Archivio Istituzionale della Ricerca- Università degli Studi di Foggia
Not a member yet
55976 research outputs found
Sort by
Comparing STRATIFY JCVTM DxSelectTM and IMMUNOWELLTM JCV IgG Tests in RRMS to Assess PML Risk
No full textBackground: The risk of developing progressive multifocal leukoencephalopathy (PML), a rare but potentially fatal opportunistic infection of the Central Nervous System caused by the J.C. virus (JCV), remains a primary concern associated with natalizumab therapy in the clinical management of patients diagnosed with multiple sclerosis (MS).
Materials and methods: This study compared two tests, STRATIFY JCVTM DxSelectTM, and IMMUNOWELL TM JCV IgG, for assessing the risk of PML in patients diagnosed with relapsingremitting multiple sclerosis (RRMS) who had received disease-modifying therapy (DMT) with branded natalizumab (Tysabri®). The main objective was to determine the comparability of these tests in classifying PML risk. Eligible patients were selected from a database, and all specimens for the STRATIFY JCVTM DxSelectTM and IMMUNOWELLTM JCV IgG tests were collected on the same day. Patients were classified into three risk categories (low, intermediate, or high) based on threshold values for each test.
Results: The analysis showed 85.5% agreement between the two tests for risk classification. Ten discordant cases were identified, mainly between intermediate- and high-risk categories. Compared to STRATIFY JCVTM DxSelectTM, IMMUNOWELLTM tended to categorize more patients as higher risk. No significant association was found between discordance and prior use of immunosuppressant drugs and >24 doses of natalizumab. The agreement between tests, assessed with the weighted Kappa coefficient, was moderate (κ=0.6222).
Conclusions: Compared to the STRATIFY JCVTM DxSelectTM, the IMMUNOWELLTM JCV test tends to place more patients in higher risk categories. Further, longitudinal studies are needed to evaluate the clinical impact of these differences in PML risk assessment
Quantum algorithms and complexity in healthcare applications: a systematic review with machine learning-optimized analysis
No full textInterconnessioni adriatiche bassomedievali: Simeon raguseus incola tranensis
No full textThis study explores the artistic connections between Apulia and Dalmatia in the 13th century, focusing on the portal of the Church of Sant’Andrea in Barletta. This portal bears the signature of a Dalmatian artist, Simeon Raguseus, who was based in the nearby city of Trani. It is a highly heterogeneous structure, later reassembled in what is likely a 14th-century architectural setting.
The research examines the figurative sources and stylistic characteristics of the sculptures to better understand the artistic environment in which Simeon operated. At the time, the coastal cities north of Bari served as dynamic creative hubs where generations of sculptors and stonecutters enriched and renewed architectural works by adding portals, canopies, decorated windows, and new liturgical furnishings.
The portal under investigation offers valuable insight into the artistic exchanges that intensified in the second half of the 13th century, linking the construction sites of the Dalmatian coast with those of peninsular Apulia
Concomitant medications in patients with metastatic urothelial carcinoma receiving enfortumab vedotin: real-world data from the ARON-2EV study
No full textPatients with metastatic urothelial carcinoma (mUC) are typically elderly and often have other comorbidities that require the use of concomitant medications. In our study we evaluated the association of concomitant use of antibiotics (ATBs), proton pump inhibitors (PPIs), corticosteroids, statins, metformin and insulin with patient outcomes and we validated the prognostic role of a concomitant drug score in mUC patients treated with enfortumab vedotin (EV) monotherapy. Data from 436 patients enrolled in the ARON-2EV retrospective study were analyzed according to the concomitant medications used at baseline. Finally, the patients were stratified into three risk groups according to the concomitant drug score based on ATBs, corticosteroids and PPIs. Statistical analysis involved Fisher exact test, Kaplan–Meier method, log-rank test, and univariate/multivariate Cox proportional hazard regression models. Inferior survival outcomes were observed in ATB users compared to non-users (OS: 7.3 months, 95%CI 5.0 − 12.3 vs 13.7 months, 95%CI 12.2 − 47.3, p = 0.001; PFS: 5.1 months 95%CI 3.3 − 17.7 vs 8.3 months, 95%CI 7.1 − 47.3, p = 0.001) and also in corticosteroid users compared to non-users (OS: 8.4 months, 95%CI 6.6 − 10.0 vs 14.2 months, 95%CI 12.7 − 47.3, p < 0.001; PFS: 6.0 months 95%CI 4.6 − 7.9 vs 8.9 months, 95%CI 7.2 − 47.3, p = 0.004). In the Cox multivariate analysis, the concomitant drug score was a significant factor predicting both OS (HR = 1.32 [95% CI 1.03 − 1.68], p = 0.026) and PFS (HR = 1.23 [95% CI 1.01 − 1.51], p = 0.044). Our findings suggest detrimental impact of concomitant use of ATBs and corticosteroids on survival outcomes and the prognostic utility of the concomitant drug score in previously treated mUC patients receiving EV
Tumor–Stroma Ratio in Head and Neck Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis
No full textBackground: Tumor-stroma ratio (TSR) has been recognized as a significant prognostic factor in various cancers. This systematic review evaluates the role of TSR in head and neck squamous cell carcinoma (HNSCC) and its association with patient outcomes such as overall survival (OS), disease-free survival (DFS), disease-specific survival (DSS), and lymph node metastasis (LNM). Methods: A comprehensive search was conducted across Scopus, Embase, PubMed, and Web of Science. Nineteen studies were included. Data extraction and quality assessment were performed progressively, with meta-analyses. All studies assessed TSR using hematoxylin and eosin staining of tissue samples. The meta-analyses focused on the impact of TSR on OS, DFS, DSS, and LNM, providing pooled hazard ratios (HRs) and odds ratios (ORs) with corresponding confidence intervals (CIs). Results: Meta-analysis revealed a significant association between TSR and OS (HR 1.99, 95% CI 1.71–2.32, p < 0.001), DFS (HR 2.07, 95% CI 1.80–2.39, p < 0.001), DSS (HR 2.33, 95% CI 1.95–2.78, p < 0.001), and LNM (OR 1.76, 95% CI 1.15–2.70, p = 0.01). Minimal to low heterogeneity was detected among studies, and no publication bias was observed. Conclusions: TSR can effectively identify high-risk patients, being a reliable prognostic marker that could be readily integrated into routine pathology practice for HNSCC
Manuale di diritto tributario. Attività conoscitiva e accertamento dei tributi.
No full textIl Manuale si propone di esporre in forma sistematica i principi che regolano le tre fasi principali dell’attività di accertamento, costituite (i) dalla raccolta dei dati e delle informazioni necessarie (secondo le diverse modalità disciplinari in cui tale fase si articola anche a livello internazionale e unionale); (ii) dal controllo e dalla rettifica, cioè l’impiego delle conoscenze acquisite nella prima fase per determinare la misura dell’imposta effettivamente dovuta; (iii) dalla formazione degli atti eventualmente conseguenti all’attività di controllo e rettifica. L’analisi di tale disciplina, oltre ad evidenziare le connessioni logiche, giuridiche e funzionali fra queste fasi, si soffermerà sugli eventuali profili di invalidità, tenuto conto della riforma tributaria, e sul sistema delle tutele
LE RECENTI RIFORME IN MATERIA DI INTERCETTAZIONI: ALCUNE CRITICITÀ E QUALCHE PROSPETTIVA
No full textNell’ultimo biennio, il legislatore ha emanato una serie di provvedimenti volti a rafforzare le esigenze di segretezza delle comunicazioni, soprattutto in rapporto a fatti processualmente irrilevanti o che coinvolgono terzi estranei al procedimento. Se è indiscutibilmente pregevole l’intento che anima le singole riforme, il risultato non è del tutto soddisfacente, mancando un disegno organico al quale ricollegare le modifiche che appaiono piuttosto episodiche e pressoché casuali. Al di là del contenuto delle novelle, l’occasione è utile per riflettere sulle peculiarità che connotano la produzione normativa dell’ultimo tempo: da un lato, si assiste ad un’ipertrofia legislativa su questioni che potrebbero essere risolte in via interpretativa, dall’altro, si nota l’assenza di riforme su aspetti che, per converso, necessitano di una tipizzazione disciplinare.In the last two years, a series of measures aimed at strengthening the requirements of secrecy of communications and confidentiality, especially in relation to procedural facts which are irrelevant or involving third parties unrelated to the proceedings. If the value of the intent that animates the individual reforms is indisputable, the product is not entirely satisfactory, lacking an organic plan to which to reconnect single changes which appear rather episodic and almost random. The occasion is useful to reflect on the undeniable paradox that characterizes recent times: on the one hand, we are witnessing legislative hypertrophy on issues that could be resolved through interpretation, on the other, we note the absence of reforms on aspects which, conversely, require regulatory stabilization
Sex-related differences in systemic inflammatory response and outcomes after cardiac surgery and cardiopulmonary bypass
No full textObjectives: Differences in inflammatory responses between men and women may contribute to sex disparities in cardiac surgery outcomes. We investigated how sex differences influence systemic inflammatory response syndrome (SIRS) and adverse outcomes after cardiac surgery. Methods: A single-centre retrospective cohort study of patients undergoing cardiac surgery from 2018 to 2020 was performed. SIRS was defined as per the American College of Chest Physicians/Society of Critical Care Medicine. Predictors of SIRS and composite adverse outcomes (death, transient ischaemic attack/stroke, renal therapy, bleeding, postcardiotomy mechanical circulatory support, prolonged Intensive Care Unit stay) were evaluated using multivariable logistic regression. Mediation effects of SIRS were assessed using structural equation modelling. Results: The cohort included 1005 patients, of whom 299 (29.8%) were women. SIRS occurred in 28.1% of patients, and 12.7% experienced the composite end point. Female sex was significantly associated with SIRS (odds ratio 1.56; 95% confidence interval 1.12-2.18, P = 0.009) and the composite outcome (odds ratio 1.72; 95% confidence interval 1.10-2.69, P = 0.017). Baseline left ventricular dysfunction and intraoperative hyperlactatemia were additional common predictors. SIRS mediated 50.8% of the effect of female sex, 17.0% of left ventricular dysfunction and 30.9% of intraoperative hyperlactatemia on the composite outcome. Conclusions: Female sex is independently associated with postoperative SIRS and poorer outcomes. Systemic inflammation, preoperative anaemia and procedural hyperlactatemia are potentially modifiable factors in the mechanisms through which female sex appears to worsen outcome after cardiac surgery
La scuola del 'riuso' e del 'materiale povero' di Rosa e Carolina Agazzi. tra sostenibilità ambientale e transizione culturale
No full textIl contributo approfondisce le ricadute pedagogiche della proposta didattica di Rosa e
Carolina Agazzi, con particolare riferimento ai principi alla base del metodo maggiormente in linea con il Piano RiGenerazione Scuola, attuativo degli obiettivi dell’Agenda
2030 dell’Organizzazione delle Nazioni Unite, promosso dal Ministero dell’Istruzione a
partire dal 2021 e progettato per accompagnare le scuole nell’attuazione di interventi
di formazione allo sviluppo sostenibile. Centrale, nella proposta agazziana, il modello di
scuola del ‘riuso’ e del ‘materiale povero’, oggi riattualizzabile, soprattutto nell’ambito
dei percorsi scolastici di transizione ecologica e culturale