Archivio Istituzionale della Ricerca- Università del Piemonte Orientale
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    Les voies de la désobéissance: la ligne ferroviaire Lyon-Turin et le cas du mouvement No Tav

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    Il saggio prende in considerazione la vicenda del movimento No Tav e la mette in relazione alla teoria della disobbedienza civile, giungendo alla conclusione che essa non sia compatibile con la forma dello Stato costituzionale di diritt

    Integration of [18F]FDG-PET radiomics with liquid biopsy improves outcome prediction in newly diagnosed diffuse large B-cell lymphoma

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    Early identification of relapsing/refractory diffuse large B-cell lymphoma (DLBCL) represents an unmet clinical need. A real-life cohort of newly diagnosed DLBCL (n = 120) treated with R-CHOP was investigated. Using the standardized uptake value (SUV) threshold of 4.0, PET/CT radiomics variables (SUVmax, tMTV, tTLG and Dmax) were collected. Circulating tumor DNA (ctDNA) analysis by CAPP-seq yielded baseline ctDNA levels and LymphGen molecular clustering. The best cut-off for both PET/CT parameters and ctDNA levels were identified by max-stat statistics. tMTV, tTLG and Dmax retained independent prognostic value when adjusted for ctDNA levels and were grouped together in a variable named high-risk PET. By multivariate analysis, ctDNA-high and high-risk PET independently predicted PFS and were combined into a 2-factor prognostic model (C-indices: 0.712 for PFS and 0.696 for OS). Molecular clustering, by capturing high-risk biological features of DLBCL, further improved outcome prediction. Consistently, BN2/EZB/ST2 clusters maintained an independent association with better PFS when adjusted for the 2-factor model variables and were therefore included in a 3-factor prognostic score (C-indices: 0.745 for PFS and 0.746 for OS), that identified a very high-risk group of patients (n = 22, 40-month PFS 12.1%) which should be prioritized for early response evaluation and for access to novel agents

    The Global Health and Forensic Dimensions of Conflict-Related Sexual Violence: An In-depth Investigation on Its Health Impacts

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    Conflict-related sexual violence (CRSV) is a form of gender-based violence (GBV), a human rights violation and a public health concern, disproportionately affecting women and marginalized individuals with intersectional identities. While traditionally viewed as a weapon of war, CRSV is now understood in broader terms, involving both armed forces and civilians, and not only as a strategy by troops but also as opportunistic violence in conflict environments. This study investigates the health consequences of CRSV using a biopsychosocial approach, integrating frameworks on access to care, and a survivor-centered, human rights-based perspective incorporating sexual and reproductive health and rights (SRHR). It addresses four key areas: physical, mental, and social health outcomes; barriers to accessing care; documentation of CRSV sequelae during forensic examinations; and survivors' descriptions of the violence they endured. The study involved two literature reviews and a qualitative study. Results show CRSV causes significant physical, psychological, and social health impacts, including pregnancy, PTSD, fear, and stigma. The connection between CRSV and SRHR is evident, particularly in sexual health consequences, self-stigma, and relationship impacts. Barriers to access to care were institutional and social, with gender-specific challenges. Forensic medical examinations rarely documented CRSV-specific sequelae. At access to care, survivors described various forms of abuse, including those encountered during migration. This research highlights the need for further investigation into the social consequences of CRSV, the experiences of cisgender men and transgender individuals, and the documentation of abuses in transit countries like Libya. It also underscores the importance of addressing care access for marginalized populations and understanding survivors' coping strategies

    Exploring the impact of EU funding on the local governance of migrant integration: the rise of project-driven governance

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    This article explores the consequences of project-based EU funding schemes for the local governance of migrant integration. In doing so, it also sheds light on some under-researched aspects of local integration governance, such as its financial and temporal dimensions and the importance of actors’ ability to develop shared action plans and attract resources to implement them. With these aims, the article bridges migration studies and the literature on the projectification of public policies, and offers fresh empirical insights into the local governance of unaccompanied minor integration in two Italian localities. To account for the observed processes, it proposes a specific type of governance, ‘project-driven governance’, which is characterised by three features: dependence on funding opportunities; a key role of ‘project entrepreneurs’, namely actors who are able to exploit these opportunities by turning their ideas into viable projects; and instability over time

    Participatory Approaches to Landscape Management in Urban Contexts: Insights from the European Landscape Convention and Bottom-Up Experiences in Rome

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    The article explores the application of the principles of the European Landscape Convention in urban contexts, with particular focus on participatory approaches such as shared mapping, community workshops, and educational activities. It highlights the central role of public involvement in the enhancement and protection of the landscape, through the creation of shared spaces and cultural pathways that promote sustainable management. The active participation of communities is essential to ensure long-lasting protection and conscious use of the landscape. Specific cases of the city of Rome (in the Appia Antica Park) will be examined, where concrete bottom-up experiences are taking place, aiming to understand how these can translate into new forms of governance for urban territories

    Leggere “Curare il mondo con Simone Weil” di Tommaso Greco con le lenti del diritto costituzionale (e una riflessione sulla burocrazia universitaria)

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    L'autrice legge il libro di Tommaso Greco, Curare il mondo con Simone Weil, indossando le lenti del diritto costituzionale, per cercare insieme a lui le risposte di Simone Weil ad alcune delle grandi questioni della riflessione gius-pubblicistica e comprendere che ruolo possono avere il diritto, le regole, le istituzioni nella cura del mondo

    Measurement of ω meson production in pp and p-Pb collisions at sqrt(sNN) = 5.02 TeV

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    We present the measurement of the pT-differential production cross section of ω mesons in pp and p-Pb collisions at √ sNN = 5.02 TeV at midrapidity by ALICE. In addition, the first measurement of the nuclear modification factor RpPb for ω mesons at LHC energies is presented, complementing the existing measurements of lighter neutral mesons such as the π0 and η.Within the measured pT range, the RpPb of ω mesons is compatible with no cold nuclear matter effects within the uncertainties, consistent with previous measurements at lower energies. The ω/π0 ratio is presented for both collision systems, showing no collision system dependence within the uncertainties. The comparison to previously published ω/π0 ratios at lower and higher collision energies in pp collisions suggests a decreasing trend of the ratio above pT = 4 GeV/c with increasing collision energy. The data in both collision systems are compared to predictions from PYTHIA 8, EPOS LHC, and DPMJET event generators, revealing significant shortcomings in these models’ ability to describe the production of ω mesons

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