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インドシアニングリーンビデオ血管造影における、多パラメーターを用いた定量的血流解析
Get PDFBACKGROUND:
Measurements of quantitative blood flow are crucial during brain vascular surgery. Indocyanine green video angiography (ICG-VAG) is an accepted method of blood flow visualization; however, quantitative techniques have not yet been established. Thus, the aim of this study was to further develop ICG analysis for visualizing intraoperative flow changes.
METHODS:
We conducted basic experiments and clinical investigations to establish a relationship between ICG-VAG and measured blood flow. We evaluated several parameters and identified optimal indicators that precisely reflect blood (or fluid) flow. Both in vitro and in vivo studies were performed to calculate the interval between baseline and the intensity peak (Grad) and to measure actual flow rate.
RESULTS:
Grad and actual flow rate showed good exponential correlation, with R2 values of 0.90 in vitro and 0.82 in vivo. In a representative patient (case 3), we performed intraoperative flow analysis using FlowInsight, which identified a marked elevation in Grad on the brain surface. Because this observation is predictive of brain hyperperfusion, we used these data to carefully manage blood pressure postoperatively.
CONCLUSIONS:
Grad is the optimum parameter for estimating flow conditions. Although ICG-VAG provides only visual profiles of blood circulation in the brain, this procedure has the potential to be widely used in clinical situations. ICG-based flow measurement can be used to identify normal and abnormal blood flow conditions, such as graft flow and vascular pathology. The novelty of this technique is that the fluorescence intensity of Grad enables surgeons to quantitatively measure real blood flow
かぐらおか 第171号
Get PDF平成29年度学位記授与式 学長挨拶 2/ 卒業にあたって 12-16/ 卒業して 17/ 赤いお守り 18/ 卒業にあたって 19-20/ 平成29年度 学位記授与式 21/ 旭川医科大学基金NEWS 23/ サークル紹介の1分間ミニ番組について 24/ 卒業目前!先輩看護師と行う｢看護技術学習会｣を実施 25/ 平成29年度 保健師卒業セミナー開催 26/ 平成29年度 助産師セミナー開催 27/ 卒業生の動向(医学科) 28/ 卒業生の動向(看護学科)29/ 飲酒事故の防止について 30/ 教員の異動 30/ 今後のスケジュール 31/ 第171号表紙 31
Role of the cannabinoid signaling in the brain orexin- and ghrelin-induced visceral antinociception in conscious rats
Get PDFThis is an open access article under the CC BY-NC-ND license(http://creativecommons.org/
licenses/by-nc-nd/4.0/)We hypothesized that the cannabinoid (CB) system may mediate the brain orexin- or ghrelin-induced visceral antinociception. Intraperitoneal injection of either CB1/2 agonist, WIN 55212 or O-Arachidonoyl ethanolamine increased the threshold volume of colonic distension-induced abdominal withdrawal reflex in rats, suggesting CB could induce visceral antinociception. Pretreatment with either the CB1 or CB2 antagonist potently blocked the centrally injected orexin-A-induced antinociceptive action against colonic distension while CB2 but not CB1 antagonist blocked the brain ghrelin-induced visceral antinociception. These results suggest that the cannabinoid signaling may be involved in the central orexin- or ghrelin-induced antinociceptive action in a different mechanistic manner
モバイルデバイスを用いたIntelligent型脊柱側弯症発見装置(i-Scolioroller)の開発と有用性の検討
Get PDF側彎症検診にて最も主要なサインである腰背部隆起を簡便に定量化できる「側彎症発見装置:i-Scolioroller」を開発した。本デバイスを用いて前屈位で腰背部をローリングする単純な操作により、左右の最大傾斜角が得られる。計測の精度、再現性とも良好であった。当科側彎外来受診者:102名において、Cobb角と本デバイス傾斜角のROC曲線解析の結果、Cobb角20度以上を発見するためのcut off値は、7度であった。博士（医学）旭川医科大