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Replacing preservative E 252 with powdered dried sumac (Rhus coriaria L.) fruits in “Suino Nero dei Nebrodi” salamis: Effects on microbiological, physicochemical, and antioxidant properties
Get PDFThe aim of this study was to develop health-oriented fermented salamis by replacing synthetic preservative (E 252) with dried Sumac (Rhus coriaria) fruit powder (DSFP). The salamis were produced at an industrial scale using meat from the “Suino Nero dei Nebrodi” breed, without adding starter cultures. The experimental design included four different salami productions: CTR, control production without nitrate salt and DSFP; CMC, commercial control production with nitrate salt but without DSFP; EXP1, experimental production without nitrate salt but with DSFP; and EXP2, experimental production with both nitrate salt and DSFP. Plate counts showed that DSFP did not inhibit the growth of lactic acid bacteria (LAB), coagulase-negative staphylococci, and yeasts, all of which reached approximately 7.0 log CFU/g in 45 d ripened salamis. Except for the CTR production, Escherichia coli levels decreased to undetectable amounts at 30 d of ripening. Culture-independent methods identified 16 taxonomic groups, with LAB being the predominant group across all trials, comprising 46.05–81.81 % of relative abundance (RA) in 45 d ripened salamis. Physicochemical analysis indicated that adding DSFP increased antioxidant activity by nearly 30 % and reduced primary lipid oxidation to levels comparable to those achieved with nitrate salt. The addition of DSFP in CMC, EXP1, and EXP2 salamis resulted in an approximate 11 % increase in total terpene aromatic profiles. Sensory evaluation indicated that the addition of DSFP did not impact overall acceptability (p > 0.05). Therefore, incorporating DSFP in fermented meat production offers a viable alternative to the use of synthetic preservatives
Le trasposizioni in fumetto dei romanzi di Sanantonio: Michaël Sanlaville
No full textAntonino Velez, en s’appuyant sur les théories de la multimodalité et de la traduction, analyse l’efficacité de la transposition de deux romans de l’auteur de noirs Frédéric Dard en bande dessinée par le
dessinateur et scénographe M. Sanlaville. Outre la difficulté de reproduire le rythme et le suspense propres au genre, ces oeuvres, qui font partie de la série Sanantonio, présentent des particularités linguistiques difficiles à reproduire, des argotismes aux formes néologiques
THE ROLE OF JAK/STAT INHIBITION IN MODULATING THE INNATE IMMUNE RESPONSE IN PATIENTS WITH RHEUMATOID ARTHRITIS
Get PDFDell'espropriazione mobiliare presso il debitore : Sezione Seconda. Dell'intervento dei creditori : commento agli artt. 525-528 c.p.c.
No full textLo scritto tratta dell'intervento dei creditori nella espropriazione mobiliareAttachment of movables goods of the debtor and joinder of other creditor
A multi-comprehensive approach to assess the responses of the Mediterranean mussel Mytilus galloprovincialis (Lamarck, 1919) to a simulation of a diesel-oil mixture spill
No full textOil spills are a major cause of pollution impacting marine ecosystems. In this work, the effects of short-term exposure to three different concentrations of a hydrocarbon mixture (HC), that simulated the action of such an event, were investigated on Mytilus galloprovincialis specimens. Physiological effects were measured using a battery of biomarkers consisting of cellular activity (phagocytosis), immune-related enzymes, chaperonins (HSP70 and HSC70), and histomorphological alterations. Different concentrations of HC led to a significant decrease in phagocytosis, especially following high concentrations. Immune-related enzymes evaluated in hemolymph and digestive gland extract showed up-regulation, suggesting the activation of antioxidant, detoxicant, and inflammatory responses. Morphological alterations of digestive gland tubules were observed after exposure to the HC. HSP70 and HSC70 activity was up regulated following the treatments, indicating their involvement in maintaining organism homeostasis. In addition, the diversity and composition of hemolymph and digestive gland microbiota exposed to HC were analyzed by automated ribosomal intergenic spacer analysis (ARISA) and a Next Generation Sequencing (NGS) approach to evaluate the connection with hydrocarbon contamination. Metagenomic analysis revealed significant differences in the hemolymph and digestive gland microbiota composition between mussels exposed and unexposed to HC. Exposure to increasing HC concentrations had a positive effect on microbial diversity with clear adaptative responses, and an increase in the relative abundance of several known degrading bacterial genera, including Alcanivorax, Roseovarius, Pseudomonas, Vibrio, Oleibacter. These results show the utility of a multi-comprehensive approach to evaluating functional adaptation in terms of immunological dysfunctions and microbiota alteration in the sentinel organism M. galloprovincialis
A model for slowing particles in random media
No full textWe present a simple model in dimension d ≥ 2 for slowing particles in random media, where point particles move in straight lines among and inside spherical identical obstacles with Poisson distributed centres. When crossing an obstacle, a particle is slowed down according to the law V ̇ = − κ ǫS(|V |)V , where V is the velocity of the point particle, κ is a positive constant, ǫ is the radius of the obstacle and S(|V |) is a given slowing profile. With this choice, the slowing rate in the obstacles is such that the variation of speed at each crossing is of order 1. We study the asymptotic limit of the particle system when ǫ vanishes and the mean free path of the point particles stays finite. We prove the convergence of the point particles density measure to the solution of a kinetic-like equation with a collision term which includes a contribution proportional to a δ function in v = 0; this contribution guarantees the conservation of mass for the limit equation
Event detection via THz generation with flat nonlinear optics [Invited]
Get PDFEvent detection is a key feature in many applications and is often achieved digitally by comparing sequential frames, and detecting changes or patterns that signify an event. While digital systems dominate most applications, optical analog methods are receiving increasing attention in areas requiring speed or operation in challenging conditions. Here we demonstrate how a simple thin film of AlGaAs can be used to realize ultrafast event detection by exploiting the THz signal generated by difference-frequency of optical event
Performance of ultrasound-guided attenuation parameter and 2D shear wave elastography in patients with metabolic dysfunction-associated steatotic liver disease
Get PDFPurpose: To assess the performance and the reproducibility of ultrasound-guided attenuation parameter (UGAP) and two-dimensional shear wave elastography (2D-SWE) in patients with biopsy-proven metabolic dysfunction-associated steatotic liver disease (MASLD).
Methods: This study included consecutive adult patients with MASLD who underwent ultrasound with UGAP, 2D-SWE and percutaneous liver biopsy. The median values of 12 consecutive UGAP measurements were acquired by two independent radiologists (R1 and R2). Hepatic steatosis was graded by liver biopsy as: (0) < 5%; (1) 5-33%; (2) > 33-66%; (3) > 66%. Areas under the curve (AUCs) were calculated to determine the diagnostic performance. Inter- and intra-observer reliability was assessed with intraclass correlation coefficient (ICC).
Results: A hundred patients (median age 55.0 years old) with MASLD were prospectively enrolled. At histopathology, 70 and 42 patients had grade ≥ 2 and 3 steatosis, respectively. Median UGAP was 0.78 dB/cm/MHz (IQR/Med: 5.55%). For the diagnosis of grade ≥ 2 steatosis, the AUCs of UGAP were 0.828 (95% CI: 0.739, 0.896) for R1 and 0.779 (95% CI: 0.685, 0.856) for R2. The inter- and intra-operator reliability of UGAP were excellent, with an ICC of 0.92 (95% CI: 0.87-0.95) and 0.95 (95% CI: 0.92-0.96), respectively. The median liver stiffness was 6.76 kPa (IQR/Med: 16.30%). For the diagnosis of advanced fibrosis, 2D-SWE had an AUC of 0.862 (95% CI: 0.757, 0.934), and the optimal cutoff value was > 6.75 kPa with a sensitivity of 80.6% and a specificity of 75.7%.
Conclusion: UGAP and 2D-SWE provide a good performance for the staging of steatosis and fibrosis in patients with MASLD with an excellent intra-operator reliability of UGAP
Spectral Information Dynamics of Cortical Signals Uncover the Hierarchical Organization of the Human Brain's Motor Network
Get PDFObjective: Understanding brain dynamics during motor tasks is a significant challenge in neuroscience, often limited to studying pairwise interactions. This study provides a comprehensive hierarchical characterization of node-specific, pairwise and higher-order interactions within the human brain's motor network during handgrip task execution. Methods: The brain source activity was reconstructed from scalp EEG signals of ten healthy subjects performing a motor task, identifying five brain regions within the contralateral and ipsilateral motor networks. Using the spectral entropy rate as the basis for the decomposition of dynamic information in the alpha and beta frequency bands, we assessed the predictability of the individual rhythms within each brain region, the information shared between the activity of pairs of regions, and the higher-order interactions among groups of signals from more than two regions. Results: An overall decrease in hierarchical interactions at different orders within the motor network was observed during motor task execution. In addition to an increase in the predictability of single-source dynamics and a decrease in the strength of pairwise interactions, a statistically significant reduction in redundancy between brain sources was found. These changes primarily affected the dynamics of the alpha frequency band, driven by the well-known sensorimotor mu rhythm. Conclusions and Significance: This work emphasizes the importance of examining hierarchically-organized brain source interactions in the frequency domain using a unified framework which fully captures the complex dynamics of the motor network
