Archivio Istituzionale della Ricerca- Università del Piemonte Orientale
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Diego Angeli tra arte e letteratura
No full textAtti della Giornata di studi dedicata a Diego Angeli, (Roma, Fondazione Primoli, 22 novembre 2023), organizzata in collaborazione con l’Università del Piemonte Orientale e con la Sovrintendenza Capitolina ai Beni Culturali
Natterin-like and legumain insect gut proteins promote the multiplication of a vector-borne bacterial plant pathogen
No full textPhytoplasmas are phloem-limited plant pathogenic bacteria causing diseases in many plant species. They are transmitted by Hemipteran insect species in a persistent-propagative manner. Phytoplasmas are wall-less, and their membrane proteins are involved in pathogen internalization into host cells. We focused on the immunodominant membrane protein (Imp) of Flavescence dorée phytoplasma (FDp), a grapevine quarantine pest and a major threat to European viticulture. Scaphoideus titanus is the main natural vector of FDp to grapevine, whereas Euscelidius variegatus is commonly used as laboratory vector. Previous works indicated that recombinant Imp of two FDp strains (FD-C and FD-D) selectively interact with gut proteins from vector species rather than those from non-vectors. Here, similar patterns of interacting insect gut proteins were obtained from both vector species, following pull-down with His-tagged FDp Imps. After identification of several targets, four S. titanus and five E. variegatus proteins interacting with Imp were further characterized by measuring expression in different insect tissues and in healthy vs. infected insects. Specific RNAi silencing of two of these vector genes, namely natterin and legumain, resulted in a significant reduction of phytoplasma multiplication in insects upon pathogen acquisition, compared to control insects. Natterin displays a DM9 domain and legumain possesses a signature of G protein receptor, supporting their involvement as FDp Imp receptors. Outcomes of this work are discussed with particular attention devoted to the gain of knowledge on host/pathogen interaction as well as to the potential impact on improvement phytoplasma disease management
The Role of Bronchoalveolar Lavage in Therapeutic Antimicrobial Choices for Hematologic Patients with Pulmonary Infiltrates
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Pharmacogenetics of opioid medications for relief of labor pain and post-cesarean pain: a systematic review and meta-analysis
Full text linkObjective: Several studies have attempted to identify genetic determinants of clinical response to opioids administered during labor or after cesarean section. However, their results were often contrasting. A systematic review and meta-analysis was conducted to quantitatively assess the association between gene polymorphisms and clinical outcomes of opioid administration in the treatment of labor pain and post-cesarean pain. Methods: A comprehensive search was performed up to December 2023 using PubMed, Web of Knowledge, Cochrane Library, and OpenGrey databases. The clinical endpoints of interest were pain score after opioid treatment, total opioid consumption, patient’s analgesic satisfaction, and incidence of opioid side effects. Random-effects meta-analyses were conducted when data were available in at least three studies. Results: Twenty-six studies enrolling 7765 patients were included in the systematic review. Overall, a total of 12 candidate polymorphic genes (OPRM1, COMT, CYP2D6, CYP3A4, ABCB1, ABCC3, UGT2B7, CGRP, OPRK1, OPRD1, KCNJ6, KCNJ9) were considered by the included studies, among which the most investigated variant was OPRM1 rs1799971. Overall pooled results indicated that individuals carrying the G allele of OPRM1 rs1799971 required higher opioid doses for pain management in comparison to rs1799971 AA subjects (standardized mean difference: 0.26; 95% CI: 0.09–0.44; P = 0.003). Such an association was confirmed in the subgroups of patients with labor pain and post-cesarean pain. Conclusion: The present meta-analysis provides strong evidence of an association between OPRM1 rs1799971 and opioid dose requirement for relief of labor pain or post-cesarean pain. However, given the insufficient evidence for other polymorphic gene variants, large studies are still needed to investigate the impact of genetic variability on the efficacy and safety of opioid medications for relief of labor pain and post-cesarean pain (INPLASY Registration No. 202410040)
What workers and robots do: An activity-based analysis of the impact of robotization on changes in local employment
Full text linkThis work investigates the impact that changes in the local exposure to robots had on changes in Italian employment over the period 2011–2018. It contributes to the debate by providing novel and granular evidence on the impact of robot adoption on new activity-based groups of occupations and by focusing on the overlap between the functional similarities of robot applications and occupations. This framework, consistently centered on workers’ and robots’ activities, reveals highly heterogeneous effects of robotization, ranging from positive to negative across different groups of occupations, thereby supporting a nuanced and granular reading of this debated phenomenon. In particular, the local share of robot operators increases where the increase in robot adoption is larger, while the local share of workers using intensively their torso decreases
Spectral convergence analysis for the Reissner-Mindlin system in any dimension
Full text linkWe establish the convergence of the resolvent of the Reissner-Mindlin system in any dimension N≥2, with any of the physically relevant boundary conditions, to the resolvent of the biharmonic operator with suitably defined boundary conditions in the vanishing thickness limit. Moreover, given a thin domain Ωδ in RN with 1≤
Las piezas mancomunadas como subgénero del teatro cortesano: el ejemplo del corpus moretiano
Full text linkEl análisis de un par de piezas del corpus moretiano de comedias escritas en colaboración, es decir La renegada de Valladolid (Moreto, Belmonte y Martínez de Meneses) y Oponerse a las estrellas (Matos Fragoso, Martínez de Meneses y Moreto) ha puesto de relieve una notable cortesanización del texto, en relación con las situaciones dramatizadas, las secuencias estáticas y refinadas de las cuestiones de amor, las acotaciones muy detalladas y la risa discreta del gracioso con alusiones tópicas en el ambiente palaciego. Tampoco faltan referencias a espacios del recreo palaciego. En el presente trabajo, que se centra en las demás obras de dicho corpus, se intenta sacar conclusiones generales que llevarían a considerar las comedias de consuno como un subtipo del teatro cortesan