International Journal of Ayurvedic Medicine
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In-vitro assessment of Urginea indica (R.) Bulb fractions against calcium oxalate crystallization: Role of Citronellal identified by GC-MS
Full text linkObjectives: The present study aimed to investigate the in-vitro antiurolithiatic activity of the methanolic bulb extract of Urginea indica (R.) and its fractions, focusing on their ability to inhibit calcium oxalate (CaOx) crystal nucleation, aggregation, and oxalate degradation. The goal was to validate its traditional use in urolithiasis and assess its potential as a clinically relevant phytotherapeutic agent. Methods: Urginea indica bulbs were extracted using Soxhlet extraction with methanol, followed by column chromatography to yield five fractions (F1–F5). A factorial approach guided the optimization and separation of fractions using TLC profiling. GC-MS analysis identified key phytoconstituents. In-vitro assays for nucleation, aggregation, oxalate degradation, and titrimetric estimation of calcium oxalate were conducted to assess antiurolithiatic efficacy. Cystone was used as the standard reference. Results: Phytochemical screening revealed the presence of alkaloids, flavonoids, terpenoids, tannins, and saponins. GC-MS identified citronellal (49.43%), camphor (12.79%), and other active compounds. Among the fractions, F5 consistently showed the highest activity: 85% nucleation inhibition, 84% aggregation inhibition, 84% oxalate degradation, and 87% inhibition of CaOx content at 1000 µg/mL, closely matching the standard Cystone. F5 was thus selected as the optimized batch based on superior efficacy across all in-vitro parameters. Conclusion: Urginea indica fraction F5 exhibits significant antiurolithiatic activity, supporting its traditional use and potential clinical application. Its multi-targeted action and natural origin make it a promising candidate for future development. Further in-vivo studies are essential for clinical translation.
High-performance Thin Layer Chromatographic quantification of hesperidin and naringenin from Citrus sinensis peel extract
Full text linkOrange peel is a member of Citrus sinensis, the Rutaceae family, and is widely used for its nutritional properties. Orange peels are the waste part of the fruit and contain various therapeutic molecules. Hesperidin and naringenin are two flavonoids present in orange peel. The present study depicted the quantification of high-performance thin layer chromatography of orange peel extract using hesperidin and naringenin. The HPTLC densitometric analysis of the ethanolic extract of orange peel was carried out using a CAMAG HPTLC system, Linomat 5 applicator, and Vision CAT software. The results were obtained in the form of chromatograms scanned at 254 & 366 nm. The Rf values of hesperidin were 0.5 with mobile phase Ethyl acetate: Methanol: Water (15:04:01) and 25.93 nanograms in 1 mg of orange peel extract. Naringenin was quantified at 254 & 366 nm with Rf value 0.6 & mobile phase used was Toluene: Ethyl acetate: Formic acid (12:8:1.6v/v/v), and 14.92 nanograms of naringenin were found in 1 mg of orange peel extract
Psychedelic Herbal Medicines: Exploring the Renaissance of a Therapeutic Frontier
Full text linkA revolutionary change in contemporary therapeutic paradigms may be seen in the renewed interest in psychedelic plant remedies. Psychedelic plants like psilocybe mushrooms, ayahuasca, iboga, and salvia divinorum, which have long been valued for their spiritual and therapeutic qualities in a variety of cultures, are now the subject of intense scientific research. According to recent clinical research, they have great promise for treating a variety of illnesses, such as addiction, PTSD, anxiety, and depression. This resurgence is fuelled by mounting evidence that these drugs may support profound psychological healing, emotional resilience, and neuroplasticity when used under careful supervision. Technological developments in ethnobotany, neurology, and psychopharmacology are revealing the intricate processes by which these herbal psychedelics work, particularly via serotonergic pathway regulation and the amplification of introspective experiences. The regulatory environment is gradually changing, indicating a cautious sense of hope about the incorporation of these traditional medicines into contemporary medical treatment. But there are still issues to be resolved, such as standardising botanical formulations, guaranteeing patient safety, and tackling the social stigma attached to psychedelics. This study highlights the need for multidisciplinary cooperation in furthering this exciting field by examining the historical origins, molecular foundations, therapeutic uses, and potential future developments of psychedelic plant medicines. Psychedelic herbal treatments provide a rare chance to rethink mental health therapy by fusing ancient wisdom with modern research, paving the door for more individualised and holistic approaches to recovery
Bergamot unleashed: Exploring the multifaceted traits and healing powers of Citrus bergamia
Full text linkIn this comprehensive review article, the focus is on Bergamot plant, elaborating on its various properties and applications. This article provides a detailed examination of the botanical aspects, significance, and characteristics of Bergamot plant, including its anatomy and chemistry. Additionally, it delves into the pharmacological activity exhibited by Bergamot plant, highlighting its diverse range of effects such as anti-anxiety, wound healing, neuroprotection, anti-depressant, antiproliferative, antibacterial, anticancer, antioxidant, anti-inflammatory, antinociceptive, anti-mycoplasmal, anti-fungal, and antiallodynic properties. The scientific designation of Bergamot, Citrus bergamia Risso, indicates its botanical lineage as a hybrid of Citrus limon L and Citrus aurantium, categorising it under the Rutaceae family and Citrus genus. This plant, is known for its unique combination of volatile and non-volatile fractions, each contributing to its therapeutic potential and aromatic profile. Through an exploration of its pharmacological activity and chemical composition, this article offers a comprehensive overview of the multifaceted nature of Bergamot plant, shedding light on its rich botanical heritage and promising therapeutic applications
Cissus quadrangularis: An Herbal Remedy Climbing Towards Health & Wellness
Full text linkTraditional medical systems, such as Ayurveda and Siddha, have long acknowledged the many medicinal uses of the succulent plant Cissus quadrangularis (CQ), which is a member of the Vitaceae family. Popularly known as "Harjor" or "Bone Setter," CQ has attracted the attention of scientists due to its powerful ability to reduce inflammation, act as an antioxidant, alleviate pain, and rebuild bone. Plants with a high concentration of bioactive components, such as flavonoids, triterpenoids, ketosteroids, and phenolic compounds, have a wide range of potential medicinal uses. It is a potential natural option for osteoporosis and bone injuries, as shown in preclinical and clinical research that it speeds up fracture healing, increases bone mineral density, and modulates osteoblastic activity. In addition to its effects on bone health, CQ shows promise in the treatment of metabolic diseases like diabetes, obesity, and hyperlipidemia by influencing insulin sensitivity, suppressing hunger, and lipid metabolism. Its multifunctional botanical properties are further supported by its gastroprotective, antibacterial, and hepatoprotective activities. Based on molecular research, CQ is thought to exert its therapeutic effects by lowering oxidative stress and inflammatory cytokines and by influencing important cellular pathways such as NF-κB, MAPK, and PPARγ. Integration into evidence-based medicine is hindered by the lack of extensive clinical validation and standardized formulations, notwithstanding the therapeutic potential. By outlining current findings and pointing out areas where more study is needed, this review offers a comprehensive overview of Cissus quadrangularis\u27 phytochemistry, pharmacology, and medicinal uses. The purpose of this paper is to encourage further research into this adaptable plant and its potential use in contemporary health and wellness programs
In-vitro Evaluation of the Siddha Formulation Mahaveera Mezhugu (MVM) for Anti-Cancer Activity Against MCF-7 Human Breast Cancer Cells
Full text linkOver one in ten new cases of cancer detected in women are related to breast cancer, making it the most common disease diagnosed in this demographic. It is the second leading cause of cancer-related deaths worldwide for women. The many cancer treatments and their potential adverse effects made people aware of the need to look for safe, affordable substitutes for cancer treatment. The Siddha system can offer a lot of formulations in the management of breast cancer. There are also many literary works that facilitate this. Efficacy of Mahaveera Mezhugu (MVM) is a Herbo-mineral siddha preparation it is indicated for Vatharogam, Megarogam. This MVM has been used for siddha clinically to treat breast cancer. but there is no scientific data to validate this medicine. Hence this study aims to evaluate the anticancer potential of Mahaveera Mezhugu through an in-vitro study in the MCF-7 Human Breast cell line, determined by dimethyl sulphoxide (DMSO, MTT and Annexin V- Fitc apoptosis by flow cytometry assay. LC50 concentration was found at 5.1879371 µg/mL. The Siddha system, which combines many well-researched drugs, has shown clinically significant improvements in the treatment of breast cancer. Further research and large randomized control trial are needed to determine the effects of the drug
Exploring the Antidiabetic and Antioxidant Potential of Celastrus paniculatus Roots Extract: Insights from preclinical studies
Full text linkBackground: Diabetes mellitus is a metabolic disorder that results from elevated blood glucose and reduced starch intake capabilities. Acute hyperglycemia has implications that entails renal deficiencies, neuropathy and even raised cardio vascular risk with long standing hyperglycemia. Objectives: The purpose of this study was to assess the Antidiabetic and Antioxidant Potential of Celastrus paniculatus Roots Extract. Material and Method: Wistar rats were fed with High fat diet for 2 weeks and on the 15th day they were injected intraperitoneal with streptozotocin (35 mg/kg) and the rats were treated with Celastrus paniculatus (150mg/kg, 250 mg/kg and 300mg/kg) and metformin (10 mg/kg) until the 28th day. The intraperitoneal glucose tolerance test and insulin tolerance test were performed on the 28th day. Furthermore, dynamic blood sugar and lipid metabolism were assessed by measuring fasting blood glucose, fasting insulin, total cholesterol, and triglyceride concentrations. Results: Both metformin and MECP showed considerable depletion in the plasma glucose levels when used in the treatment of animals with T2DM. In the same context, the present work revealed that Celastrus paniculatus has hepatoprotective effect as observed by a significant decrease in the liver markers of oxidative stress and levels of serum liver enzymes (ALT and AST) that help in sustaining of β cells. Based on these results, CEPC has the prospect of exhibiting antioxidant and antidiabetic properties and has the possibility of addressing the issue of diabetes mellitus before its occurrence. Conclusion: Therefore, the result of this study suggests that Celastrus paniculatus has Antidiabetic and Antioxidant Potential against T2DM
Evaluation of efficacy of Dhoopana (polyherbal nasal fumigation) versus polyherbal steam inhalation in children with Pratishyaya (rhinitis): A pilot study
Full text linkBackground: According to Ayurveda, Pratishyaya is characterized by the continuous outward flow of Vata, Pitta, and Kapha from the nostrils, resembling rhinitis, where the nasal mucosa becomes inflamed due to infection, allergy, or injury. The study aims to evaluate the efficacy of polyherbal steam inhalation versus nasal fumigation (Dhoopana) in children with rhinitis. Material and methods: Randomized reference controlled open label equivalence pilot study. Patients after initial screening were subjected to randomization and were included in two groups; Group C (Control group) and Group T (Trial group). 10 subjects in each group. Group C (Control group) Polyherbal steam inhalation, Arka prepared from Tulsi, Nirgundi, Vasa and Nilgiri were used for steam inhalation. Group T (Trial group) Dhoopana (Polyherbal nasal fumigation). Dhoomvarti prepared from dry leaves of Tulsi,Nirgundi, Vasa and Nilgiri. Results: From the observations of the clinical trial, it can be concluded that efficacy of Dhoopana (polyherbal fumigation) is better as compare to polyherbal steam inhalation. Statistically significant difference is seen in objective criteria of nasal patency and symptoms of nasal itching and coughing whereas no significant difference is observed in symptoms rhinorrhoea, nasal obstruction, headache and anorexia. Conclusion: Rhinitis in acute stage is one of the frequently troubling conditions in children, though many medicines are available in the market in every system of medicine for its management, but it is difficult to administer them orally in pediatric population. Polyherbal Dhoopana (Nasal Fumigation) is safe and easy to administer, so, can be used in general pediatric practice in patients suffering from acute condition of rhinitis
Scientific Basis for the Therapeutic Uses of Semecarpus anacardium Linn. (Bhallataka): A Systematic Review
Full text linkThe present review highlights the chemical qualities, therapeutic benefits, toxicity profile of Semecarpus anacardium Linn. (Bhallataka) which is a commonly used plant in Ayurvedic medicine. While there has been some scientific research conducted on the potential therapeutic effects of the plant, more studies are needed to confirm its effectiveness and safety. Due to the generally different approaches taken by each examination, no factual pooling of results or assessment of the nature of the investigations was carried out. Some studies have found that compounds found in Semecarpus anacardium Linn., such as anacardic acid, have anti-inflammatory, antioxidant and anticancer properties. However, further research is needed to understand the full range of therapeutic uses and potential side effects of the plant. Semecarpus anacardium Linn. (Bhallataka) is widely used plant in Ayurvedic medicine, with numerous reported therapeutic benefits. This review provides an overview of the plant\u27s chemical composition, therapeutic effects, and toxicity profile. While some scientific studies have investigated its potential therapeutic effects, further research is necessary to validate its efficacy and safety. Due to the heterogeneity of the studies reviewed, no meta-analysis was conducted. However, several studies have reported that Semecarpus anacardium Linn. contains compounds, such as anacardic acid, with anti-inflammatory, antioxidant, and anticancer properties. Further research is required to fully elucidate its therapeutic uses and potential side effects. Preliminary research suggests that Bhallataka may have beneficial effects on the cardiovascular system, glucose metabolism, circulatory system, and digestive system, with low toxicity. These findings are promising and support the potential use of Bhallataka as a therapeutic agent
An ayurvedic management of Amniotic band syndrome with a focus on antenatal care and complication free outcome - A case study
Full text linkAyurveda explains Jarayu as the membranous covering of foetus. The liquor amni secreted from amnion can be considered as ambu / garbhodaka. According to Sarangadhara, jarayu dosha can be considered under all abnormalities of amnion and chorion that includes unusual friability, amnionitis, cyst, amnionnodosum, amniotic adhesions along with poly-hydramnios and oligo-hydramnios. Amniotic Band Syndrome (ABS) is a rare condition caused by the strands of amniotic sac that separate and entangle digits, limbs or other parts of the fetus. It is believed that ABS occurs when inner membrane (amnion) ruptures, tears, without injury to outer membrane (chorion). A 21-year-old pregnant woman at 14 weeks of gestation came to Prasuti Tantra and Stree Roga OPD of KLE Ayurveda medical college Belagavi and diagnosed as Amniotic Band Syndrome (ABS) and it was effectively managed by using Ayurvedic formulations such as Laghu Malati Vasant Rasa and Shatavari Ksheera Paka focusing on enhancing amniotic fluid levels and supporting fetal growth. This holistic approach led to a healthy delivery without complications, showcasing the potentiality of Ayurveda in addressing rare and challenging prenatal conditions