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管理期保健師と中堅期保健師の活動の継承に対する意識 ケアカフェの分析から
Get PDF本研究は管理期と中堅期の保健師活動の継承に対する意識を明らかにすることを目的とした。B保健所管内の市町村・保健所に勤務する管理期と中堅期の保健師を対象とし、ケアカフェのグループ記録と無記名自記式質問紙を質的に分析した。対象は管理期6名、中堅期8名であり、継承に対する意識として、管理期4カテゴリー、中堅期6カテゴリーを生成した。管理期は世代交代の危機感を後輩と共有する必要性を強く感じていた。中堅期は先輩から学んだ地区活動や目に見えにくい協働の技術を継承すべきものと意識し、後輩につないでいこうとしていた。また、管理期と中堅期が考える保健師活動のコアはほぼ一致していたが、管理期が抱く継承の危機感は中堅期と共有されていなかった。継承のための方策として、世代交代の危機感を共有し、保健師活動の技やマインドを世代間で言語化していくことの重要性が示唆された
A Case of Alpha-Fetoprotein-Producing Adenocarcinoma of the Esophagogastric Junction in which Long-Term Survival Was Achieved by Means of Individualized Multidisciplinary Therapy
Get PDFThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/
かぐらおか 第173号
Get PDF教授就任の挨拶 2/ 教授就任の挨拶 3/ 教授就任の挨拶 4/ 教授就任の挨拶 5/ 第65回北海道地区大学体育大会 結果報告 6/ 大学の森みどりの保育園で「ぬいぐるみ病院」を実施 8/ 平成30年度解剖体慰霊式を執り行いました 9/ 学生表彰式 10/ 旭川医科大学基金「感謝の集い」を開催しました 14/ 学生団体代表者との懇談会を実施しました 15/ ギター部&ジャズ研究会合同クリスマスコンサート 16/ 室内合奏団クリスマスコンサート 17/ 合唱部クリスマスコンサート 18/ ブラスアンサンブルクリスマスコンサート 19/ 平成31年度前期授業料免除の申請について 20/ 安否確認システムによる訓練を実施しました 21/ 事故防止について 22/ 大学構内における駐車について 23/ 迷惑行為の防止について 23/ 教員の異動 24/ 今後のスケジュール 24
Alteration of serum thymus and activation-regulated chemokine level during biologic therapy for psoriasis: Possibility as a marker reflecting favorable response to anti-interleukin-17A agents.
Get PDFBiologics show great efficacy in treating psoriasis, a chronic inflammatory skin disease. The high cost and side‐effects of biologics, dose‐reduction, elongation of administration interval and suspension are possible options. However, there has been no reliable biomarker we can use when we consider these moderations in therapy. This study was conducted to test the possibility of using serum thymus and activation‐regulated chemokine (TARC) level as an indicator for step down of biologic therapy. Serum TARC level was measured in 70 psoriatic patients at Asahikawa Medical University, and a correlation of TARC and severity of skin lesions was analyzed. Referring to serum TARC level, psoriatic patients can be divided into two groups. One is a population in which serum TARC level is positively correlated with severity of skin lesions, and the other is a population with low psoriatic severity and high TARC level. Serum TARC level was higher in the group that achieved PASI‐clear with biologics than in the group which did not achieve PASI‐clear. Among biologics, the group treated with secukinumab, an anti‐interleukin (IL)‐17A agent, showed significantly higher TARC level compared with the group treated with anti‐tumor necrosis factor agents. In certain populations achieving PASI‐clear, serum TARC level may be a potent marker reflecting better response to IL‐17A inhibitors, and in this case step down of treatment for psoriasis is possible
減数分裂停止及びSertoli cell-only syndromeに起因する日本人無精子症患者におけるヒトRAD21L遺伝子の解析に関する研究
Get PDFGenetic mechanisms are implicated in some cases of male infertility. Recently, it was demonstrated that male mice lacking the gene for RAD21L exhibited azoospermia caused by meiotic arrest. Mouse RAD21L is a functionally relevant meiotic α-kleisin that is essential for male fertility. Therefore, we hypothesized that RAD21L mutations or polymorphisms may be associated with male infertility, especially azoospermia secondary to meiotic arrest. To determine if RAD21L defects are associated with azoospermia in groups of patients with meiotic arrest, we performed direct sequencing of the RAD21L coding regions in 38 Japanese patients with meiotic arrest and in 200 normal controls. Three coding single-nucleotide polymorphisms (SNP1-SNP3) were detected in the meiotic arrest patient group. Sertoli cell-only syndrome is considered a common cause of non-obstructive azoospermia. For comparison, the RAD21L coding regions in which SNP1-SNP3 were detected were sequenced in 140 patients with Sertoli cell-only syndrome. Statistical analyses were used to compare the two groups of patients with the control group. Genotype and allele frequencies of SNP2 and SNP3 were notably higher in the two patient groups compared with the control group (Bonferroni adjusted p value <0.016). These results suggest a critical role for RAD21L in human spermatogenesis.博士（医学）旭川医科大