Archivio istituzionale della ricerca - Alma Mater Studiorum Università di Bologna
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White wine dealcoholization by osmotic distillation: An experimental study and impact on key quality parameters
Get PDFThis study aimed at investigating the impact of the osmotic distillation (OD) process parameters, including feed and stripping flow rates, on the removal of ethanol from white wine for the production of dealcoholized wine (0.5% v/v ethanol). The research evaluated the dealcoholization kinetics and ethanol mass transfer behavior using mathematical modeling, alongside investigating the impact of different ethanol levels on physico-chemical parameters, color profile and volatile composition of the wine. The results showed that without renewing the stripping solution, ethanol reduction stabilizes after several dealcoholization cycles due to an equilibrium between ethanol content in the feed and stripping side. However, renewing the stripping solution increased ethanol removal rates, facilitating the production of dealcoholized wine. Additionally, variations in feed and stripping flow rates without renewing the stripping solution, in the range of investigated values, did not significantly impact the ethanol removal rate. The total weight loss during the production of dealcoholized wine (0.5% v/v) was 20.7%. Partial dealcoholization (up to 4.6–5.0% v/v) showed minor changes in physico-chemical parameters of wine, while full dealcoholization at 0.5% v/v resulted in changes in acidity, pH, several non-volatile compounds and color of wine. The reduction in total volatile compounds showed a positive correlation (r = 0.93) with ethanol removal, in particular for the loss of esters (reduced by 89%), alcohols (78%), acids (86%), carbonyl compounds (96%) and volatile phenols (88%)
Nuova linfa per l’asse franco-tedesco?
No full textIl contributo colloca il voto tedesco del febbraio 2025 nell'orizzonte europeo e soprattutto dei rapporti franco-tedesch
Long-term survival can be achieved in a significant fraction of older patients with core binding factor acute myeloid leukemia treated with intensive chemotherapy
Get PDF: Acute myeloid leukemia (AML) is mainly a disease of the elderly: however, knowledge about the outcomes of treatment of core-binding factor (CBF) AML in an older population is limited. We retrospectively collected data on 229 patients with CBF-AML followed long-term in the last two decades. The 5-year overall survival was 44.2% (95% confidence interval [95% CI]: 39.9-47.5) and the 5-year event-free survival was 32.9% (95% CI: 25.5-40.1). In a subgroup of patients ≥70 years old who completed intensive therapy (induction + ≥3 courses of consolidation including autologous stem cell transplantation: 10 patients) the median event-free survival was 11.8 months (95% CI: 9.4-15.2) and overall survival was 40.0% (95% CI: 36.4- 44.1) at 5 years. In univariate analysis, age ≥70 years (hazard ratio [HR]=1.78, 95% CI: 1.15-2.54, P=0.008), failure to achieve remission following induction (HR=8.96, 95% CI: 5.5-13.8; P<0.0001), no consolidation therapy (HR=0.75, 95% CI: 0.47-1.84, P=0.04) and fewer than three cycles of consolidation (HR=1.48, 95% CI: 0.75-3.2; P=0.0004) predicted poorer event-free survival. Our study shows that intensive therapy, in selected older CBF-AML patients, leads to longer survival. Achieving a complete remission seems to be the most important first step and at least three cycles of consolidation, an important second one. The analysis suggests that these patients should not be excluded from studies with intensive therapies
L’attività della Soprintendenza archeologica della Soprintendenza per i Beni Culturali e ambientali di Ragusa
No full textThe economic crisis in the last few years did not arrest the activity of the Superintendence of
Cultural and Environmental Heritage of Ragusa which promptly replayed to the communities’
requests in order to enrich the cultural oπer and improve the use of the archaeological heritage.
And so it is that both small municipalities and private individuals oπered means and economic
resources for archaeological research which has been given increased depth by the the valuable
collaboration between Italian and foreign universities that operating in unison with the cultural
heritage protection o√ce of Ragusa. At the same time, thanks to specific focused projects, approved
and financed by the EU, it was possible to resume and deepen research in the archaeological
areas of Camarina, Cava d’Ispica and Parco Forza and improve their accessibility and
museum oπering. Finally, thanks to a widespread control activity of all public works and the
consequent preventive archeology practices requested by current laws, has been found important
evidences of the ancient population previously unknown
Directional Ring Translocation in a pH‐ and Redox‐Driven Tristable [2]Rotaxane
Get PDFWe describe the synthesis and characterization of a [2]rotaxane comprising a dibenzo-24-crown-8 (DB24C8) macrocyclic component and a thread containing three recognition sites: ammonium (AmH+), bipyridinium (Bpy2+) and triazolium (Trz+). AmH+ and Bpy2+ are responsive to fully orthogonal stimuli, pH and electrochemical, which allows to precisely control the directional translation of the macrocycle along the axle. A better understanding of the processes driving the operation of the system was obtained thanks to an in-depth thermodynamic characterization. Orthogonal stimuli responsive tristable rotaxanes represent the starting point for the creation of linear motors and the development of molecular logic gates
Luigi Ferdinando Marsili e la bevanda asiatica
Get PDFNel mondo moderno il caffè, ovvero la “bevanda asiatica” cui si fa riferimento nel titolo, simboleggia socialità, produttività e piacere. È un rituale quotidiano, un motore creativo per artisti e pensatori, un simbolo di status e convivialità. Dai caffè letterari alla pausa ufficio, rappresenta energia, introspezione e cultura, trasformandosi in un’icona del lavoro, del relax e dello stile di vita. Molti studi sono dedicati agli scritti di Luigi Ferdinando Marsili sul caffè. Quelli di taglio storico analizzano la “Bevanda asiatica” in quanto fonte documentale sui rapporti di scambi commerciali e culturali tra Occidente e Oriente alla fine del XVII secolo. Teatro di quegli eventi i Balcani, che costituivano la fascia di transizione tra i due mondi, tra loro in contrapposizione, ma anche in rapporto osmotico di scambio. Per ogni approfondimento si rimanda alla letteratura indicata in calce, limitandoci in questa sede a ripercorrere alcuni passi essenziali della “Bevanda asiatica”, rimarcando il ruolo fondamentale dell’acqua, senza cui nessun evento geologico e biologico potrebbe aver luogo
Spatial Cancer-Immune phenotypes predict shorter recurrence free survival in the NSMP molecular subtype of endometrial carcinoma
No full textCompartmentation of the immune response into 3 main spatial cancer-immune phenotypes (SCIs) - inflamed, excluded, and desert - has been proposed as the main predictor of response to immune checkpoint inhibitors in solid tumors. The objective of the study was to define and characterize the SCI in a consecutive series of 213 endometrial carcinomas (ECs) by correlating it with molecular subtypes, clinicopathologic features, and prognosis. Immunohistochemistry (IHC) and next-generation sequencing were used to assign surrogate molecular EC subtypes: POLE mutant (POLE), mismatch repair deficient (MMRd), TP53 mutant (p53abn), and no specific molecular profile (NSMP). Immune cell markers (CD20, CD3, CD8, CD68, PD-L1) were assessed by IHC on whole sections and quantified by digital image analysis to define the 3 SCIs. ECs were stratified into 4 molecular subtypes: 17 (8.0%) POLE, 68 (31.9%) MMRd, 42 (19.7%) p53abn, and 86 (40.4%) NSMP. SCI determination showed 105 (49.3%) inflamed, 62 (29.1%) desert, and 46 (25.6%) excluded tumors. The inflamed phenotype was more prevalent in MMRd (64.7%) and POLE (76.5%) subtypes compared with NSMP (45.3%) and p53abn (21.4%). SCI revealed a strong correlation with disease-free survival in NSMP tumors: inflamed 96.2%, desert 83.2%, and excluded 40.5%. The SCI prognostic impact was also maintained in NSMP cases treated with adjuvant therapy resulting in a significant difference in recurrence between the inflamed and excluded phenotypes. To simplify SCI determination, a subset of immune cell markers was selected as appropriate to define the 3 SCI patterns: high intraepithelial CD8 for the inflamed phenotype; CD68, CD20, and PD-L1 to discriminate between desert and excluded tumors. The integration of SCI into molecular classification could be a promising opportunity to improve the prognostic risk stratification of patients and may guide the therapeutic approach, particularly in the NSMP subtype. Thus, the different patterns of immune response are a new prognostic parameter in the NSMP subtype
Monitoring Theophylline and Caffeine Levels in Suspected Toxicity is a Good Tool for Physician
No full textTo the Editor. We have read with great interest the case of caffeine intoxication reported by Yoshimine et al., in which the theophylline level served as an indicator of treatment, and the caffeine level was measured. Based on our reading, we found that it is important to consider the clinical management of caffeine intoxication
EnBloc Resection of a Chordoma of the Thoracic Spine by “L”-Shaped Osteotomy for Spinal Canal Preservation
Get PDFBackground/Objectives: EnBloc resections of bone tumors of the spine are very demanding as the target to achieve a tumor-free margin specimen (sometimes impossible due to the extracompartimental tumor extension) is sometimes conflicting with the integrity of neurological functions and spine stability. Methods: The surgical treatment of a huge multi-level chordoma of the thoracic spine with unusual extension is reported. Anteriorly, the tumor widely invaded the mediastinum and displaced the aorta; on the left side, it expanded in the subpleuric region; posteriorly, it was uncommonly distant 13 mm from the posterior wall. Results: EnBloc resection is largely performed for primary bone tumors of the spine and many reports have been published concerning brilliant solutions to difficult issues of surgical anatomy. One of the major challenges is still the compatibility between oncological and functional requirements. Conclusions: Oncological staging, careful imaging analysis, a multidisciplinary surgical team, and utilization of the most recent technologies like navigation and robotics have made an oncologically appropriate EnBloc resection of a multi-level chordoma of the thoracic spine possible without affecting the continuity of the spinal canal and without any involvement of its content by an original “L”-shaped osteotomy