Archivio Istituzionale della Ricerca- Università del Piemonte Orientale
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    L'urobòro che dunque siamo

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    Innovative Use of Fostamatinib in Managing Refractory Immune Thrombocytopenia in an HIV ‐Positive Patient: A Case Report

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    : Managing immune thrombocytopenia (ITP) in HIV patients remains challenging due to refractory cases and treatment limitations. This report highlights fostamatinib as a safe, effective, and antiretroviral therapy-compatible option, offering durable platelet stabilization in a difficult-to-treat population

    Board gender diversity, spillover effects on managerial training and firm performance

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    This study provides the framework and the methodological premises for studying the relevance of board gender diversity in firms’ decisions to engage in managerial training and the ultimate effect on firm performance. Results will be based on a unique, manually compiled panel dataset of 12234 listed and non-listed Italian firms observed from 2010 to 2018: we expect that having more women on the board enhances the likelihood that firms invest in managerial education, especially for women, and that this leads to higher performance in terms of productivity. The paper will contribute to the evidence that board diversity matters to firm value by influencing the decision-making process and the accumulation of managerial human capital

    La caserma Perrone diventa sede universitaria

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    Study of and its higher moments, and extraction of the speed of sound in Pb-Pb collisions with ALICE

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    Ultrarelativistic heavy-ion collisions produce a state of hot and dense strongly interacting QCD matter called quark-gluon plasma (QGP). On an event-by-event basis, the volume of the QGP in ultracentral collisions is mostly constant, while its total entropy can vary significantly due to quantum fluctuations, leading to variations in the temperature of the system. Exploiting this unique feature of ultracentral collisions allows for the interpretation of the correlation of the mean transverse momentum (⟨pT⟩) of produced charged hadrons and the number of charged hadrons as a measure for the speed of sound, cs. This speed is related to the rate at which compression waves travel in the QGP and is determined by fitting the relative increase in ⟨pT⟩ with respect to the relative change in the average charged-particle density (⟨dNch/dη⟩) measured at mid-rapidity. This study reports the event-average ⟨pT⟩ of charged particles as well as the variance, skewness, and kurtosis of the event-by-event transverse momentum per charged particle ([pT]) distribution in ultracentral Pb-Pb collisions at a center-of-mass energy of 5.02 TeV per nucleon pair using the ALICE detector. Different centrality estimators based on charged-particle multiplicity or the transverse energy of the event are used to select ultracentral collisions. By ensuring a pseudorapidity gap between the region used to define the centrality and the region used to perform the measurement, the influence of biases and their potential effects on the rise of the mean transverse momentum is tested. The measured c2 s is found to strongly depend on the exploited centrality estimator and ranges between 0.1146±0.0028 (stat.)±0.0065 (syst.) and 0.4374±0.0006 (stat.)±0.0184 (syst.) JHEP11(2025)076in natural units. The self-normalized variance shows a steep decrease towards ultracentral collisions, while the self-normalized skewness variables show a maximum, followed by a fast decrease. These non-Gaussian features are understood in terms of the vanishing of the impact-parameter fluctuations contributing to the event-to-event [pT] distribution

    L’INTRECCIO E LA SUCCESSIONE DELLE POSIZIONI DI GARANZIA NEL DIRITTO PENALE

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    Le catastrofi e i c.d. disastri tecnologici non sono quasi mai frutto dell’‘agire’ dell’individuo, bensì di un ‘agire organizzato’ difettoso. Penetrare nelle organizzazioni complesse per ricostruire la causa di un evento massivo e ascrivere quote di responsabilità penale è un’attività delicata, esposta al rischio di trasformare i singoli individui in altrettanti capri espiatori. Il volume sviluppa un’analisi critica delle tesi dottrinali e degli orientamenti giurisprudenziali che hanno provato ad allocare le responsabilità individuali attraverso l’istituto della posizione di garanzia, riguardata nelle sue diverse e più note manifestazioni. È il caso, per esempio, della delega di funzioni o della successione tra garanti. Gli intrecci sincronici e diacronici tra soggetti deputati a proteggere beni giuridici, o a controllare fonti di rischio, possono raggiungere oggi, in determinati contesti produttivi, un’elevata articolazione di livelli di interazione. Essa richiede di comprendere se, a quali condizioni e con quali ripercussioni applicative possa attribuirsi rilievo all’errore organizzativo nella genesi del macro-evento di danno, anche al fine di escludere o mitigare la responsabilità delle persone fisiche “ingranaggi della macchina”. Sono quesiti ai quali l’autore fornisce risposta sia sul piano interpretativo, sia in una prospettiva progettuale volta a suggerire correttivi alla legislazione in vigore

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