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    Digital bridges to social connection: A systematic review and meta-analysis of digital interventions for loneliness and social isolation

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    As loneliness and social isolation emerge as pressing public health concerns, identifying effective interventions is essential. Digital solutions offer flexible, scalable, and cost-effective approaches, yet their effectiveness remains uncertain. This systematic review and meta-analysis assess the impact of randomized controlled trials (RCTs) on digital interventions to reduce loneliness and social isolation. Following PRISMA 2020 guidelines, we searched seven databases and grey literature (2022–) and applied random-effects models to pool effect sizes by intervention type. A total of 40 RCTs involving 6062 participants were included, with one-third focusing on younger individuals. Loneliness was assessed in 36 studies, while eight examined social isolation. Interventions were classified as psychological (k = 25), social (k = 4), activity-based (k = 4), robot-based (k = 4), and social media reduction (k = 5). Psychological interventions—especially those with group or social components—along with group-based activities and robotic pets, were effective in reducing loneliness. In contrast, social contact interventions, self-guided individual activities, and conversational robots showed limited impact. Social media reduction interventions suggested potential benefits, though results were not statistically significant. The evidence base exhibited moderate to high risk of bias, heterogeneity, and limited long-term follow-up. We provide specific recommendations for future interventions and research, including leveraging digital technologies for enhanced personalization, using digital tools for signposting non-digital interventions, systematically comparing digital and non-digital versions of the same intervention, and, most critically, examining the impact of increasingly popular AI-driven and humanlike social chatbots.Digital bridges to social connection: A systematic review and meta-analysis of digital interventions for loneliness and social isolationpublishedVersio

    Benzene exposure and risk of colorectal cancer by anatomical subsite in the Norwegian offshore petroleum workers cohort

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    Objective To investigate the association between low levels of benzene exposure (≤0.879 parts per million [ppm]-years) and risk of colorectal cancer (CRC) including its anatomical subsites. Methods Among 25,347 male workers in the Norwegian Offshore Petroleum Workers (NOPW) cohort with offshore work history (1965–1998), 455 CRC cases were diagnosed 1999–2021. We compared these with a subcohort (n = 2031) drawn from the full cohort. Work histories were linked to a previously developed industry-specific benzene job-exposure matrix (JEM). Cox regression for case-cohort analyses was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for CRC, adjusted for age, body mass index, smoking, alcohol intake, red/processed meat intake, and physical activity. Results Risks of CRC increased with increasing benzene exposure. For all CRC, the HRs (95% CI) for the most exposed [quartile 4] vs. the unexposed were 1.32 (0.96 to 1.81, [0.177–0.879 ppm-years]; p-trend = 0.085) for cumulative, 1.52 (1.11 to 2.07, [17–34 years]; p-trend = 0.032) for duration, and 1.56 (1.15 to 2.12, [0.015–0.046 ppm]; p-trend = 0.005) for average intensity of benzene exposure. For right-sided colon cancer, the association was most evident for exposure duration (HR = 2.25 (1.33 to 3.80), quartile 4 [17–34 years] vs. unexposed; p-trend = 0.007). Sensitivity analyses showed consistent associations. Conclusion This study found positive exposure-response associations between low-level benzene exposure and CRC risk in offshore petroleum workers. These findings add to emerging evidence that benzene can be associated with solid tumours including lung and bladder, which potentially has important occupational and public health implications.Benzene exposure and risk of colorectal cancer by anatomical subsite in the Norwegian offshore petroleum workers cohortpublishedVersio

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