Archivio Istituzionale della Ricerca- Università degli Studi di Foggia
Not a member yet
55976 research outputs found
Sort by
Global Andrology Forum Clinical Guidelines on Antioxidant Use in the Treatment of Male Infertility
No full textPurpose: Antioxidant (AOX) therapy has long been investigated for the management of male infertility. It has potential benefits, but persistent controversy affects its broad acceptance and clinical utility. This study aimed to develop standardized, evidence-based guidelines for AOX use by synthesizing the best available evidence and achieving global expert consensus.
Materials and methods: A comprehensive literature review was conducted by senior experts of the Global Andrology Forum (GAF). Additionally, data on the real-life use of oxidative stress (OS) testing and AOX use obtained from the largest global survey of practicing physicians conducted by GAF, which served as a reference point for this study. In phase one, 151 international specialists (>5 years' experience) participated in a modified Delphi process to evaluate AOX therapy in male infertility. Experts reviewed draft statements and rated agreement on a 10-point Likert scale. Statements achieving >80% consensus (with score >7/10) were accepted. The original eight statements were expanded to 19 and finalized into 18. In phase two, 84 senior physicians (>10 years' experience) graded the Delphi-approved statements using the GRADE approach.
Results: Four out of the 18 statements failed to reach consensus and were excluded. Of the final 14 statements, seven (50%) were graded as "Strong" and seven (50%) as "Weak." Current evidence indicates that AOX therapy can reduce OS, improve sperm quality, and potentially enhance reproductive outcomes. However, benefits vary by agent, regimen, and patient population. The guidelines emphasize the need to document OS and to consider underlying factors before initiating AOX therapy, and caution against indiscriminate or prolonged use.
Conclusions: Developed through a dual-validation process and endorsed by a globally diverse expert panel, these GAF guidelines represent the first standardized, evidence-based guidelines for AOX use in male infertility. By addressing heterogeneity in research and practice, they provide clinicians with practical, safe, and patient-centered recommendations for rational AOX therapy worldwide
La responsabilità dei beneciari per i debiti tributari di un trust cessato
No full textI debiti tributari facenti capo ad un trust cessato si trasferiscono ai beneficiari in ragione del naturale perfezionamento di una fattispecie a formazione progressiva, che vede costoro divenire titolari dei rapporti attivi e passivi in precedenza imputati al trust, senza che ciò possa configurare un fenomeno successorio, affinchéne alla successione mortis causa di diritto civile. Il trasferimento dell’asse ereditario agli eredi presuppone, al contrario, l’accettazione di costoro, espressa o tacita, quale atto giuridico unilaterale e a contenuto negoziale, che giustifica la confusione delle masse patrimoniali
Angiotensin Receptor and Neprilysin Inhibitors in CKD
No full text: Combined inhibition of neprilysin and the angiotensin II receptor through Angiotensin Receptor-Neprilysin inhibitors (ARNI) has transformed heart failure management and is garnering increasing attention in nephrology. This article explores the renal role of neprilysin and critically reviews preclinical and clinical evidence on the use of ARNIs in CKD, following a "bench to bedside" approach. Experimental data show that neprilysin inhibition improves proteinuria, fibrosis, and endothelial function, with enhanced benefits when combined with RAAS blockade. Randomized Clinical Trials (RCTs) in Heart Failure patients (PARADIGM-HF, PARAGON-HF, PARAGLIDE-HF) have demonstrated renal safety and potential benefit emerged in secondary endpoints and prespecified analysis. The only RCT performed with primary kidney outcome, the UK HARP-III trial, confirmed the tolerability of Sac/Val, and reported a significant reduction in proteinuria. No clear nephroprotective effect was observed; however, the trial design may not have been adequately structured to detect such an effect. On the other hand, real-world data indicate that ARNIs have an acceptable risk profile when patients are appropriately monitored, as Renin-Angiotensin-Aldosterone System blockers. Moreover, the benefits of the treatment clearly outweigh the adverse effects. Therefore, Sac/Val may emerge as a promising therapeutic option in nephrology, especially in patients with cardiorenal disease, pending further trials to better define its role in CKD
The Implications of Advanced Technology Adoption in Healthcare Organizations on Workforce Dynamics
No full textDiversity of specialized metabolites in Phaeoacremonium species revealed by untargeted metabolomics and bioactivity assays
No full textFungi belonging to the genus Phaeoacremonium are recognized as cross-kingdom pathogens, that affect both agricultural crops and human health. Here, we report the first comprehensive large-scale chemotaxonomic study based on untargeted MS-based metabolomics of 28 isolates representing 24 Phaeoacremonium species. The chemometric analysis was integrated with in vitro toxicity on human keratinocytes and cucumber (Cucumis sativus) cotyledons, serving as representative models for human and plant hosts, respectively. A targeted LC-MS/MS method validated the production of the naphthoquinones scytalone and isosclerone, previously associated with grapevine trunk diseases, but revealed high interspecific variability in their abundance. Chemometric analysis revealed that cultures of Phaeoacremonium species can be distinguished based on their chemical fingerprints. In total, 206 significant metabolic features were uncovered, spanning several chemical classes including prenol lipids, carboxylic acid derivatives, organooxygen compounds, and macrolides. Nevertheless, 36 metabolites were putatively identified. Under our experimental conditions, scytalone and isosclerone showed negligible cytotoxicity and only mild phytotoxicity. In contrast, several crude extracts gave strong toxic effects, suggesting that activity may depend on complex metabolite interactions rather than single compounds. Notably, extracts from grapevine-associated species displayed stronger phytotoxicity and cytotoxicity compared to those from olive or human sources, highlighting a more diverse or more potent array of bioactive metabolites. Together, these results expand the known chemical space of Phaeoacremonium and underscore the need for targeted in vivo studies to elucidate the ecological roles and potential health implications of their secondary metabolites
Su taluni profili del rapporto tra disinformazione, guerra e diritto internazionale
No full textThe paper examines the relationship between disinformation, war, and international law. It highlights how digital technologies have transformed the production and dissemination of false or manipulated content. After distinguishing between misinformation, disinformation, and malinformation, the paper analyzes the impact of these phenomena on freedom of opinion and expression online in the context of international human rights law and the principle of technological neutrality. Then, the paper reconstructs the obligations of states in combating disinformation, including limitations from conventional instruments that are often overlooked. Particular attention is given to international humanitarian law, which permits stratagems of war but prohibits perfidy; however, it currently offers insufficient protection for civilians exposed to digital forms of information manipulation. Finally, the paper proposes possible international remedies—rectification, reply, and counter-propaganda—and identifies proportionality and the concrete effects of information practices as decisive criteria for assessing their lawfulness
Manufacturing of self-support thin structures with extrusion and sinter-based technology
No full textLevitas. Lessico stereotipi di genere e teoria dei generi letterari in Roma antica (e oltre)
No full textIn Vitro Assessment of Gut Microbiota Modulation Through Functional Biscuits Enriched with Almond By-Products
No full textA Biblio-Ecological Study on Sustainable Land Planning Research: Evidence from Machine Learning Methods
No full textSustainable land planning (SLP) plays a vital role in addressing the ecological, social, and economic pressures of urbanization, land degradation, and climate change. As global interest in land-use governance grows, there is a need to clarify the conceptual structure of SLP and its evolving policy relevance. This study analyzes 4,883 publications indexed in Scopus from 2021 to 2024 using a mixed-method bibliometric approach. Ensemble community detection on keyword co-occurrence networks is combined with Multiple Correspondence Analysis (MCA) and hierarchical clustering to identify robust thematic clusters and semantic cores. The results reveal six major conceptual areas: smart technologies for land monitoring and degradation control; stakeholder engagement and nature-based solutions aligned with the Sustainable Development Goals (SDGs); tourism’s ecological impacts and mitigation strategies; valuation of ecosystem services amid urban expansion; integration of green infrastructure and urban agriculture for livable cities; and spatial planning responses to rising temperatures and green space loss. These clusters reflect the interdisciplinary nature of SLP and its responsiveness to emerging environmental and governance challenges. The study introduces a set of biblio-ecological indicators that support evidence-based policymaking and strategic planning. By enhancing the robustness of thematic detection, the proposed framework offers a replicable tool for tracking conceptual shifts and guiding future research. It is recommended for use in ecological economics, urban governance, and sustainability science to foster integrated land-use strategies and resilient planning practices