitro antibacterial assay, the zone of inhibition for Sireesha and Kataka showed the highest activity with inhibition zones >18 mm. In contrast, Haridra, Manjistha, Chandana and Slesmataka were moderately active with inhibition zones between 13–18 mm. The methanolic extracts of the Vishaghna Gana tablet showed remarkable antibacterial activity against C.acnes. These findings validate Sireesha as an Agrya aushadha (best medicine) for Visha(poison) as quoted in Ayurveda classics and corroborate Kataka\u27s folk usage in water purification (Ambu prasadina). The results underscore the necessity of optimising extraction techniques and concentrations to improve antibacterial activity
Anti-Adipogenicity of Garcinia Indica Choisy. and Pterocarpus Marsupium Roxb. in 3T3-L1 cell line – A comparative study
Get PDFIntroduction: Obesity is a multifactorial metabolic disorder associated with several chronic diseases. Modulating adipocyte differentiation, particularly during the early phase of mitotic clonal expansion (MCE), is an important approach for limiting adipogenesis. Garcinia indica Choisy. (Family: Clusiaceae) and Pterocarpus marsupium Roxb. (Family: Fabaceae) are classical Ayurvedic plants described for their potential in managing Medoroga and related metabolic disorders. This study investigates and compares their anti-adipogenic effects using the 3T3-L1 preadipocyte model. Materials and Methods: Aqueous extracts of Garcinia Indica Choisy and Pterocarpus Marsupium Roxb. were prepared and assessed for cytotoxicity on Human Mesenchymal Stem Cells (hMSCs) to determine safe concentrations. Non-toxic doses were used to treat 3T3-L1 preadipocytes during differentiation. Lipid accumulation was quantified following induction. The influence of both extracts on MCE and related adipogenic signaling markers was evaluated to understand underlying mechanisms. Results: Cytotoxicity studies confirmed that both plant extracts were safe and non-toxic on hMSCs. Differentiation assays demonstrated a significant reduction in lipid accumulation in 3T3-L1 cells treated with either extract. Garcinia Indica Choisy produced a more substantial inhibition of adipogenesis, particularly by attenuating proliferation during the MCE phase. Molecular analyses supported these observations, revealing down regulation of adipogenic pathways in treated groups. Conclusion: Both Garcinia Indica Choisy. and Pterocarpus Marsupium Roxb. exhibit promising anti-adipogenic potential. Garcinia Indica Roxb. showed superior activity, likely due to its stronger regulatory effects on MCE and associated signaling mechanisms. These findings support the traditional Ayurvedic use of these plants and highlight Garcinia Indica Roxb. as a more potent natural candidate for obesity management
Neuroprotective assessment of methanolic root extract of Moringa Concanensis against Cisplatin-induced peripheral neuropathy in rats
Get PDFObjective: Investigation of the methanolic root extract of Moringa concanensis nimmo (MC) as a potential treatment for cisplatin-induced peripheral neuropathy in rats. Methods Male Albino Wistar rats were divided into 5 groups: Normal control, positive control, low dose MC root extract (200 mg / kg, p.o.), high dose MC root extract (400 mg / kg, p.o.), standard (Ascorbic acid) (45 mg / kg, p.o.). Cisplatin (2.5 mg / kg, ip) was administered in the second week and continued for 4 weeks, while MC root extract and ascorbic acid were administered orally from the first week for 5 weeks. After 5 weeks, Behavioural assessments, and antioxidant activity in sciatic nerve homogenate were performed. Histopathological analysis of sciatic nerve samples was performed using H&E stain. Results: Treatment with methanolic root extract of MC at low dose and high dose for 5 weeks significantly improved behavioral parameters, antioxidant levels, attenuated oxidative stress, and restored histopathological deterioration of sciatic nerve compared to the positive control group. However, grip strength and motor coordination of animals treated with standard showed no significant difference when compared to high dose. Conclusion: The study indicates that methanolic root extract of MC protects Cisplatin-Induced Peripheral Neuropathy in rats, as demonstrated by improved behavioral parameters, enhanced antioxidant levels, and restored histopathological features. MC root extract appears promising as a preventive measure for Cisplatin-Induced Peripheral Neuropathy, potentially benefiting cancer patients undergoing chemotherapy
Mahakumbh
Get PDFThe concept of Mahakumbh represents a significant cultural and spiritual gathering that transcends religious and social divides. It emphasizes the dynamic nature of knowledge and spiritual growth, advocating for the unity of human beings regardless of their individual identities. Drawing parallels with Newton’s law of inertia, the article highlights how stagnation in knowledge and belief systems leads to fanaticism and superstition, while a continuous engagement with traditions through modern perspectives ensures spiritual and intellectual relevance. The Mahakumbh, organized at the confluence of sacred rivers, symbolizes the purification of both body and soul. The mythological significance of the Kumbh as a vessel for nectar is linked to the metaphorical cleansing of human beings, removing the impurities caused by desires, anger, and greed. This gathering fosters unity, transcending caste, religion, and other divisions, encouraging a collective spirit of renunciation, knowledge, and devotion. It promotes the idea that true spirituality is not about personal pride or differences but about universal unity and self-reflection. The Mahakumbh serves as a living example of the eternal quest for truth, offering a platform for spiritual renewal and connection to the divine
Formulation & Evaluation of Polyherbal Fruit Peel Shampoo
Get PDFScalp disorders are now-a-days affecting all ages of people. Different types of Scalp disorders include dandruff, seborrheic dermatitis and even parasitic infections like Pediculosis capitis. Various microbes (Bacteria and Fungi) and Non-microbes are responsible for the scalp disorders. The study intends to formulate and evaluate the polyherbal fruit peel Shampoo. The formulated composition not only removes filth and dandruff but also leaves hair silky and lustrous and promotes hair development. The primary purpose of the current study is to develop and assess shampoo for treating various hair concerns. The composition minimizes the use of hazardous chemical compounds that affect hair. The formulation uses various fruit peels such as Pomegranate, Banana, grapes, and oranges for preparing shampoos with additives such as SLS, gelatin, and sodium benzoate which act as surfactants, viscosity modifiers and preservatives. The formulated shampoo was subjected to evaluation parameters like visual inspection, pH, viscosity, dirt dispersion, surface tension, foaming ability, foam stability, antimicrobial test and stability studies, etc. Invitro anti-bacterial activity was done against Staphylococcus epidermidis MTCC-435. Zone of Inhibition was found to be 9.5mm at 250μg/ml. The formulated shampoo has anti-bacterial activity and it is used in treating scalp problems which cannot be eliminated but can only be managed and effectively controlled.