International Journal of Ayurvedic Medicine
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In-Silico Prediction of Phytoconstituents from Manilkara hexandra for Antidiabetic Activity targeting LRH-1
Get PDFObjective: A complex metabolic condition known as diabetes mellitus is caused by either inadequate or dysfunctional insulin. Once more, medicinal plants are being researched for the treatment of diabetes. Prototypical compounds found in medicinal plants have been the source of many conventional medications. In-silico testing of Manilkara hexandra phytoconstituents for antidiabetic efficacy was a part of our investigation. Design: Utilizing Discovery studio, molecular docking is done to assess the pattern of interaction between the phytoconstituents from the Manilkara hexandra plant and the crystal structure of the antidiabetic proteins (PDB ID: 4DOS). Later, SwissADME and pkCSM were used to screen for toxicity as well as the pharmacokinetic profile. Results: The docked results suggest that Quercetin (-8.8 kcal/mol),Kaempferol (-8.2 kcal/mol), P-coumaric acid (-6.3 kcal/mol) and cinnamic acid (-6.2 kcal/mol), for 4DOS macromolecule has best binding affinity towards LRH-1 for antidiabetic activity as compared to the standard drug metformin (-4.8 kcal/mol). Furthermore, pharmacokinetics and toxicity parameters were within acceptable limits according to ADMET studies. Conclusion: Results from the binding potential of phytoconstituents aimed at antidiabetic activity were encouraging. It promotes the usage of Manilkara hexandra and offers crucial details on pharmaceutical research and clinical care
A Clinical Case Report on the Management of Unintended Adverse Reaction following Panchatikta Kashaya Basti Administration in Vicharchika (contact dermatitis)
Get PDFIntroduction: Cutaneous adverse drug reactions (CADRs) are the most common manifestations of drug hypersensitivity. Although Ayurvedic treatments are generally considered natural and safe, they may also result in adverse effects. This report highlights a case of a CADR potentially associated with the use of Niruha Basti, a therapeutic enema used in Panchakarma. Methods: A 56-year-old female with chronic skin lesions over the dorsum of the bilateral foot and ankle joints visited the Panchakarma OPD. She was treated with Panchatikta Kashaya Basti following the Kala Basti protocol and Anuvasana Basti with Tiktaka Ghrita. Results: Following the administration of the first Niruha Basti, the patient developed severe pruritus and generalised swelling, suggestive of a cutaneous adverse reaction. The condition was managed with Sarvanga Parisheka (full-body decoction pouring), followed by external application of Tiktaka Ghrita, and Yastimadhu Choorna Lepa mixed with Ksheera. The patient experienced significant symptomatic relief after the intervention. Conclusion: This case highlights the potential for adverse cutaneous reactions to Ayurvedic formulations, especially when ingredients with Tikshna (sharp) and Ushna (hot) properties are used in Basti. A detailed patient evaluation is important to help prevent adverse effects, particularly in susceptible individuals
Potential of Siddha and Ayurvedic herbs in oral healthcare: A comparative study of Terminalia Chebula and Withania Somnifera
Get PDFThe increasing prevalence of antibiotic resistance and oral infections has spurred interest in plant-based alternatives with antimicrobial and antioxidant properties. Traditional Indian medicinal systems, such as Siddha and Ayurveda, have long utilized Terminalia chebula, (T.chebula) (Kadukkai) and Withania somnifera (W.somnifera) (Ashwagandha) for their therapeutic benefits. Objectives To assess and compare the antimicrobial activity of ethanolic extracts of Terminalia chebula (T. chebula) and Withania somnifera (W. somnifera) against Streptococcus mutans(S.mutans) and Candida albicans (C.albicans), and to evaluate their antioxidant capacity using the DPPH assay. Methods: Ethanolic extracts of T. chebula and W. somnifera were prepared and tested for antimicrobial activity using the agar well diffusion method. Minimum inhibitory concentration (MIC) was determined using serial dilution. Antioxidant activity was assessed via DPPH free radical-scavenging assay at various concentrations. Results: T.chebula showed superior antimicrobial activity compared to W. somnifera, with larger zones of inhibition and lower MIC values against both S. mutans and C. albicans. Both extracts demonstrated dose-dependent antioxidant activity, with T. chebula exhibiting greater radical-scavenging potential. The strong antimicrobial and antioxidant effects of T. chebula are attributed to its high content of tannins, gallic acid, and phenolic compounds. Conclusion: T.chebula and W.somnifera exhibit significant antimicrobial and antioxidant properties, supporting their traditional use in oral healthcare. T. chebula in particular demonstrates strong potential as a natural agent in the prevention and management of oral infections. Further research, including phytochemical isolation, cytotoxicity studies, and clinical evaluation, is warranted to develop effective herbal formulations for dental applications
Comparative oral and dermal bio accessibility study of Ayurvedic Antidote (Manjishthadi Agada) by Franz Diffusion method
Get PDFBackground & objectives: Manjishtadi Agada described in Bharat Bhaishajya Ratnakar is indicated in all type of poisoning but the route of administration is not mentioned. Agada are used mainly from most of the routes of administration like internally (excluding parental routes) and externally in poisoning condition. In emergency condition like poisoning or snake bite, fast absorption of the drug is needed to achieve its peak and effect. The present study was conducted to compare the absorption of Manjishtadi Agada through oral and dermal route. Methods: In this study, Manjishtadi Agada was prepared which was subjected to physicochemical analysis and dermal as well as oral bio accessibility study with the help of Franz cell diffusion apparatus. The absorbance and its time were recorded and the graphs were plotted for dermal and oral bio accessibility of Manjishthadi Agada. Assessment was done with the help of calibration curve to estimate the absorption of the drugs with different time interval and dilutions. Pearson’s Correlation coefficient was estimated to observe the correlation between rate and time of absorption of both the routes. Results: It was observed that there is statistically significant difference in the absorbance of Manjishthadi Agada through dermal and oral route. Interpretation and Conclusions: Bio accessibility of Manjishtadi Agada is more with oral route than that of dermal route. Manjishthadi Agada may be absorbed earlier when administered through oral route at higher concentration. In acute and chronic condition of poisoning, it should be administered through oral route.
A cross-sectional health-related socioeconomic demographic study of the tribal population in Kamrup (R) district Assam
Get PDFIntroduction: Scheduled Tribes, forming a significant segment of India\u27s diverse demographic landscape, often confront health challenges rooted in a complex interplay of factors such as geographic isolation, limited access to healthcare facilities, and socio-economic disparities.
Objective: The primary objective was to estimate the health-related socioeconomic demographic profile of the tribal communities of Boko and Chhayagaon block, Kamrup district, Assam. A secondary objective was to estimate the prevalent diseases among the tribal population.
Methods: It was a community-based descriptive type, cross-sectional study. Data was collected by face-to-face interviews with the participants of the five selected villages of Kamrup district, Assam, during 2020-2021.
Results: During the survey, 1312 households were interviewed. It was observed that 59.98% of houses were kutcha, 55.56% had inadequate ventilation, 69.59% of the population depended upon hand pumps for water supply, and 41.39% of houses used boiling methods to purify drinking water. Approximately 62.9% of the total population reported indulging in different kinds of addictions.
Conclusion: These villages have progressed with electrification and LPG adoption, yet challenges in housing quality, healthcare, and higher education access remain. This data forms a strong basis for targeted community development initiatives in housing, health, sanitation and lifestyle improvements.
Keywords: Addiction, Boko, Block, Rabha, Sanitation, Ventilation, Water suppl
Efficacy of Ksharjala a vegetable wash on pesticide residue in Cauliflower: An experimental study
Get PDFBackground: Cauliflower is a common vegetable in Indian households; it is highly nutritious which is often sprayed with pesticides. The majority of the residue is still on the vegetable even after washing it with tap water. It poses a risk to consumer safety and the security of the food industry. Thus, A study was conducted to find out an easy method to lower the pesticidal residue which was detected in large amounts on cauliflower. Methods: A pilot study was done to identify the pesticide residue on cauliflower sample which were selected at random. Pesticide residue was analysed using gas liquid chromatography and mass spectrometry, and sample extraction was carried out using the QuEChERS (Quick, Easy, Cheap, Effective, Rugged, Safe) method. The sample were divided into two groups; control group and experimental group. The experimental group samples were washed with ksharjala. Ksharajala was prepared by mixing 20 grams of sodium bicarbonate into 1000 ml of water (2% alkaline solution). Result: The mean pesticide residue of the experimental groups i.e. ksharajala (17.29 ppm) differed significantly from that of the control group (107.44ppm,). Ksharjala dhavana decrease chlorpyrifos residue. Positive alterations have been observed in the colour, taste, and smell of cauliflower. Conclusion: Study has shown that ksharjala effectively reduces the amount of pesticide residue on cauliflower
Unveiling the Physicochemical Properties, Mineral Profile and Hemo-Protective Potential of Acacia Suma
Get PDFAnemia is condition when haemoglobin (Hgb) level is <13.0gm/dL in men and <12.0gm/dL in female. In women blood disorders like anemia, menstruation problems, miscarriage, fetus death, ischemia and stroke all are life threatening problems. The Acacia suma has been reported in Ayurvedic Pharmacopeia of India for traditional role in treatment of blood disorders. The hydroalcoholic extract yield was 9.75% and shown presence of phenols, flavonoides and tannins. The hemolytic assay and osmotic fragility assay were performed and percent hemolysis was analysed as Mean ± SD. Further, mineral content of the extract was determined using flame Atomic Absorption Spectrometry. In phytochemical screening the hydroalcoholic extract of Acacia suma shown presence of carbohydrate, proteins, amino acid, steroids, saponin, flavonoids, alkaloids, tannins and phenols. At concentration 250µl/ml, 150µl/ml and 50µl/ml the extract revealed 24.53 ± 3.92 %, 30.63 ± 4.18 % and 54.66 ± 8.92 percent hemolysis respectively. In mineral calcium was found highest among the elements (390.58 ± 7.39 ppm) followed by zinc (26.488 ± 0.32 ppm) and iron (25.84 ± 0.79 ppm). As concentration increases, extract exhibited significant hemo-protective potential and it could be an effective medicine for the treatment of iron deficiency anemia and hemolytic anemia
Antibacterial potential of Anogeissus acuminata against ESBL and carbapenemase-producing multidrug-resistant UPEC
Get PDFBackground: The increasing prevalence of antibiotic-resistant Escherichia coli (E. coli) presents significant challenges in managing urinary tract infections (UTIs), particularly in resource-limited settings. Nearly 50% of E. coli isolates are extended-spectrum β-lactamase (ESBL) producers, often harboring resistance genes such as CTX-M-15 and NDM, which confer resistance to last-line antibiotics. Aim: To evaluate the antibacterial efficacy of Anogeissus acuminataextract against genetically confirmed ESBL- and carbapenemase-producing uropathogenic E. coli (UPEC) strains isolated from UTI patients. Methods: A total of 273 UPEC strains were isolated from symptomatic UTI patients (146 females, 127 males). ESBL and carbapenemase production was confirmed using phenotypic and molecular methods per CLSI 2022 guidelines. PCR was used to detect CTX-M and NDM resistance genes. The antibacterial potential of A. acuminata extract was assessed using the Kirby-Bauer disc diffusion method and compared to gentamicin. Results: Among the 273 isolates, 70% exhibited multidrug resistance (MDR); 82 were ESBL producers and 62 were carbapenemase producers. The extract of A. acuminata demonstrated substantial antibacterial activity, with inhibition zones of 20.18 ± 0.89 mm (ESBL-producers) and 20.91 ± 1.3 mm (carbapenemase-producers), comparable to 100% gentamicin. Resistance was more prevalent in hospitalized patients and slightly higher in males. CTX-M and NDM were the most common resistance genes. Conclusion: The study reveals a high prevalence of MDR UPEC strains and emphasizes the urgent need for alternative therapies. A. acuminata showed promising antibacterial activity against resistant UPEC isolates, supporting its potential as an adjunct or alternative treatment for UTIs, especially in low-resource settings
Ameliorating COVID-19-related Acute respiratory distress syndrome (ARDS) with the multi-target strategy utilising natural supplements-from in-silico to a randomised controlled clinical trial
Get PDFBackground: COVID-19, several issues concerning this global dilemma is still unknown with no efficient cure protocol. Relieve respiratory distress and lung failure in acute and moderate cases of COVID-19 infections and control of the common signs are the major aims of the current research. Methods: Cure options selected reviewing available information of virus life cycle, host cell involved signal-transduction, and evaluation by in-silico experiments using natural available supplements. We randomly assigned non-hospitalised and hospitalized patients in the trial in the following groups: Control (Lopinavir/Ritonavir, Azithromycin, Hydroxychloroquine sulfate, and Naproxen); Intervention (Artemisinin, Hesperidin, Resveratrol, Noscapine, N-Acetyl Cysteine, and Vitamin C). The outcome included all-cause viability and treatment within 10 days and the clinical improvement of infection characteristics defined in X-ray Computed Tomography, blood factors examination, and ordinal elimination of the signs with statistical assessing the results. Results: In-silico results indicated that the supplements interfere with the virus in multi-state behaviour. In the trial, all hospitalised intervention patients were cured within 10 days. One of the hospitalised control patients died. The blood oxygen level, CT scan results for lung cleansing, amount of Lymphocytes, Neutrophil, LDH, PLTs, ESR, and WBC of the intervention patients were effectively improved than control patients. The comparison of symptoms demonstrated a significant elimination in the prevalence of fever, sore throat, chest pain, for intervention patients (5.40±1.80 hospitalisation days; 3.84±0.8 treatment days) rather than the control group (13.25±8.96 hospitalisation days; 8.80±3.51 treatment days). Conclusions: We found improved clinical status in lung treatment and blood characteristics with no mortality for intervention participants
Cervical spondylosis: A case based exploration of Panchakarma therapeutic Potential
Get PDFBackground: People\u27s modern lives are mostly dependent on and hooked to digital lifestyles due to the nature of their jobs prolong sitting works for hours in one spot can lead to cervical issues, such as cervical spondylosis. This degenerative condition is persistent age-related wear and tear on the cervical spine\u27s disc and vertebrae is known as cervical spondylosis. In Ayurveda cervical spondylosis can be corelated to the Manyastambha which is one among the 80 types of vata vyadhi. Aim and Objective: To study the effect of Greeva basti (localised cervical oil pooling therapy) and Kukutanda pinda sweda (hens’ egg bolus fomentation) along with Internal medication in the management of Manyastambha. Materials and methods: A 29-year-old female patient came with complaints of pain and stiffness in the back of neck region and mild radiating pain to left shoulder. Patient had complaints since three years and increased since six months used many medications but didn’t get any relief. X-ray finding shows Disc space narrowing at C4-C5, C5-C6 and Straightening of cervical Lordosis due to paraspinal muscle spasm. According to Ayurveda the treatment of vata vyadhi is snehan (oleation) and swedan (Fomentation). So, the treatment like Greeva basti and Kuktanda pinda (hen’s egg bolus) sweda are advised for nine days and followed by Ayurvedic internal medicines for one month. Result: The patient was assessed with subjective and objective parameter before and after treatment. The score of pain reduced from 3 to 0, stiffness from 2 to 0, range of neck movements Flexion from 3 to 0, extension from 3 to 1, lateral flexion rt and lt from 2 to 0, rotation of neck from rt and lt 2 to 0. Conclusion: A treatment protocol, consisting of Greeva basti (localized oil pooling therapy) and Kukutanda pinda sweda (hens’ egg bolus fomentation), and oral herbal medications, significantly improved cervical spondylosis symptoms by 90% and enhanced cervical curvature, as confirmed by radiographic evidence