Archivio Istituzionale della Ricerca- Università del Piemonte Orientale
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The migration of a critically endangered damselfly calls for habitat-specific conservation actions
No full textEuropean Association of Urology Guidelines on Renal Cell Carcinoma: The 2025 Update
No full textBackground and objective: The European Association of Urology (EAU) renal cell carcinoma (RCC) guideline panel has updated their evidence-based guidelines and recommendations for the management of RCC. Here we present a summary of the 2025 RCC guidelines updated with standardised methodology to provide reproducible evidence for the management of RCC. Methods: For the 2025 update, a literature search was performed covering the period from May 1, 2023 to May 1, 2024 using the Medline, EMBASE, and Cochrane Libraries. The data search focused on meta-analyses, systematic reviews, randomised controlled trials (RCTs), and retrospective or controlled comparator-arm studies. Evidence was synthesised as outlined for all EAU guidelines. Key findings and limitations: Clinical practise recommendations were updated in all chapters of the RCC guidelines on the basis of a structured literature search. The studies included were predominantly retrospective with matched or unmatched cohorts based on single- or multi-institutional data. Several prospective studies and RCTs provided data that resulted in recommendations based on higher levels of evidence. Specifically, updates include new recommendations on stereotactic body radiotherapy for localised RCC, adjuvant therapy, systemic therapy for clear-cell RCC in later lines, other subtypes, and a new chapter on hereditary RCC. Conclusions and clinical implications: The 2025 RCC guidelines have been updated by a multidisciplinary panel of experts using methodological standards to provide a contemporary evidence base for the management of RCC
Re: Gedde et al: Special Commentary: Reporting clinical endpoints in studies of minimally invasive glaucoma surgery (Ophthalmology. 2025;132:141-153)
No full textVoices of the future: insights from a survey on radiology training experiences and needs
No full textTrajectory and predictors of psychological distress and posttraumatic growth among rectal cancer patients undergoing combined modality treatment: An exploratory prospective study
No full textObjective: This exploratory prospective cohort study aimed to investigate the trajectory of psychological distress and posttraumatic growth (PTG) in rectal cancer patients from diagnosis to follow-up and to explore factors that could predict PTG and psychological distress at follow-up. Method: We assessed psychological distress (anxiety and depression), PTG, physical symptoms, quality of life, cancer-related coping, state and trait affectivity, resilience, and alexithymia in 43 rectal cancer patients, M (SD) age: 61.6 (12.6); 67.4% men, after diagnosis (T0), after preoperative radiochemotherapy (T1), after surgical resection (T2), and 1 year after surgery (T3, follow-up). Results: Psychological distress, especially anxiety symptoms, showed a significant reduction between T0 and T1 (p <.001), which increased again between T1 and T2 (p =.048). PTG showed a progressive increase, with a significant increase between T2 and T3 (p <.001). The exploratory hierarchical multiple regression analyses showed that low positive state affectivity (p =.005) and high health anxiety (p =.007) at T1 and high negative state affectivity (p =.012) at T3 were significant predictors of psychological distress at follow-up. Higher levels of PTG at T1 (p <.001) and greater use of adaptive coping styles of Fighting Spirit at T0 (p =.009) and Fatalism at T1 (p =.031) were significant predictors of PTG at follow-up. Conclusions: The (fluctuating and linear, respectively) trajectories of psychological distress and PTG seem to be related to the psychological reactions to the different treatment phases, especially diagnosis and preoperative treatment. Data suggest the need to implement psychological screening and tailored support programs aimed at fostering PTG and reducing psychological distress from the earliest phases of cancer treatment
Gabriele d'Annunzio, La parabola dell'uomo ricco e del povero Lazaro. Edizione critica
No full textLa parabola dell’uomo ricco e del povero Lazaro è una delle tre riscritture evangeliche composte da Gabriele d’Annunzio tra il 1897 e il 1898 e incluse poi nelle Faville del maglio (1924). Il reperimento della minuta autografa, ricchissima di correzioni, consente di allestire l’edizione critica, qui oπerta seguendo i criteri filologici adottati dall’Edizione Nazionale delle Opere di Gabriele d’Annunzio.
L’edizione è preceduta da uno studio introduttivo nel quale si ricostruisce la genesi dell’opera, il cui manoscritto fu donato dall’autore al conte Giuseppe Primoli, protagonista della vita culturale e mondana di Roma e di Parigi durante la Belle époque. Vengono quindi illustrati lo stile con cui l’autore emula, a modo suo, quello della fonte evangelica (Luca 15,11-32) e le correzioni volte a perfezionarlo: come e più delle altre due parabole, d’Annunzio rovescia qui il messaggio evangelico, sostenendo le scelte del ricco epulone, dedito al lusso e alla lussuria, esponente estremo del superomismo edonista ed estetizzante ma anche di un sadismo nei confronti del quale l’autore pare mostrare una inquietante empatia
Aggression and sport: A cross-sectional study on behavioral tendencies of athletes
Get PDF: This cross-sectional study aimed to measure aggression in a more heterogeneous population of athletes, with the purpose of determining whether some specific conditions are related to aggressive behaviour. Athletes of 18-64 years old were enrolled in the study. The Italian version of Buss Perry Aggression Questionnaire (BPAQ) was self-administered. A total of 390 questionnaires were collected. Males showed higher levels of physical aggression (19.58 ± 6.32) than females (15.69 ± 6.65), p < 0.001 and a significant reduction in all domains of the questionnaire with advancing age, except for physical aggression. Furthermore, subjects who practiced full contact sports showed higher levels of physical aggression (20.23 ± 6.68) than those who practiced partial contact (17.89 ± 5.86) or non-contact sports (17.19 ± 6.64) p < 0.006. Finally, those who have played competitively in the past showed lower levels of anger (14.95 ± 5.22) than those who have played amateurishly (16.05 ± 5.54), p < 0.05. Age and gender appeared to be significant in aggression scores. Martial artists and combat sports players showed significantly higher levels of physical aggression than those who practice partial contact or non-contact sports. The type of sport (individual or team players), the practice time (beginners or experts) and the current level of sport (amateurs or competitive players) did not affect the aggression scores. Instead, the past level of sport participation is correlated with current anger
The Anti-Inflammatory, Immunomodulatory, and Pro-Autophagy Activities of Probiotics for Colorectal Cancer Prevention and Treatment: A Narrative Review
No full textColorectal cancer (CRC) is a major global health concern, particularly in Western countries where there is high consumption of processed food. Gut microbiota, intestinal inflammation, and autophagy play pivotal roles in CRC initiation and progression. Probiotics and probiotic metabolites (particularly short-chain fatty acids) have emerged as potential preventive and adjuvant therapeutics by restoring a balanced gut microbiota, dampening inflammation, stimulating immune response, and improving barrier integrity and intestinal epithelial homeostasis by modulating autophagy. This narrative review discusses the current evidence supporting the anti-inflammatory, immunomodulatory, and pro-autophagy effects of probiotics and their metabolites and explores their potential preventive and therapeutic applications in CRC management
Peripheral Blood Immune Cell Profiling as Predictive Biomarkers for Neoadjuvant Therapy Response in Early Breast Cancer Patients
No full textBackground: In breast cancer (BC), pathological complete response (pCR) to neoadjuvant therapy (NAT) improves survival. Escalated NATs aim to increase pCR, requiring predictive biomarkers. Tumor-induced T cell exhaustion and senescence impair anti-tumor immunity, but their role in NAT response is unclear. We assessed their potential as pCR biomarkers across BC subtypes. Methods: In this prospective study at Maggiore Hospital (Novara, Italy), blood samples from BC patients were collected before and after NAT. Circulating CD3+CD4+ and CD3+CD8+ T cells were profiled by flow cytometry for exhaustion markers (PD-1, LAG-3, TIGIT) and senescence markers (CD57, KLRG-1). Myeloid-derived suppressor cells (MDSCs) were also evaluated and classified into monocytic (M-MDSCs) and polymorphonuclear (PMN-MDSCs), the latter characterized by LOX-1 expression. Systemic inflammation indices (NLR, LMR) were calculated. Results: At baseline, ER+ tumors showed high NLR and exhausted CD8+PD-1+TIGIT+ cells; HER2+ tumors had more senescent CD8+CD57+KLRG-1+ cells. TN patients had elevated LMR. Lower NLR (OR=0.57, p=0.026) and higher LMR (OR=1.36, p=0.033) correlated with pCR. In HER2+ cases, fewer CD8+CD28−CD57−KLRG-1+ T cells were linked to better response (OR=0.68, p=0.029). Non-responders had higher NLR and more CD4+PD-1+TIGIT+ cells. ER+ non-responders showed increased exhausted and senescent CD4+ subsets. Post-NAT, HER2+ and TN patients displayed expansions in exhausted and senescent T cells. MDSC levels did not differ by pCR status but showed subtype-specific correlations: LOX-1+ PMN-MDSCs correlated with exhausted T cells in ER+, M-MDSCs with senescent T cells in HER2+, and inversely with LAG-3+ cells in TN. Conclusion: T cell exhaustion and senescence predict poor pCR in ER+ and HER2+ BC. Low NLR and high LMR correlate with better response. MDSCs may contribute to immune suppression via subtype-specific interactions with dysfunctional T cells