Archivio Istituzionale della Ricerca- Università del Piemonte Orientale
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Exploring the chemical space around Cannabis sativa L. leaves as a source of bioactive compounds of pharmaceutical interest
No full textObservation of the Singly Cabibbo Suppressed Decay D0 →b1 (1235)-e+νe and Evidence for D+ →b1 (1235)0e+νe
Full text linkDietary Terpenoid Lactones are Promiscuous Agonists of Bitter Taste Receptors (TAS2Rs)
No full textThe observation that a lactone ring is present in structurally distinct natural classes of sesquiterpenoid and diterpenoid activators of bitter receptor TAS2R46 provided a rationale to investigate the potency of a set of these natural products across the whole range of human bitter receptors. TAS2Rs are responsible for detecting bitter taste and, with some exceptions, are broadly tuned to recognize a wide range of compounds. The ectopical expression of TAS2Rs suggests additional role(s) beyond sensory perception, but no general bitter chemotype has emerged so far to inspire the design of a specific agonist. From our study, a complex pattern of TAS2Rs activation emerged, showing that the lactone pharmacophore is not specific for TAS2R46 but, depending on its framework, can also activate different sets of taste receptors. Taken together, our results expand the role of the lactone ring as a bitter chemotype and qualify dietary terpenoid lactones as excellent lead for the design of specific bitter receptors modulators
Evaluation of dECM hydrogel-NAP on 3D organotypic human corneal epithelium in diabetic keratopathy model
No full text
Witt on social role normativity and the paradox of self-creation
No full textCharlotte Witt contends that her externalist model of social role normativity, which
draws on Aristotle’s artisanal model, can explain the puzzling phenomenon of selfcreation,
while no internalist model of social role normativity can do the same. She
concludes from this that externalism on social role normativity is preferable to internalism,
all else being equal. In this contribution, I argue that the paradox of self-creation
does not break the tie between internalism and externalism, since both Kantian
and Hegelian internalists can resolve this paradox by offering explanations similar to
Witt’s, from an internalist perspective
N=2 universality at strong coupling
No full textWe present a detailed analysis of integrated correlators for an superconformal field theory on a squashed sphere with SU(N) gauge group and fundamental/anti-symmetric matter. Employing the matrix model arising from supersymmetric localisation, we compute derivatives of the partition function with respect to the fundamental mass (μ), the anti-symmetric mass (m) and the squashing parameter (b), corresponding to integrated insertions of the flavour-current and stress-tensor multiplets, which are holographically dual to gluon and graviton scatterings in the presence of D7-branes. For correlators dual to only graviton scatterings, we confirm the planar-limit equivalence with SYM. Our main result is a remarkable universality for the mixed gluon-graviton scattering amplitudes off D7-branes. We show that the leading and sub-leading large-N contributions in the strong-coupling regime are governed by universal asymptotic series, identical to those found for integrated giant-graviton correlators in SYM. We also propose an SL(2, Z)-invariant completion of these results in terms of non-holomorphic Eisenstein series. This completion provides exact constraints on higher-derivative terms in the dual AdS5 brane-string amplitudes and highlights an unexpected universality across distinct superconformal theories at strong coupling
The Role of Vitamin D in Autoimmune Diseases
Full text link: Vitamin D is a steroid hormone whose relevant immunomodulatory role has been widely described. Therefore, its contribution to the pathogenesis of immune-mediated diseases is an important and ongoing matter of research. Specifically, the active form of vitamin D, i.e., 1,25-dihydroxyvitamin D, through the interaction with its receptor, exerts different activities on the innate and adaptive immune system, among which are suppression of inflammation and promotion of tolerogenic responses. Indeed, vitamin D insufficiency/deficiency has been related to the pathogenesis and/or disease activity of several autoimmune diseases, including, amongst others, multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, and type 1 diabetes mellitus. Based on these premises, in this review, we will describe the main molecular mechanisms modulated by vitamin D in the regulation of immune responses, including the induction of immune tolerance. Moreover, we will focus on the current knowledge regarding the contribution of vitamin D depletion to the aforementioned autoimmune diseases, seeking to provide evidence as to why its supplementation in the context of these immune-mediated disorders may potentially ameliorate disease activity and its related clinical manifestations
