9510 research outputs found
Sort by
PREDICTION OF FLOW FIELD AND ROTOR PERFORMANCE OF THREE-ROTOR PARALLEL LAYOUT OF EXPERIMENTAL MINIATURE VERTICAL AXIS WIND TURBINES BY A FAST COMPUTATION METHOD
No full textVertical-axis wind turbines (VAWTs), which do not require wind-direction tracking control, are well-suited for wind environments with frequent direction change. It is important to determine the optimal turbine arrangement to suit the site shape and wind conditions for configuring a wind farm. This study investigates the performance of actual three miniature VAWTs arranged in parallel, using an original fast-calculation method which uses the two-dimensional computational fluid dynamics (2D-CFD) data of an isolated single wind turbine as the input. To apply the method for three-dimensional miniature VAWTs, the 2D-CFD-based input is replaced with velocity distributions (triangular-wake model: TWM) derived from experimental wake measurements, which is improved by introducing two correction functions based on Gaussian functions; the improved wake model was denoted TWMimp. We first apply the method using the TWMimp to a pair of wind turbines and modify the original model by introducing additional functions to reduce the difference between the experimental and numerical prediction results for specific directions. The improved method is applied for four different parallel arrangements of three miniature VAWTs by adjusting the rotor spacing from 10 mm to 150 mm. However, the results using the measurement-based wake model (TWMimp) did not adequately represent the effects of the turbine rotation direction shown in the experiments, while predictions using the velocity field obtained by 2D-CFD produced large errors at short spacings, but the trend in the effect of the rotation direction matched the experiments
アガリクス・マルモレウス （ブナシメジ） キンシタイ バイヨウ ニオケル エキタイ バイチ ヘノ タンサン カルシウム ノ テンカ コウカ ニ カンスル ケンキュウ
No full text鳥取大学Tottori University博士（農学
Selective PPARα Modulator (SPPARMα) in the Era of the MASLD Pandemic: Current Insights and Future Prospects
No full textMetabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as a significant global health concern, affecting approximately 30% of the population. In Japan, its prevalence is also rising rapidly and is expected to reach 50% by 2040. This situation can be described as a “MASLD pandemic”, emphasizing the urgent need for effective therapeutic interventions. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that play essential roles in lipid metabolism, inflammation regulation, and fibrosis modulation. Among them, PPARα is a key regulator of lipid homeostasis, primarily expressed in the liver and other metabolically active tissues. Its activation promotes fatty acid oxidation and improves lipid profiles, making it a crucial target for metabolic disorders. In Japan, a novel selective PPARα modulator (SPPARMα) was developed as a lipid-lowering agent for treating dyslipidemia. Over time, increasing clinical evidence has suggested that SPPARMα has beneficial effects on MASLD patients’ liver function. This review aims to summarize the therapeutic potential of SPPARMα in MASLD by examining the functional mechanisms of PPARα, preclinical studies in animal models, and accumulating clinical evidence from MASLD patients. Furthermore, we provide an overview of ongoing clinical trials investigating SPPARMα for MASLD treatment
Acute Promyelocytic Leukemia Diagnosed Due to Pericoronitis : A Case Report
No full textHerein, we report the case of a 60-year-old female patient diagnosed with acute promyelocytic leukemia (APL) following pericoronitis. The patient was referred to our department for the extraction of a wisdom tooth. On initial examination, tissue swelling and necrosis were observed in the gingiva around the right mandibular wisdom tooth. After 1 week of no improvement, purpura were observed on the patient’s forearms and lower legs, signifying the presence of a blood disorder. Following the detection of pancytopenia, the patient was referred to the Department of Hematology and Oncology. Bone marrow aspiration confirmed the diagnosis of APL. Chemotherapy with all-trans retinoic acid was started immediately, and the patient is currently in complete molecular remission. The mandibular wisdom tooth was extracted after complete molecular remission and the patient is doing well
Immune evasion from macrophages by NEAT1-induced CD24 in liver cancer
No full textThe limited efficacy of immune checkpoint inhibitors in hepatocellular carcinoma (HCC) can arise from the involvement of immunosuppressive cells, such as macrophages. In the present study, we found that the long noncoding RNA NEAT1, particularly its short isoform (NEAT1v1) induced the expression of CD24, which is known as an immune checkpoint molecule for macrophages. Mechanistically, NEAT1v1 sponged miR-320a-3p to upregulate the transcription factor SP1, which in turn, activated CD24 transcription. A spheroid co-culture of primary or THP-1-derived macrophages with HCC cells revealed that NEAT1v1 suppressed M1 marker expression and phagocytic activity in macrophages. In a syngeneic subcutaneous model of HCC, Neat1v1 increased the tumor infiltration of M2-like macrophages and induced resistance to anti-Pd-1 antibody, while combination of the anti-Pd-1 and anti-Cd24 antibodies significantly suppressed the tumor growth. Finally, NEAT1, SP1, and CD24 expression increased in tumor tissues from patients with HCC, compared to adjacent normal tissues, whereas miR-320a-3p was significantly downregulated. Moreover, plasma NEAT1 cell-free RNA was significantly decreased after therapeutic intervention. Taken together, NEAT1v1 protects HCC cells from macrophages by sending a “Don't Eat Me” signal via CD24, and is therefore, a potential target molecule for the treatment and diagnosis of HCC
A Pilot Pre-Post Study of an Internet-Based Sleep Education Program for Parents of Children with Autism Spectrum Disorder and Sleep Disturbance in Japan
No full textBackground, Children with autism spectrum disorder frequently experience persistent sleep difficulties that persist into adulthood. These issues are linked to adverse outcomes like behavioral issues, poor academic performance, and increased parental stress, highlighting the importance of early interventions. We assessed an internet-based sleep education program for parents of children with autism spectrum disorder and conducted a reliminary examination of its potential to improve sleep quality and behavioral outcomes. Methods, Eighteen parent-child pairs participated in an internet-based sleep education program. Outcomes related to the program were assessed at three time points: baseline, 4 weeks post-intervention, and 10 weeks post-intervention. Key measures analyzed included sleep parameters, sleep habits, children’s behavioral problems, parental mental health, and parenting attitudes, using validated assessment tools. Results, At 4 weeks post-intervention, the program demonstrated a reduction in the time required for children to fall asleep, an enhancement in sleep efficiency, and an improvement in parental mental health. At 10 weeks post-intervention, improvements were also observed in children’s externalizing behavior problems. Parents reported increased confidence in managing their children’s sleep issues and noted a positive impact on family dynamics. Conclusion, The findings suggest that the internet-based sleep education program may be an effective and acceptable intervention for addressing sleep difficulties in children with autism spectrum disorder. This study contributes substantially to the existing literature, highlighting the potential for internet-based interventions to enhance sleep management strategies. This study was retrospectively registered with the jRCT on September 30, 2024 (jRCT1062240058
Epidural Anesthesia Is Effective in Lower-Extremity Burn Pain Treatment : A Case Report
No full textBurn wounds cause pain through various mechanisms, making pain management challenging. Although treatment and management strategies for healing burns have been developed, clear guidelines for analgesia in burn injuries are lacking. Opioids are commonly used for pain relief, but regional anesthesia performed by anesthesiologists has shown effectiveness in some cases. We encountered a case in which epidural anesthesia was effective for analgesia of a lower-extremity burn injury in a 19-year-old man. The patient with burn injuries to his lower extremities was transferred to the emergency department. On the day of the injury, an epidural catheter was administered for burn pain. The epidural anesthesia was removed during hospitalization, but the pain worsened, so it was placed again to provide adequate analgesia. In this case, epidural anesthesia proved effective for managing the lower-extremity burn pain and facilitated patient rehabilitation. Epidural anesthesia should be actively considered for the management of burn pain
A Case of Perioperative Management of Tongue Cancer Polycythemia Vera
No full textPolycythemia vera is a chronic myeloproliferative neoplasm characterized by a marked increase in circulating erythrocyte volume in middle-aged and elderly patients; it is associated with increased white blood cell and platelet counts and splenomegaly. There is a high risk of conflicting complications during surgical treatment, such as thrombosis and hemorrhage, with thrombosis being the leading cause of death. Hence, it is important to take measures against both in the perioperative management. We report a case of perioperative management of a patient with polycythemia vera and resection of an intraepithelial carcinoma of the tongue. The patient, a 46-year-old man, had been under observation at our hospital’s Department of Internal Medicine for 10 years with a diagnosis of polycythemia vera. He came to our department with a complaint of white spots on the left tongue margin. Phlebotomy was performed when his blood count, hemoglobin, and hematocrit levels were elevated. The biopsy showed intraepithelial carcinoma. Preoperative examination revealed no abnormality, and a partial left-sided tongue resection was performed under general anesthesia. To prevent thromboembolism, the patient wore an elastic stocking from the time he entered the operating room. The patient underwent local hemostasis to prevent bleeding and systemic management centered on infusion therapy to prevent blood concentration. Four years and three months have passed since the surgery without recurrence
