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Circadian Clocks in Two Intertidal Species, the American Horseshoe Crab and the Mummichog
No full textAlthough the molecular mechanism of animal circadian clocks has been outlined in a few model species, much less is known in other animals. In fruit flies and mice, the molecular clock is composed of a transcription translation feedback loop that is composed of a set of core and accessory proteins. However, since even these two clocks differ in a number of fundamental ways, an analysis of non-model species may help to uncover both common and novel circadian clock mechanisms. The American Horseshoe crab (Limulus polyphemus) and the mummichog (Fundulus heteroclitus) are intertidal organisms that both exhibit circadian rhythms. In addition, because they live in the intertidal zone, these animals may also have another clock that serves to synchronize them to the twice per day tidal changes. The two goals of this thesis were to identify putative circadian clock proteins in the mummichog using publicly available data and to quantify potential changes in abundance of putative circadian proteins in the horseshoe crab. Bioinformatical analysis of the mummichog proteome demonstrated the presence of putative proteins of all five of the core vertebrate circadian proteins as well as 17 accessory proteins. This is the first study to identify core, accessory, input and output clock proteins in a single fish and this work will help to establish ground work for future circadian work in fish. In addition, this work allows for comparative bioinformatics work on intertidal species and may help to provide insights on the molecular mechanisms of the clock system that controls circatidal rhythms. In Horseshoe crabs, three putative circadian proteins (CLOCK, CYCLE1, and photoreceptive CRYPTOCHROME) were detected in the central nervous system using western blotting and authentic antibodies. Interestingly, although these proteins have been shown to cycle by time of day and circadian time in other species, there was a lack of cycling in the abundance of these proteins. While this may suggest that post-translational modifications of core proteins by accessory proteins may drive their circadian clock, other core proteins may instead be responsible for driving circadian rhythms in horseshoe crabs. Overall, the results presented in this thesis will provide the basis for further investigations into the circadian systems of these species
Guiding Students Most in Need
No full textFirst generation and low income college students enter college with a different perspective for our “traditional” college students. Here at PSU the majority of our students fall into one of these categories. It is our hope that through our office’s 30 years of experience serving these populations of students we may be able to give you some insight into their world and allow you to see the challenges that they may be facing in the classroom and workplace
Climb Above Addiction Image 066
No full textThe Climb Above Addiction cluster project addresses the need for awareness, support, and education for those affected by addiction. The event component of the project, similar to the Relay for Life but with climbing rather than walking a track, raised money to support a scholarship for the Plymouth House recovery program. This photo was taken at the event.https://digitalcommons.plymouth.edu/climbabove/1065/thumbnail.jp
Climb Above Addiction Image 077
No full textThe Climb Above Addiction cluster project addresses the need for awareness, support, and education for those affected by addiction. The event component of the project, similar to the Relay for Life but with climbing rather than walking a track, raised money to support a scholarship for the Plymouth House recovery program. This photo was taken at the event.https://digitalcommons.plymouth.edu/climbabove/1076/thumbnail.jp
LRPC Presentations Part I [Video]
No full textThe Lakes Region Planning Commission (LRPC) is a non-profit association of local governments that provides comprehensive planning services to meet the diverse needs of New Hampshire’s Lakes Region. Their mission is to provide effective planning, in order to achieve and sustain a quality environment, a dynamic economy, and local cultural values by supporting community efforts through leadership, education, technical assistance, information advocacy, coordination and responsive representation.
In this video, students in the LRPC Communication & Outreach Initiative cluster project provide more clarity about target audiences, education and outreach methods, and effective communication strategies for social media platforms and other publications
Business Feasibility Consulting Class Project [video]
No full textInnovation & Entrepreneurship Cluster Experience: Business Feasibility Consulting
Professor Jonathan Dapra leads this intensive eight-week consulting experience class. Students work with real world clients to evaluate potential business opportunities, providing comprehensive research and actionable outcome advice. This is a video of the final client meeting in which team members provided their findings. A discussion followed in which all further explored the nature of the recommendations and implications found in the research