Archivio Istituzionale della Ricerca- Università degli Studi di Foggia
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Papa Francesco e l'educazione. Messaggi di fraternità universale
No full textI saggi che compongono il volume rappresentano un contributo a un attento approfondimento delle suggestioni pastorali di Papa Francesco, per farne ulteriore oggetto di azione educativa e pedagogica
Consequences of the addition of bread making improvers to strong flour-based formulations
No full textBread improvers are used to enhance key attributes of bread quality that, in turn, affect consumer preference and acceptability. They are used to counterbalance the deficiencies of weak soft flours, while the effects of their addition to strength flours are controversial. For this reason, this study investigated the effects of adding gluten (replacing 2% of flour, w/w), lecithin (1% of flour, w/w), xylanase (0.01% of flour, w/w), ascorbic acid (0.02% of flour, w/w), and combinations of lecithin (1% of flour, w/w) with gluten (1% of flour, w/w) or ascorbic acid (0.02% of flour, w/w) on the quality of Manitoba flour breads. Xylanase gave bread with the darkest colour (L* values of 52.5 and 59.3 for crust and crumb, respectively), the highest total phenolic content (TPC, 140.5 mg gallic acid/100 g dm) and quantity of crust (41.4%), as well as the lowest specific volume (1.98 mL/g) and overall sensory quality (6.0). The crumb pores of bread produced with xylanase had a shape closer to a perfect circle than the other types. Ascorbic acid allowed obtaining breads with the highest volume (2.78 mL/g), crumb cohesiveness (8.5), stickiness (1.5), and similar TPC (137.9 mg gallic acid/100 g dm) as the bred with the addition of xylanase. The control breads and those produced with combinations of lecithin and ascorbic acid exhibited the highest antioxidant capacity. The use of improver combinations almost never exerted synergistic effects on bread quality. Only the antioxidant capacity of these breads was higher than that of the samples in which the improvers were used alone. The overall sensory quality was significantly, positively correlated with specific volume, malty and freshly baked bread aroma with correlation coefficients above 0.8. According to the experimental data, the best improvers that can be conveniently added to a strong flour are those that influence the bread structural characteristics (increasing its volume and alveolation). Due to the positive relationship between the overall sensory quality and structural properties, the choice of an improver to be added to a strong flour in baking should fall on those addi- tives that improve variables such as volume and alveolation
Conversion From Venovenous to Venoarterial or Hybrid Extracorporeal Membrane Oxygenation: Analysis From the Extracorporeal Life Support Organization Registry
No full textObjectives: Venovenous extracorporeal membrane oxygenation (ECMO) represents a standard and well-accepted modality of treating patients with refractory respiratory failure. Nevertheless, some patients might develop refractory hypoxemia, hemodynamic compromise or end-organ perfusion requiring a change. This study analyzed characteristics and outcomes of patients requiring a change from venovenous to a different ECMO configuration. Design: Multicenter, retrospective, observational analysis of the Extracorporeal Life Support Organization Registry (2010-2020) in adult patients (≥ 18 yr old) underwent venovenous ECMO as initial cannulation strategy. Setting and patients: Comparison of patients who remained on venovenous ECMO vs. those who underwent configuration conversion and multivariable analysis to assess variables associated with configuration change. Interventions: None. Measurements and main results: Among 28,888 eligible venovenous ECMO runs, 702 (2.4%) received a change from the original configuration, including 399 (56.8%) conversions to venoarterial and 303 (43.2%) to hybrid ECMO configurations. Variables associated with conversion included: pre-ECMO cardiac conditions, bridge to lung transplant as indication, use of milrinone, epinephrine, sildenafil, bicarbonate, and 24-hour Pao2 value. Conversion occurred at a median of 56 hours (interquartile range, 11.5-210 hr) after ECMO initiation, with earlier conversion to hybrid configuration. Increased rates of cardiovascular, hemorrhagic, vascular, renal, metabolic, infective, and circuit-related complications were reported in converted patients. In-hospital mortality was higher in converted patients (60.8%) overall, and highest for venovenous to venoarterial patients (63.2%). Conclusions: The venovenous patients converted to other ECMO configurations were 2.4% and experienced higher complication and mortality rates. Variables associated with conversion highlight the importance of initial configuration selection and should be considered as part of the risk stratification framework when evaluating a patient for individualized ECMO support mode/configuration
Privacy Risks in Connected Vehicles: Profiling Threats and Mitigation Strategies
No full textThe increasing connectivity of modern vehicles enables advanced services but also raises serious privacy concerns. Continuous data collection from sensors and V2X communications can lead to detailed user profiling and potential misuse, such as tracking, discrimination, or identity theft. This work presents a preliminary methodology for analyzing and mitigating privacy risks in connected vehicles. It combines a Privacy Impact Assessment (PIA) with misuse-case-based threat modeling to identify critical scenarios involving unauthorized access, data tampering, and data loss. We propose targeted technical and organizational mitigation strategies, taking into account the real-time and resource constraints of automotive systems. A re-evaluation of the PIA demonstrates a notable reduction in the likelihood and impact of these risks. Our results highlight the value of structured risk assessments and practical safeguards in protecting user privacy. Beyond enhancing privacy posture, the proposed approach supports alignment with increasingly strict European regulations such as the GDPR and the AI Act, promoting the compliant and responsible deployment of connected vehicle technologies
Abitare la città universitaria. Il diritto allo studio per mettere in pratica il diritto alla città
No full textPositioning siponimod and the post-treatment gap: the unmet needs of SPMS patients in Italian real-world practice
No full textBackground: Siponimod, a selective sphingosine-1-phosphate receptor modulator was approved for patients with Secondary progressive Multiple Sclerosis (SPMS) with ongoing disease activity. However, its real-world positioning and management after discontinuation remain challenging.
Objectives: To evaluate the real-world use of siponimod in Italian real world setting, focusing on discontinuation rates, possible predictors, and post-treatment management.
Methods: A retrospective, multicenter study on patients treated with siponimod across six Italian MS centers. Demographics, prior disease modifying therapy (DMTs), reasons for discontinuation, adverse events, and subsequent therapies were collected. Statistical analyses included propensity-adjusted Cox model.
Results: A total cohort of 188 patients (63.8% female, median age 52 years) was enrolled, out of them 76(40.4%) discontinued siponimod, with a median treatment duration of 26 months. The main reason for discontinuation was safety concerns (72.4%), particularly persistent lymphopenia (43.6%) and recurrent infections (27.3%). Disease activity accounted for 27.6% of discontinuations. No significant demographic or clinical predictors of discontinuation were identified. After discontinuation, 49 patients (64%) started a new DMT, most commonly ocrelizumab (n = 22) or cladribine (n = 15), while 25 (32.9%) received no further therapy.
Conclusion: High discontinuation rates, mainly due to safety, and frequent post-treatment gaps highlight the need for improved, individualized management strategies for SPMS after siponimod
La Magna Grecia e la “piccola Italia” di Antonio Galateo
No full textL’articolo analizza la figura dell'umanista pugliese Antonio de Ferrariis Galateo, evidenziando il suo profondo legame con la cultura e la lingua greca. Galateo considerava il Salento, la sua terra d'origine, come un'ultima roccaforte della classicità, un luogo dove la cultura greca era ancora viva e non un semplice reperto archeologico. Attraverso l'analisi di opere come il De situ Iapygiae, emerge la visione di Galateo del Salento come una “piccola Italia” e un baluardo culturale contro la decadenza dei suoi tempi. Galateo propone un ritorno alla sapienza antica, fondata sulla filosofia greca, come rimedio alla crisi politica e culturale che affliggeva l'Italia tra il XV e il XVI secolo
Understanding suicide risk in mild cognitive impairment: a systematic review of suicide epidemiology in older adults
No full textFaster but less accurate: An explorative study on the effects of three weeks of ketogenic diet on cognitive functions in undergraduate students
No full textThe ketogenic diet (KD) is a low-carbohydrate diet that induces and sustains a ketosis state and minimizes somatic glucose levels. Several psychological studies have described the positive effects of ketosis on cognitive functions for a wide range of neuropsychiatric conditions (e.g., Alzheimer’s disease; epilepsy), leading to greater interest in the KD today. However, the psychological and cognitive effects of inducing ketosis via diet remain unclear, especially in healthy people. From an initial pool of thirty participants, eight undergraduate students performed a cognitive assessment before (baseline) and after three weeks (follow-up) of an isocaloric ketogenic diet. Several neuropsychological measures and psychometric tests have been administered to investigate psychological chronotype, sleep quality, eating habits, anxiety and cognitive components of attention, inhibition, and memory. Non-parametric Bayesian analysis showed that the ketogenic diet affected cognitive functions. Participants performed cognitive tests faster at follow-up than at baseline, showing improvements in visual-motor cognitive and processing speed components. However, they were less accurate on working memory tasks, suggesting a decreasing performance of higher cognitive functions. Finally, no differences in anxiety levels were found between baseline and follow-up. The results could have significant implications for identifying specific cognitive models of students based on specific lifestyle habits and nutritional patterns, allowing the implementation of targeted interventions to improve university learning conditions
