International Journal of Ayurvedic Medicine
Not a member yet
1492 research outputs found
Sort by
Effects of Panchakarma followed by Medhya Rasayana in overcoming PTSD – A Case Report
Get PDFA mental health condition known as post-traumatic stress disorder (PTSD) is brought on by stressful experiences like abuse, violence, pandemics, wars, and more. Even while there are allopathic medicines including antidepressants, anxiety reducers, and antipsychotics, they frequently have adverse effects. Ayurveda, specially Panchakarma (detoxification therapy) along with Medhya Rasayana (brain tonic), aims at restoring balance within the body and mind. A 30 years old woman presented with stress induced insomnia and cognitive impairment, was diagnosed with PTSD and treated using Ayurvedic principles. The Athens Insomnia Scale (AIS) was used to measure insomnia, and the Cognitive Failures Questionnaire (CFQ) for cognitive deterioration. Virechana (bowel purge), Basti (bowel lavage) for eight days, Pratimarsha nasya (nasal therapy) for twenty-one days, Brahmi ghan vati for sixty days, and Mahakalyanak ghee for one month were part of the treatment plan. Within two months, the patient\u27s AIS score jumped from 13 to 1, and their CFQ score decreased from 62 to 17. Neither side effects nor recurrence were noted during or following therapy. This case highlights Ayurveda’s effectiveness in managing PTSD symptoms.
Exploring the Anti-inflammatory Potential of Blue-Green Algae: Formulation and Evaluation of Spirulina Ointment
Get PDFBlue-green algae, also known as cyanobacteria, are a diverse and ancient group of photosynthetic microorganisms that have been of great interest to scientists due to their nutritional, medicinal, and industrial applications. These microbes, some of the oldest organisms on our planet, are currently being discovered as a rich reservoir of bioactive compounds with applications ranging from nutrition to drug discovery. Spirulina and other cyanobacterial genera, in specific, have exhibited strong anti-inflammatory, antioxidant, and immunomodulatory activities and are potential drugs for topical and systemic therapy. Bioactives like phycocyanin, polysaccharides, and carotenoids are key players in exerting these properties and have been effectively added to ointments for better delivery and efficacy. Cyanobacteria exhibit significant utility in promoting human health and possess extensive applications in the field of cosmeceuticals due to their photoprotective properties and skin-regenerative capabilities. Furthermore, they are employed in bioremediation, biofuel generation, and nutraceutical synthesis, thereby constituting a vital component of sustainable biotechnological innovations. Despite these advantages, challenges such as the occurrence of cyanotoxins like microcystins, variability in bioactive compound content, and constraints associated with cultivation underscore the imperative for additional research and standardization efforts. The current investigation aimed to examine the anti-inflammatory properties of the blue-green algae Spirulina, alongside the formulation and evaluation of Spirulina-based ointments. This review endeavors to highlight recent advancements in the anti-inflammatory potential of blue-green algae, with particular focus on the formulation of topical ointments
Unlocking the Anticancer Potential of Metal-Curcumin Complexes: Docking Insights with EGFR
Get PDFThe Epidermal Growth Factor Receptor (EGFR) plays a pivotal role in cervical cancer progression by driving uncontrolled cell proliferation and survival. Given its oncogenic significance, EGFR remains a prime therapeutic target for cancer drug development. Curcumin, a bioactive polyphenol, exhibits promising anticancer properties but suffers from poor solubility and bioavailability, limiting its clinical application. To enhance its pharmacological potential, metal complexation has been explored as a strategy to improve its pharmacokinetics and bioactivity. This study employed molecular docking to assess the binding affinities of curcumin and its metal complexes (Ca, Cu, Mg, Na, Zn) with two EGFR conformations: the active kinase domain (PDB ID: 1M17) and the extracellular ligand-binding domain (PDB ID: 4ZSE). Docking analyses revealed that Ca-Bicurcumin (-11.1 kcal/mol), Na-Bicurcumin (-11.0 kcal/mol), and Cu, Mg, and Zn-Bicurcumin complexes (-10.8 kcal/mol each) exhibited strong binding affinities toward 1M17, outperforming the reference ligand AQ4 (-7.0 kcal/mol) and native curcumin (-7.3 kcal/mol). Similarly, Cu-Bicurcumin (-11.0 kcal/mol), along with Ca, Mg, and Na-Bicurcumin complexes (-10.9 kcal/mol each), displayed superior interactions with 4ZSE, exceeding the binding of ANP (-9.4 kcal/mol) and curcumin (-7.2 kcal/mol). These enhanced interactions resulted from strong hydrogen bonding, hydrophobic interactions, and electrostatic forces, improving receptor complementarity. The findings suggest that metal-curcumin complexes hold promise as EGFR-targeted therapeutics, potentially overcoming curcumin’s pharmacokinetic limitations while enhancing its anticancer efficacy. Further, in vitro kinase inhibition assays and in vivo tumor regression studies are necessary to validate their therapeutic potential in EGFR-driven cancers
Pharmacognostic Exploration, Formulation and Evaluation of Caesalpinia bonduc seeds syrup and candy formulation
Get PDFThe pharmacognostic exploration and formulation development of Caesalpinia bonduc seeds for anthelmintic activity. Caesalpinia bonduc, a member of the Fabaceae family, is traditionally used in various indigenous systems of medicine for its diverse therapeutic effects. The present study focuses on the detailed pharmacognostic investigation of the seeds, including their morphological, microscopic, and physicochemical properties. Formulation development efforts involved creating herbal formulations incorporating Caesalpinia bonduc seed extracts, followed by an evaluation study. The formulation of herbal syrup and herbal candies containing C. bonduc not only offers a practical and enjoyable method of ingestion but also paves the way for the incorporation of traditional medicinal practices into contemporary lifestyles. These formulations enhance the compliance of pediatric patients towards anthelmintic medication. The findings emphasize the need for further clinical studies to confirm the safety and efficacy of Caesalpinia bonduc in treating helminthic infections, which could lead to the development of novel, affordable treatments for worm-related diseases
Formulation, Characterisation and In Vitro Evaluation of Herbosome Sunscreen Lotion
Get PDFIntroduction: The global market for sunscreen ingredients is rising day by day. Herbosomes are essentially the substance encapsulated in liposomes, which are tiny vesicles with a lipid bilayer. The benefits lie in the enhanced bioavailability and targeted delivery of the active ingredients.
Material and Methods: Herbosomes were prepared by using aloe vera and resveratrol in various ratios against phosphotidylcholine. Herbosomes of aloe vera and resveratrol were incorporated into the lotion. Two formulations, F1 and F2, of herbosome lotion were prepared.
Results and Discussion: This study set out to develop and standardize herbosomal sunscreen lotion that has a significant sun protection factor and enticing qualities. The sunscreen lotions F1 and F2 were developed using two distinct ratios of aloe and resveratrol, and their physicochemical properties and SPF were also assessed. Herbosme lotion thus formed was evaluated for visualization, homogeneity, viscosity, irritancy test, spreadability, and pH. The efficacy of the developed formulation, which possesses SPF in the range of 19 to 23, when tested with a standard, was observed to be satisfactory to that of a marketed sunscreen with SPF 55.
Conclusion: In this research study, formulation F2 was found to have a higher SPF and be more stable and effective than formulation F
Melodies for the gut : A Randomised Double-Arm Pilot Study to assess the effect of Mantra Therapy with Hymn (prayer) on Gastrointestinal Quality of Life Index
Get PDFBackground: Manipur Chakra situated at naval region governs the digestive health and affects the functions of the abdominal organs. Intoning the Beeja mantra of Manipur Chakra may activate its vitality and dormant potential. The study aims to evaluate the effect of Beeja Mantra therapy on gut health using Gastrointestinal Quality of Life Index scale. Material and Method: In the study, total 50 participants between the age group of 20 to 60 without any chronic digestive issues, who gave informed consent were enrolled and randomly divided into two groups; study group (Beeja mantra chanting) and control group (prayer chanting). Study group was asked to follow the regime of chanting Ram Beeja mantra (108 times) and Rama Raksha Stotra (once) while control group was asked to recite Nirvan Shtakam (once a day) for a duration of 30 days. GIQLI Scale was used to evaluate the effect of mantra meditation on gastrointestinal health at three different time points day 0, day 15, day 30. The statistical analysis was done using non-parametric tests of significance, Friedman ANOVA and Mann Whitney U test. Result: When both the groups were compared, the study group showed a notably higher mean difference compared to the control group with a significant p-value for Domain 1, Domain 2, Domain 3, Domain5 whereas Domain 4 did not show a significant difference between the two groups, as indicated by a non-significant p-value (0.349, NS). Conclusion: Mind body interventions like mantra therapy can enhance the gastrointestinal quality of life index scale.
Management of Vipadika (Palmoplantar Psoriasis) by Jalaukavcharana (Leech Therapy) - A Pediatric Case Report
Get PDFVipadika is a dermatological disorder related to Teevravedana (extreme pain) and Panipadasphutana (cracking of the palms and soles) described under the concept of Kshudra Kushta. It mostly results from an imbalance of Vatakaphadosha, the two basic constituents in Ayurveda that represent air and phlegm. This dermatological illness is linked to Kshudra Kushta and can be related to the concept of Palmoplantar Psoriasis in conventional medicine. This type of psoriasis typically affects the skin of the palms and soles. This case report of an 8-year-old male child with palmoplantar psoriasis (Vipadika) demonstrates the severe debilitating nature of the condition. The child has been experiencing foot soreness, occasional bleeding, peeling, and discoloration from fissures across both hands and both feet for the past 2 years. Aims and Objectives: The main objective is to improve the patient\u27s quality of life by relieving their symptoms of palmoplantar psoriasis (Vipadika), with a particular emphasis on minimizing pain, bleeding, and skin abnormalities. Methods: The treatment approach involved Raktamokshana (Bloodletting) by Jalaukavcharana (Leech therapy) followed by local application of Sarjarasa Malhara topically for 1 month. Shamana Aushadis, including Panchtikta Grutha, Khadirarishta, and Arogyavardhini Vati, known for their anti-inflammatory and skin healing properties were employed additionally to address the underlying causes and symptoms of Palmoplantar Psoriasis (Vipadika). Observations and Results: Excellent improvement in Palmoplantar Psoriasis (Vipadika) symptoms, such as decreased pain and bleeding, and commendable skin tissue recovery with ESIF Score of 15, m-PPPASI score of 21.4, DLQ Index of 5, PGA and VAS on the milder side were noted. Earlier the ESIF Score was 89.59% and then it improved to 31.25%, similarly, the m-PPPASI score that was 80% improved to 29.73% after following the recommended treatment regimen for 2 months. This suggests that the Ayurved Treatment Protocol incorporated in this patient successfully treats Vipadika (Palmoplantar Psoriasis)
Misdiagnosed case of an ano-scrotal fistula treated with partial excision of tract and Ksharasutra - A case report
Get PDFAnal fistula can sometimes extend to the scrotum, resulting in varied presentations that can lead to misdiagnoses such as scrotal infection, abscess, or sinus, particularly when minimal or no symptoms are present in the anus. This case report presents a 50-year-old male patient initially diagnosed with a scrotal sinus who underwent excision one year ago. He presented with persistent pus discharge from the scrotum without anal complaints. So the case was initially diagnosed as a scrotal sinus based on clinical examination and ultrasonography findings, the true pathology of an ano-scrotal fistula was only revealed during surgery. This unexpected finding was effectively managed by partial fistulectomy and Ksharasutra therapy. This case underscores the importance of thorough preoperative assessment and intraoperative vigilance. The successful outcome demonstrates the necessity for flexibility in surgical planning and the potential benefits of integrative approaches in complex fistula-in ano.
Investigating the effect of Cynodon dactylon on the secretion of growth factors from Dental pulp stem cells and angiogenic potential in chick embryo model
Get PDFBackground: Durva (Cynodon dactylon) is an abundantly available plant in India with great medicinal properties. It is used for the treatment of various cardiovascular diseases such as heart failure and atherosclerosis. It is a one of the drugs that maintain and stabilise pregnancy. We investigated the effects of the aqueous extract prepared from the rhizomes of C. dactylon on stem cells growth factor secretion and angiogenesis in chick embryo model. Methods: MTT assay was performed to assess cytotoxicity of aqueous extract of Cynodon dactylon at various concentrations (2, 5, 10, 15, 20, 25 and 50 µg/ml). Human dental pulp stem cells (hDPSCs) were treated with non-toxic aqueous extract concertation of Cynodon dactylon to collect the preconditioned media. Chicken Yolk Sac models model was deployed to observe angiogenic the effect of aqueous extract. Further growth factor analysis of pre-treated hDPSCs condition media analysed for the angiogenic growth factors that affect the angiogenic process. Results: Cynodon dactylon does not show cytotoxic effects at any concentration tested. At 10 µg/ml aqueous extract show good proliferation rate compare with other concentration. Preconditioned media of Cynodon dactylon showed high amount of growth factors secretion than that of the control conditioned media. The chick embryos treated with 10 µg/ml aqueous extract of Cynodon dactylon, showed highest growth of blood vessels followed by the preconditioned media as compared to the control groups. Conclusion: Our study concludes that Cynodon dactylon promotes the process of angiogenesis by stimulating secretion of essential growth factors and potential angiogenic properties.
Effect of Panchatikta Ksheera Basti and Praval Panchamrut Vati in Asthikshaya w.s.r. to Osteopenia/ Osteoporosis – A Randomized Controlled Pilot Study
Get PDFBackground: Osteopenia and Osteoporosis are common prevailing ailments exhibiting reduced bone density and occur especially aging population. Various factors lead to Osteopenia/Osteoporosis including sedentary lifestyle and hormonal changes that affect the bone metabolism. Conventional management of Osteopenia/Osteoporosis focuses primarily on Calcium and Vitamin D supplementation. Asthi kshaya, a similar condition to Osteoporosis, has been mentioned in Ayurveda wherein vitiated Vata causes reduction in bone mass and is associated with same symptoms as Osteoporosis. Panchatikta Ksheera Basti is a formulation made from tikta dravya siddha Ksheera (milk decoction made from five bitter herbs), Panchatikta Ghrita and honey. Objective: To evaluate the efficacy of Panchatikta Ksheera basti and Praval Panchamruta Vati in Asthikshaya (Osteopenia/Osteoporosis) and compare the same with the conventional treatment. Trial Design: A Randomized Controlled Pilot Study. Method: Patients with signs and symptoms of Asthi kshaya and BMD (T-score) =<-1 were randomized, Group A (Trial group) patients received Panchatikta Ksheera Basti and Praval Panchamrut Vati while Group B (Control group) patients received oral organic Calcium and Vitamin D for 30 days. Primary Outcome: To improve the functional and physical activities of the patients. Secondary Outcome: To improve Serum Calcium, Serum Phosphorus and Vitamin D levels and BMD score. Results: Statistically significant results were observed in both the groups, however pain relief was better in Study group A, while Serum Calcium levels were significantly improved in both the groups. Conclusion: Panchatikta Ksheera Basti and Praval Panchamruta Vati have equal potential for addressing Asthi Kshaya (Osteopenia /Osteoporosis) in comparison to conventional management