International Journal of Ayurvedic Medicine
Not a member yet
1492 research outputs found
Sort by
Mahakumbh 2025: Churning of Poison and Nectar
Get PDFThe Mahakumbh Mela, one of the most significant religious and cultural events in Sanatan Dharma, symbolizes the eternal cycle of churning—where both poison and nectar emerge, reflecting the balance of adversity and divinity. Mahakumbh-2025, a grand spiritual gathering occurring after 144 years, stands as a testament to India\u27s rich traditions and unity, bringing together millions of devotees in sacred observances. This paper explores the historical, religious, and cultural significance of Kumbh Parv, emphasizing its role in self-purification, societal evolution, and the unification of the Indian subcontinent. Through the lens of Sanatan Dharma, the paper examines the adaptations of Kumbh traditions over time, the role of Dharma Sansads in addressing contemporary challenges, and the broader spiritual and administrative implications of such a massive congregation. As the churning continues, the Mahakumbh remains a beacon of Sanatan philosophy, promoting faith, resilience, and the pursuit of divine wisdom
Anti-inflammatory effect of Solanum nigrum Linn. ethanolic leaves extract for oral ulcer in LPS stimulated THP 1 cell line
Get PDFBackground: Recurrent Aphthous Stomatitis (RAS) is a common inflammatory condition of oral mucosa characterized by recurrent ulcers, significantly affecting the quality of life. The first line of treatment involves corticosteroids, which are associated with a range of adverse effects. Solanum nigrum Linn. (Black nightshade) is a common medicinal herb in India and has demonstrated anti-gastric ulcer effects of S. nigrum L. in previous research. However, to the best of our knowledge, no studies have been conducted to assess the effects of S. nigrum L. on the inflammatory mediators involved in RAS. This study aimed to investigate the anti-inflammatory effects of Solanum nigrum L. on inflammatory mediators of RAS using the THP1 cell line, an in vitro model for studying the pathogenesis of various inflammatory diseases. Materials and methods: Ethanolic extract of S. nigrum L. leaves was done using the Soxhlet apparatus and phytochemical screening for presence of secondary metabolites was performed. THP 1 cells were differentiated into macrophages using phorbol 12- myristate 13- acetate and activated by lipopolysaccharide (LPS). MTT assay was done to measure the cell viability. Results: THP1 cells were pretreated with concentrations (5, 10, 50, 100 µg/mL) of the extract. In vitro evaluation of S. nigrum L. extract at 100µg/mL revealed a statistically significant decrease in inflammatory mediators TNF-α, IL-1ꞵ, and IL-6. Conclusion: This demonstrated that S. nigrum L. extract downregulates the inflammatory responses in RAS. Hence, S. nigrum L. demonstrated significant anti-inflammatory properties and can be used as a potential therapeutic formulation for managing RAS
Suggestions for re-purposing of Siddha Herbal formulations to COVID-19 positive patients with comorbidity - A review
Get PDFSARS-CoV-2 causes COVID-19, a disease that has killed millions of people around the world. Comorbidities are non-communicable diseases that account for roughly two- thirds of all deaths worldwide. COVID-19 mortality risk rises with age, particularly in males over 60 and in those with chronic diseases such diabetes, cancer, and cardiovascular disease. The key variables for COVID-19 vulnerability have been identified as advanced age and underlying illnesses. There is currently no new drug available to combat this fatal illness. Siddha is a traditional system of medicine which has many Herbal formulations with antiviral activity and anti-inflammatory activity. The pharmacological actions of Siddha Herbal formulations which was already in practice for the above-mentioned comorbidities were reviewed by searching key words botanical names and pharmacological actions against COVID -19 and botanical names in Google Scholar and PubMed databases. Here, we explore the scientific evidences of Siddha Herbal formulations which has antiviral, anti-inflammatory, anti-oxidant, anti-platelet, and immune-modulator actions for re-purposing them in the management of Covid-19 with comorbidity
Unhealthy Diets and Sthoulya (Obesity): A literary and Survey-Based Analysis
Get PDFBackground: Sthoulya (obesity) a growing global health concern, is closely linked to dietary habits and food choices. This is a multifaceted health condition resulting from an imbalance between calorie intake and expenditure, influenced by genetic, environmental and life style factors. According to recent studies of World Health Organization (WHO) over one billion people globally are living with obesity as of 2024. This number includes rapid increases in both children and adolescents, where obesity rates have quadrupled since 1990. Among adults, obesity prevalence has more than doubled during the same period. The findings show that obesity is now burgeoning problem not only India but also worldwide. This is one of the life style disease which is mainly caused by irregular food habits and lack of physical activities. In Ayurveda obesity is considered as Sthoulya and explained under santarpanajanya vikaras. Material and methods: A survey study on 30 participants conducted to revalidate the concepts related to Nidana (causative factors) of Sthoulya through a questionnaire, which was prepared on the basis of classical Nidanas of Sthoulya. Results: From the results it has been proved that the nidahas mentioned in the Ayurvedic texts can be validated today. Conclusion: By bridging traditional wisdom with modern science, this article underscores the transformative potential of food as a therapeutic tool for preventing and managing Sthoulya
Efficacy of Kushmand Avaleha in slow learners as a memory enhancer for improving IQ: A randomized placebo-controlled clinical study
Get PDFBackground: Slow learners are students with an intellectual quotient level between 70 to 81 range and are characterized by difficulty in learning, writing, grasping, and memory. Medhya Rasayana is a polyherbal formulation in Ayurveda called a brain tonic that helps enhance brain functions and cognitive ability. Benincasa hispida is one of the ingredients used in the Medhya Rasayana. Kushmanda Avaleha, which has the same effect as the Medhya Rasayana in enhancing memory, is made of B. hispid. The present study aims to evaluate the efficacy of Kushmanda Avaleha’s in improving the IQ of students categorized as slow learners. Methods: Students were divided into two groups (groups A and B). Group A (trial group) students were given Kushmanda Avaleha, and Group B students (control group) were given a placebo. The students were selected based on their last year\u27s academic performance. Results: The results revealed that group A students administered Kushmanda Avaleha showed improved IQ and academic performance after treatment. A higher statistical significance was observed within Group A before and after treatment (P<0.001). However, group B students provided with a placebo did not show improvement in their IQ or academic performance. The significance between groups A and B was also observed after treatment. Conclusion: The study\u27s findings revealed that Kushmanda Avaleha can increase students\u27 IQ levels by enhancing their memory power, thus suggesting that it can be used as a therapeutic agent for enhancing cognitive ability.
Ushah Pana Rasayanam – Practices for Drinking Water in the Early Morning-A Panacea
Get PDFIntroduction: Water makes up the majority of the human body\u27s composition. Ayurveda gives utmost priority to water based on its utility in various health conditions. The practice of drinking water in the early morning is highly prevalent. It is termed as Ushah Pana Rasayanam in Ayurveda. Due to the popularity around the world it is essential to study and present the antiquity of Ayurvedicrefers to the manner of drinking water in the early morning. It is also termed as Jalapana rasayana. This practice is widely prevalent. Materials and Methods: This study meticulously explored for information pertaining to Ushah pana (healthy water drinking practices) from Anandakanda, A text on Indian Alchemy and emphasized its significance. It was extensively analysed in ayurvedic perspective as well as modern paralence. Results: Study revealed the details such as Preparation of Hamsodaka (medicated water), Intake of water early in the morning and Quantity of water to be consumed as per age etc are the valuable contributions in Ananda Kanda. Highest quantity of water that can be consumed for an adult in the early morning is 16 Prasruta (1536ml). Extensive Pathya and Apathya (do’s and don’ts) have been suggested during Jalapana rasayana. Signs and symptoms of proper and improper digestion of water along with its remedies are elaborated. Scientific studies reveal that drinking water early in the morning improves the metabolism and energy expenditure. Nasal instillation of water strengthens the sense organs and prevents wrinkles and grey hair. Conclusion: The practice of drinking water early in the morning has numerous health advantages and has a potential to treat a wide range of diseases. Thus, Ushah pana rasayana and Nasa jala pana are innovative means to achieve good health
Comparative Anthelmintic activity of three Ayurvedic medicinal plants
Get PDFHelminthiasis, which is the infection by helminths or worms, is a major public health issue, especially in developing nations where it leads to malnutrition, anaemia, and death. The traditional treatment with synthetic anthelmintic drugs like albendazole and mebendazole is usually accompanied by adverse effects like gastrointestinal upsets and neurological manifestations. Additionally, the growing problem of drug resistance has created a need for safer and more effective natural alternatives. The present study aims to explore, evaluate and compare the anthelmintic potential of three traditionally used Ayurvedic medicinal plants Annona squamosa, Murraya koenigii, and Cassia tora as herbal alternatives to synthetic deworming agents. Method: Plant materials were obtained from parts of Maharashtra state and identified. Petroleum ether and hydroalcoholic extracts of each plant were obtained through Soxhlet and reflux processes. Phytochemical screening was carried out using standard procedures. Anthelmintic activity was analysed on Pheretima posthuma (Earthworm) at concentrations of 50, 100, and 150 mg/mL, with Albendazole as reference standard. The activity was found to be dose dependent on concentration with maximum in Murraya koenigii. Results: All three plants exhibited dose-dependent anthelmintic activity, with hydroalcoholic extracts generally showing greater efficacy than petroleum ether extracts. Among them, the hydroalcoholic extract of Murraya koenigii exhibited the highest efficacy, compared to the standard drug. Conclusion: The findings support the traditional use of these plants in managing helminth infections. Given their promising efficacy and presumed safety, these herbal candidates may serve as potential alternatives or complementary therapies to conventional anthelmintic drugs. Further studies involving phytochemical analysis and in vivo evaluations are recommended to validate their therapeutic potential and mechanisms of action
Extraction and Profiling of Fatty Acids obtained from different Marine Seaweeds/Macro Algae
Get PDFSeaweeds are acknowledged as potentially abundant sources of bioactive molecules with diverse applications in food, nutraceutical, and pharmaceutical industries. This study investigated the fatty acid (FA) composition of selected seaweed species collected from the Indian coastline, encompassing representatives from the Chlorophyta, Phaeophyta, and Rhodophyta phyla. Using gas chromatography, approximately 20 FAs were identified and quantified, including polyunsaturated fatty acids (PUFAs), monounsaturated fatty acids (MUFAs) and saturated fatty acids (SFAs). Among SFAs, palmitic acid (16:0) was the most prevalent across all species, followed by oleic acid (18:1) among MUFAs and linoleic acid (18:2) and eicosapentaenoic acid (20:5) among PUFAs. The variation in FA profiles among species suggests species-specific metabolic pathways influenced by environmental conditions. Additionally, the availability of essential FAs and notable PUFA/SFA ratios indicates the nutritional value of these seaweeds. These findings not only enhance our understanding of the biochemical diversity in Indian seaweeds but also support their potential utilization in health-promoting and therapeutic formulations
In-Silico Analysis Bioactive Compounds from Carica papaya and Triticum aestivum for Androgen Receptor Modulation in Polycystic Ovary Syndrome (PCOS)
Get PDFPolycystic Ovary Syndrome (PCOS) is a multifactorial endocrine disorder that affects a large population of women in their reproductive years. A key feature of PCOS is hyperandrogenism, which contributes significantly to the clinical manifestations of the syndrome, including irregular menstrual cycles, infertility, and metabolic disturbances. The androgen receptor (AR), a nuclear transcription factor that mediates the biological effects of androgens such as testosterone and dihydrotestosterone (DHT), has become a critical molecular target in efforts to develop effective therapeutic strategies for PCOS. With the growing interest in computational drug discovery, in-silico techniques such as molecular docking and virtual screening have gained prominence for identifying promising compounds that interact favourably with target receptors. These approaches provide valuable insights into the structural compatibility and binding affinity of ligand-receptor complexes. The present study focuses on exploring natural therapeutic alternatives by investigating the binding potential of phytoconstituents derived from two traditionally significant medicinal plants—Carica papaya and Triticum aestivum. C. papaya is rich in bioactive molecules like flavonoids, alkaloids, and papain, known for their anti-inflammatory and hormonal balancing properties. T. aestivum, or wheatgrass, contains chlorophyll, phenolic compounds, and micronutrients reputed for detoxification and endocrine modulation. Molecular docking simulations were performed using UCSF Chimera for ligand preparation, AutoDock Vina for docking, and Discovery Studio for interaction analysis. The findings revealed that several compounds from these herbs showed strong binding affinities to the androgen receptor, suggesting their potential as natural therapeutic agents for the management of PCOS
Investigation of Phytochemicals and Pharmacognostic Features of Feronia Limonia Fruit and Its In Vivo Effects on Oxidative Stress
Get PDFFeronia limonia, commonly known as wood apple, is a medicinal plant widely used in traditional medicine for its therapeutic properties. This study investigates the phytochemical constituents, pharmacognostic characteristics, and in vivo antioxidant potential of F. limonia fruit to provide a scientific foundation for its medicinal applications. Phytochemical screening revealed the presence of key bioactive compounds, including alkaloids, flavonoids, tannins, saponins, and phenolic compounds. Pharmacognostic and physicochemical analyses were performed to establish quality control and standardization parameters for the fruit. In addition, the methanolic extract was evaluated for its antioxidant activity using a carbon tetrachloride (CCl₄)-induced oxidative stress model in Wistar rats. The extract significantly reduced malondialdehyde (MDA) levels and restored antioxidant enzyme activities (SOD, CAT, GSH) in a dose-dependent manner, supported by histopathological findings of hepatoprotection. These results validate the traditional use of F. limonia and highlight its potential as a natural source of antioxidant agents for pharmaceutical and nutraceutical development