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Palabras del Rector, José Manuel Pagán, en el Solemne Acto académico Santo Tomás de Aquino 2024
No full textEl rector propone al santo dominico como referente a los nuevos doctoresActos académico
Causes and risk factors for same‑day discharge failure after total hip and knee arthroplasty: a meta‑analysis
Full text linkAll authors have read and approved of the submission of this manuscript. Study concept and design, J.M.L.-
E, G.M., J.G.-A., M.B. and M.S.-J.; acquisition of data, J.M.L.-E, G.M., J.G.-A., M.B. and M.S.-J; analysis and
interpretation of data, J.M.L.-E, G.M., J.G.-A., M.B. and M.S.-J; Statistical expertise: J.M.L-E., G.M.; preparation
of manuscript, J.M.L.-E, G.M., J.G.-A., M.B. and M.S.-J; and final approval of the manuscript, J.M.L.-E, G.M.,
J.G.-A., M.B. and M.S.-J.In recent decades, the trend toward early same‑day discharge (SDD) after surgery has dramatically
increased. Efforts to develop adequate risk stratification tools to guide decision‑making regarding
SDD versus prolonged hospitalization after total hip arthroplasty (THA) remain largely incomplete.
The purpose of this report is to identify the most frequent causes and risk factors associated with
SDD failure in patients undergoing THA and total knee arthroplasty (TKA). A systematic search
following PRISMA guidelines of four bibliographic databases was conducted for comparative studies
between patients who were successfully discharged on the same day and those who failed. Outcomes
of interests were causes and risk factors associated with same‑day discharge failure. Odds ratios
(OR) were calculated for dichotomous variables, whereas mean differences (MD) were calculated for
continuous variables. Meta‑analysis was performed using RevMan software. Random effects were
used if there was evidence of heterogeneity. Eight studies with 3492 patients were included. The
most common cause of SDD failure was orthostatic hypotension, followed by inadequate physical
condition, nausea/vomiting, pain, and urinary retention. Female sex was a risk factor for failure (OR
0.77, 95% CI 0.63–0.93), especially in the THA subgroup. ASA score IV (OR 0.33, 95% CI 0.14–0.76) and
III (OR 0.72, 95% CI 0.52–0.99) were risk factors, as were having > 2 allergies and smoking patients.
General anesthesia increased failure risk (OR 0.58, 95% CI 0.42–0.80), while spinal anesthesia
was protective (OR 1.62, 95% CI 1.17–2.24). The direct anterior and posterior approaches showed
no significant differences. In conclusion, orthostatic hypotension was the primary cause of SDD
failure. Risk factors identified for SDD failure in orthopedic surgery include female sex, ASA III and
IV classifications, a higher number of allergies, smoking patients and the use of general anesthesia.
These factors can be addressed to enhance SDD outcomes.Medicin
Improved effect of the combination naltrexone/D-penicillamine in the prevention of alcohol relapse-like drinking in rats
No full textOpioid antagonists are licensed drugs for treating alcohol use disorders; nonetheless, clinical studies have evidenced their limited effectiveness. Preclinical findings indicate that opioid receptor (OR) antagonists, such as naltrexone (NTX), reduce the alcohol deprivation effect (ADE). However, a detailed analysis of published data shows the existence of a delayed increase in ethanol consumption after continuous OR blockade, a phenomenon originally called as 'delayed ADE'. We have recently reported that D-penicillamine (DP) is able to prevent ADE through a mechanism dependent on the inactivation of acetaldehyde, the main metabolite of ethanol. Hypothetically, OR activation would be triggered by acetaldehyde after ethanol consumption. Hence, we conjecture that the combination of NTX and DP, due to their distinct but complementary mechanisms to impede OR activation, may be more efficacious in the prevention of the ADE and, specifically, the 'delayed ADE'. Herein, we compare the effects of the combination NTX/DP (NTX: 2×5 mg/kg SC injection daily/DP: SC infusion (0.25 mg/h)) versus NTX on the ADE in long-term ethanol-experienced rats. As expected, NTX-treated animals displayed a delayed ADE. However, NTX/DP treatment prevented this delayed effect. Our present data indicate that this combination therapy shows an adequate anti-relapse preclinical efficacy being able to overcome the preclinical limitations of NTX alone.Medicin
Colorectal polypectomy and endoscopic mucosal resection: European Society of Gastrointestinal Endoscopy (ESGE) Guideline – Update 2024
Full text linkThis Guideline is an official statement of the European
Society of Gastrointestinal Endoscopy (ESGE). The Grading of Recommendations Assessment, Development and
Evaluation (GRADE) system was adopted to define the
strength of recommendations and the quality of evidence.Medicin
Temporal Muscle Thickness Predicts Mortality and Disability in Older Adults Diagnosed with Mild Dementia
Full text linkSarcopenia contributes to increased hospitalizations,
cognitive impairment, falls, and all-cause mortality. Current diagnostic
methods, like body Magnetic Resonance Imaging and dual-energy
X-ray absorptiometry, are costly and impractical. Notably, there is no
standardized approach for assessing sarcopenia in dementia clinics. We
studied the association of temporal muscle thickness (TMT) with key
prognostic factors in people with Alzheimer’s disease (AD) and Lewy
body dementia (DLB).This paper represents independent research supported by the Norwegian
government, through hospital owner Helse Vest (Western Norway Regional Health
Authority). Also, funded by the National Institute for Health Research (NIHR) Biomedical
Research Centre at South London and Maudsley NHS Foundation Trust and King’s
College London. This work was supported by NordForsk through the funding to Nordic-
Japan multidomain interventions for healthy aging and prevention of dementia and
disability, project number 119886. Open access funding provided by University of
Stavanger & Stavanger University Hospital.Medicin
The role of the heading in the assessment continues: finance area
No full textThe interest in this work using rubrics occurs from a process of analysis and reflection of the evaluation criteria to date have been applied within the finance module. Thus, it appears that the assessment criteria not clearly show the degree of learning achieved by the student, not only knowledge but also skills previously defined in that module. The application of these criteria, present result reinforce the evaluation of activities through practical implementation of cooperative learning techniques.Administración y Dirección de Empresa
Simulation of oil spill trajectories using Opendrift: case study on Canary Islands
Full text linkThis study examines the simulation of oil spills in the eastern part of the Canary Islands using a modelling system called OpenOil, integrated into the open-source OpenDrift trajectory framework. These simulations focus on tracking the trajectories and assessing the weathering processes of oil spills under specific wind, wave, and ocean current conditions. We simulated four incidents that occurred in February, April, July, and October of 2023 involving a set of crude oil spilled onto the sea surface. Results showed that oil trajectories and slicks were influenced mainly by wind drift and ocean currents, directing the spilled oil towards Lanzarote and Fuerteventura coastlines in February and October, and toward Marocco and Sahara coastlines in April and July. Oil weathering effects, such as evaporation and water content were also simulated throughout the year. This process gradually increased the water fraction, potentially leading to the formation of tar balls along affected coastlines within the simulated areas. Wind speed emerged as a critical factor, accelerating the evaporation of spilled oil in the warm waters of the Canary Islands Sea. The application of OpenOil in predicting oil spills and weathering processes in the Canary Islands has proven to be a valuable tool, offering insights to enhance planning control measures for potential oil spills. Future simulations could benefit from higher spatial and temporal resolution databases to further improve the accuracy and effectiveness of the results.Este estudio examina la simulación de vertidos de petróleo en la parte oriental de las Islas Canarias utilizando el software de modelado OpenOil, el cual está integrado en el código abierto OpenDrift para la evaluación de vertidos de petróleo. Las simulaciones se orientaron a rastrear las trayectorias y evaluar los procesos de degradación de un posible vertido de petróleo en condiciones específicas. Se simularon cuatro posibles incidentes en febrero, abril, julio y octubre de 2023 a partir de una cantidad potencial de petróleo crudo vertido sobre la superficie del mar. Los resultados mostraron que las trayectorias y las manchas de petróleo estaban influenciadas principalmente por la deriva producida por el viento y por las corrientes oceánicas, dirigiendo el petróleo hacia las costas de Lanzarote y Fuerteventura en febrero y octubre, y hacia las costas de Marruecos y el Sahara en abril y julio. También se simularon a lo largo de las simulaciones los efectos de la degradación del petróleo. Este proceso aumentó gradualmente la fracción de agua, lo que podría conducir a la formación de agregados de alquitrán a lo largo de las costas afectadas dentro de las áreas donde se realizó la simulación. La aplicación de OpenOil en la predicción del comportamiento de los vertidos de petróleo y en los procesos de degradación en las Islas Canarias ha demostrado ser una herramienta valiosa, que ofrece información para mejorar la planificación de diferentes medidas de control ante posibles derrames de petróleo.Ciencias del Ma
Los lugares sagrados (cc. 1205-1243)
No full textEste es el origen de este libro que hoy tienes en tus manos, y que forma parte de un proyecto mucho más amplio dirigido a la elaboración de una monografía sobre toda esta parte del libro IV. Se trata de un proyecto vivo y que no está cerrado, por lo que el contenido de este libro y el que en su día publiqué sobre los sacramentales, las bendiciones, los exorcismos, la liturgia de las horas y las exequias, estarán en revisión y ampliación hasta que se culmine la profundización y estudio sobre todas las materias contenidas en esta parte del libro IV.
Gran parte de este libro es fruto de estudios previos publicados como artículos que exponían el proceso de codificación de los cánones, la exégesis de los mismos, o exponían alguna concreta cuestión de sus contenidos. Algunos de ellos fueron elaborados como fruto de las estancias de investigación en el Centro de Estudios Eclesiásticos anejo a la Iglesia Nacional Española de Santiago y Montserrat. Sirvan estas palabras como agradecimiento a esta institución y a las personas que la dirigieron y me aceptaron en ella, como a las que actualmente están ejerciendo esta tarea.Ayuda del Centro Español de Estudios Eclesiásticos anejo a la Iglesia Nacional Española de Santiago y Montserrat en Roma en el marco de los proyectos de investigación desarrollados por el autor en esta Institución.Derecho canónic
In Vitro Study on the Influence of the Buccal Surface Convexity of the Tooth upon Enamel Loss after Bracket Removal
Full text linkConceptualization, S.P.-S.; methodology, S.P.-S. and A.P.-S. (Antonio Pallarés-
Sabater); validation, S.P.-S., A.P.-S. (Antonio Pallarés-Serrano), A.P.-S. (Alba Pallarés-Serrano) and
A.P.-S. (Antonio Pallarés-Sabater); formal analysis, S.P.-S. and A.P.-S. (Antonio Pallarés-Sabater);
investigation, S.P.-S., A.P.-S. (Alba Pallarés-Serrano), A.P.-S. (Antonio Pallarés-Serrano) and A.P.-S.
(Antonio Pallarés-Sabater). All authors have read and agreed to the published version of the manuscript.Polishing after the removal of brackets is the final step in orthodontic treatment. It is simple
to perform, though some studies have reported that polishing causes damage to the enamel surface.
An in vitro study was made of the influence of the buccal surface convexity of the tooth upon possible
enamel loss when the remaining resin and adhesive are removed after bracket decementing using
two different polishing modes: a tungsten carbide bur at low and high speeds. The convexity of the
buccal surface was quantified in 30 incisors and 30 premolars. A stereoscopic microscope was used to
obtain photographs of the profile of the crown, and Image J software was used to calculate convexity
by dividing the length of a line from the cementoenamel junction to the incisal margin by another
line from the mentioned junction to the maximum convexity of the buccal surface. Brackets were
cemented on all the teeth and were decemented 24 h later. In both groups, the residual composite
was removed with a tungsten carbide bur at a low speed in one-half of the teeth and at a high speed
in the other half. The buccal surface of each tooth was then photographed again, and the convexity
was calculated and compared against the baseline value. The difference between the two values were
taken to represent the enamel loss. The convexity of the premolars was significantly greater than that
of the incisors, but this did not result in greater enamel loss when the same polishing mode was used.
However, the tungsten carbide bur at a high speed proved more aggressive, causing significantly
greater enamel loss than when used at a low speed.Odontologí
Risk of Cardiovascular Events After Influenza: A Population-Based Self-Controlled Case Series Study, Spain, 2011–2018
Full text linkAll authors contributed to the study
conception and design. Material preparation, data collection,
and analysis were performed by M. L. L. and C. M. Q. The first
draft of the manuscript was written by C. M. Q. and M. L. L. and
all authors commented on previous versions of the manuscript.
All authors read and approved the final manuscript.This study explores the relationship between influenza infection, both clinically diagnosed in primary care and laboratory confirmed
in hospital, and atherothrombotic events (acute myocardial infarction and ischemic stroke) in Spain. A population-based self-
controlled case series design was used with individual-level data from electronic registries (n = 2 230 015). The risk of
atherothrombotic events in subjects ≥50 years old increased more than 2-fold during the 14 days after the mildest influenza
cases in patients with fewer risk factors and more than 4-fold after severe cases in the most vulnerable patients, remaining in
them more than 2-fold for 2 months. The transient increase of the association, its gradient after influenza infection, and the
demonstration by 4 different sensitivity analyses provide further evidence supporting causality. This work reinforces the official
recommendations for influenza prevention in at-risk groups and should also increase the awareness of even milder influenza
infection and its possible complications in the general population.This work was supported by Sanofi-
Aventis S.A. through an agreement signed with Fundación
para el Fomento de la Investigación Sanitaria y Biomédica de
la Comunitat Valenciana and the Catholic University of
Valencia San Vicente Mártir.Medicin