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„Ein vertieftes Verständnis der Evolution“ – Forschenden am Karlsruher Institut für Technologie gelingt ein weltweit einzigartiger Durchbruch bei der Editierung von Chromosomen bei Pflanzen - Campus-Report am 06.01.2026
No full textDas Erbgut des Lebendigen lässt sich mit einem Buch vergleichen. Die vier DNA-Basen bilden dabei das Alphabet, mit dem alle Informationen des Textes geschrieben werden. Jeweils drei Buchstaben bilden ein Wort. Mehrere Wörter zusammen ergeben ein Gen, das den Bauplan eines speziellen Proteins beschreibt. Die Gene sind in Kapiteln zusammengefasst. Diese werden in der Molekularbiologie als Chromosomen bezeichnet. Das gesamte Genom eines Organismus schließlich setzt sich aus einer bestimmten Anzahl von Kapiteln oder Genomen zusammen. Mit der 2012 eingeführten revolutionären Methode der sogenannten Genscheren oder CRISPR/Cas gelang es, das Erbgut auf der Ebene einzelner Sätze gezielt zu verändern. Die Zahl der Chromosomen eines Organismus aber und ihre Anordnung, – also um im Bild des Buches zu bleiben -, Zahl und Anordnung der Kapitel galten als nur sehr schwer veränderbar. In einem weltweit einzigartigen wissenschaftlichen Durchbruch gelang es jetzt Forschenden des Karlsruher Institut für Technologie in Zusammenarbeit mit einer Arbeitsgruppe in Tschechien diese Grenze bei der Acker-schmalwand-Pflanze zu überwinden. Ein Erfolg der Grundlagenforschung, der ein vertieftes Verständnis der Evolution erlaubt
Scan2BIM: Automatisierte Detektion von Störobjekten in Wänden in der Punktwolke und Visualisierung mit Hilfe von BIM
No full textStability and dynamics of planar fronts in reaction- diffusion systems under nonlocalized pertubations
No full textWe analyze the stability and dynamics of bistable planar fronts in multicomponent reaction-diffusion systems on . Under standard spectral stability assumptions, we establish Lyapunov stability of the front against fully nonlocalized perturbations. Such perturbations could previously be treated only for scalar equations via comparison principles. We also prove that the leading-order dynamics of the perturbed front are governed by a modulation that tracks the motion of the front interface and evolves according to a viscous Hamilton–Jacobi equation. This effective description reveals that asymptotic orbital stability does not hold in general. However, asymptotic stability can be recovered by imposing localization of perturbations in the transverse spatial directions. The treatment of nonlocalized perturbations on poses significant challenges, both at the linear and nonlinear level. At the linear level, the neutral translational mode gives rise to continuous spectrum which touches the origin and cannot be projected out by conventional means, resulting in merely algebraic decay rates for the residual. Our linear estimates are necessarily -based, yielding significantly weaker decay rates than those available for -localized perturbations. At the nonlinear level, quadratic gradient terms decay at a critical rate and cannot be treated perturbatively. We overcome these challenges by carefully decomposing the linearized dynamics, blending semigroup methods with ideas from the stability analysis of viscous shock waves, and introducing a novel nonlinear tracking scheme that combines spatiotemporal modulation with forcing techniques and the Cole–Hopf transform
SSZ‐13 Zeolite with Isolated Co Sites as an Efficient and Durable Catalyst System for Non‐Oxidative Ethane Dehydrogenation
No full textNon-oxidative dehydrogenation of ethane (EDH) is an attractive method for on-purpose ethene production, but achieving high activity and, especially, durability with catalysts based on earth-abundant metals remains challenging. Herein, we introduce the Co/SSZ-13 system with exclusively divalent cobalt (Co) ions that meets the above requirements. The use of complementary characterization techniques enabled us to reveal two Cu species: Co─Z located in the six-membered-ring windows and [Co(OH)]─Z in the eight-membered-ring windows, with Z representing a charged zeolite framework site. A quantitative correlation between the rate of ethene formation and the site population establishes Co─Z as the active species. In situ X-ray absorption spectroscopy confirms their structural and electronic stability under high-temperature reaction conditions. The optimized 0.9Co/SSZ-13 (0.9Co) catalyst showed highly durable operation over 200 dehydrogenation/oxidative regeneration cycles at 600–650°C lasting for 150 h with industrially relevant productivity. In this regard, it outperforms almost all previously developed catalysts even those with platinum as an active component. The obtained results uncover the atomic-level origins of EDH activity/durability of the Co/SSZ-13 system and highlight the critical role of metal site location in designing highly active, selective, and durable catalysts for on-purpose ethene production
Accessible Augmented Reality in Sheltered Workshops: A Mixed-Methods Evaluation for Users with Mental Disabilities
No full textA prominent application of Augmented Reality (AR) is to provide step-by-step guidance for procedural tasks as it allows information to be displayed in situ by overlaying it directly onto the user’s physical environment. While the potential of AR is well known, the perspectives and requirements of individuals with mental disabilities, who face both cognitive and psychological barriers at work, have yet to be addressed, particularly on Head-Mounted Displays (HMDs). To understand practical limitations of such a system, we conducted a mixed-methods user study with 29 participants, including individuals with mental disabilities, their colleagues, and support professionals. Participants used a commercially available system on an AR HMD to perform a machine setup task. Quantitative results revealed that participants with mental disabilities perceived the system as less usable than those without. Qualitative findings point towards actionable leverage points of improvement such as privacy-aware human support, motivating but lightweight gamification, user-controlled pacing with clear feedback, confidence-building interaction patterns, and clearer task intent of multimodal instructions
